STRINGSTRING
ALDH1A2 ALDH1A2 RECK RECK OSR2 OSR2 PAM PAM KRT84 KRT84 SHOX2 SHOX2 KREMEN2 KREMEN2 FBN2 FBN2 KREMEN1 KREMEN1 HNF1A HNF1A TULP3 TULP3 KAT2A KAT2A FERMT2 FERMT2 IFT80 IFT80 CHST11 CHST11 TGFB2 TGFB2 IFT122 IFT122 MED1 MED1 RC3H2 RC3H2 BMPR1A BMPR1A ITGA6 ITGA6 SMOC1 SMOC1 CACNA1C CACNA1C HDAC2 HDAC2 FGF4 FGF4 ZIC3 ZIC3 LRP4 LRP4 B9D1 B9D1 SFRP2 SFRP2 SMAD4 SMAD4 FGFR2 FGFR2 WDR19 WDR19 IFT172 IFT172 HOXA11 HOXA11 H0X6U7_OTOGA H0X6U7_OTOGA PRRX1 PRRX1 GLI3 GLI3 SLC7A11 SLC7A11 PCSK5 PCSK5 MEGF8 MEGF8 SALL4 SALL4 H0X9V6_OTOGA H0X9V6_OTOGA CHD7 CHD7 SKI SKI MAP3K20 MAP3K20 ECE1 ECE1 IHH IHH PLXNA2 PLXNA2 DLX6 DLX6 BMP7 BMP7 TBX2 TBX2 NOTCH2 NOTCH2 BAK1 BAK1 HOXD12 HOXD12 HOXD10 HOXD10 HOXD9 HOXD9 BBS7 BBS7 CTNNB1 CTNNB1 TBX5 TBX5 TBX3 TBX3 PBX2 PBX2 EXT1 EXT1 KAT2B KAT2B CRABP2 CRABP2 MED31 MED31 SOX11 SOX11 BAX BAX FBXW4 FBXW4 H0XHU9_OTOGA H0XHU9_OTOGA SCX SCX LOC100966244 LOC100966244 IMPAD1 IMPAD1 DYNC2H1 DYNC2H1 Shh Shh ALX4 ALX4 ACD ACD WNT7A WNT7A SALL1 SALL1 PITX1 PITX1 ATRX ATRX WNT7B WNT7B FGF8 FGF8 IQCE IQCE EN1 EN1 GDF5 GDF5 RARG RARG ZBTB16 ZBTB16 TMEM107 TMEM107 HOXC11 HOXC11 RSPO2 RSPO2 ZNF219 ZNF219 WDPCP WDPCP NOG NOG HOXC13 HOXC13 RARA RARA FREM2 FREM2 TAF10 TAF10 BCL2L11 BCL2L11 SOX4 SOX4 EVX2 EVX2 SP9 SP9 MBNL1 MBNL1 RSPO4 RSPO4 MEOX2 MEOX2 BMP4 BMP4 IRF6 IRF6 ALX3 ALX3 FGF9 FGF9 H0XZG3_OTOGA H0XZG3_OTOGA DLX5 DLX5 HOXD13 HOXD13 HAND2 HAND2 HOXA10 HOXA10 PITX2 PITX2 SOX9 SOX9 RNF165 RNF165 SLC39A1 SLC39A1 BMPR2 BMPR2 WNT5A WNT5A IFT52 IFT52 TBX4 TBX4 FOXN1 FOXN1 ASPH ASPH GNA12 GNA12 MKS1 MKS1 NIPBL NIPBL WNT3 WNT3 COL3A1 COL3A1 CYP26B1 CYP26B1 INTU INTU HDAC1 HDAC1 PRKAB1 PRKAB1 COL2A1 COL2A1 RPGRIP1L RPGRIP1L CPLANE2 CPLANE2 COMP COMP GRHL2 GRHL2 LEF1 LEF1 DKK1 DKK1 SEMA3C SEMA3C RDH10 RDH10 TP63 TP63 TFAP2A TFAP2A HOXC10 HOXC10 PKDCC PKDCC MYH3 MYH3 PTCH1 PTCH1 OSR1 OSR1 FAM92A FAM92A RAX RAX RARB RARB CREBBP CREBBP FZD6 FZD6 LMBR1 LMBR1 KDF1 KDF1 ITGB4 ITGB4 C2CD3 C2CD3 PIAS4 PIAS4 TBC1D32 TBC1D32 IFT140 IFT140 FGF10 FGF10 TFAP2B TFAP2B FLVCR1 FLVCR1 GREM1 GREM1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (501 aa)
RECKReversion inducing cysteine rich protein with kazal motifs. (971 aa)
OSR2Odd-skipped related transciption factor 2. (312 aa)
PAMPeptidylglycine alpha-amidating monooxygenase. (972 aa)
KRT84Keratin 84; Belongs to the intermediate filament family. (598 aa)
SHOX2Short stature homeobox 2. (328 aa)
KREMEN2Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (461 aa)
FBN2Fibrillin 2. (2799 aa)
KREMEN1Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (492 aa)
HNF1AHNF1 homeobox A. (631 aa)
TULP3Tubby-like protein; Belongs to the TUB family. (414 aa)
KAT2ALysine acetyltransferase 2A. (838 aa)
FERMT2Fermitin family member 2. (680 aa)
IFT80Intraflagellar transport 80. (777 aa)
CHST11Carbohydrate sulfotransferase. (352 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
IFT122Intraflagellar transport 122. (1292 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1584 aa)
RC3H2Ring finger and CCCH-type domains 2. (1190 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (537 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa)
SMOC1SPARC related modular calcium binding 1. (435 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2005 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (422 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
ZIC3Zic family member 3. (467 aa)
LRP4LDL receptor related protein 4. (1898 aa)
B9D1B9 domain containing 1. (200 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
FGFR2Fibroblast growth factor receptor. (822 aa)
WDR19WD repeat domain 19. (1279 aa)
IFT172Intraflagellar transport 172. (1752 aa)
HOXA11Homeobox A11 (Predicted). (314 aa)
H0X6U7_OTOGAUncharacterized protein. (2086 aa)
PRRX1Paired related homeobox 1. (245 aa)
GLI3GLI family zinc finger 3. (1462 aa)
SLC7A11Solute carrier family 7 member 11. (503 aa)
PCSK5Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1734 aa)
MEGF8Multiple EGF like domains 8. (2848 aa)
SALL4Spalt like transcription factor 4. (1019 aa)
H0X9V6_OTOGAUncharacterized protein. (150 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2998 aa)
SKISKI proto-oncogene. (729 aa)
MAP3K20Protein kinase domain-containing protein. (456 aa)
ECE1Endothelin converting enzyme 1. (753 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
PLXNA2Plexin A2. (1894 aa)
DLX6Distal-less homeobox 6. (288 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
TBX2T-box transcription factor 2. (716 aa)
NOTCH2Notch receptor 2. (2432 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
HOXD12Homeobox D12. (240 aa)
HOXD10Homeobox D10. (340 aa)
HOXD9Homeobox D9. (354 aa)
BBS7Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. (715 aa)
CTNNB1Catenin beta 1. (781 aa)
TBX5T-box transcription factor 5. (518 aa)
TBX3T-box transcription factor 3. (745 aa)
PBX2PBX homeobox 2. (430 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (793 aa)
CRABP2Cellular retinoic acid binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (139 aa)
MED31Mediator of RNA polymerase II transcription subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (131 aa)
SOX11Transcription factor SOX. (421 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
FBXW4F-box and WD repeat domain containing 4. (411 aa)
H0XHU9_OTOGAHomeobox A13. (257 aa)
SCXScleraxis bHLH transcription factor. (200 aa)
LOC100966244Uncharacterized protein. (260 aa)
IMPAD1Inositol monophosphatase domain containing 1. (363 aa)
DYNC2H1Dynein cytoplasmic 2 heavy chain 1. (4314 aa)
ShhSonic hedgehog. (249 aa)
ALX4ALX homeobox 4. (407 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (483 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
SALL1Spalt like transcription factor 1. (1318 aa)
PITX1Homeobox protein. (314 aa)
ATRXATRX chromatin remodeler. (2453 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
IQCEIQ motif containing E. (697 aa)
EN1Homeobox protein engrailed-like. (394 aa)
GDF5Growth differentiation factor 5. (498 aa)
RARGRetinoic acid receptor gamma. (458 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
TMEM107Transmembrane protein 107. (140 aa)
HOXC11Homeobox C11. (373 aa)
RSPO2R-spondin 2. (204 aa)
ZNF219Zinc finger protein 219. (716 aa)
WDPCPWD repeat containing planar cell polarity effector. (739 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
HOXC13Homeobox C13. (329 aa)
RARARetinoic acid receptor alpha. (492 aa)
FREM2FRAS1 related extracellular matrix 2. (3163 aa)
TAF10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa)
BCL2L11BCL2 like 11. (200 aa)
SOX4Transcription factor SOX. (476 aa)
EVX2Even-skipped homeobox 2. (472 aa)
SP9Sp9 transcription factor. (482 aa)
MBNL1Muscleblind like splicing regulator 1. (331 aa)
RSPO4R-spondin 4. (202 aa)
MEOX2Mesenchyme homeobox 2. (303 aa)
BMP4Bone morphogenetic protein 4 (Predicted). (409 aa)
IRF6Interferon regulatory factor 6. (544 aa)
ALX3ALX homeobox 3. (343 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
H0XZG3_OTOGAUncharacterized protein. (162 aa)
DLX5Distal-less homeobox 5. (289 aa)
HOXD13Homeobox D13. (333 aa)
HAND2Heart and neural crest derivatives expressed 2. (182 aa)
HOXA10Homeobox A10 isoform a (Predicted). (413 aa)
PITX2Homeobox protein. (317 aa)
SOX9SRY-box transcription factor 9. (568 aa)
RNF165Ring finger protein 165. (347 aa)
SLC39A1Solute carrier family 39 member 1. (324 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
IFT52Intraflagellar transport 52. (436 aa)
TBX4T-box transcription factor 4. (547 aa)
FOXN1Forkhead box N1. (650 aa)
ASPHAspartate beta-hydroxylase. (433 aa)
GNA12G protein subunit alpha 12. (367 aa)
MKS1MKS transition zone complex subunit 1. (559 aa)
NIPBLNipped-B protein. (2806 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
COL3A1Collagen type III alpha 1 chain. (1463 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (513 aa)
INTUInturned planar cell polarity protein. (938 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
COL2A1Collagen type II alpha 1 chain. (1469 aa)
RPGRIP1LRPGRIP1 like. (1103 aa)
CPLANE2Ciliogenesis and planar polarity effector 2. (258 aa)
COMPCartilage oligomeric matrix protein. (756 aa)
GRHL2Grainyhead like transcription factor 2. (627 aa)
LEF1Lymphoid enhancer binding factor 1. (398 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (268 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (746 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (583 aa)
TFAP2ATranscription factor AP-2 alpha. (444 aa)
HOXC10Homeobox C10. (342 aa)
PKDCCProtein kinase domain containing, cytoplasmic. (398 aa)
MYH3Myosin heavy chain 3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1941 aa)
PTCH1Patched 1. (1447 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
FAM92AFamily with sequence similarity 92 member A. (285 aa)
RAXRetina and anterior neural fold homeobox. (344 aa)
RARBRetinoic acid receptor beta. (303 aa)
CREBBPCREB binding protein. (2443 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
LMBR1Limb development membrane protein 1; Belongs to the LIMR family. (390 aa)
KDF1Keratinocyte differentiation factor 1. (394 aa)
ITGB4Integrin beta. (1835 aa)
C2CD3C2 domain containing 3 centriole elongation regulator. (2340 aa)
PIAS4Protein inhibitor of activated STAT 4. (511 aa)
TBC1D32TBC1 domain family member 32. (1299 aa)
IFT140Intraflagellar transport 140. (1462 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
TFAP2BTranscription factor AP-2 beta. (462 aa)
FLVCR1Feline leukemia virus subgroup C cellular receptor 1. (545 aa)
GREM1Gremlin. (184 aa)
Your Current Organism:
Otolemur garnettii
NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago
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