STRINGSTRING
FGF1 FGF1 FGF10 FGF10 FGFBP1 FGFBP1 FGF22 FGF22 FGFR2 FGFR2 FGF7 FGF7 FGFBP3 FGFBP3 FGF3 FGF3 FGF2 FGF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGFBP1Fibroblast growth factor binding protein 1. (235 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (167 aa)
FGFR2Fibroblast growth factor receptor. (822 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
FGFBP3Fibroblast growth factor binding protein 3. (247 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (233 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
Your Current Organism:
Otolemur garnettii
NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago
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