63 items (Otolemur garnettii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100944801	AAA domain-containing protein; Belongs to the AAA ATPase family. (441 aa)
	PSMA3	Proteasome subunit alpha type. (255 aa)
	PSMA7	Proteasome subunit alpha type. (248 aa)
	PSMB2	Proteasome subunit beta. (202 aa)
	PSMD4	Proteasome 26S non-ATPase subunit 4 (Predicted). (427 aa)
	PSMD13	Proteasome 26S subunit, non-ATPase 13. (376 aa)
	PSMB7	Proteasome subunit beta. (277 aa)
	PSMB4	Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
	PSMD8	Proteasome 26S subunit, non-ATPase 8. (351 aa)
	PSMD14	Proteasome 26S subunit, non-ATPase 14. (308 aa)
	PSMB5	Proteasome subunit beta. (263 aa)
	PSMC2	Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (434 aa)
	PSMD10	ANK_REP_REGION domain-containing protein. (223 aa)
	H0WUK3_OTOGA	AAA domain-containing protein; Belongs to the AAA ATPase family. (364 aa)
	PSMC4	Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
	KXD1	KxDL motif containing 1. (123 aa)
	PSMC5	Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
	PSMA6	Proteasome subunit alpha type. (246 aa)
	PSMB3	Proteasome subunit beta. (210 aa)
	PSME3	Proteasome activator subunit 3. (254 aa)
	PSMB6	Proteasome subunit beta. (239 aa)
	PSMD5	Uncharacterized protein. (504 aa)
	PSMC6	Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (389 aa)
	PSME4	Proteasome activator subunit 4. (1840 aa)
	PSMA4	Proteasome subunit alpha type. (261 aa)
	PSMD3	Proteasome 26S subunit, non-ATPase 3. (536 aa)
	PSMA8	Proteasome subunit alpha type. (250 aa)
	PSMB1	Proteasome subunit beta. (235 aa)
	PSMD12	Proteasome 26S subunit, non-ATPase 12. (467 aa)
	PSMA1	Proteasome subunit alpha type. (263 aa)
	PSMD1	26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
	PSMA5	Proteasome subunit alpha type. (241 aa)
	PSMB8	Proteasome subunit beta. (276 aa)
	PSMB9	Proteasome subunit beta. (219 aa)
	PSMF1	Proteasome inhibitor subunit 1. (271 aa)
	PSMD7	MPN domain-containing protein. (324 aa)
	PSMD6	Proteasome 26S subunit, non-ATPase 6. (442 aa)
	PSMD2	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
	H0XCY9_OTOGA	AAA domain-containing protein; Belongs to the AAA ATPase family. (466 aa)
	PSMD11	Proteasome 26S subunit, non-ATPase 11. (430 aa)
	COP1	COP1 E3 ubiquitin ligase. (735 aa)
	PSMB10	Proteasome subunit beta. (273 aa)
	LOC100963968	Uncharacterized protein. (244 aa)
	PSMA2	Proteasome subunit alpha type. (234 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3051 aa)
	H0XI75_OTOGA	JAB_MPN domain-containing protein. (295 aa)
	H0XI83_OTOGA	Ubiquitin-like domain-containing protein. (155 aa)
	UBA52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	H0XJC9_OTOGA	Uncharacterized protein. (287 aa)
	H0XJL7_OTOGA	Uncharacterized protein. (153 aa)
	H0XLK2_OTOGA	Uncharacterized protein. (247 aa)
	H0XRI3_OTOGA	AAA domain-containing protein; Belongs to the AAA ATPase family. (439 aa)
	H0XUE4_OTOGA	Ubiquitin-like domain-containing protein. (155 aa)
	PSMD9	PDZ domain-containing protein. (223 aa)
	H0XUT0_OTOGA	AAA domain-containing protein. (392 aa)
	H0XVD2_OTOGA	ANK_REP_REGION domain-containing protein. (226 aa)
	H0XX44_OTOGA	Ubiquitin-like domain-containing protein. (155 aa)
	H0XX75_OTOGA	PROTEASOME_ALPHA_1 domain-containing protein. (231 aa)
	PSME1	Proteasome activator subunit 1. (249 aa)
	H0XYI8_OTOGA	Proteasome subunit alpha type. (234 aa)
	PSME2	Uncharacterized protein. (239 aa)
	PSMB11	Proteasome subunit beta. (300 aa)

Your Current Organism:

Otolemur garnettii

NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	COP1	ENSOGAP00000015450	ENSOGAP00000013848	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	COP1 E3 ubiquitin ligase.	0.845
ATM	H0XI75_OTOGA	ENSOGAP00000015450	ENSOGAP00000015815	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	JAB_MPN domain-containing protein.	0.465
ATM	H0XJL7_OTOGA	ENSOGAP00000015450	ENSOGAP00000016307	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Uncharacterized protein.	0.682
ATM	PSMD14	ENSOGAP00000015450	ENSOGAP00000004405	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Proteasome 26S subunit, non-ATPase 14.	0.540
ATM	PSMD7	ENSOGAP00000015450	ENSOGAP00000013319	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	MPN domain-containing protein.	0.465
ATM	TP53	ENSOGAP00000015450	ENSOGAP00000015106	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.996
COP1	ATM	ENSOGAP00000013848	ENSOGAP00000015450	COP1 E3 ubiquitin ligase.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.845
COP1	H0WUK3_OTOGA	ENSOGAP00000013848	ENSOGAP00000005920	COP1 E3 ubiquitin ligase.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.487
COP1	H0XI75_OTOGA	ENSOGAP00000013848	ENSOGAP00000015815	COP1 E3 ubiquitin ligase.	JAB_MPN domain-containing protein.	0.488
COP1	H0XI83_OTOGA	ENSOGAP00000013848	ENSOGAP00000015823	COP1 E3 ubiquitin ligase.	Ubiquitin-like domain-containing protein.	0.693
COP1	H0XJL7_OTOGA	ENSOGAP00000013848	ENSOGAP00000016307	COP1 E3 ubiquitin ligase.	Uncharacterized protein.	0.717
COP1	H0XRI3_OTOGA	ENSOGAP00000013848	ENSOGAP00000018725	COP1 E3 ubiquitin ligase.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.487
COP1	H0XUE4_OTOGA	ENSOGAP00000013848	ENSOGAP00000019736	COP1 E3 ubiquitin ligase.	Ubiquitin-like domain-containing protein.	0.693
COP1	H0XVD2_OTOGA	ENSOGAP00000013848	ENSOGAP00000020074	COP1 E3 ubiquitin ligase.	ANK_REP_REGION domain-containing protein.	0.532
COP1	H0XX44_OTOGA	ENSOGAP00000013848	ENSOGAP00000020687	COP1 E3 ubiquitin ligase.	Ubiquitin-like domain-containing protein.	0.693
COP1	LOC100944801	ENSOGAP00000013848	ENSOGAP00000020287	COP1 E3 ubiquitin ligase.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.487
COP1	PSMC2	ENSOGAP00000013848	ENSOGAP00000004622	COP1 E3 ubiquitin ligase.	Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family.	0.604
COP1	PSMC4	ENSOGAP00000013848	ENSOGAP00000006127	COP1 E3 ubiquitin ligase.	Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family.	0.569
COP1	PSMC5	ENSOGAP00000013848	ENSOGAP00000007429	COP1 E3 ubiquitin ligase.	Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family.	0.604
COP1	PSMD10	ENSOGAP00000013848	ENSOGAP00000005736	COP1 E3 ubiquitin ligase.	ANK_REP_REGION domain-containing protein.	0.532