STRINGSTRING
KLF4 KLF4 SPCS2 SPCS2 PLA2G7 PLA2G7 FAP FAP GCG GCG IGF1 IGF1 SPCS3 SPCS3 SPCS1 SPCS1 BCHE BCHE LEP LEP SEC11A SEC11A PCSK1 PCSK1 SEC11C SEC11C GHRL GHRL ACHE ACHE MBOAT4 MBOAT4 INS INS KLF2 KLF2 UCN UCN CRHR2 CRHR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KLF4Kruppel like factor 4. (487 aa)
SPCS2Signal peptidase complex subunit 2. (230 aa)
PLA2G7Platelet-activating factor acetylhydrolase. (442 aa)
FAPFibroblast activation protein alpha; Belongs to the peptidase S9B family. (760 aa)
GCGGlucagon. (180 aa)
IGF1Insulin like growth factor 1. (189 aa)
SPCS3Signal peptidase complex subunit 3. (180 aa)
SPCS1Signal peptidase complex subunit 1. (169 aa)
BCHECarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (601 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
SEC11ASignal peptidase complex catalytic subunit SEC11. (181 aa)
PCSK1Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (754 aa)
SEC11CSignal peptidase complex catalytic subunit SEC11. (192 aa)
GHRLGhrelin and obestatin prepropeptide. (111 aa)
ACHECarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (606 aa)
MBOAT4Membrane bound O-acyltransferase domain containing 4; Belongs to the membrane-bound acyltransferase family. (435 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
KLF2Kruppel like factor 2. (354 aa)
UCNUrocortin. (127 aa)
CRHR2Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family. (411 aa)
Your Current Organism:
Otolemur garnettii
NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago
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