STRINGSTRING
RPGRIP1L RPGRIP1L PSMC2 PSMC2 GLI1 GLI1 EFCAB7 EFCAB7 GAS8 GAS8 ULK3 ULK3 INTU INTU PRKACB PRKACB SPATA5 SPATA5 GSK3B GSK3B ADCY4 ADCY4 PSMD10 PSMD10 SEL1L3 SEL1L3 HHAT HHAT H0WUK3_OTOGA H0WUK3_OTOGA PRKAR1B PRKAR1B IFT88 IFT88 MKS1 MKS1 PRKAR2A PRKAR2A PSMC4 PSMC4 HHIP HHIP GLIS3 GLIS3 TULP2 TULP2 KXD1 KXD1 IFT52 IFT52 PSMC5 PSMC5 PSMA6 PSMA6 VCP VCP PSMB3 PSMB3 H0WZC1_OTOGA H0WZC1_OTOGA CDON CDON TULP3 TULP3 NUMB NUMB PSME3 PSME3 TUBA1A TUBA1A SPATA5L1 SPATA5L1 PSMB6 PSMB6 DISP2 DISP2 PSMD5 PSMD5 SMURF1 SMURF1 PSMC6 PSMC6 IFT122 IFT122 ERLEC1 ERLEC1 PSME4 PSME4 PSMA4 PSMA4 GRK2 GRK2 PSMD3 PSMD3 PSMA8 PSMA8 ADCY7 ADCY7 PSMB1 PSMB1 HHATL HHATL H0X4N7_OTOGA H0X4N7_OTOGA PSMD12 PSMD12 ARRB1 ARRB1 PSMA1 PSMA1 BOC BOC THAP6 THAP6 PRKACA PRKACA CUL3 CUL3 PSMD1 PSMD1 PSMB11 PSMB11 GLI2 GLI2 DHH DHH TULP1 TULP1 PSME2 PSME2 ADCY10 ADCY10 H0XYI8_OTOGA H0XYI8_OTOGA FUZ FUZ PSME1 PSME1 H0XX75_OTOGA H0XX75_OTOGA H0XX44_OTOGA H0XX44_OTOGA LOC100963051 LOC100963051 LOC100944801 LOC100944801 H0XVD2_OTOGA H0XVD2_OTOGA H0XUT0_OTOGA H0XUT0_OTOGA TUBA4A TUBA4A PSMD9 PSMD9 H0XUE4_OTOGA H0XUE4_OTOGA H0XU80_OTOGA H0XU80_OTOGA ENSOGAP00000018960 ENSOGAP00000018960 H0XRI3_OTOGA H0XRI3_OTOGA GNAS GNAS PSMA2 PSMA2 ITCH ITCH DISP1 DISP1 LOC100963968 LOC100963968 TTC21B TTC21B PRKAR1A PRKAR1A PSMB10 PSMB10 KIF3A KIF3A PSMD11 PSMD11 SMURF2 SMURF2 H0XCY9_OTOGA H0XCY9_OTOGA PSMD2 PSMD2 PSMD6 PSMD6 NOTUM NOTUM SPOPL SPOPL PDIA2 PDIA2 PSMD7 PSMD7 CUL1 CUL1 BTRC BTRC PSMF1 PSMF1 ADCY5 ADCY5 OS9 OS9 IHH IHH SCUBE2 SCUBE2 PDCD2 PDCD2 PSMB9 PSMB9 PSMB8 PSMB8 WDR19 WDR19 ADCY6 ADCY6 H0XI83_OTOGA H0XI83_OTOGA SEL1L2 SEL1L2 H0XI75_OTOGA H0XI75_OTOGA GAS1 GAS1 RBX1 RBX1 PSMD8 PSMD8 DZIP1 DZIP1 SMO SMO PSMA5 PSMA5 LOC100947302 LOC100947302 TUBB1 TUBB1 TUB TUB PRKAR2B PRKAR2B LRP2BP LRP2BP SPOP SPOP GLI3 GLI3 IFT172 IFT172 H0XJL7_OTOGA H0XJL7_OTOGA H0XK44_OTOGA H0XK44_OTOGA DYNC2H1 DYNC2H1 ARR3 ARR3 Shh Shh GLIS1 GLIS1 H0XLK2_OTOGA H0XLK2_OTOGA ADCY1 ADCY1 SKP1 SKP1 H0XJC9_OTOGA H0XJC9_OTOGA ARRB2 ARRB2 UBA52 UBA52 TTC21A TTC21A SUFU SUFU PSMD14 PSMD14 SEL1L SEL1L PSMB5 PSMB5 DZIP1L DZIP1L H0XN06_OTOGA H0XN06_OTOGA H0XN74_OTOGA H0XN74_OTOGA SYVN1 SYVN1 TUBB6 TUBB6 IQCE IQCE THAP7 THAP7 CDC73 CDC73 PSMA3 PSMA3 ADAM17 ADAM17 EVC2 EVC2 EVC EVC CNBD2 CNBD2 PTRHD1 PTRHD1 ADCY3 ADCY3 PSMA7 PSMA7 ADCY2 ADCY2 IFT140 IFT140 FOPNL FOPNL ADCY8 ADCY8 DERL2 DERL2 DISP3 DISP3 PSMB2 PSMB2 ADCY9 ADCY9 P4HB P4HB IFT57 IFT57 PSMD4 PSMD4 OFD1 OFD1 WDR35 WDR35 PTCH1 PTCH1 GPR161 GPR161 NUMBL NUMBL PSMD13 PSMD13 H0WME2_OTOGA H0WME2_OTOGA PSMB7 PSMB7 DELE1 DELE1 PSMB4 PSMB4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPGRIP1LRPGRIP1 like. (1103 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (434 aa)
GLI1GLI family zinc finger 1. (1108 aa)
EFCAB7EF-hand calcium binding domain 7. (629 aa)
GAS8Growth arrest specific 8. (478 aa)
ULK3Unc-51 like kinase 3; Belongs to the protein kinase superfamily. (473 aa)
INTUInturned planar cell polarity protein. (938 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (396 aa)
SPATA5Spermatogenesis associated 5. (832 aa)
GSK3BGlycogen synthase kinase 3 beta. (387 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
PSMD10ANK_REP_REGION domain-containing protein. (223 aa)
SEL1L3SEL1L family member 3. (1133 aa)
HHATHedgehog acyltransferase; Belongs to the membrane-bound acyltransferase family. (492 aa)
H0WUK3_OTOGAAAA domain-containing protein; Belongs to the AAA ATPase family. (364 aa)
PRKAR1BProtein kinase cAMP-dependent type I regulatory subunit beta. (381 aa)
IFT88Intraflagellar transport 88. (827 aa)
MKS1MKS transition zone complex subunit 1. (559 aa)
PRKAR2AProtein kinase cAMP-dependent type II regulatory subunit alpha. (396 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
HHIPHedgehog interacting protein. (700 aa)
GLIS3GLIS family zinc finger 3. (931 aa)
TULP2TUB like protein 2; Belongs to the TUB family. (494 aa)
KXD1KxDL motif containing 1. (123 aa)
IFT52Intraflagellar transport 52. (436 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (804 aa)
PSMB3Proteasome subunit beta. (210 aa)
H0WZC1_OTOGAPDCD2_C domain-containing protein. (358 aa)
CDONCell adhesion associated, oncogene regulated. (1247 aa)
TULP3Tubby-like protein; Belongs to the TUB family. (414 aa)
NUMBNUMB endocytic adaptor protein. (615 aa)
PSME3Proteasome activator subunit 3. (254 aa)
TUBA1ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
SPATA5L1Spermatogenesis associated 5 like 1. (754 aa)
PSMB6Proteasome subunit beta. (239 aa)
DISP2Dispatched RND transporter family member 2. (1397 aa)
PSMD5Uncharacterized protein. (504 aa)
SMURF1E3 ubiquitin-protein ligase. (757 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (389 aa)
IFT122Intraflagellar transport 122. (1292 aa)
ERLEC1Endoplasmic reticulum lectin 1. (485 aa)
PSME4Proteasome activator subunit 4. (1840 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (686 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (536 aa)
PSMA8Proteasome subunit alpha type. (250 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1113 aa)
PSMB1Proteasome subunit beta. (235 aa)
HHATLHedgehog acyltransferase like; Belongs to the membrane-bound acyltransferase family. (504 aa)
H0X4N7_OTOGAUncharacterized protein. (712 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (467 aa)
ARRB1Arrestin beta 1. (418 aa)
PSMA1Proteasome subunit alpha type. (263 aa)
BOCBOC cell adhesion associated, oncogene regulated. (974 aa)
THAP6THAP domain containing 6. (222 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
CUL3Cullin 3; Belongs to the cullin family. (746 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
PSMB11Proteasome subunit beta. (300 aa)
GLI2GLI family zinc finger 2. (1522 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (397 aa)
TULP1Tubby-like protein; Belongs to the TUB family. (545 aa)
PSME2Uncharacterized protein. (239 aa)
ADCY10Adenylate cyclase 10. (1608 aa)
H0XYI8_OTOGAProteasome subunit alpha type. (234 aa)
FUZFuzzy planar cell polarity protein. (447 aa)
PSME1Proteasome activator subunit 1. (249 aa)
H0XX75_OTOGAPROTEASOME_ALPHA_1 domain-containing protein. (231 aa)
H0XX44_OTOGAUbiquitin-like domain-containing protein. (155 aa)
LOC100963051Protein kinase domain-containing protein. (327 aa)
LOC100944801AAA domain-containing protein; Belongs to the AAA ATPase family. (441 aa)
H0XVD2_OTOGAANK_REP_REGION domain-containing protein. (226 aa)
H0XUT0_OTOGAAAA domain-containing protein. (392 aa)
TUBA4ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
PSMD9PDZ domain-containing protein. (223 aa)
H0XUE4_OTOGAUbiquitin-like domain-containing protein. (155 aa)
H0XU80_OTOGATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (452 aa)
ENSOGAP00000018960annotation not available (189 aa)
H0XRI3_OTOGAAAA domain-containing protein; Belongs to the AAA ATPase family. (439 aa)
GNASGNAS complex locus. (1146 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
ITCHE3 ubiquitin-protein ligase. (853 aa)
DISP1Dispatched RND transporter family member 1. (1518 aa)
LOC100963968Uncharacterized protein. (244 aa)
TTC21BTetratricopeptide repeat domain 21B. (1313 aa)
PRKAR1AProtein kinase cAMP-dependent type I regulatory subunit alpha. (381 aa)
PSMB10Proteasome subunit beta. (273 aa)
KIF3AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (696 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (430 aa)
SMURF2E3 ubiquitin-protein ligase. (732 aa)
H0XCY9_OTOGAAAA domain-containing protein; Belongs to the AAA ATPase family. (466 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (442 aa)
NOTUMNotum, palmitoleoyl-protein carboxylesterase. (498 aa)
SPOPLSpeckle type BTB/POZ protein like. (374 aa)
PDIA2Protein disulfide isomerase family A member 2. (460 aa)
PSMD7MPN domain-containing protein. (324 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (526 aa)
PSMF1Proteasome inhibitor subunit 1. (271 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1230 aa)
OS9OS9 endoplasmic reticulum lectin. (656 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
SCUBE2Signal peptide, CUB domain and EGF like domain containing 2. (984 aa)
PDCD2Programmed cell death 2. (344 aa)
PSMB9Proteasome subunit beta. (219 aa)
PSMB8Proteasome subunit beta. (276 aa)
WDR19WD repeat domain 19. (1279 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1167 aa)
H0XI83_OTOGAUbiquitin-like domain-containing protein. (155 aa)
SEL1L2SEL1L2 adaptor subunit of ERAD E3 ligase. (592 aa)
H0XI75_OTOGAJAB_MPN domain-containing protein. (295 aa)
GAS1Growth arrest specific 1. (339 aa)
RBX1Ring-box 1. (108 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (351 aa)
DZIP1DAZ interacting zinc finger protein 1. (854 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
LOC100947302Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
TUBB1Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (453 aa)
TUBTubby-like protein; Belongs to the TUB family. (506 aa)
PRKAR2BProtein kinase cAMP-dependent type II regulatory subunit beta. (419 aa)
LRP2BPLRP2 binding protein. (349 aa)
SPOPSpeckle type BTB/POZ protein. (374 aa)
GLI3GLI family zinc finger 3. (1462 aa)
IFT172Intraflagellar transport 172. (1752 aa)
H0XJL7_OTOGAUncharacterized protein. (153 aa)
H0XK44_OTOGAGuanylate cyclase domain-containing protein. (1490 aa)
DYNC2H1Dynein cytoplasmic 2 heavy chain 1. (4314 aa)
ARR3Arrestin 3. (393 aa)
ShhSonic hedgehog. (249 aa)
GLIS1GLIS family zinc finger 1. (624 aa)
H0XLK2_OTOGAUncharacterized protein. (247 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (163 aa)
H0XJC9_OTOGAUncharacterized protein. (287 aa)
ARRB2Arrestin beta 2. (409 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
TTC21ATetratricopeptide repeat domain 21A. (1321 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (485 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (308 aa)
SEL1LSEL1L adaptor subunit of ERAD E3 ubiquitin ligase. (797 aa)
PSMB5Proteasome subunit beta. (263 aa)
DZIP1LDAZ interacting zinc finger protein 1 like. (769 aa)
H0XN06_OTOGAProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (364 aa)
H0XN74_OTOGATubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
SYVN1Synoviolin 1. (611 aa)
TUBB6Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (445 aa)
IQCEIQ motif containing E. (697 aa)
THAP7THAP domain containing 7. (304 aa)
CDC73Cell division cycle 73. (531 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
ADAM17ADAM metallopeptidase domain 17. (828 aa)
EVC2EvC ciliary complex subunit 2. (1197 aa)
EVCEvC ciliary complex subunit 1. (993 aa)
CNBD2Cyclic nucleotide binding domain containing 2. (582 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
PSMA7Proteasome subunit alpha type. (248 aa)
ADCY2Adenylate cyclase 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (880 aa)
IFT140Intraflagellar transport 140. (1462 aa)
FOPNLFGFR1OP N-terminal like. (174 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1120 aa)
DERL2Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (239 aa)
DISP3Dispatched RND transporter family member 3. (1393 aa)
PSMB2Proteasome subunit beta. (202 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
P4HBProtein disulfide-isomerase. (510 aa)
IFT57Intraflagellar transport 57. (429 aa)
PSMD4Proteasome 26S non-ATPase subunit 4 (Predicted). (427 aa)
OFD1OFD1 centriole and centriolar satellite protein. (1006 aa)
WDR35WD repeat-containing protein 35; As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking. (1180 aa)
PTCH1Patched 1. (1447 aa)
GPR161G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family. (546 aa)
NUMBLNUMB like endocytic adaptor protein. (600 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (376 aa)
H0WME2_OTOGAProtein kinase domain-containing protein. (236 aa)
PSMB7Proteasome subunit beta. (277 aa)
DELE1DAP3 binding cell death enhancer 1. (518 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
Your Current Organism:
Otolemur garnettii
NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago
Server load: low (18%) [HD]