33 items (Otolemur garnettii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (599 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (508 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	GAB1	GRB2 associated binding protein 1. (695 aa)
	FGF17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	FGF23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (252 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	FGF20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	FGF22	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (167 aa)
	ERAS	ES cell expressed Ras. (229 aa)
	FGF16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	FGF5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (269 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
	CSDE1	Cold shock domain containing E1. (813 aa)
	FGFR2	Fibroblast growth factor receptor. (822 aa)
	FRS3	Fibroblast growth factor receptor substrate 3 (Predicted). (490 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	KRAS	KRAS proto-oncogene, GTPase. (243 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (549 aa)
	H0XJC1_OTOGA	PID domain-containing protein. (486 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	FGF3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (233 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	SHC1	Uncharacterized protein. (577 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)

Your Current Organism:

Otolemur garnettii

NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSDE1	ERAS	ENSOGAP00000010855	ENSOGAP00000007333	Cold shock domain containing E1.	ES cell expressed Ras.	0.431
CSDE1	FGF1	ENSOGAP00000010855	ENSOGAP00000004540	Cold shock domain containing E1.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.481
CSDE1	FGF10	ENSOGAP00000010855	ENSOGAP00000001025	Cold shock domain containing E1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.443
CSDE1	FGF16	ENSOGAP00000010855	ENSOGAP00000008668	Cold shock domain containing E1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.457
CSDE1	FGF17	ENSOGAP00000010855	ENSOGAP00000004359	Cold shock domain containing E1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.472
CSDE1	FGF18	ENSOGAP00000010855	ENSOGAP00000012201	Cold shock domain containing E1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.605
CSDE1	FGF2	ENSOGAP00000010855	ENSOGAP00000021960	Cold shock domain containing E1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.458
CSDE1	FGF20	ENSOGAP00000010855	ENSOGAP00000004883	Cold shock domain containing E1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.457
CSDE1	FGF22	ENSOGAP00000010855	ENSOGAP00000007086	Cold shock domain containing E1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.443
CSDE1	FGF23	ENSOGAP00000010855	ENSOGAP00000004657	Cold shock domain containing E1.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.535
CSDE1	FGF3	ENSOGAP00000010855	ENSOGAP00000018677	Cold shock domain containing E1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.552
CSDE1	FGF4	ENSOGAP00000010855	ENSOGAP00000010297	Cold shock domain containing E1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.562
CSDE1	FGF5	ENSOGAP00000010855	ENSOGAP00000010066	Cold shock domain containing E1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.465
CSDE1	FGF6	ENSOGAP00000010855	ENSOGAP00000004659	Cold shock domain containing E1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.459
CSDE1	FGF7	ENSOGAP00000010855	ENSOGAP00000011911	Cold shock domain containing E1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.485
CSDE1	FGF8	ENSOGAP00000010855	ENSOGAP00000017738	Cold shock domain containing E1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.502
CSDE1	FGF9	ENSOGAP00000010855	ENSOGAP00000021485	Cold shock domain containing E1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.457
CSDE1	FGFR2	ENSOGAP00000010855	ENSOGAP00000010920	Cold shock domain containing E1.	Fibroblast growth factor receptor.	0.774
CSDE1	FRS2	ENSOGAP00000010855	ENSOGAP00000002060	Cold shock domain containing E1.	Fibroblast growth factor receptor substrate 2.	0.523
CSDE1	FRS3	ENSOGAP00000010855	ENSOGAP00000011680	Cold shock domain containing E1.	Fibroblast growth factor receptor substrate 3 (Predicted).	0.514