STRINGSTRING
PTPN11 PTPN11 FGF10 FGF10 FRS2 FRS2 ANOS1 ANOS1 PPP2CB PPP2CB GRB2 GRB2 SPRY2 SPRY2 FGF17 FGF17 FGF1 FGF1 FGF23 FGF23 FGF6 FGF6 FGF20 FGF20 KL KL CBL CBL FNDC3B FNDC3B FGF22 FGF22 MKNK2 MKNK2 MAPK1 MAPK1 FNDC3A FNDC3A BRAF BRAF PPP2CA PPP2CA FGF5 FGF5 FGF4 FGF4 PPP2R1A PPP2R1A MKNK1 MKNK1 FGFR1 FGFR1 SRC SRC H0XI83_OTOGA H0XI83_OTOGA UBA52 UBA52 FGF8 FGF8 H0XQW2_OTOGA H0XQW2_OTOGA FGF3 FGF3 MAPK3 MAPK3 H0XUE4_OTOGA H0XUE4_OTOGA H0XX44_OTOGA H0XX44_OTOGA FGF9 FGF9 FGF2 FGF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (599 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
ANOS1Anosmin 1. (596 aa)
PPP2CBSerine/threonine-protein phosphatase. (308 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (252 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
KLKlotho. (1016 aa)
CBLCbl proto-oncogene. (905 aa)
FNDC3BFibronectin type III domain containing 3B. (1142 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (167 aa)
MKNK2MAPK interacting serine/threonine kinase 2; Belongs to the protein kinase superfamily. (468 aa)
MAPK1Mitogen-activated protein kinase. (323 aa)
FNDC3AFibronectin type III domain containing 3A. (1149 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (740 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (269 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (591 aa)
MKNK1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (415 aa)
FGFR1Fibroblast growth factor receptor. (792 aa)
SRCTyrosine-protein kinase. (542 aa)
H0XI83_OTOGAUbiquitin-like domain-containing protein. (155 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
H0XQW2_OTOGAUncharacterized protein. (1372 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (233 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (336 aa)
H0XUE4_OTOGAUbiquitin-like domain-containing protein. (155 aa)
H0XX44_OTOGAUbiquitin-like domain-containing protein. (155 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
Your Current Organism:
Otolemur garnettii
NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago
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