STRINGSTRING
MCM8 MCM8 TK1 TK1 ORC2 ORC2 PSMD1 PSMD1 PSMA1 PSMA1 WEE1 WEE1 CCND1 CCND1 PSMD12 PSMD12 FNBP4 FNBP4 PSMB1 PSMB1 PSMD3 PSMD3 PSMD4 PSMD4 LIN54 LIN54 PPP2CB PPP2CB H0WK58_OTOGA H0WK58_OTOGA PSMB2 PSMB2 CDK3 CDK3 H0WHP7_OTOGA H0WHP7_OTOGA PSMA7 PSMA7 ORC6 ORC6 CDKN1A CDKN1A PSMA3 PSMA3 MCM4 MCM4 TFDP2 TFDP2 E2F4 E2F4 CDK7 CDK7 H0XJL1_OTOGA H0XJL1_OTOGA SKP1 SKP1 H0XJC9_OTOGA H0XJC9_OTOGA RPA3 RPA3 UBA52 UBA52 PPP2R3B PPP2R3B H0XI83_OTOGA H0XI83_OTOGA H0XI75_OTOGA H0XI75_OTOGA MCM7 MCM7 PSMA2 PSMA2 LOC100963968 LOC100963968 AKT3 AKT3 ORC3 ORC3 CCNA2 CCNA2 H0XJL7_OTOGA H0XJL7_OTOGA LOC100944047 LOC100944047 CDT1 CDT1 H0XLK2_OTOGA H0XLK2_OTOGA PCNA PCNA CDC7 CDC7 RPA1 RPA1 POLE3 POLE3 H0XNJ8_OTOGA H0XNJ8_OTOGA MAX MAX WEE2 WEE2 AKT1 AKT1 H0XPR2_OTOGA H0XPR2_OTOGA H0XQC2_OTOGA H0XQC2_OTOGA H0XRI3_OTOGA H0XRI3_OTOGA PSMA4 PSMA4 H0XRL0_OTOGA H0XRL0_OTOGA H0XS38_OTOGA H0XS38_OTOGA E2F1 E2F1 H0XTC3_OTOGA H0XTC3_OTOGA H0XTS9_OTOGA H0XTS9_OTOGA CCNE2 CCNE2 H0XU64_OTOGA H0XU64_OTOGA H0XUE4_OTOGA H0XUE4_OTOGA PSMD9 PSMD9 H0XUP0_OTOGA H0XUP0_OTOGA H0XUT0_OTOGA H0XUT0_OTOGA CKS2 CKS2 LOC100943441 LOC100943441 H0XVD2_OTOGA H0XVD2_OTOGA CCNH CCNH CCNA1 CCNA1 MCM2 MCM2 PSMC6 PSMC6 CDK1 CDK1 PSMD5 PSMD5 PPP2CA PPP2CA PSMB6 PSMB6 LOC100948041 LOC100948041 PSME3 PSME3 PSMB3 PSMB3 MCM6 MCM6 CDC6 CDC6 H0WYM5_OTOGA H0WYM5_OTOGA ORC5 ORC5 PSMA6 PSMA6 PPP2R3C PPP2R3C PSMC5 PSMC5 CABLES1 CABLES1 KXD1 KXD1 RB1 RB1 H0WW89_OTOGA H0WW89_OTOGA LIN9 LIN9 SKP2 SKP2 RRM2 RRM2 CDK2 CDK2 PSMC4 PSMC4 PPP2R3A PPP2R3A POLE POLE H0WUK3_OTOGA H0WUK3_OTOGA FBXO5 FBXO5 PSMD10 PSMD10 CKS1B CKS1B H0XVG4_OTOGA H0XVG4_OTOGA LOC100944801 LOC100944801 H0XX44_OTOGA H0XX44_OTOGA RELCH RELCH H0XWX5_OTOGA H0XWX5_OTOGA H0XX75_OTOGA H0XX75_OTOGA PSME1 PSME1 CDC45 CDC45 H0XYI8_OTOGA H0XYI8_OTOGA H0XYJ3_OTOGA H0XYJ3_OTOGA TYMS TYMS H0XZ50_OTOGA H0XZ50_OTOGA H0XZ85_OTOGA H0XZ85_OTOGA PSME2 PSME2 H0Y0Y6_OTOGA H0Y0Y6_OTOGA MNAT1 MNAT1 POLE4 POLE4 RPA2 RPA2 PSMB10 PSMB10 MCM3 MCM3 MCM5 MCM5 PSMD11 PSMD11 ORC1 ORC1 H0XCY9_OTOGA H0XCY9_OTOGA PSMD2 PSMD2 PSMD6 PSMD6 PSMD7 PSMD7 PPP4R1 PPP4R1 CUL1 CUL1 POLA2 POLA2 PSMF1 PSMF1 RBL2 RBL2 CDK4 CDK4 POLA1 POLA1 RBL1 RBL1 AKT2 AKT2 PSMB9 PSMB9 PSMB8 PSMB8 E2F6 E2F6 PSMA5 PSMA5 PPP2R1A PPP2R1A POLE2 POLE2 E2F5 E2F5 PPP2R1B PPP2R1B CCNE1 CCNE1 PPP4R4 PPP4R4 HDAC1 HDAC1 DBF4 DBF4 H0WSK8_OTOGA H0WSK8_OTOGA MYC MYC PSMC2 PSMC2 PSMB5 PSMB5 MCM9 MCM9 LOC100960730 LOC100960730 PSMD14 PSMD14 LIN37 LIN37 PSMD8 PSMD8 PSMB4 PSMB4 ORC4 ORC4 CDKN1B CDKN1B TFDP1 TFDP1 PSMB7 PSMB7 PSMD13 PSMD13 LIN52 LIN52 CDC25A CDC25A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MCM8MCM domain-containing protein; Belongs to the MCM family. (832 aa)
TK1Thymidine kinase. (236 aa)
ORC2Origin recognition complex subunit 2. (580 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
PSMA1Proteasome subunit alpha type. (263 aa)
WEE1Wee1-like protein kinase. (643 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (467 aa)
FNBP4Formin binding protein 4. (1030 aa)
PSMB1Proteasome subunit beta. (235 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (536 aa)
PSMD4Proteasome 26S non-ATPase subunit 4 (Predicted). (427 aa)
LIN54Lin-54 DREAM MuvB core complex component. (751 aa)
PPP2CBSerine/threonine-protein phosphatase. (308 aa)
H0WK58_OTOGACyclin N-terminal domain-containing protein; Belongs to the cyclin family. (427 aa)
PSMB2Proteasome subunit beta. (202 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa)
H0WHP7_OTOGAUncharacterized protein. (122 aa)
PSMA7Proteasome subunit alpha type. (248 aa)
ORC6Origin recognition complex subunit 6. (252 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (193 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
MCM4DNA helicase; Belongs to the MCM family. (867 aa)
TFDP2Transcription factor. (426 aa)
E2F4E2F transcription factor 4. (403 aa)
CDK7Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa)
H0XJL1_OTOGAUncharacterized protein; Belongs to the cyclin family. (367 aa)
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (163 aa)
H0XJC9_OTOGAUncharacterized protein. (287 aa)
RPA3Uncharacterized protein. (121 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
PPP2R3BProtein phosphatase 2 regulatory subunit B''beta. (470 aa)
H0XI83_OTOGAUbiquitin-like domain-containing protein. (155 aa)
H0XI75_OTOGAJAB_MPN domain-containing protein. (295 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
LOC100963968Uncharacterized protein. (244 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ORC3Origin recognition complex subunit 3. (672 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
H0XJL7_OTOGAUncharacterized protein. (153 aa)
LOC100944047Uncharacterized protein; Belongs to the cyclin family. (427 aa)
CDT1Chromatin licensing and DNA replication factor 1. (552 aa)
H0XLK2_OTOGAUncharacterized protein. (247 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
CDC7Cell division cycle 7. (576 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (642 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (147 aa)
H0XNJ8_OTOGAUncharacterized protein. (473 aa)
MAXMYC associated factor X. (166 aa)
WEE2Wee1-like protein kinase. (567 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
H0XPR2_OTOGADIRP domain-containing protein. (496 aa)
H0XQC2_OTOGAUncharacterized protein; Belongs to the cyclin family. (426 aa)
H0XRI3_OTOGAAAA domain-containing protein; Belongs to the AAA ATPase family. (439 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
H0XRL0_OTOGAUncharacterized protein. (211 aa)
H0XS38_OTOGAF-box domain-containing protein. (410 aa)
E2F1E2F transcription factor 1. (385 aa)
H0XTC3_OTOGADIRP domain-containing protein. (496 aa)
H0XTS9_OTOGAUncharacterized protein. (147 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (321 aa)
H0XU64_OTOGABHLH domain-containing protein. (146 aa)
H0XUE4_OTOGAUbiquitin-like domain-containing protein. (155 aa)
PSMD9PDZ domain-containing protein. (223 aa)
H0XUP0_OTOGAUncharacterized protein. (178 aa)
H0XUT0_OTOGAAAA domain-containing protein. (392 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
LOC100943441Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa)
H0XVD2_OTOGAANK_REP_REGION domain-containing protein. (226 aa)
CCNHCyclin H; Belongs to the cyclin family. (323 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (426 aa)
MCM2DNA helicase; Belongs to the MCM family. (903 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (389 aa)
CDK1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa)
PSMD5Uncharacterized protein. (504 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
PSMB6Proteasome subunit beta. (239 aa)
LOC100948041Mcm10 domain-containing protein. (873 aa)
PSME3Proteasome activator subunit 3. (254 aa)
PSMB3Proteasome subunit beta. (210 aa)
MCM6DNA helicase; Belongs to the MCM family. (822 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (554 aa)
H0WYM5_OTOGAUncharacterized protein. (549 aa)
ORC5Origin recognition complex subunit 5. (435 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
PPP2R3CProtein phosphatase 2 regulatory subunit B''gamma. (453 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
CABLES1Cdk5 and Abl enzyme substrate 1. (562 aa)
KXD1KxDL motif containing 1. (123 aa)
RB1RB transcriptional corepressor 1. (929 aa)
H0WW89_OTOGAUncharacterized protein. (615 aa)
LIN9Lin-9 DREAM MuvB core complex component. (548 aa)
SKP2F-box domain-containing protein. (424 aa)
RRM2Ribonucleotide reductase regulatory subunit M2. (388 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1151 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2284 aa)
H0WUK3_OTOGAAAA domain-containing protein; Belongs to the AAA ATPase family. (364 aa)
FBXO5F-box protein 5. (450 aa)
PSMD10ANK_REP_REGION domain-containing protein. (223 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (78 aa)
H0XVG4_OTOGAUncharacterized protein. (174 aa)
LOC100944801AAA domain-containing protein; Belongs to the AAA ATPase family. (441 aa)
H0XX44_OTOGAUbiquitin-like domain-containing protein. (155 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1216 aa)
H0XWX5_OTOGAWee1-like protein kinase. (561 aa)
H0XX75_OTOGAPROTEASOME_ALPHA_1 domain-containing protein. (231 aa)
PSME1Proteasome activator subunit 1. (249 aa)
CDC45Cell division cycle 45. (616 aa)
H0XYI8_OTOGAProteasome subunit alpha type. (234 aa)
H0XYJ3_OTOGAUncharacterized protein. (180 aa)
TYMSThymidylate synthetase. (313 aa)
H0XZ50_OTOGAUncharacterized protein; Belongs to the cyclin family. (375 aa)
H0XZ85_OTOGACyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (78 aa)
PSME2Uncharacterized protein. (239 aa)
H0Y0Y6_OTOGAE2F_TDP domain-containing protein. (278 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (285 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (117 aa)
RPA2Replication protein A2. (268 aa)
PSMB10Proteasome subunit beta. (273 aa)
MCM3DNA helicase; Belongs to the MCM family. (791 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (430 aa)
ORC1Origin recognition complex subunit 1. (727 aa)
H0XCY9_OTOGAAAA domain-containing protein; Belongs to the AAA ATPase family. (466 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (442 aa)
PSMD7MPN domain-containing protein. (324 aa)
PPP4R1Protein phosphatase 4 regulatory subunit 1. (951 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa)
PSMF1Proteasome inhibitor subunit 1. (271 aa)
RBL2RB transcriptional corepressor like 2. (1140 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
POLA1DNA polymerase. (1353 aa)
RBL1RB transcriptional corepressor like 1. (906 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PSMB9Proteasome subunit beta. (219 aa)
PSMB8Proteasome subunit beta. (276 aa)
E2F6E2F transcription factor 6. (281 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (591 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (525 aa)
E2F5E2F transcription factor 5. (347 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (602 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
PPP4R4Protein phosphatase 4 regulatory subunit 4. (873 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
DBF4DBF4 zinc finger. (678 aa)
H0WSK8_OTOGAUncharacterized protein. (173 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (452 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (434 aa)
PSMB5Proteasome subunit beta. (263 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (658 aa)
LOC100960730Uncharacterized protein. (210 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (308 aa)
LIN37Lin-37 DREAM MuvB core complex component. (245 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (351 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
TFDP1Transcription factor. (410 aa)
PSMB7Proteasome subunit beta. (277 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (376 aa)
LIN52Lin-52 DREAM MuvB core complex component. (116 aa)
CDC25ACell division cycle 25A. (525 aa)
Your Current Organism:
Otolemur garnettii
NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago
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