Your Input: | |
| | BARD1 | BRCA1 associated RING domain 1. (773 aa) |
| | PIAS4 | Protein inhibitor of activated STAT 4. (511 aa) |
| | CHEK1 | Checkpoint kinase 1. (449 aa) |
| | CDK3 | Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa) |
| | PSMB2 | Proteasome subunit beta. (202 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1518 aa) |
| | H0WK58_OTOGA | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (427 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (758 aa) |
| | PSMD4 | Proteasome 26S non-ATPase subunit 4 (Predicted). (427 aa) |
| | CDC25A | Cell division cycle 25A. (525 aa) |
| | CCNB3 | Cyclin B3; Belongs to the cyclin family. (1301 aa) |
| | PSMD13 | Proteasome 26S subunit, non-ATPase 13. (376 aa) |
| | PSMB7 | Proteasome subunit beta. (277 aa) |
| | CHEK2 | Checkpoint kinase 2. (544 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa) |
| | PSMB4 | Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa) |
| | PSMD8 | Proteasome 26S subunit, non-ATPase 8. (351 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1059 aa) |
| | CLSPN | Claspin. (1269 aa) |
| | PSMD14 | Proteasome 26S subunit, non-ATPase 14. (308 aa) |
| | MCM9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (658 aa) |
| | PSMB5 | Proteasome subunit beta. (263 aa) |
| | PSMC2 | Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (434 aa) |
| | BRCC3 | BRCA1/BRCA2-containing complex subunit 3 (Predicted). (128 aa) |
| | RCBTB1 | RCC1 and BTB domain containing protein 1. (531 aa) |
| | DBF4 | DBF4 zinc finger. (678 aa) |
| | BLM | BLM RecQ like helicase. (1401 aa) |
| | TDRD3 | Tudor domain containing 3. (744 aa) |
| | YWHAE | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (233 aa) |
| | H2BC21 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | PSMD10 | ANK_REP_REGION domain-containing protein. (223 aa) |
| | UIMC1 | Ubiquitin interaction motif containing 1. (726 aa) |
| | H0WUK3_OTOGA | AAA domain-containing protein; Belongs to the AAA ATPase family. (364 aa) |
| | EXO1 | Exonuclease 1. (835 aa) |
| | PSMC4 | Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa) |
| | WDR41 | WD repeat domain 41. (459 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (417 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa) |
| | BABAM2 | BRISC and BRCA1 A complex member 2. (320 aa) |
| | RCBTB2 | RCC1 and BTB domain containing protein 2. (551 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (1011 aa) |
| | KXD1 | KxDL motif containing 1. (123 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (897 aa) |
| | LOC100942503 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | LOC100941637 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2BC5 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC100942503-2 | Histone H4. (103 aa) |
| | H0WXI2_OTOGA | Histone H2B; Belongs to the histone H2B family. (135 aa) |
| | H4C8 | Histone H4. (103 aa) |
| | RFC5 | Replication factor C subunit 5. (343 aa) |
| | PSMC5 | Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa) |
| | BABAM1 | BRISC and BRCA1 A complex member 1. (330 aa) |
| | PSMA6 | Proteasome subunit alpha type. (246 aa) |
| | ORC5 | Origin recognition complex subunit 5. (435 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (554 aa) |
| | PKMYT1 | Protein kinase, membrane associated tyrosine/threonine 1; Belongs to the protein kinase superfamily. (489 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (822 aa) |
| | PSMB3 | Proteasome subunit beta. (210 aa) |
| | YWHAB | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (246 aa) |
| | CDC25C | Cell division cycle 25C. (467 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (241 aa) |
| | PSME3 | Proteasome activator subunit 3. (254 aa) |
| | LOC100948041 | Mcm10 domain-containing protein. (873 aa) |
| | WRN | WRN RecQ like helicase. (1371 aa) |
| | PSMB6 | Proteasome subunit beta. (239 aa) |
| | PSMD5 | Uncharacterized protein. (504 aa) |
| | CDK1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa) |
| | PSMC6 | Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (389 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (903 aa) |
| | PSME4 | Proteasome activator subunit 4. (1840 aa) |
| | PSMA4 | Proteasome subunit alpha type. (261 aa) |
| | RFC4 | Replication factor C subunit 4. (365 aa) |
| | PSMD3 | Proteasome 26S subunit, non-ATPase 3. (536 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (930 aa) |
| | PSMA8 | Proteasome subunit alpha type. (250 aa) |
| | PSMB1 | Proteasome subunit beta. (235 aa) |
| | PSMD12 | Proteasome 26S subunit, non-ATPase 12. (467 aa) |
| | WEE1 | Wee1-like protein kinase. (643 aa) |
| | PSMA1 | Proteasome subunit alpha type. (263 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (625 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (712 aa) |
| | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa) |
| | ORC2 | Origin recognition complex subunit 2. (580 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (280 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1002 aa) |
| | CCNB2 | Cyclin B2; Belongs to the cyclin family. (398 aa) |
| | MCM8 | MCM domain-containing protein; Belongs to the MCM family. (832 aa) |
| | RECQL4 | RecQ like helicase 4. (1201 aa) |
| | PSMA5 | Proteasome subunit alpha type. (241 aa) |
| | PSMB8 | Proteasome subunit beta. (276 aa) |
| | PSMB9 | Proteasome subunit beta. (219 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa) |
| | ABRAXAS1 | Abraxas 1, BRCA1 A complex subunit. (412 aa) |
| | ATRIP | ATR interacting protein. (788 aa) |
| | PSMF1 | Proteasome inhibitor subunit 1. (271 aa) |
| | RAD1 | RAD1 checkpoint DNA exonuclease. (282 aa) |
| | PSMD7 | MPN domain-containing protein. (324 aa) |
| | NSD2 | Nuclear receptor binding SET domain protein 2. (1175 aa) |
| | RFC2 | Replication factor C subunit 2. (354 aa) |
| | PSMD6 | Proteasome 26S subunit, non-ATPase 6. (442 aa) |
| | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa) |
| | H0XCY9_OTOGA | AAA domain-containing protein; Belongs to the AAA ATPase family. (466 aa) |
| | ORC1 | Origin recognition complex subunit 1. (727 aa) |
| | PSMD11 | Proteasome 26S subunit, non-ATPase 11. (430 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (734 aa) |
| | RAD50 | RAD50 homolog isoform 1 (Predicted). (1311 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (791 aa) |
| | PSMB10 | Proteasome subunit beta. (273 aa) |
| | RNF169 | Ring finger protein 169. (708 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (484 aa) |
| | ORC3 | Origin recognition complex subunit 3. (672 aa) |
| | LOC100940682 | Histone H2B type 1. (126 aa) |
| | LOC100942503-3 | Histone H4. (103 aa) |
| | LOC100942503-4 | Histone H4. (103 aa) |
| | LOC100942503-5 | Histone H4. (103 aa) |
| | LOC100963968 | Uncharacterized protein. (244 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | PSMA2 | Proteasome subunit alpha type. (234 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3051 aa) |
| | H0XI59_OTOGA | 14_3_3 domain-containing protein. (62 aa) |
| | LOC100942503-6 | Histone H4. (103 aa) |
| | H0XI75_OTOGA | JAB_MPN domain-containing protein. (295 aa) |
| | H0XI83_OTOGA | Ubiquitin-like domain-containing protein. (155 aa) |
| | LOC100957578 | Histone H2B type 2-E. (126 aa) |
| | RPA3 | Uncharacterized protein. (121 aa) |
| | H0XJC9_OTOGA | Uncharacterized protein. (287 aa) |
| | H0XJL1_OTOGA | Uncharacterized protein; Belongs to the cyclin family. (367 aa) |
| | H0XJL7_OTOGA | Uncharacterized protein. (153 aa) |
| | LOC100944047 | Uncharacterized protein; Belongs to the cyclin family. (427 aa) |
| | LOC100942503-7 | Histone H4. (103 aa) |
| | YWHAG | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa) |
| | HUS1B | Checkpoint protein; Belongs to the HUS1 family. (279 aa) |
| | H0XLJ0_OTOGA | Histone domain-containing protein; Belongs to the histone H2B family. (122 aa) |
| | H0XLK2_OTOGA | Uncharacterized protein. (247 aa) |
| | CDC7 | Cell division cycle 7. (576 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (642 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (685 aa) |
| | H0XMK6_OTOGA | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (151 aa) |
| | LOC100961609 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC100945692 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | H0XNJ8_OTOGA | Uncharacterized protein. (473 aa) |
| | LOC100942503-8 | Histone H4. (103 aa) |
| | H2BC1 | Histone H2B; Belongs to the histone H2B family. (136 aa) |
| | LOC100961925 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | WEE2 | Wee1-like protein kinase. (567 aa) |
| | RMI1 | RecQ mediated genome instability 1. (621 aa) |
| | H2BC11 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H0XPX5_OTOGA | Histone domain-containing protein; Belongs to the histone H2B family. (141 aa) |
| | LOC100941637-2 | Histone H2B type 1. (126 aa) |
| | H0XQC2_OTOGA | Uncharacterized protein; Belongs to the cyclin family. (426 aa) |
| | LOC100957578-2 | Histone H2B type 2-E. (126 aa) |
| | MDC1 | Mediator of DNA damage checkpoint 1. (1877 aa) |
| | LOC100942503-9 | Histone H4. (103 aa) |
| | H0XR91_OTOGA | Histone domain-containing protein; Belongs to the histone H2B family. (169 aa) |
| | H0XRI3_OTOGA | AAA domain-containing protein; Belongs to the AAA ATPase family. (439 aa) |
| | H0XRL0_OTOGA | Uncharacterized protein. (211 aa) |
| | H0XSP9_OTOGA | Histone domain-containing protein; Belongs to the histone H2B family. (121 aa) |
| | LOC100944154 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H0XTS4_OTOGA | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (735 aa) |
| | H0XTS7_OTOGA | CtIP_N domain-containing protein. (599 aa) |
| | LOC100945989 | Histone H2B; Belongs to the histone H2B family. (135 aa) |
| | LOC100944085 | Histone H2B; Belongs to the histone H2B family. (137 aa) |
| | H0XUE4_OTOGA | Ubiquitin-like domain-containing protein. (155 aa) |
| | PSMD9 | PDZ domain-containing protein. (223 aa) |
| | H0XUT0_OTOGA | AAA domain-containing protein. (392 aa) |
| | LOC100943441 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa) |
| | H0XVD2_OTOGA | ANK_REP_REGION domain-containing protein. (226 aa) |
| | LOC100944801 | AAA domain-containing protein; Belongs to the AAA ATPase family. (441 aa) |
| | LOC100966022 | Histone domain-containing protein; Belongs to the histone H2B family. (126 aa) |
| | PIEZO1 | Piezo-type mechanosensitive ion channel component. (2785 aa) |
| | PIEZO2 | Piezo-type mechanosensitive ion channel component. (2717 aa) |
| | H0XWX5_OTOGA | Wee1-like protein kinase. (561 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (391 aa) |
| | LOC100953470 | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (247 aa) |
| | H0XX44_OTOGA | Ubiquitin-like domain-containing protein. (155 aa) |
| | H0XX75_OTOGA | PROTEASOME_ALPHA_1 domain-containing protein. (231 aa) |
| | PSME1 | Proteasome activator subunit 1. (249 aa) |
| | RMI2 | RecQ mediated genome instability 2. (148 aa) |
| | H0XY57_OTOGA | MPN domain-containing protein. (291 aa) |
| | CDC45 | Cell division cycle 45. (616 aa) |
| | H0XYF5_OTOGA | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (165 aa) |
| | LOC100942503-10 | Histone H4. (103 aa) |
| | H0XYI8_OTOGA | Proteasome subunit alpha type. (234 aa) |
| | H0XYU7_OTOGA | NIBRIN_BRCT_II domain-containing protein. (421 aa) |
| | H0XZ35_OTOGA | Histone domain-containing protein; Belongs to the histone H2B family. (165 aa) |
| | H0XZ50_OTOGA | Uncharacterized protein; Belongs to the cyclin family. (375 aa) |
| | H2BC14 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H0XZI5_OTOGA | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (246 aa) |
| | PSME2 | Uncharacterized protein. (239 aa) |
| | ANKRD12 | Ankyrin repeat domain 12. (2053 aa) |
| | SFN | Stratifin; Belongs to the 14-3-3 family. (254 aa) |
| | YWHAH | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide (Predicted); Belongs to the 14-3-3 family. (246 aa) |
| | LOC100942503-11 | Histone H4. (103 aa) |
| | PSMB11 | Proteasome subunit beta. (300 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1969 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2642 aa) |
| | HERC2 | HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4810 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (867 aa) |
| | PSMA3 | Proteasome subunit alpha type. (255 aa) |
| | YWHAQ | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta; Belongs to the 14-3-3 family. (245 aa) |
| | ORC6 | Origin recognition complex subunit 6. (252 aa) |
| | PSMA7 | Proteasome subunit alpha type. (248 aa) |
| | H0WHP7_OTOGA | Uncharacterized protein. (122 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (572 aa) |
