STRINGSTRING
TMEM198 TMEM198 TAB1 TAB1 ARHGEF40 ARHGEF40 SPPL2B SPPL2B TAX1BP1 TAX1BP1 ADAM17 ADAM17 HDAC3 HDAC3 BCL2L11 BCL2L11 BIRC7 BIRC7 H0XX44_OTOGA H0XX44_OTOGA LINGO2 LINGO2 TRADD TRADD H0XY59_OTOGA H0XY59_OTOGA NGF NGF ARHGEF33 ARHGEF33 H0XZG3_OTOGA H0XZG3_OTOGA H0XZQ1_OTOGA H0XZQ1_OTOGA LINGO1 LINGO1 H0Y1A1_OTOGA H0Y1A1_OTOGA H0Y217_OTOGA H0Y217_OTOGA H0XUE4_OTOGA H0XUE4_OTOGA H0XTR4_OTOGA H0XTR4_OTOGA TAB2 TAB2 GNA13 GNA13 TRAF1 TRAF1 H0XSZ0_OTOGA H0XSZ0_OTOGA CCDC71L CCDC71L RTN4R RTN4R H0XSF2_OTOGA H0XSF2_OTOGA MAGED1 MAGED1 UBE2D1 UBE2D1 H0XQ16_OTOGA H0XQ16_OTOGA IKBKG IKBKG FGD1 FGD1 PLEKHG5 PLEKHG5 CHUK CHUK ECT2L ECT2L OMG OMG RBCK1 RBCK1 LOC100951719 LOC100951719 H0XKP4_OTOGA H0XKP4_OTOGA OTUD7B OTUD7B CYLD CYLD H0XJL7_OTOGA H0XJL7_OTOGA MIB2 MIB2 MAG MAG UBA52 UBA52 OTUD1 OTUD1 H0XI83_OTOGA H0XI83_OTOGA VAV2 VAV2 APH1B APH1B H0XH70_OTOGA H0XH70_OTOGA MCF2L MCF2L ULK2 ULK2 VAV3 VAV3 PSEN2 PSEN2 RNF31 RNF31 ARHGEF15 ARHGEF15 FADD FADD ITSN1 ITSN1 ARHGEF4 ARHGEF4 SMPD2 SMPD2 NGFR NGFR KALRN KALRN BAG4 BAG4 IRAK1 IRAK1 RACK1 RACK1 MAPK10 MAPK10 BEX3 BEX3 H0XBY3_OTOGA H0XBY3_OTOGA ARHGEF10L ARHGEF10L ARHGEF10 ARHGEF10 SOS2 SOS2 OTULINL OTULINL TRIO TRIO RELA RELA MAP3K20 MAP3K20 AATF AATF CASP2 CASP2 LOC100949391 LOC100949391 NSMAF NSMAF TRAF2 TRAF2 UBE2D3 UBE2D3 NFKB1 NFKB1 SPPL2A SPPL2A RIPK2 RIPK2 MADD MADD SMPD3 SMPD3 TNFRSF1A TNFRSF1A PRDM4 PRDM4 FASLG FASLG TIAM2 TIAM2 TNFAIP3 TNFAIP3 CFLAR CFLAR ARHGEF2 ARHGEF2 FGD4 FGD4 CLIP3 CLIP3 MAPKAPK2 MAPKAPK2 ARHGEF26 ARHGEF26 SESTD1 SESTD1 H0XV34_OTOGA H0XV34_OTOGA HDAC2 HDAC2 ABR ABR CASP8 CASP8 CASP10 CASP10 ARHGEF12 ARHGEF12 ARHGEF5 ARHGEF5 BIRC2 BIRC2 H0XVC6_OTOGA H0XVC6_OTOGA OPTN OPTN TNF TNF USP21 USP21 CLIP4 CLIP4 NGEF NGEF TNFSF10 TNFSF10 OTULIN OTULIN TAB3 TAB3 MAPK8 MAPK8 IKBKE IKBKE FGD3 FGD3 WDR31 WDR31 ARHGEF39 ARHGEF39 ARHGEF3 ARHGEF3 H0WWX9_OTOGA H0WWX9_OTOGA FGD2 FGD2 KXD1 KXD1 TRAF6 TRAF6 RIPK1 RIPK1 SHARPIN SHARPIN USP2 USP2 SPATA2 SPATA2 BAD BAD FAS FAS MYD88 MYD88 YWHAE YWHAE NFATC4 NFATC4 MAP3K7 MAP3K7 CASP3 CASP3 BIRC3 BIRC3 HDAC1 HDAC1 ARHGEF1 ARHGEF1 PRKCI PRKCI IKBKB IKBKB ARHGEF38 ARHGEF38 ARHGEF19 ARHGEF19 LINGO4 LINGO4 ULK1 ULK1 ARHGEF16 ARHGEF16 TBK1 TBK1 APH1A APH1A ARHGEF9 ARHGEF9 ARHGEF6 ARHGEF6 TGM6 TGM6 PSENEN PSENEN TIAM1 TIAM1 STUB1 STUB1 NFKBIA NFKBIA NET1 NET1 ECT2 ECT2 ARHGEF37 ARHGEF37 H0WLC2_OTOGA H0WLC2_OTOGA RASGRF2 RASGRF2 SPPL2C SPPL2C PREX1 PREX1 H0WKN8_OTOGA H0WKN8_OTOGA SOS1 SOS1 SQSTM1 SQSTM1 VAV1 VAV1 ARHGEF7 ARHGEF7 USP4 USP4 ARHGEF11 ARHGEF11 NCSTN NCSTN MCF2 MCF2 ARHGEF17 ARHGEF17 MCF2L2 MCF2L2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TMEM198Transmembrane protein 198 (Predicted). (360 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (639 aa)
ARHGEF40Rho guanine nucleotide exchange factor 40. (1517 aa)
SPPL2BSignal peptide peptidase like 2B. (596 aa)
TAX1BP1Tax1 binding protein 1. (817 aa)
ADAM17ADAM metallopeptidase domain 17. (828 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (434 aa)
BCL2L11BCL2 like 11. (200 aa)
BIRC7Baculoviral IAP repeat containing 7. (296 aa)
H0XX44_OTOGAUbiquitin-like domain-containing protein. (155 aa)
LINGO2Leucine rich repeat and Ig domain containing 2. (606 aa)
TRADDTNFRSF1A associated via death domain. (309 aa)
H0XY59_OTOGAUncharacterized protein. (129 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (244 aa)
ARHGEF33Rho guanine nucleotide exchange factor 33. (872 aa)
H0XZG3_OTOGAUncharacterized protein. (162 aa)
H0XZQ1_OTOGANACHT domain-containing protein. (1439 aa)
LINGO1Leucine rich repeat and Ig domain containing 1. (620 aa)
H0Y1A1_OTOGAUncharacterized protein. (195 aa)
H0Y217_OTOGAUncharacterized protein. (412 aa)
H0XUE4_OTOGAUbiquitin-like domain-containing protein. (155 aa)
H0XTR4_OTOGAUBIQUITIN_CONJUGAT_2 domain-containing protein. (168 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (698 aa)
GNA13G protein subunit alpha 13. (379 aa)
TRAF1TNF receptor-associated factor. (409 aa)
H0XSZ0_OTOGAWD_REPEATS_REGION domain-containing protein. (215 aa)
CCDC71LCoiled-coil domain containing 71 like. (234 aa)
RTN4RReticulon 4 receptor. (473 aa)
H0XSF2_OTOGARING-type domain-containing protein. (236 aa)
MAGED1MAGE family member D1. (782 aa)
UBE2D1Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
H0XQ16_OTOGAUncharacterized protein. (816 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (420 aa)
FGD1FYVE, RhoGEF and PH domain containing 1. (959 aa)
PLEKHG5Pleckstrin homology and RhoGEF domain containing G5. (1078 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (747 aa)
ECT2LEpithelial cell transforming 2 like. (905 aa)
OMGOligodendrocyte myelin glycoprotein. (440 aa)
RBCK1RANBP2-type and C3HC4-type zinc finger containing 1. (510 aa)
LOC100951719Uncharacterized protein. (598 aa)
H0XKP4_OTOGAUncharacterized protein. (369 aa)
OTUD7BOTU deubiquitinase 7B. (844 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
H0XJL7_OTOGAUncharacterized protein. (153 aa)
MIB2Mindbomb E3 ubiquitin protein ligase 2. (958 aa)
MAGMyelin associated glycoprotein. (634 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
OTUD1OTU deubiquitinase 1. (404 aa)
H0XI83_OTOGAUbiquitin-like domain-containing protein. (155 aa)
VAV2Vav guanine nucleotide exchange factor 2. (713 aa)
APH1BAph-1 homolog B, gamma-secretase subunit. (257 aa)
H0XH70_OTOGAUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (153 aa)
MCF2LMCF.2 cell line derived transforming sequence like. (1179 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1040 aa)
VAV3Vav guanine nucleotide exchange factor 3. (624 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (451 aa)
RNF31Uncharacterized protein. (1071 aa)
ARHGEF15Rho guanine nucleotide exchange factor 15. (841 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (205 aa)
ITSN1Intersectin 1. (1716 aa)
ARHGEF4Rho guanine nucleotide exchange factor 4. (547 aa)
SMPD2Sphingomyelin phosphodiesterase 2. (422 aa)
NGFRNerve growth factor receptor. (430 aa)
KALRNKalirin RhoGEF kinase. (2985 aa)
BAG4BCL2 associated athanogene 4. (456 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (710 aa)
RACK1WD_REPEATS_REGION domain-containing protein. (317 aa)
MAPK10Mitogen-activated protein kinase. (426 aa)
BEX3Brain expressed X-linked 3. (112 aa)
H0XBY3_OTOGAUncharacterized protein. (352 aa)
ARHGEF10LRho guanine nucleotide exchange factor 10 like. (1279 aa)
ARHGEF10Rho guanine nucleotide exchange factor 10. (1329 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
OTULINLOTU deubiquitinase with linear linkage specificity like. (336 aa)
TRIOTrio Rho guanine nucleotide exchange factor. (3051 aa)
RELARELA proto-oncogene, NF-kB subunit. (429 aa)
MAP3K20Protein kinase domain-containing protein. (456 aa)
AATFApoptosis antagonizing transcription factor. (531 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (452 aa)
LOC100949391UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
NSMAFNeutral sphingomyelinase activation associated factor. (896 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
UBE2D3Ubiquitin conjugating enzyme E2 D3; Belongs to the ubiquitin-conjugating enzyme family. (148 aa)
NFKB1Nuclear factor kappa B subunit 1. (964 aa)
SPPL2ASignal peptide peptidase like 2A. (510 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (539 aa)
MADDMAP kinase activating death domain. (1647 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (657 aa)
TNFRSF1ATNF receptor superfamily member 1A. (465 aa)
PRDM4PR domain zinc finger protein 4; May function as a transcription factor involved in cell differentiation. (796 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (280 aa)
TIAM2T cell lymphoma invasion and metastasis 2. (1699 aa)
TNFAIP3TNF alpha induced protein 3. (783 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (486 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (987 aa)
FGD4FYVE, RhoGEF and PH domain containing 4. (874 aa)
CLIP3CAP-Gly domain containing linker protein 3. (525 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (398 aa)
ARHGEF26Rho guanine nucleotide exchange factor 26. (874 aa)
SESTD1SEC14 and spectrin domain containing 1. (698 aa)
H0XV34_OTOGADUF4203 domain-containing protein. (310 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (422 aa)
ABRABR activator of RhoGEF and GTPase. (813 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (488 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (530 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1526 aa)
ARHGEF5Rho guanine nucleotide exchange factor 5. (1606 aa)
BIRC2Uncharacterized protein. (618 aa)
H0XVC6_OTOGAUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (150 aa)
OPTNOptineurin. (581 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (235 aa)
USP21Ubiquitin specific peptidase 21; Belongs to the peptidase C19 family. (462 aa)
CLIP4CAP-Gly domain containing linker protein family member 4. (727 aa)
NGEFNeuronal guanine nucleotide exchange factor. (620 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (284 aa)
OTULINOTU deubiquitinase with linear linkage specificity. (352 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (712 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
FGD3FYVE, RhoGEF and PH domain containing 3. (737 aa)
WDR31WD repeat domain 31. (368 aa)
ARHGEF39Rho guanine nucleotide exchange factor 39. (323 aa)
ARHGEF3Rho guanine nucleotide exchange factor 3. (534 aa)
H0WWX9_OTOGAUncharacterized protein. (1089 aa)
FGD2FYVE, RhoGEF and PH domain containing 2. (654 aa)
KXD1KxDL motif containing 1. (123 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (535 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (663 aa)
SHARPINSHANK associated RH domain interactor. (382 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (606 aa)
SPATA2Spermatogenesis associated 2. (519 aa)
BADBCL2 associated agonist of cell death. (168 aa)
FASFas cell surface death receptor. (324 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (233 aa)
NFATC4Nuclear factor of activated T cells 4. (940 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (579 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
BIRC3Baculoviral IAP repeat containing 3. (605 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1. (941 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (609 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (729 aa)
ARHGEF38Rho guanine nucleotide exchange factor 38. (687 aa)
ARHGEF19Rho guanine nucleotide exchange factor 19. (806 aa)
LINGO4Leucine rich repeat and Ig domain containing 4. (607 aa)
ULK1Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (1045 aa)
ARHGEF16Rho guanine nucleotide exchange factor 16. (705 aa)
TBK1TANK binding kinase 1. (729 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (265 aa)
ARHGEF9Cdc42 guanine nucleotide exchange factor 9. (523 aa)
ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor 6. (850 aa)
TGM6Transglutaminase 6. (707 aa)
PSENENPresenilin enhancer, gamma-secretase subunit. (101 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1495 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
NET1Neuroepithelial cell transforming 1. (600 aa)
ECT2Epithelial cell transforming 2. (916 aa)
ARHGEF37Rho guanine nucleotide exchange factor 37. (661 aa)
H0WLC2_OTOGAReticulon. (648 aa)
RASGRF2Ras protein specific guanine nucleotide releasing factor 2. (1239 aa)
SPPL2CSignal peptide peptidase like 2C. (673 aa)
PREX1Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1654 aa)
H0WKN8_OTOGAUncharacterized protein. (1165 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
SQSTM1Sequestosome 1. (446 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (784 aa)
USP4Ubiquitin specific peptidase 4; Belongs to the peptidase C19 family. (952 aa)
ARHGEF11Rho guanine nucleotide exchange factor 11. (1561 aa)
NCSTNNicastrin. (709 aa)
MCF2MCF.2 cell line derived transforming sequence. (1065 aa)
ARHGEF17Rho guanine nucleotide exchange factor 17. (2063 aa)
MCF2L2MCF.2 cell line derived transforming sequence-like 2. (1035 aa)
Your Current Organism:
Otolemur garnettii
NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago
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