STRINGSTRING
FRS2 FRS2 H0Y238_OTOGA H0Y238_OTOGA KLB KLB FGF2 FGF2 FGFR3 FGFR3 SHC1 SHC1 SPEM2 SPEM2 FGF9 FGF9 NRAS NRAS INS INS MAPK3 MAPK3 FGF3 FGF3 HRAS HRAS FGF19 FGF19 FGF8 FGF8 H0XJC1_OTOGA H0XJC1_OTOGA PDE3B PDE3B FLT3 FLT3 LOC100961427 LOC100961427 TRIB3 TRIB3 PIK3R1 PIK3R1 KRAS KRAS FGFR1 FGFR1 AKT2 AKT2 FGF18 FGF18 FGF7 FGF7 GAB2 GAB2 PIK3C3 PIK3C3 FGFR2 FGFR2 FGF4 FGF4 FGFR4 FGFR4 SPEM1 SPEM1 FGF5 FGF5 FGF16 FGF16 MAPK1 MAPK1 ERAS ERAS FGF22 FGF22 PIK3R4 PIK3R4 KL KL PIK3CA PIK3CA GRB10 GRB10 FGF20 FGF20 FGF6 FGF6 FGF23 FGF23 PDPK1 PDPK1 FGF1 FGF1 FGF17 FGF17 PIK3CB PIK3CB GAB1 GAB1 THEM4 THEM4 GRB2 GRB2 INSR INSR SOS1 SOS1 FGF10 FGF10 H0WHZ3_OTOGA H0WHZ3_OTOGA PTPN11 PTPN11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
H0Y238_OTOGAUncharacterized protein. (72 aa)
KLBKlotho beta. (1043 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGFR3Fibroblast growth factor receptor. (808 aa)
SHC1Uncharacterized protein. (577 aa)
SPEM2SPEM family member 2. (503 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (336 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (233 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
H0XJC1_OTOGAPID domain-containing protein. (486 aa)
PDE3BPhosphodiesterase. (788 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
LOC100961427Uncharacterized protein. (1127 aa)
TRIB3Tribbles pseudokinase 3. (358 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (549 aa)
KRASKRAS proto-oncogene, GTPase. (243 aa)
FGFR1Fibroblast growth factor receptor. (792 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
GAB2GRB2 associated binding protein 2. (654 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (888 aa)
FGFR2Fibroblast growth factor receptor. (822 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGFR4Fibroblast growth factor receptor 4. (969 aa)
SPEM1Spermatid maturation 1. (310 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (269 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
MAPK1Mitogen-activated protein kinase. (323 aa)
ERASES cell expressed Ras. (229 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (167 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa)
KLKlotho. (1016 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
GRB10Growth factor receptor bound protein 10. (549 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (252 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (559 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (859 aa)
GAB1GRB2 associated binding protein 1. (695 aa)
THEM4Thioesterase superfamily member 4. (244 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
INSRTyrosine-protein kinase receptor. (1366 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
H0WHZ3_OTOGAUncharacterized protein. (731 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (599 aa)
Your Current Organism:
Otolemur garnettii
NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago
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