STRINGSTRING
MAML2 MAML2 PSMA3 PSMA3 EP300 EP300 ZFHX4 ZFHX4 CDKN1A CDKN1A PSMA7 PSMA7 TCF7L1 TCF7L1 NINJ2 NINJ2 PSMB2 PSMB2 CREBBP CREBBP PSMD4 PSMD4 YAP1 YAP1 TEAD3 TEAD3 PSMD13 PSMD13 PSMB7 PSMB7 PSMB4 PSMB4 PSMD8 PSMD8 LEF1 LEF1 CBFB CBFB HDAC4 HDAC4 PSMD14 PSMD14 PSMB5 PSMB5 PSMC2 PSMC2 TEAD4 TEAD4 MYC MYC PSMD10 PSMD10 BRD2 BRD2 H0WUK3_OTOGA H0WUK3_OTOGA PSMC4 PSMC4 FNDC3B FNDC3B RBPJ RBPJ PSMC5 PSMC5 PSMA6 PSMA6 PSMB3 PSMB3 FNDC3A FNDC3A PSME3 PSME3 KAT2A KAT2A PSMB6 PSMB6 PSMD5 PSMD5 SMURF1 SMURF1 PSMC6 PSMC6 TEAD2 TEAD2 PSMA4 PSMA4 ZFHX3 ZFHX3 PSMD3 PSMD3 SPP1 SPP1 JAG1 JAG1 PSMB1 PSMB1 PSMD12 PSMD12 CCND1 CCND1 PSMA1 PSMA1 SMAD4 SMAD4 PSMD1 PSMD1 MAMLD1 MAMLD1 PSMA5 PSMA5 PSMB8 PSMB8 PSMB9 PSMB9 H0XAK4_OTOGA H0XAK4_OTOGA SMAD3 SMAD3 TCF7L2 TCF7L2 PSMF1 PSMF1 PSMD7 PSMD7 PSMD6 PSMD6 PSMD2 PSMD2 H0XCY9_OTOGA H0XCY9_OTOGA SMURF2 SMURF2 PSMD11 PSMD11 SRC SRC PSMB10 PSMB10 ITGA4 ITGA4 CTNNB1 CTNNB1 LOC100963968 LOC100963968 KAT2B KAT2B PSMA2 PSMA2 TP53 TP53 H0XI75_OTOGA H0XI75_OTOGA H0XI83_OTOGA H0XI83_OTOGA ITGAL ITGAL UBA52 UBA52 H0XJC9_OTOGA H0XJC9_OTOGA H0XLK2_OTOGA H0XLK2_OTOGA RBPJL RBPJL FOXO3 FOXO3 H0XQW2_OTOGA H0XQW2_OTOGA HES6 HES6 H0XRI3_OTOGA H0XRI3_OTOGA TGFB1 TGFB1 H0XUE4_OTOGA H0XUE4_OTOGA PSMD9 PSMD9 H0XUT0_OTOGA H0XUT0_OTOGA RORC RORC RUNX3 RUNX3 H0XVD2_OTOGA H0XVD2_OTOGA LOC100944801 LOC100944801 BCL2L11 BCL2L11 MAML1 MAML1 CCN2 CCN2 H0XX44_OTOGA H0XX44_OTOGA H0XX75_OTOGA H0XX75_OTOGA MAML3 MAML3 PSME1 PSME1 SNW1 SNW1 MDM2 MDM2 ZFHX2 ZFHX2 H0XYI8_OTOGA H0XYI8_OTOGA PSME2 PSME2 TCF7 TCF7 WWTR1 WWTR1 HES1 HES1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAML2Mastermind like transcriptional coactivator 2. (1113 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
EP300E1A binding protein p300. (2420 aa)
ZFHX4Zinc finger homeobox 4. (3614 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (193 aa)
PSMA7Proteasome subunit alpha type. (248 aa)
TCF7L1Transcription factor 7 like 1. (574 aa)
NINJ2Ninjurin 2. (143 aa)
PSMB2Proteasome subunit beta. (202 aa)
CREBBPCREB binding protein. (2443 aa)
PSMD4Proteasome 26S non-ATPase subunit 4 (Predicted). (427 aa)
YAP1Yes associated protein 1. (501 aa)
TEAD3Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (471 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (376 aa)
PSMB7Proteasome subunit beta. (277 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (351 aa)
LEF1Lymphoid enhancer binding factor 1. (398 aa)
CBFBCore-binding factor subunit beta. (185 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1043 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (308 aa)
PSMB5Proteasome subunit beta. (263 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (434 aa)
TEAD4Transcriptional enhancer factor TEF-3; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (434 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (452 aa)
PSMD10ANK_REP_REGION domain-containing protein. (223 aa)
BRD2Bromodomain containing 2. (835 aa)
H0WUK3_OTOGAAAA domain-containing protein; Belongs to the AAA ATPase family. (364 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
FNDC3BFibronectin type III domain containing 3B. (1142 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (486 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
PSMB3Proteasome subunit beta. (210 aa)
FNDC3AFibronectin type III domain containing 3A. (1149 aa)
PSME3Proteasome activator subunit 3. (254 aa)
KAT2ALysine acetyltransferase 2A. (838 aa)
PSMB6Proteasome subunit beta. (239 aa)
PSMD5Uncharacterized protein. (504 aa)
SMURF1E3 ubiquitin-protein ligase. (757 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (389 aa)
TEAD2TEA domain transcription factor 2. (449 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
ZFHX3Zinc finger homeobox 3. (2592 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (536 aa)
SPP1Secreted phosphoprotein 1. (272 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
PSMB1Proteasome subunit beta. (235 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (467 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
PSMA1Proteasome subunit alpha type. (263 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
MAMLD1Mastermind like domain containing 1. (744 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
PSMB8Proteasome subunit beta. (276 aa)
PSMB9Proteasome subunit beta. (219 aa)
H0XAK4_OTOGAUncharacterized protein. (356 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
TCF7L2Transcription factor 7 like 2. (471 aa)
PSMF1Proteasome inhibitor subunit 1. (271 aa)
PSMD7MPN domain-containing protein. (324 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (442 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
H0XCY9_OTOGAAAA domain-containing protein; Belongs to the AAA ATPase family. (466 aa)
SMURF2E3 ubiquitin-protein ligase. (732 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (430 aa)
SRCTyrosine-protein kinase. (542 aa)
PSMB10Proteasome subunit beta. (273 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1031 aa)
CTNNB1Catenin beta 1. (781 aa)
LOC100963968Uncharacterized protein. (244 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (793 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
H0XI75_OTOGAJAB_MPN domain-containing protein. (295 aa)
H0XI83_OTOGAUbiquitin-like domain-containing protein. (155 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1168 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
H0XJC9_OTOGAUncharacterized protein. (287 aa)
H0XLK2_OTOGAUncharacterized protein. (247 aa)
RBPJLRecombination signal binding protein for immunoglobulin kappa J region like. (524 aa)
FOXO3Forkhead box O3. (672 aa)
H0XQW2_OTOGAUncharacterized protein. (1372 aa)
HES6Hes family bHLH transcription factor 6. (226 aa)
H0XRI3_OTOGAAAA domain-containing protein; Belongs to the AAA ATPase family. (439 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (403 aa)
H0XUE4_OTOGAUbiquitin-like domain-containing protein. (155 aa)
PSMD9PDZ domain-containing protein. (223 aa)
H0XUT0_OTOGAAAA domain-containing protein. (392 aa)
RORCRAR related orphan receptor C. (516 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (459 aa)
H0XVD2_OTOGAANK_REP_REGION domain-containing protein. (226 aa)
LOC100944801AAA domain-containing protein; Belongs to the AAA ATPase family. (441 aa)
BCL2L11BCL2 like 11. (200 aa)
MAML1Mastermind like transcriptional coactivator 1. (1012 aa)
CCN2Cellular communication network factor 2. (349 aa)
H0XX44_OTOGAUbiquitin-like domain-containing protein. (155 aa)
H0XX75_OTOGAPROTEASOME_ALPHA_1 domain-containing protein. (231 aa)
MAML3Mastermind like transcriptional coactivator 3. (962 aa)
PSME1Proteasome activator subunit 1. (249 aa)
SNW1SNW domain containing 1. (536 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (493 aa)
ZFHX2Zinc finger homeobox 2. (2570 aa)
H0XYI8_OTOGAProteasome subunit alpha type. (234 aa)
PSME2Uncharacterized protein. (239 aa)
TCF7Transcription factor 7. (419 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
Your Current Organism:
Otolemur garnettii
NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago
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