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ATRNL1 ATRNL1 MGRN1 MGRN1 EVC2 EVC2 EVC EVC CSNK1E CSNK1E GKAP1 GKAP1 LMBR1 LMBR1 BCL2 BCL2 PTCH1 PTCH1 GPR161 GPR161 H0WME2_OTOGA H0WME2_OTOGA GRK3 GRK3 SUFU SUFU CCND2 CCND2 GLI1 GLI1 ATRN ATRN LMBR1L LMBR1L KIF27 KIF27 PRKACB PRKACB GSK3B GSK3B HHIP HHIP LRP2 LRP2 PTCH2 PTCH2 CDON CDON SMURF1 SMURF1 GRK2 GRK2 CCND1 CCND1 ARRB1 ARRB1 H0X541_OTOGA H0X541_OTOGA BOC BOC PRKACA PRKACA LRP4 LRP4 FBXW11 FBXW11 CUL3 CUL3 GLI3 GLI3 SPOP SPOP MEGF8 MEGF8 TSPAN33 TSPAN33 SMO SMO IHH IHH BTRC BTRC CUL1 CUL1 SPOPL SPOPL SMURF2 SMURF2 CSNK1G1 CSNK1G1 GAS1 GAS1 ARRB2 ARRB2 ARR3 ARR3 Shh Shh H0XMG1_OTOGA H0XMG1_OTOGA H0XN06_OTOGA H0XN06_OTOGA H0XP74_OTOGA H0XP74_OTOGA KIF7 KIF7 H0XRN2_OTOGA H0XRN2_OTOGA CSNK1G2 CSNK1G2 H0XTT1_OTOGA H0XTT1_OTOGA LOC100963051 LOC100963051 DHH DHH GLI2 GLI2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ATRNL1Attractin like 1. (1378 aa)
MGRN1Mahogunin ring finger 1. (554 aa)
EVC2EvC ciliary complex subunit 2. (1197 aa)
EVCEvC ciliary complex subunit 1. (993 aa)
CSNK1EProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (416 aa)
GKAP1G kinase anchoring protein 1. (367 aa)
LMBR1Limb development membrane protein 1; Belongs to the LIMR family. (390 aa)
BCL2BCL2 apoptosis regulator. (238 aa)
PTCH1Patched 1. (1447 aa)
GPR161G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family. (546 aa)
H0WME2_OTOGAProtein kinase domain-containing protein. (236 aa)
GRK3G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (646 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (485 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
GLI1GLI family zinc finger 1. (1108 aa)
ATRNAttractin. (1423 aa)
LMBR1LLimb development membrane protein 1 like; Belongs to the LIMR family. (489 aa)
KIF27Kinesin family member 27; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1400 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (396 aa)
GSK3BGlycogen synthase kinase 3 beta. (387 aa)
HHIPHedgehog interacting protein. (700 aa)
LRP2LDL receptor related protein 2. (4631 aa)
PTCH2Patched 2. (1208 aa)
CDONCell adhesion associated, oncogene regulated. (1247 aa)
SMURF1E3 ubiquitin-protein ligase. (757 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (686 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
ARRB1Arrestin beta 1. (418 aa)
H0X541_OTOGAProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (426 aa)
BOCBOC cell adhesion associated, oncogene regulated. (974 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
LRP4LDL receptor related protein 4. (1898 aa)
FBXW11F-box and WD repeat domain containing 11. (580 aa)
CUL3Cullin 3; Belongs to the cullin family. (746 aa)
GLI3GLI family zinc finger 3. (1462 aa)
SPOPSpeckle type BTB/POZ protein. (374 aa)
MEGF8Multiple EGF like domains 8. (2848 aa)
TSPAN33Tetraspanin. (283 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (526 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
SPOPLSpeckle type BTB/POZ protein like. (374 aa)
SMURF2E3 ubiquitin-protein ligase. (732 aa)
CSNK1G1Casein kinase 1 gamma 1. (363 aa)
GAS1Growth arrest specific 1. (339 aa)
ARRB2Arrestin beta 2. (409 aa)
ARR3Arrestin 3. (393 aa)
ShhSonic hedgehog. (249 aa)
H0XMG1_OTOGAProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (410 aa)
H0XN06_OTOGAProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (364 aa)
H0XP74_OTOGAProtein kinase domain-containing protein. (348 aa)
KIF7Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1329 aa)
H0XRN2_OTOGAUncharacterized protein. (198 aa)
CSNK1G2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (417 aa)
H0XTT1_OTOGAProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (429 aa)
LOC100963051Protein kinase domain-containing protein. (327 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (397 aa)
GLI2GLI family zinc finger 2. (1522 aa)
Your Current Organism:
Otolemur garnettii
NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago
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