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THSD4 THSD4 GDF7 GDF7 RGMB RGMB PITX2 PITX2 GREM2 GREM2 PITX3 PITX3 ID4 ID4 BMP6 BMP6 BMP4 BMP4 TGIF1 TGIF1 SMAD7 SMAD7 GDF6 GDF6 TGFB1 TGFB1 H0XTZ8_OTOGA H0XTZ8_OTOGA FSTL3 FSTL3 TGIF2 TGIF2 RHOC RHOC NOG NOG HJV HJV ACVR1B ACVR1B ACVR2B ACVR2B MAPK3 MAPK3 H0XR31_OTOGA H0XR31_OTOGA GDF5 GDF5 H0XQJ1_OTOGA H0XQJ1_OTOGA AMH AMH SP1 SP1 PITX1 PITX1 AMHR2 AMHR2 LTBP3 LTBP3 SKP1 SKP1 NBL1 NBL1 H0XI62_OTOGA H0XI62_OTOGA INHBB INHBB RBX1 RBX1 BMP5 BMP5 ZFYVE9 ZFYVE9 SMAD6 SMAD6 SMURF2 SMURF2 CUL1 CUL1 BMP7 BMP7 SMAD3 SMAD3 RBL1 RBL1 PPP2R1A PPP2R1A E2F5 E2F5 FBN3 FBN3 PPP2R1B PPP2R1B ID2 ID2 ROCK1 ROCK1 SMAD4 SMAD4 ID3 ID3 ACVR1C ACVR1C ACVR1 ACVR1 CDKN2B CDKN2B BMPR1A BMPR1A RPS6KB2 RPS6KB2 RGMA RGMA TNF TNF TGFB2 TGFB2 SMURF1 SMURF1 PPP2CA PPP2CA SMAD5 SMAD5 FBN1 FBN1 TGFB3 TGFB3 ID1 ID1 MAPK1 MAPK1 INTS8 INTS8 THBS1 THBS1 DCN DCN FBN2 FBN2 RPS6KB1 RPS6KB1 BMPR2 BMPR2 MATN4 MATN4 ADAMTSL4 ADAMTSL4 BMP2 BMP2 SNAPIN SNAPIN NODAL NODAL MYC MYC INHBE INHBE INHBC INHBC ZFYVE16 ZFYVE16 ANKFN1 ANKFN1 IFNG IFNG TGFBR1 TGFBR1 ACVR2A ACVR2A INHBA INHBA PKNOX1 PKNOX1 TFDP1 TFDP1 LTBP4 LTBP4 BMPR1B BMPR1B BAMBI BAMBI LOC100958496 LOC100958496 PKNOX2 PKNOX2 LTBP1 LTBP1 H0WLE0_OTOGA H0WLE0_OTOGA LTBP2 LTBP2 PPP2CB PPP2CB CREBBP CREBBP FST FST NEO1 NEO1 CHRD CHRD USF2 USF2 MATN2 MATN2 SMAD2 SMAD2 EP300 EP300 FMOD FMOD LDAH LDAH SMAD1 SMAD1 GREM1 GREM1 TGFBR2 TGFBR2 E2F4 E2F4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
THSD4Thrombospondin type 1 domain containing 4. (642 aa)
GDF7Growth differentiation factor 7. (421 aa)
RGMBRepulsive guidance molecule BMP co-receptor b. (441 aa)
PITX2Homeobox protein. (317 aa)
GREM2Gremlin. (168 aa)
PITX3Homeobox protein. (302 aa)
ID4Inhibitor of DNA binding 4, HLH protein. (161 aa)
BMP6Bone morphogenetic protein 6. (516 aa)
BMP4Bone morphogenetic protein 4 (Predicted). (409 aa)
TGIF1TGFB induced factor homeobox 1. (390 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
GDF6Growth differentiation factor 6. (461 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (403 aa)
H0XTZ8_OTOGATGF_BETA_2 domain-containing protein. (420 aa)
FSTL3Follistatin like 3. (263 aa)
TGIF2TGFB induced factor homeobox 2. (238 aa)
RHOCRas homolog family member C. (193 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
HJVHemojuvelin BMP co-receptor. (432 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (483 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (525 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (336 aa)
H0XR31_OTOGAUncharacterized protein. (404 aa)
GDF5Growth differentiation factor 5. (498 aa)
H0XQJ1_OTOGATGF_BETA_2 domain-containing protein. (414 aa)
AMHAnti-Mullerian hormone. (557 aa)
SP1Sp1 transcription factor. (761 aa)
PITX1Homeobox protein. (314 aa)
AMHR2Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. (560 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1140 aa)
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (163 aa)
NBL1Neuroblastoma suppressor of tumorigenicity 1. (179 aa)
H0XI62_OTOGATGF_BETA_2 domain-containing protein. (341 aa)
INHBBInhibin subunit beta B. (407 aa)
RBX1Ring-box 1. (108 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1421 aa)
SMAD6Mothers against decapentaplegic homolog. (493 aa)
SMURF2E3 ubiquitin-protein ligase. (732 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
RBL1RB transcriptional corepressor like 1. (906 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (591 aa)
E2F5E2F transcription factor 5. (347 aa)
FBN3Fibrillin 3. (2865 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (602 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1365 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ID3Inhibitor of DNA binding 3, HLH protein. (119 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (479 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (489 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (131 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (537 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (480 aa)
RGMARepulsive guidance molecule BMP co-receptor a. (457 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (235 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
SMURF1E3 ubiquitin-protein ligase. (757 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
FBN1Fibrillin 1. (2875 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
MAPK1Mitogen-activated protein kinase. (323 aa)
INTS8Integrator complex subunit 8. (995 aa)
THBS1Thrombospondin 1. (1170 aa)
DCNDecorin; May affect the rate of fibrils formation. (358 aa)
FBN2Fibrillin 2. (2799 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
MATN4Matrilin 4. (624 aa)
ADAMTSL4ADAMTS like 4. (1094 aa)
BMP2Bone morphogenetic protein 2. (393 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
NODALNodal growth differentiation factor. (344 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (452 aa)
INHBEInhibin subunit beta E. (352 aa)
INHBCInhibin subunit beta C. (350 aa)
ZFYVE16FYVE-type domain-containing protein. (1542 aa)
ANKFN1Ankyrin repeat and fibronectin type III domain containing 1. (763 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (469 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (516 aa)
INHBAInhibin subunit beta A. (426 aa)
PKNOX1PBX/knotted 1 homeobox 1. (438 aa)
TFDP1Transcription factor. (410 aa)
LTBP4Latent transforming growth factor beta binding protein 4. (1620 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
LOC100958496Left-right determination factor. (364 aa)
PKNOX2PBX/knotted 1 homeobox 2. (472 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1356 aa)
H0WLE0_OTOGAMothers against decapentaplegic homolog. (429 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1815 aa)
PPP2CBSerine/threonine-protein phosphatase. (308 aa)
CREBBPCREB binding protein. (2443 aa)
FSTFollistatin. (344 aa)
NEO1Neogenin 1. (1408 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (959 aa)
USF2Upstream transcription factor 2, c-fos interacting. (346 aa)
MATN2Matrilin 2. (899 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
EP300E1A binding protein p300. (2420 aa)
FMODFibromodulin. (376 aa)
LDAHLipid droplet associated hydrolase. (277 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
GREM1Gremlin. (184 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
E2F4E2F transcription factor 4. (403 aa)
Your Current Organism:
Otolemur garnettii
NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago
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