STRINGSTRING
TEAD2 TEAD2 TGFB2 TGFB2 WNT4 WNT4 BIRC2 BIRC2 SNAI2 SNAI2 DLG2 DLG2 RASSF6 RASSF6 BMPR1A BMPR1A PPP2R2B PPP2R2B ACTRT2 ACTRT2 CRB1 CRB1 FZD4 FZD4 CCND1 CCND1 AMOT AMOT PPP2R2C PPP2R2C DLG3 DLG3 WTIP WTIP FBXW11 FBXW11 SMAD4 SMAD4 LIMD1 LIMD1 LATS1 LATS1 ID2 ID2 LOC100943305 LOC100943305 PPP2R1B PPP2R1B MYO15A MYO15A LLGL1 LLGL1 LRRC1 LRRC1 LOC100951798 LOC100951798 PPP2R2D PPP2R2D WNT9A WNT9A WNT3A WNT3A PPP2R1A PPP2R1A WNT2 WNT2 WNT2B WNT2B WNT6 WNT6 SMAD3 SMAD3 TCF7L2 TCF7L2 ACTL8 ACTL8 BTRC BTRC BMP7 BMP7 AXIN1 AXIN1 PPP1CB PPP1CB BMP5 BMP5 DVL3 DVL3 CTNNB1 CTNNB1 STK3 STK3 NF2 NF2 DLG5 DLG5 WNT10B WNT10B LOC100950637 LOC100950637 APC2 APC2 NKD1 NKD1 H0XI59_OTOGA H0XI59_OTOGA BIRC5 BIRC5 WNT10A WNT10A LOC100950579 LOC100950579 FZD9 FZD9 LOC100951719 LOC100951719 YWHAG YWHAG WNT5B WNT5B H0XLI4_OTOGA H0XLI4_OTOGA LOC100966429 LOC100966429 SCRIB SCRIB CRB2 CRB2 FZD1 FZD1 FZD3 FZD3 WNT7A WNT7A H0XMG1_OTOGA H0XMG1_OTOGA APC APC WNT7B WNT7B PARD6A PARD6A PPP2R2A PPP2R2A CTNNA1 CTNNA1 ACTL9 ACTL9 AMH AMH BBC3 BBC3 ACTL7B ACTL7B WNT8A WNT8A LOC100950013 LOC100950013 H0XQJ1_OTOGA H0XQJ1_OTOGA GDF5 GDF5 PARD6G PARD6G NKD2 NKD2 MPP5 MPP5 FZD10 FZD10 H0XTT1_OTOGA H0XTT1_OTOGA H0XTZ8_OTOGA H0XTZ8_OTOGA TGFB1 TGFB1 GDF6 GDF6 PPP1CA PPP1CA SOX3 SOX3 SMAD7 SMAD7 WNT1 WNT1 RASSF1 RASSF1 CCND3 CCND3 FZD7 FZD7 CCN2 CCN2 LOC100953470 LOC100953470 FZD8 FZD8 LOC100952117 LOC100952117 BMP4 BMP4 H0XYF5_OTOGA H0XYF5_OTOGA DVL1 DVL1 BMP6 BMP6 AJUBA AJUBA H0XZI5_OTOGA H0XZI5_OTOGA SAV1 SAV1 TCF7 TCF7 AREG AREG FZD5 FZD5 GLI2 GLI2 WWTR1 WWTR1 WNT8B WNT8B GDF7 GDF7 YWHAH YWHAH H0Y1X4_OTOGA H0Y1X4_OTOGA SOX2 SOX2 H0Y264_OTOGA H0Y264_OTOGA TGFBR2 TGFBR2 SMAD1 SMAD1 LDAH LDAH SMAD2 SMAD2 YWHAQ YWHAQ CTNNA2 CTNNA2 TCF7L1 TCF7L1 LLGL2 LLGL2 H0WIM4_OTOGA H0WIM4_OTOGA H0WIM7_OTOGA H0WIM7_OTOGA CSNK1E CSNK1E WNT11 WNT11 PRKCZ PRKCZ FZD2 FZD2 FZD6 FZD6 PPP2CB PPP2CB YAP1 YAP1 TEAD3 TEAD3 PATJ PATJ BMPR1B BMPR1B CTNNA3 CTNNA3 H0WMW6_OTOGA H0WMW6_OTOGA PARD3 PARD3 TGFBR1 TGFBR1 WNT16 WNT16 LEF1 LEF1 DLG4 DLG4 DVL2 DVL2 FGF1 FGF1 TEAD4 TEAD4 CCND2 CCND2 MYC MYC PARD6B PARD6B PRKCI PRKCI LATS2 LATS2 BIRC3 BIRC3 GSK3B GSK3B TP73 TP73 WNT3 WNT3 WNT9B WNT9B YWHAE YWHAE BMP2 BMP2 WWC1 WWC1 FRMD6 FRMD6 SERPINE1 SERPINE1 WNT5A WNT5A BMPR2 BMPR2 MOB1B MOB1B DLG1 DLG1 ACTG1 ACTG1 ACTB ACTB AXIN2 AXIN2 YWHAB YWHAB ACTL7A ACTL7A ID1 ID1 TGFB3 TGFB3 H0X0V5_OTOGA H0X0V5_OTOGA ITGB2 ITGB2 PPP2CA PPP2CA AFP AFP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TEAD2TEA domain transcription factor 2. (449 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (333 aa)
BIRC2Uncharacterized protein. (618 aa)
SNAI2Uncharacterized protein. (268 aa)
DLG2Discs large MAGUK scaffold protein 2. (856 aa)
RASSF6Ras association domain family member 6. (324 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (537 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (443 aa)
ACTRT2Actin related protein T2; Belongs to the actin family. (377 aa)
CRB1Crumbs cell polarity complex component 1. (1334 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
AMOTAngiomotin. (1073 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
DLG3Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family. (853 aa)
WTIPWT1 interacting protein. (303 aa)
FBXW11F-box and WD repeat domain containing 11. (580 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
LIMD1LIM domains containing 1. (675 aa)
LATS1Large tumor suppressor kinase 1. (1133 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
LOC100943305Uncharacterized protein; Belongs to the actin family. (377 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (602 aa)
MYO15AMyosin XVA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (3522 aa)
LLGL1LLGL scribble cell polarity complex component 1. (1042 aa)
LRRC1Leucine rich repeat containing 1. (604 aa)
LOC100951798Uncharacterized protein; Belongs to the actin family. (377 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (420 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (591 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (368 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
TCF7L2Transcription factor 7 like 2. (471 aa)
ACTL8Actin like 8; Belongs to the actin family. (366 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (526 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
AXIN1Axin 1. (867 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (322 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
DVL3Dishevelled segment polarity protein 3. (722 aa)
CTNNB1Catenin beta 1. (781 aa)
STK3Serine/threonine kinase 3. (450 aa)
NF2Neurofibromin 2. (553 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1917 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
LOC100950637Uncharacterized protein; Belongs to the actin family. (377 aa)
APC2APC regulator of WNT signaling pathway 2. (2292 aa)
NKD1NKD inhibitor of WNT signaling pathway 1. (452 aa)
H0XI59_OTOGA14_3_3 domain-containing protein. (62 aa)
BIRC5Baculoviral IAP repeat containing 5. (142 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
LOC100950579Uncharacterized protein; Belongs to the actin family. (377 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (592 aa)
LOC100951719Uncharacterized protein. (598 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
H0XLI4_OTOGAUncharacterized protein. (186 aa)
LOC100966429Uncharacterized protein. (375 aa)
SCRIBScribble planar cell polarity protein. (1162 aa)
CRB2Crumbs cell polarity complex component 2. (1275 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (647 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
H0XMG1_OTOGAProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (410 aa)
APCAPC regulator of WNT signaling pathway. (2812 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
PARD6APar-6 family cell polarity regulator alpha. (345 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
CTNNA1Catenin alpha 1. (969 aa)
ACTL9Actin like 9; Belongs to the actin family. (416 aa)
AMHAnti-Mullerian hormone. (557 aa)
BBC3Uncharacterized protein. (193 aa)
ACTL7BActin like 7B; Belongs to the actin family. (417 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
LOC100950013Uncharacterized protein; Belongs to the actin family. (377 aa)
H0XQJ1_OTOGATGF_BETA_2 domain-containing protein. (414 aa)
GDF5Growth differentiation factor 5. (498 aa)
PARD6GPar-6 family cell polarity regulator gamma. (367 aa)
NKD2NKD inhibitor of WNT signaling pathway 2. (456 aa)
MPP5Membrane palmitoylated protein 5; Belongs to the MAGUK family. (675 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
H0XTT1_OTOGAProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (429 aa)
H0XTZ8_OTOGATGF_BETA_2 domain-containing protein. (420 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (403 aa)
GDF6Growth differentiation factor 6. (461 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
SOX3SRY-box transcription factor 3. (332 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
RASSF1Ras association domain family member 1. (348 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (292 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
CCN2Cellular communication network factor 2. (349 aa)
LOC10095347014_3_3 domain-containing protein; Belongs to the 14-3-3 family. (247 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (513 aa)
LOC100952117Uncharacterized protein; Belongs to the actin family. (377 aa)
BMP4Bone morphogenetic protein 4 (Predicted). (409 aa)
H0XYF5_OTOGA14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (165 aa)
DVL1Dishevelled segment polarity protein 1. (696 aa)
BMP6Bone morphogenetic protein 6. (516 aa)
AJUBAAjuba LIM protein. (538 aa)
H0XZI5_OTOGA14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (246 aa)
SAV1Salvador family WW domain containing protein 1. (385 aa)
TCF7Transcription factor 7. (419 aa)
AREGAmphiregulin. (253 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
GLI2GLI family zinc finger 2. (1522 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
GDF7Growth differentiation factor 7. (421 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide (Predicted); Belongs to the 14-3-3 family. (246 aa)
H0Y1X4_OTOGAUncharacterized protein; Belongs to the actin family. (1226 aa)
SOX2SRY-box transcription factor 2. (319 aa)
H0Y264_OTOGAUncharacterized protein. (191 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
LDAHLipid droplet associated hydrolase. (277 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
YWHAQTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta; Belongs to the 14-3-3 family. (245 aa)
CTNNA2Catenin alpha 2. (601 aa)
TCF7L1Transcription factor 7 like 1. (574 aa)
LLGL2LLGL scribble cell polarity complex component 2. (1022 aa)
H0WIM4_OTOGASH3 domain-containing protein. (862 aa)
H0WIM7_OTOGAUncharacterized protein. (509 aa)
CSNK1EProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (416 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (588 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
PPP2CBSerine/threonine-protein phosphatase. (308 aa)
YAP1Yes associated protein 1. (501 aa)
TEAD3Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (471 aa)
PATJPATJ crumbs cell polarity complex component. (1825 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
CTNNA3Catenin alpha 3. (893 aa)
H0WMW6_OTOGAUncharacterized protein. (212 aa)
PARD3Par-3 family cell polarity regulator. (1058 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (469 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
LEF1Lymphoid enhancer binding factor 1. (398 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (808 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
TEAD4Transcriptional enhancer factor TEF-3; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (434 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (452 aa)
PARD6BPar-6 family cell polarity regulator beta. (372 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (609 aa)
LATS2Non-specific serine/threonine protein kinase. (1071 aa)
BIRC3Baculoviral IAP repeat containing 3. (605 aa)
GSK3BGlycogen synthase kinase 3 beta. (387 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (642 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (233 aa)
BMP2Bone morphogenetic protein 2. (393 aa)
WWC1WW and C2 domain containing 1. (1180 aa)
FRMD6FERM domain containing 6. (622 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (404 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
MOB1BMOB kinase activator 1B. (221 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (925 aa)
ACTG1Actin gamma 1. (375 aa)
ACTBUncharacterized protein. (375 aa)
AXIN2Axin 2. (844 aa)
YWHAB14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (246 aa)
ACTL7AActin like 7A; Belongs to the actin family. (440 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
H0X0V5_OTOGAUncharacterized protein. (569 aa)
ITGB2Integrin beta. (737 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
AFPAlpha fetoprotein. (623 aa)
Your Current Organism:
Otolemur garnettii
NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago
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