STRINGSTRING
PRKCZ PRKCZ PARD6G PARD6G GDF5 GDF5 H0XQJ1_OTOGA H0XQJ1_OTOGA LOC100950013 LOC100950013 WNT8A WNT8A ACTL7B ACTL7B BBC3 BBC3 AMH AMH ACTL9 ACTL9 CTNNA1 CTNNA1 PPP2R2A PPP2R2A PARD6A PARD6A WNT7B WNT7B APC APC H0XMG1_OTOGA H0XMG1_OTOGA WNT7A WNT7A FZD3 FZD3 FZD1 FZD1 CRB2 CRB2 SCRIB SCRIB LOC100966429 LOC100966429 H0XLI4_OTOGA H0XLI4_OTOGA WNT5B WNT5B YWHAG YWHAG LOC100951719 LOC100951719 FZD9 FZD9 LOC100950579 LOC100950579 WNT10A WNT10A BIRC5 BIRC5 H0XI59_OTOGA H0XI59_OTOGA NKD1 NKD1 APC2 APC2 LOC100950637 LOC100950637 WNT10B WNT10B DLG5 DLG5 NF2 NF2 STK3 STK3 CTNNB1 CTNNB1 DVL3 DVL3 BMP5 BMP5 PPP1CB PPP1CB AXIN1 AXIN1 BMP7 BMP7 BTRC BTRC ACTL8 ACTL8 TCF7L2 TCF7L2 SMAD3 SMAD3 WNT6 WNT6 WNT2B WNT2B WNT2 WNT2 PPP2R1A PPP2R1A WNT3A WNT3A WNT9A WNT9A PPP2R2D PPP2R2D LOC100951798 LOC100951798 LRRC1 LRRC1 LLGL1 LLGL1 MYO15A MYO15A PPP2R1B PPP2R1B LOC100943305 LOC100943305 ID2 ID2 LATS1 LATS1 LIMD1 LIMD1 SMAD4 SMAD4 FBXW11 FBXW11 WTIP WTIP DLG3 DLG3 PPP2R2C PPP2R2C AMOT AMOT CCND1 CCND1 FZD4 FZD4 CRB1 CRB1 ACTRT2 ACTRT2 PPP2R2B PPP2R2B BMPR1A BMPR1A RASSF6 RASSF6 DLG2 DLG2 SNAI2 SNAI2 BIRC2 BIRC2 WNT4 WNT4 TGFB2 TGFB2 TEAD2 TEAD2 AFP AFP PPP2CA PPP2CA ITGB2 ITGB2 H0X0V5_OTOGA H0X0V5_OTOGA TGFB3 TGFB3 ID1 ID1 ACTL7A ACTL7A YWHAB YWHAB AXIN2 AXIN2 ACTB ACTB ACTG1 ACTG1 DLG1 DLG1 MOB1B MOB1B BMPR2 BMPR2 WNT5A WNT5A SERPINE1 SERPINE1 FRMD6 FRMD6 WWC1 WWC1 BMP2 BMP2 YWHAE YWHAE WNT9B WNT9B WNT3 WNT3 TP73 TP73 GSK3B GSK3B BIRC3 BIRC3 LATS2 LATS2 PRKCI PRKCI PARD6B PARD6B MYC MYC CCND2 CCND2 TEAD4 TEAD4 FGF1 FGF1 DVL2 DVL2 DLG4 DLG4 LEF1 LEF1 WNT16 WNT16 TGFBR1 TGFBR1 PARD3 PARD3 H0WMW6_OTOGA H0WMW6_OTOGA CTNNA3 CTNNA3 BMPR1B BMPR1B PATJ PATJ TEAD3 TEAD3 YAP1 YAP1 PPP2CB PPP2CB FZD6 FZD6 FZD2 FZD2 NKD2 NKD2 WNT11 WNT11 CSNK1E CSNK1E H0WIM7_OTOGA H0WIM7_OTOGA H0WIM4_OTOGA H0WIM4_OTOGA LLGL2 LLGL2 TCF7L1 TCF7L1 CTNNA2 CTNNA2 YWHAQ YWHAQ SMAD2 SMAD2 LDAH LDAH SMAD1 SMAD1 TGFBR2 TGFBR2 H0Y264_OTOGA H0Y264_OTOGA SOX2 SOX2 H0Y1X4_OTOGA H0Y1X4_OTOGA YWHAH YWHAH GDF7 GDF7 WNT8B WNT8B WWTR1 WWTR1 GLI2 GLI2 FZD5 FZD5 AREG AREG TCF7 TCF7 SAV1 SAV1 H0XZI5_OTOGA H0XZI5_OTOGA AJUBA AJUBA BMP6 BMP6 DVL1 DVL1 H0XYF5_OTOGA H0XYF5_OTOGA BMP4 BMP4 LOC100952117 LOC100952117 FZD8 FZD8 LOC100953470 LOC100953470 CCN2 CCN2 FZD7 FZD7 CCND3 CCND3 RASSF1 RASSF1 WNT1 WNT1 SMAD7 SMAD7 SOX3 SOX3 PPP1CA PPP1CA GDF6 GDF6 TGFB1 TGFB1 H0XTZ8_OTOGA H0XTZ8_OTOGA H0XTT1_OTOGA H0XTT1_OTOGA FZD10 FZD10 MPP5 MPP5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
PARD6GPar-6 family cell polarity regulator gamma. (367 aa)
GDF5Growth differentiation factor 5. (498 aa)
H0XQJ1_OTOGATGF_BETA_2 domain-containing protein. (414 aa)
LOC100950013Uncharacterized protein; Belongs to the actin family. (377 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
ACTL7BActin like 7B; Belongs to the actin family. (417 aa)
BBC3Uncharacterized protein. (193 aa)
AMHAnti-Mullerian hormone. (557 aa)
ACTL9Actin like 9; Belongs to the actin family. (416 aa)
CTNNA1Catenin alpha 1. (969 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
PARD6APar-6 family cell polarity regulator alpha. (345 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
APCAPC regulator of WNT signaling pathway. (2812 aa)
H0XMG1_OTOGAProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (410 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (647 aa)
CRB2Crumbs cell polarity complex component 2. (1275 aa)
SCRIBScribble planar cell polarity protein. (1162 aa)
LOC100966429Uncharacterized protein. (375 aa)
H0XLI4_OTOGAUncharacterized protein. (186 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa)
LOC100951719Uncharacterized protein. (598 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (592 aa)
LOC100950579Uncharacterized protein; Belongs to the actin family. (377 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
BIRC5Baculoviral IAP repeat containing 5. (142 aa)
H0XI59_OTOGA14_3_3 domain-containing protein. (62 aa)
NKD1NKD inhibitor of WNT signaling pathway 1. (452 aa)
APC2APC regulator of WNT signaling pathway 2. (2292 aa)
LOC100950637Uncharacterized protein; Belongs to the actin family. (377 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1917 aa)
NF2Neurofibromin 2. (553 aa)
STK3Serine/threonine kinase 3. (450 aa)
CTNNB1Catenin beta 1. (781 aa)
DVL3Dishevelled segment polarity protein 3. (722 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (322 aa)
AXIN1Axin 1. (867 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (526 aa)
ACTL8Actin like 8; Belongs to the actin family. (366 aa)
TCF7L2Transcription factor 7 like 2. (471 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (368 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (591 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (420 aa)
LOC100951798Uncharacterized protein; Belongs to the actin family. (377 aa)
LRRC1Leucine rich repeat containing 1. (604 aa)
LLGL1LLGL scribble cell polarity complex component 1. (1042 aa)
MYO15AMyosin XVA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (3522 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (602 aa)
LOC100943305Uncharacterized protein; Belongs to the actin family. (377 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
LATS1Large tumor suppressor kinase 1. (1133 aa)
LIMD1LIM domains containing 1. (675 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
FBXW11F-box and WD repeat domain containing 11. (580 aa)
WTIPWT1 interacting protein. (303 aa)
DLG3Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family. (853 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
AMOTAngiomotin. (1073 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
CRB1Crumbs cell polarity complex component 1. (1334 aa)
ACTRT2Actin related protein T2; Belongs to the actin family. (377 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (443 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (537 aa)
RASSF6Ras association domain family member 6. (324 aa)
DLG2Discs large MAGUK scaffold protein 2. (856 aa)
SNAI2Uncharacterized protein. (268 aa)
BIRC2Uncharacterized protein. (618 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (333 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
TEAD2TEA domain transcription factor 2. (449 aa)
AFPAlpha fetoprotein. (623 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
ITGB2Integrin beta. (737 aa)
H0X0V5_OTOGAUncharacterized protein. (569 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
ACTL7AActin like 7A; Belongs to the actin family. (440 aa)
YWHAB14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (246 aa)
AXIN2Axin 2. (844 aa)
ACTBUncharacterized protein. (375 aa)
ACTG1Actin gamma 1. (375 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (925 aa)
MOB1BMOB kinase activator 1B. (221 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (404 aa)
FRMD6FERM domain containing 6. (622 aa)
WWC1WW and C2 domain containing 1. (1180 aa)
BMP2Bone morphogenetic protein 2. (393 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (233 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (642 aa)
GSK3BGlycogen synthase kinase 3 beta. (387 aa)
BIRC3Baculoviral IAP repeat containing 3. (605 aa)
LATS2Non-specific serine/threonine protein kinase. (1071 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (609 aa)
PARD6BPar-6 family cell polarity regulator beta. (372 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (452 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
TEAD4Transcriptional enhancer factor TEF-3; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (434 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (808 aa)
LEF1Lymphoid enhancer binding factor 1. (398 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (469 aa)
PARD3Par-3 family cell polarity regulator. (1058 aa)
H0WMW6_OTOGAUncharacterized protein. (212 aa)
CTNNA3Catenin alpha 3. (893 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
PATJPATJ crumbs cell polarity complex component. (1825 aa)
TEAD3Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (471 aa)
YAP1Yes associated protein 1. (501 aa)
PPP2CBSerine/threonine-protein phosphatase. (308 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (588 aa)
NKD2NKD inhibitor of WNT signaling pathway 2. (456 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
CSNK1EProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (416 aa)
H0WIM7_OTOGAUncharacterized protein. (509 aa)
H0WIM4_OTOGASH3 domain-containing protein. (862 aa)
LLGL2LLGL scribble cell polarity complex component 2. (1022 aa)
TCF7L1Transcription factor 7 like 1. (574 aa)
CTNNA2Catenin alpha 2. (601 aa)
YWHAQTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta; Belongs to the 14-3-3 family. (245 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
LDAHLipid droplet associated hydrolase. (277 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
H0Y264_OTOGAUncharacterized protein. (191 aa)
SOX2SRY-box transcription factor 2. (319 aa)
H0Y1X4_OTOGAUncharacterized protein; Belongs to the actin family. (1226 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide (Predicted); Belongs to the 14-3-3 family. (246 aa)
GDF7Growth differentiation factor 7. (421 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
GLI2GLI family zinc finger 2. (1522 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
AREGAmphiregulin. (253 aa)
TCF7Transcription factor 7. (419 aa)
SAV1Salvador family WW domain containing protein 1. (385 aa)
H0XZI5_OTOGA14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (246 aa)
AJUBAAjuba LIM protein. (538 aa)
BMP6Bone morphogenetic protein 6. (516 aa)
DVL1Dishevelled segment polarity protein 1. (696 aa)
H0XYF5_OTOGA14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (165 aa)
BMP4Bone morphogenetic protein 4 (Predicted). (409 aa)
LOC100952117Uncharacterized protein; Belongs to the actin family. (377 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (513 aa)
LOC10095347014_3_3 domain-containing protein; Belongs to the 14-3-3 family. (247 aa)
CCN2Cellular communication network factor 2. (349 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (292 aa)
RASSF1Ras association domain family member 1. (348 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
SOX3SRY-box transcription factor 3. (332 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
GDF6Growth differentiation factor 6. (461 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (403 aa)
H0XTZ8_OTOGATGF_BETA_2 domain-containing protein. (420 aa)
H0XTT1_OTOGAProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (429 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
MPP5Membrane palmitoylated protein 5; Belongs to the MAGUK family. (675 aa)
Your Current Organism:
Otolemur garnettii
NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago
Server load: low (24%) [HD]