STRINGSTRING
H0XT98_OTOGA H0XT98_OTOGA SMAD1 SMAD1 SMAD2 SMAD2 POU5F1 POU5F1 MYF5 MYF5 PCGF1 PCGF1 H0WHZ3_OTOGA H0WHZ3_OTOGA KAT6A KAT6A PCGF5 PCGF5 STAT3 STAT3 WNT11 WNT11 MAP2K2 MAP2K2 FZD2 FZD2 ISL2 ISL2 LIFR LIFR FZD6 FZD6 DUSP9 DUSP9 H0WLE0_OTOGA H0WLE0_OTOGA MAPK14 MAPK14 MAPK13 MAPK13 LOC100958496 LOC100958496 BMPR1B BMPR1B GRB2 GRB2 IGF1 IGF1 LHX5 LHX5 TCF3 TCF3 INHBA INHBA ONECUT1 ONECUT1 ACVR2A ACVR2A PIK3CB PIK3CB WNT16 WNT16 DVL2 DVL2 INHBC INHBC INHBE INHBE MYC MYC NODAL NODAL GSK3B GSK3B WNT3 WNT3 WNT9B WNT9B RIF1 RIF1 MEIS2 MEIS2 H0WU85_OTOGA H0WU85_OTOGA PIK3CA PIK3CA IL6ST IL6ST WNT5A WNT5A BMPR2 BMPR2 PAX6 PAX6 ERAS ERAS AXIN2 AXIN2 ESRRB ESRRB MAPK1 MAPK1 ID1 ID1 SMAD5 SMAD5 JAK3 JAK3 WNT4 WNT4 SETDB1 SETDB1 BMPR1A BMPR1A ZFHX3 ZFHX3 JAK1 JAK1 FGFR4 FGFR4 SMARCAD1 SMARCAD1 FZD4 FZD4 LOC100944176 LOC100944176 ACVR1 ACVR1 ZIC3 ZIC3 NFIL3 NFIL3 ACVR1C ACVR1C ID3 ID3 SMAD4 SMAD4 CSDE1 CSDE1 IGF1R IGF1R FGFR2 FGFR2 JAK2 JAK2 HOXA1 HOXA1 ID2 ID2 PRRX1 PRRX1 LIF LIF WNT9A WNT9A WNT3A WNT3A WNT2 WNT2 LHX1 LHX1 AKT2 AKT2 WNT2B WNT2B WNT6 WNT6 MAPK12 MAPK12 MAPK11 MAPK11 SMAD3 SMAD3 FGFR1 FGFR1 ESRRG ESRRG KRAS KRAS TBX2 TBX2 JARID2 JARID2 AXIN1 AXIN1 PIK3R1 PIK3R1 PIK3CD PIK3CD MEIS1 MEIS1 PCGF3 PCGF3 HOXD1 HOXD1 MAP2K1 MAP2K1 REST REST DVL3 DVL3 CTNNB1 CTNNB1 TBX3 TBX3 AKT3 AKT3 WNT10B WNT10B PCGF6 PCGF6 HOXB1 HOXB1 INHBB INHBB APC2 APC2 H0XI62_OTOGA H0XI62_OTOGA H0XIR4_OTOGA H0XIR4_OTOGA WNT10A WNT10A ZIC1 ZIC1 FZD9 FZD9 WNT5B WNT5B FZD1 FZD1 H0XLZ0_OTOGA H0XLZ0_OTOGA FZD3 FZD3 WNT7A WNT7A RAF1 RAF1 APC APC WNT7B WNT7B AKT1 AKT1 WNT8A WNT8A HRAS HRAS ONECUT2 ONECUT2 OTX1 OTX1 MAPK3 MAPK3 ACVR2B ACVR2B ACVR1B ACVR1B PCGF2 PCGF2 ONECUT3 ONECUT3 H0XT64_OTOGA H0XT64_OTOGA H0XT76_OTOGA H0XT76_OTOGA FZD10 FZD10 SOX3 SOX3 WNT1 WNT1 NRAS NRAS ISL1 ISL1 ZIC2 ZIC2 FZD7 FZD7 FZD8 FZD8 BMP4 BMP4 HESX1 HESX1 SKIL SKIL DVL1 DVL1 ID4 ID4 KLF4 KLF4 FGFR3 FGFR3 TCF7 TCF7 DLX5 DLX5 H0Y0N8_OTOGA H0Y0N8_OTOGA FGF2 FGF2 FZD5 FZD5 WNT8B WNT8B HAND1 HAND1 SOX2 SOX2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
H0XT98_OTOGAUncharacterized protein. (156 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
POU5F1POU domain protein. (359 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
PCGF1Polycomb group ring finger 1. (259 aa)
H0WHZ3_OTOGAUncharacterized protein. (731 aa)
KAT6AHistone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (2032 aa)
PCGF5Polycomb group ring finger 5. (256 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (588 aa)
ISL2ISL LIM homeobox 2. (359 aa)
LIFRLIF receptor subunit alpha. (1097 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
DUSP9Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (382 aa)
H0WLE0_OTOGAMothers against decapentaplegic homolog. (429 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
LOC100958496Left-right determination factor. (364 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
IGF1Insulin like growth factor 1. (189 aa)
LHX5LIM homeobox 5. (402 aa)
TCF3Transcription factor 3. (666 aa)
INHBAInhibin subunit beta A. (426 aa)
ONECUT1One cut domain family member. (465 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (516 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (859 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
INHBCInhibin subunit beta C. (350 aa)
INHBEInhibin subunit beta E. (352 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (452 aa)
NODALNodal growth differentiation factor. (344 aa)
GSK3BGlycogen synthase kinase 3 beta. (387 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
RIF1Replication timing regulatory factor 1. (2464 aa)
MEIS2Meis homeobox 2. (477 aa)
H0WU85_OTOGAUncharacterized protein. (451 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
IL6STInterleukin 6 signal transducer. (919 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
PAX6Paired box 6. (442 aa)
ERASES cell expressed Ras. (229 aa)
AXIN2Axin 2. (844 aa)
ESRRBEstrogen related receptor beta. (496 aa)
MAPK1Mitogen-activated protein kinase. (323 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
JAK3Tyrosine-protein kinase. (1104 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (333 aa)
SETDB1SET domain bifurcated histone lysine methyltransferase 1. (1288 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (537 aa)
ZFHX3Zinc finger homeobox 3. (2592 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
FGFR4Fibroblast growth factor receptor 4. (969 aa)
SMARCAD1Uncharacterized protein. (1028 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
LOC100944176RING-type domain-containing protein. (326 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (489 aa)
ZIC3Zic family member 3. (467 aa)
NFIL3Nuclear factor interleukin-3-regulated protein; Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T- cells. Competes for the same consensus-binding site with PAR DNA- bi [...] (462 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (479 aa)
ID3Inhibitor of DNA binding 3, HLH protein. (119 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
CSDE1Cold shock domain containing E1. (813 aa)
IGF1RTyrosine-protein kinase receptor. (1158 aa)
FGFR2Fibroblast growth factor receptor. (822 aa)
JAK2Tyrosine-protein kinase. (1133 aa)
HOXA1Homeobox A1 isoform a (Predicted). (335 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
PRRX1Paired related homeobox 1. (245 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
LHX1LIM homeobox 1. (407 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (368 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
MAPK11Mitogen-activated protein kinase. (372 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
FGFR1Fibroblast growth factor receptor. (792 aa)
ESRRGEstrogen related receptor gamma. (450 aa)
KRASKRAS proto-oncogene, GTPase. (243 aa)
TBX2T-box transcription factor 2. (716 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1240 aa)
AXIN1Axin 1. (867 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (549 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
MEIS1Meis homeobox 1. (454 aa)
PCGF3Polycomb group ring finger 3. (242 aa)
HOXD1Homeobox D1. (325 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
RESTUncharacterized protein. (1067 aa)
DVL3Dishevelled segment polarity protein 3. (722 aa)
CTNNB1Catenin beta 1. (781 aa)
TBX3T-box transcription factor 3. (745 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
PCGF6Polycomb group ring finger 6. (336 aa)
HOXB1Homeobox B1. (301 aa)
INHBBInhibin subunit beta B. (407 aa)
APC2APC regulator of WNT signaling pathway 2. (2292 aa)
H0XI62_OTOGATGF_BETA_2 domain-containing protein. (341 aa)
H0XIR4_OTOGAHomeobox domain-containing protein. (230 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
ZIC1Zic family member 1. (447 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (592 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (647 aa)
H0XLZ0_OTOGAHomeobox domain-containing protein. (217 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (708 aa)
APCAPC regulator of WNT signaling pathway. (2812 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ONECUT2One cut domain family member. (400 aa)
OTX1Orthodenticle homeobox 1. (355 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (336 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (525 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (483 aa)
PCGF2Polycomb group ring finger 2. (344 aa)
ONECUT3One cut domain family member. (493 aa)
H0XT64_OTOGAHomeobox domain-containing protein. (153 aa)
H0XT76_OTOGAHomeobox domain-containing protein. (232 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
SOX3SRY-box transcription factor 3. (332 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
ISL1ISL LIM homeobox 1. (361 aa)
ZIC2Zic family member 2. (362 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (513 aa)
BMP4Bone morphogenetic protein 4 (Predicted). (409 aa)
HESX1HESX homeobox 1. (200 aa)
SKILSKI like proto-oncogene. (692 aa)
DVL1Dishevelled segment polarity protein 1. (696 aa)
ID4Inhibitor of DNA binding 4, HLH protein. (161 aa)
KLF4Kruppel like factor 4. (487 aa)
FGFR3Fibroblast growth factor receptor. (808 aa)
TCF7Transcription factor 7. (419 aa)
DLX5Distal-less homeobox 5. (289 aa)
H0Y0N8_OTOGAC2H2-type domain-containing protein. (454 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
HAND1Heart and neural crest derivatives expressed 1. (217 aa)
SOX2SRY-box transcription factor 2. (319 aa)
Your Current Organism:
Otolemur garnettii
NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago
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