(53 nodes) Cytosolic DNA-sensing pathway network (Otolemur garnettii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PYCARD	PYD and CARD domain containing. (193 aa)
	POLR2F	RNA polymerase II subunit F. (127 aa)
	LOC100947950	Uncharacterized protein. (204 aa)
	CXCL10	C-X-C motif chemokine. (98 aa)
	H0Y0D2_OTOGA	Uncharacterized protein. (194 aa)
	H0XWX2_OTOGA	Uncharacterized protein. (72 aa)
	H0XV88_OTOGA	C-C motif chemokine. (118 aa)
	TREX2	Three prime repair exonuclease 2. (254 aa)
	IKBKG	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (420 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (747 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	H0XM60_OTOGA	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (108 aa)
	POLR2L	RNA polymerase II subunit L. (67 aa)
	IFNB1	Interferon beta 1. (187 aa)
	POLR3E	RNA polymerase III subunit E. (709 aa)
	TREX1	Three prime repair exonuclease 1. (314 aa)
	POLR1C	RNA polymerase I and III subunit C. (348 aa)
	POLR3B	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1133 aa)
	POLR3C	RNA polymerase III subunit C3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (534 aa)
	ZBP1	Z-DNA binding protein 1. (401 aa)
	POLR1D	RNA polymerase I and III subunit D. (133 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (429 aa)
	CGAS	Cyclic GMP-AMP synthase. (529 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (964 aa)
	POLR2E	RNA polymerase II subunit E. (210 aa)
	IRF3	Interferon regulatory factor 3. (428 aa)
	CCL5	C-C motif chemokine. (91 aa)
	POLR3A	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1390 aa)
	DDX58	DExD/H-box helicase 58. (926 aa)
	STING1	Transmembrane protein 173. (379 aa)
	H0WYF9_OTOGA	Uncharacterized protein. (67 aa)
	NFKBIB	NFKB inhibitor beta. (355 aa)
	IKBKE	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (663 aa)
	RIPK3	Receptor interacting serine/threonine kinase 3. (505 aa)
	ADAR	Adenosine deaminase RNA specific. (1157 aa)
	POLR3G	DNA-directed RNA polymerase III subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. (224 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (729 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
	IRF7	Interferon regulatory factor 7. (495 aa)
	TBK1	TANK binding kinase 1. (729 aa)
	PIWIL2	Piwi like RNA-mediated gene silencing 2; Belongs to the argonaute family. (972 aa)
	POLR3D	RNA polymerase III subunit D. (397 aa)
	H0WQ32_OTOGA	Uncharacterized protein. (148 aa)
	H0WPC6_OTOGA	Uncharacterized protein. (211 aa)
	NFKBIA	NFKB inhibitor alpha. (314 aa)
	POLR3F	DNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family. (316 aa)
	POLR3H	Uncharacterized protein. (204 aa)
	POLR3K	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (108 aa)
	POLR2H	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
	MAVS	Mitochondrial antiviral signaling protein. (525 aa)
	AIM2	Absent in melanoma 2. (343 aa)
	H0WFX9_OTOGA	DNA-directed RNA polymerase III subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. (222 aa)

Your Current Organism:

Otolemur garnettii

NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAR	DDX58	ENSOGAP00000004997	ENSOGAP00000009435	Adenosine deaminase RNA specific.	DExD/H-box helicase 58.	0.431
ADAR	IRF7	ENSOGAP00000004997	ENSOGAP00000004454	Adenosine deaminase RNA specific.	Interferon regulatory factor 7.	0.496
ADAR	ZBP1	ENSOGAP00000004997	ENSOGAP00000013144	Adenosine deaminase RNA specific.	Z-DNA binding protein 1.	0.420
AIM2	CGAS	ENSOGAP00000000234	ENSOGAP00000012238	Absent in melanoma 2.	Cyclic GMP-AMP synthase.	0.441
AIM2	DDX58	ENSOGAP00000000234	ENSOGAP00000009435	Absent in melanoma 2.	DExD/H-box helicase 58.	0.551
AIM2	IL18	ENSOGAP00000000234	ENSOGAP00000017348	Absent in melanoma 2.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.721
AIM2	IL1B	ENSOGAP00000000234	ENSOGAP00000004815	Absent in melanoma 2.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.728
AIM2	PYCARD	ENSOGAP00000000234	ENSOGAP00000007931	Absent in melanoma 2.	PYD and CARD domain containing.	0.989
AIM2	STING1	ENSOGAP00000000234	ENSOGAP00000008752	Absent in melanoma 2.	Transmembrane protein 173.	0.779
CCL5	CXCL10	ENSOGAP00000010493	ENSOGAP00000022139	C-C motif chemokine.	C-X-C motif chemokine.	0.990
CCL5	H0WPC6_OTOGA	ENSOGAP00000010493	ENSOGAP00000003727	C-C motif chemokine.	Uncharacterized protein.	0.615
CCL5	H0XV88_OTOGA	ENSOGAP00000010493	ENSOGAP00000020030	C-C motif chemokine.	C-C motif chemokine.	0.901
CCL5	IL18	ENSOGAP00000010493	ENSOGAP00000017348	C-C motif chemokine.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.408
CCL5	IL1B	ENSOGAP00000010493	ENSOGAP00000004815	C-C motif chemokine.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.604
CCL5	IRF3	ENSOGAP00000010493	ENSOGAP00000010680	C-C motif chemokine.	Interferon regulatory factor 3.	0.418
CCL5	IRF7	ENSOGAP00000010493	ENSOGAP00000004454	C-C motif chemokine.	Interferon regulatory factor 7.	0.416
CCL5	MAVS	ENSOGAP00000010493	ENSOGAP00000000571	C-C motif chemokine.	Mitochondrial antiviral signaling protein.	0.463
CCL5	NFKB1	ENSOGAP00000010493	ENSOGAP00000011515	C-C motif chemokine.	Nuclear factor kappa B subunit 1.	0.888
CCL5	NFKBIA	ENSOGAP00000010493	ENSOGAP00000003301	C-C motif chemokine.	NFKB inhibitor alpha.	0.659
CCL5	RELA	ENSOGAP00000010493	ENSOGAP00000012644	C-C motif chemokine.	RELA proto-oncogene, NF-kB subunit.	0.853