(77 nodes) Prolactin signaling pathway network (Otolemur garnettii)

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	MAPK8	Mitogen-activated protein kinase. (427 aa)
	ESR2	Estrogen receptor 2. (530 aa)
	CGA	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (120 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	H0WU85_OTOGA	Uncharacterized protein. (451 aa)
	CCDC170	Coiled-coil domain containing 170. (720 aa)
	GSK3B	Glycogen synthase kinase 3 beta. (387 aa)
	CCND2	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
	SHC2	Uncharacterized protein. (580 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (859 aa)
	SOCS4	Suppressor of cytokine signaling 4. (441 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	STAT1	Signal transducer and activator of transcription. (762 aa)
	MAPK13	Mitogen-activated protein kinase. (366 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
	MAP2K2	Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)
	STAT5A	Signal transducer and activator of transcription. (793 aa)
	PRLR	Prolactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (625 aa)
	H0WHZ3_OTOGA	Uncharacterized protein. (731 aa)
	SOCS2	Suppressor of cytokine signaling 2. (198 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
	LHB	Cys_knot domain-containing protein. (141 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (336 aa)
	FOXO3	Forkhead box O3. (672 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
	LHCGR	Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (699 aa)
	MAPK1	Mitogen-activated protein kinase. (323 aa)
	SLC2A2	Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (518 aa)
	TNIK	TRAF2 and NCK interacting kinase. (1325 aa)
	SOCS5	Suppressor of cytokine signaling 5. (536 aa)
	CCND1	Cyclin D1; Belongs to the cyclin family. (295 aa)
	SHC3	SHC adaptor protein 3. (594 aa)
	SOCS3	Suppressor of cytokine signaling 3. (224 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (708 aa)
	CISH	Cytokine inducible SH2 containing protein. (256 aa)
	H0XK12_OTOGA	Uncharacterized protein. (477 aa)
	H0XJC1_OTOGA	PID domain-containing protein. (486 aa)
	TNFRSF11A	TNF receptor superfamily member 11a. (613 aa)
	CSN2	Casein beta. (220 aa)
	STAT5B	Signal transducer and activator of transcription. (788 aa)
	TH	Tyrosine hydroxylase. (494 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	SRC	Tyrosine-protein kinase. (542 aa)
	IRF1	Interferon regulatory factor. (328 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (549 aa)
	MAPK10	Mitogen-activated protein kinase. (426 aa)
	KRAS	KRAS proto-oncogene, GTPase. (243 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
	MAPK11	Mitogen-activated protein kinase. (372 aa)
	MAPK12	Mitogen-activated protein kinase. (367 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (429 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	CYP17A1	Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family. (510 aa)
	SHC4	SHC adaptor protein 4. (632 aa)
	CEP152	Centrosomal protein 152. (1661 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (964 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (598 aa)
	SOCS7	Suppressor of cytokine signaling 7. (577 aa)
	JAK2	Tyrosine-protein kinase. (1133 aa)
	CSDE1	Cold shock domain containing E1. (813 aa)
	SOCS6	Suppressor of cytokine signaling 6. (535 aa)
	SHC1	Uncharacterized protein. (577 aa)
	TNFSF11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (315 aa)
	SOCS1	Suppressor of cytokine signaling 1. (212 aa)
	RELCH	RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1216 aa)
	GCK	Phosphotransferase. (466 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	H0XTT7_OTOGA	SOCS box domain-containing protein. (276 aa)
	PRL	Growth hormone A1. (231 aa)
	ERAS	ES cell expressed Ras. (229 aa)

Your Current Organism:

Otolemur garnettii

NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	AKT2	ENSOGAP00000018100	ENSOGAP00000012516	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.961
AKT1	AKT3	ENSOGAP00000018100	ENSOGAP00000014695	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.910
AKT1	CCND1	ENSOGAP00000018100	ENSOGAP00000010293	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cyclin D1; Belongs to the cyclin family.	0.613
AKT1	CSDE1	ENSOGAP00000018100	ENSOGAP00000010855	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cold shock domain containing E1.	0.461
AKT1	ERAS	ENSOGAP00000018100	ENSOGAP00000007333	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	ES cell expressed Ras.	0.524
AKT1	ESR1	ENSOGAP00000018100	ENSOGAP00000011271	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.580
AKT1	ESR2	ENSOGAP00000018100	ENSOGAP00000007012	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Estrogen receptor 2.	0.412
AKT1	FOS	ENSOGAP00000018100	ENSOGAP00000017662	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Fos proto-oncogene, AP-1 transcription factor subunit.	0.620
AKT1	FOXO3	ENSOGAP00000018100	ENSOGAP00000018360	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box O3.	0.973
AKT1	GRB2	ENSOGAP00000018100	ENSOGAP00000002746	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Growth factor receptor bound protein 2.	0.706
AKT1	GSK3B	ENSOGAP00000018100	ENSOGAP00000005385	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Glycogen synthase kinase 3 beta.	0.983
AKT1	H0WHZ3_OTOGA	ENSOGAP00000018100	ENSOGAP00000001020	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.904
AKT1	H0WU85_OTOGA	ENSOGAP00000018100	ENSOGAP00000005767	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.892
AKT1	H0XJC1_OTOGA	ENSOGAP00000018100	ENSOGAP00000016211	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	PID domain-containing protein.	0.517
AKT1	HRAS	ENSOGAP00000018100	ENSOGAP00000018331	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	HRas proto-oncogene, GTPase.	0.524
AKT1	INS	ENSOGAP00000018100	ENSOGAP00000019490	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.613
AKT1	IRF1	ENSOGAP00000018100	ENSOGAP00000013870	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Interferon regulatory factor.	0.642
AKT1	JAK2	ENSOGAP00000018100	ENSOGAP00000010961	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Tyrosine-protein kinase.	0.637
AKT1	KRAS	ENSOGAP00000018100	ENSOGAP00000013268	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	KRAS proto-oncogene, GTPase.	0.524
AKT1	MAP2K1	ENSOGAP00000018100	ENSOGAP00000014222	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily.	0.551