STRINGSTRING
AIPL1 AIPL1 PBX1 PBX1 CDKN1A CDKN1A PTRHD1 PTRHD1 ADCY3 ADCY3 NCEH1 NCEH1 ADCY2 ADCY2 TCF7L1 TCF7L1 RASD1 RASD1 ADCY8 ADCY8 WNT11 WNT11 MAP2K2 MAP2K2 CREB3L3 CREB3L3 CACNA1S CACNA1S FZD2 FZD2 FZD6 FZD6 ADCY9 ADCY9 CRHR1 CRHR1 CACNA1I CACNA1I LOC100958146 LOC100958146 CYP11A1 CYP11A1 CDKN2C CDKN2C ITPR1 ITPR1 CDKN1B CDKN1B SCARB1 SCARB1 WNT16 WNT16 E2F3 E2F3 LEF1 LEF1 DVL2 DVL2 ARNT ARNT CACNA1G CACNA1G CAMK2A CAMK2A ARSI ARSI ADCY1 ADCY1 RAP1B RAP1B PRKACB PRKACB GSK3B GSK3B ADCY4 ADCY4 WNT3 WNT3 WNT9B WNT9B CCNE1 CCNE1 NR4A1 NR4A1 PLCB1 PLCB1 KCNK3 KCNK3 H0WV86_OTOGA H0WV86_OTOGA CDK2 CDK2 CREB1 CREB1 PLCB3 PLCB3 PLCB4 PLCB4 ORAI1 ORAI1 RBBP5 RBBP5 PBX4 PBX4 RB1 RB1 WNT5A WNT5A CDKN2A CDKN2A KCNK2 KCNK2 AIP AIP AXIN2 AXIN2 AGTR1 AGTR1 CREB3L1 CREB3L1 WDR5 WDR5 EGFR EGFR MAPK1 MAPK1 H0X0D7_OTOGA H0X0D7_OTOGA CYP21A2 CYP21A2 BRAF BRAF ITPR2 ITPR2 PLCB2 PLCB2 FH FH CACNA1F CACNA1F WNT4 WNT4 CAMK2D CAMK2D CREB5 CREB5 CREB3L2 CREB3L2 CACNA1C CACNA1C CDKN2B CDKN2B AGT AGT ADCY7 ADCY7 ATF2 ATF2 FZD4 FZD4 CCND1 CCND1 MC2R MC2R PRKACA PRKACA E2F2 E2F2 USP8 USP8 GNAI2 GNAI2 H0X7F6_OTOGA H0X7F6_OTOGA CACNA1H CACNA1H H0X8J2_OTOGA H0X8J2_OTOGA CRHR2 CRHR2 KMT2D KMT2D WNT9A WNT9A WNT3A WNT3A CYP17A1 CYP17A1 WNT2 WNT2 GNAI3 GNAI3 WNT2B WNT2B WNT6 WNT6 PDE8A PDE8A CDK4 CDK4 TCF7L2 TCF7L2 ADCY5 ADCY5 AXIN1 AXIN1 ASH2L ASH2L STAR STAR MAP2K1 MAP2K1 LDLR LDLR DVL3 DVL3 CTNNB1 CTNNB1 ADCY6 ADCY6 WNT10B WNT10B CREB3L4 CREB3L4 NR5A1 NR5A1 MRAP MRAP CAMK2G CAMK2G APC2 APC2 KCNA4 KCNA4 H0XID8_OTOGA H0XID8_OTOGA WNT10A WNT10A KCNA5 KCNA5 LOC100966244 LOC100966244 KCNA1 KCNA1 FZD9 FZD9 WNT5B WNT5B LOC100966795 LOC100966795 ARMC5 ARMC5 KCNA3 KCNA3 FZD1 FZD1 ATF4 ATF4 FZD3 FZD3 WNT7A WNT7A CAMK2B CAMK2B APC APC WNT7B WNT7B SP1 SP1 WNT8A WNT8A GNAS GNAS POMC POMC CDK6 CDK6 KCNA10 KCNA10 LOC100941765 LOC100941765 ITPR3 ITPR3 MAPK3 MAPK3 E2F1 E2F1 FZD10 FZD10 MEN1 MEN1 CCNE2 CCNE2 CRH CRH WNT1 WNT1 KCNA2 KCNA2 FZD7 FZD7 RAP1A RAP1A FZD8 FZD8 DVL1 DVL1 ATF6B ATF6B WDR5B WDR5B TCF7 TCF7 FZD5 FZD5 WNT8B WNT8B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AIPL1Aryl hydrocarbon receptor interacting protein like 1. (380 aa)
PBX1PBX homeobox 1. (430 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (193 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
NCEH1Neutral cholesterol ester hydrolase 1. (408 aa)
ADCY2Adenylate cyclase 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (880 aa)
TCF7L1Transcription factor 7 like 1. (574 aa)
RASD1Ras related dexamethasone induced 1. (283 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1120 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (463 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1874 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (588 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
CRHR1Corticotropin releasing hormone receptor 1; Belongs to the G-protein coupled receptor 2 family. (415 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2152 aa)
LOC100958146Uncharacterized protein. (374 aa)
CYP11A1Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (521 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2754 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (468 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
E2F3E2F transcription factor 3. (463 aa)
LEF1Lymphoid enhancer binding factor 1. (398 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (792 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2342 aa)
CAMK2AProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (490 aa)
ARSIArylsulfatase family member I. (572 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
RAP1BUncharacterized protein. (184 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (396 aa)
GSK3BGlycogen synthase kinase 3 beta. (387 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (598 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1079 aa)
KCNK3Potassium channel subfamily K member. (343 aa)
H0WV86_OTOGAPhosphodiesterase. (780 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1234 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
ORAI1ORAI calcium release-activated calcium modulator 1. (305 aa)
RBBP5RB binding protein 5, histone lysine methyltransferase complex subunit. (538 aa)
PBX4PBX homeobox 4. (341 aa)
RB1RB transcriptional corepressor 1. (929 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (156 aa)
KCNK2Potassium two pore domain channel subfamily K member 2. (269 aa)
AIPPeptidylprolyl isomerase. (330 aa)
AXIN2Axin 2. (844 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
WDR5WD repeat domain 5. (334 aa)
EGFRReceptor protein-tyrosine kinase. (1178 aa)
MAPK1Mitogen-activated protein kinase. (323 aa)
H0X0D7_OTOGAHistone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (3893 aa)
CYP21A2Cytochrome P450 family 21 subfamily A member 2; Belongs to the cytochrome P450 family. (488 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (740 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2647 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1187 aa)
FHFumarate hydratase. (509 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1976 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (333 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (502 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (507 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (486 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2005 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (131 aa)
AGTAngiotensinogen; Belongs to the serpin family. (492 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1113 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
MC2RMelanocortin 2 receptor. (297 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
E2F2E2F transcription factor 2. (438 aa)
USP8Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1117 aa)
GNAI2G protein subunit alpha i2. (355 aa)
H0X7F6_OTOGAUncharacterized protein. (851 aa)
CACNA1HCalcium voltage-gated channel subunit alpha1 H. (2323 aa)
H0X8J2_OTOGAPhosphodiesterase. (710 aa)
CRHR2Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family. (411 aa)
KMT2DLysine methyltransferase 2D. (5528 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
CYP17A1Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family. (510 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
GNAI3G protein subunit alpha i3. (354 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (368 aa)
PDE8APhosphodiesterase. (826 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
TCF7L2Transcription factor 7 like 2. (471 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1230 aa)
AXIN1Axin 1. (867 aa)
ASH2LASH2 like, histone lysine methyltransferase complex subunit. (625 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
LDLRLow density lipoprotein receptor. (869 aa)
DVL3Dishevelled segment polarity protein 3. (722 aa)
CTNNB1Catenin beta 1. (781 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1167 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (368 aa)
NR5A1Nuclear receptor subfamily 5 group A member 1. (461 aa)
MRAPMelanocortin 2 receptor accessory protein. (177 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (651 aa)
APC2APC regulator of WNT signaling pathway 2. (2292 aa)
KCNA4Potassium voltage-gated channel subfamily A member 4; Belongs to the potassium channel family. (654 aa)
H0XID8_OTOGAUncharacterized protein. (119 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (605 aa)
LOC100966244Uncharacterized protein. (260 aa)
KCNA1Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family. (495 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (592 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
LOC1009667953Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (373 aa)
ARMC5Armadillo repeat containing 5. (948 aa)
KCNA3Potassium voltage-gated channel subfamily A member 3; Belongs to the potassium channel family. (488 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (647 aa)
ATF4Activating transcription factor 4. (352 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (664 aa)
APCAPC regulator of WNT signaling pathway. (2812 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
SP1Sp1 transcription factor. (761 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
GNASGNAS complex locus. (1146 aa)
POMCProopiomelanocortin. (265 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
KCNA10Potassium voltage-gated channel subfamily A member 10; Belongs to the potassium channel family. (511 aa)
LOC100941765Uncharacterized protein. (193 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2728 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (336 aa)
E2F1E2F transcription factor 1. (385 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
MEN1Menin 1. (607 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (321 aa)
CRHCorticotropin releasing hormone. (197 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
KCNA2Potassium voltage-gated channel subfamily A member 2; Belongs to the potassium channel family. (499 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (513 aa)
DVL1Dishevelled segment polarity protein 1. (696 aa)
ATF6BActivating transcription factor 6 beta. (705 aa)
WDR5BWD repeat domain 5B. (330 aa)
TCF7Transcription factor 7. (419 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
Your Current Organism:
Otolemur garnettii
NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago
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