STRINGSTRING
SLC5A7 SLC5A7 CSDE1 CSDE1 RAC3 RAC3 SLC44A3 SLC44A3 PDGFRA PDGFRA PDGFC PDGFC PLCG1 PLCG1 RHEBL1 RHEBL1 PRKCA PRKCA MTOR MTOR AKT2 AKT2 SLC44A4 SLC44A4 SOS2 SOS2 KRAS KRAS H0XC24_OTOGA H0XC24_OTOGA MAPK10 MAPK10 PIK3R1 PIK3R1 PIK3CD PIK3CD SLC22A4 SLC22A4 SLC22A5 SLC22A5 DGKQ DGKQ MAP2K1 MAP2K1 H0XEJ2_OTOGA H0XEJ2_OTOGA PLA2G4E PLA2G4E HIF1A HIF1A AKT3 AKT3 TSC2 TSC2 MAPK9 MAPK9 DGKK DGKK RAC1 RAC1 PLPP2 PLPP2 JMJD7 JMJD7 SLC44A2 SLC44A2 JUN JUN RAF1 RAF1 H0XNG7_OTOGA H0XNG7_OTOGA FOS FOS SP1 SP1 AKT1 AKT1 HRAS HRAS EIF4EBP1 EIF4EBP1 MAPK3 MAPK3 H0XSY9_OTOGA H0XSY9_OTOGA WASF2 WASF2 H0XUZ5_OTOGA H0XUZ5_OTOGA NRAS NRAS PDGFA PDGFA PLA2G4A PLA2G4A PLA2G4F PLA2G4F PLA2G4D PLA2G4D DGKI DGKI RPS6KB2 RPS6KB2 PIP5K1C PIP5K1C PLD1 PLD1 PDGFD PDGFD PLD2 PLD2 PIP5K1B PIP5K1B DGKD DGKD MAPK1 MAPK1 EGFR EGFR H0WZF7_OTOGA H0WZF7_OTOGA TSC1 TSC1 RHEB RHEB WASF1 WASF1 DGKH DGKH ERAS ERAS MAPK8 MAPK8 PRKCG PRKCG GPCPD1 GPCPD1 RPS6KB1 RPS6KB1 DGKA DGKA WASF3 WASF3 PIK3CA PIK3CA H0WU85_OTOGA H0WU85_OTOGA PCYT1B PCYT1B SLC44A1 SLC44A1 DGKG DGKG SLC22A2 SLC22A2 SLC22A1 SLC22A1 PDPK1 PDPK1 EGF EGF PDGFRB PDGFRB SLC22A3 SLC22A3 RAC2 RAC2 PIK3CB PIK3CB DGKE DGKE LYPLA1 LYPLA1 WAS WAS GRB2 GRB2 DGKB DGKB PLPP1 PLPP1 PIP5K1A PIP5K1A DGKZ DGKZ SOS1 SOS1 MAP2K2 MAP2K2 PCYT1A PCYT1A SLC44A5 SLC44A5 CHPT1 CHPT1 PRKCB PRKCB H0WHZ3_OTOGA H0WHZ3_OTOGA CHKA CHKA CHKB CHKB PDGFB PDGFB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SLC5A7Solute carrier family 5 member 7; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (580 aa)
CSDE1Cold shock domain containing E1. (813 aa)
RAC3Rac family small GTPase 3. (192 aa)
SLC44A3Solute carrier family 44 member 3; Belongs to the CTL (choline transporter-like) family. (619 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1095 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (308 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
RHEBL1Uncharacterized protein. (183 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (691 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
SLC44A4Solute carrier family 44 member 4; Belongs to the CTL (choline transporter-like) family. (706 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
KRASKRAS proto-oncogene, GTPase. (243 aa)
H0XC24_OTOGAacidPPc domain-containing protein. (267 aa)
MAPK10Mitogen-activated protein kinase. (426 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (549 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
SLC22A4Solute carrier family 22 member 4. (553 aa)
SLC22A5Solute carrier family 22 member 5. (557 aa)
DGKQDiacylglycerol kinase. (941 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
H0XEJ2_OTOGAPhospholipase A2. (807 aa)
PLA2G4EPhospholipase A2. (850 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (827 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
TSC2TSC complex subunit 2. (1814 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
DGKKDiacylglycerol kinase. (1056 aa)
RAC1Rac family small GTPase 1. (156 aa)
PLPP2Phospholipid phosphatase 2. (287 aa)
JMJD7Jumonji domain containing 7. (316 aa)
SLC44A2Solute carrier family 44 member 2; Belongs to the CTL (choline transporter-like) family. (706 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (708 aa)
H0XNG7_OTOGAUncharacterized protein. (181 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
SP1Sp1 transcription factor. (761 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (336 aa)
H0XSY9_OTOGAUncharacterized protein. (514 aa)
WASF2WASP family member 2. (498 aa)
H0XUZ5_OTOGARas-GEF domain-containing protein. (526 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
PLA2G4APhospholipase A2. (748 aa)
PLA2G4FPhospholipase A2. (865 aa)
PLA2G4DPhospholipase A2. (829 aa)
DGKIDiacylglycerol kinase. (934 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (480 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (614 aa)
PLD1Phospholipase. (1075 aa)
PDGFDPlatelet derived growth factor D. (247 aa)
PLD2Phospholipase. (1007 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (500 aa)
DGKDDiacylglycerol kinase. (1098 aa)
MAPK1Mitogen-activated protein kinase. (323 aa)
EGFRReceptor protein-tyrosine kinase. (1178 aa)
H0WZF7_OTOGAUncharacterized protein. (959 aa)
TSC1TSC complex subunit 1. (1161 aa)
RHEBRas homolog, mTORC1 binding. (168 aa)
WASF1WASP family member 1. (464 aa)
DGKHDiacylglycerol kinase. (1236 aa)
ERASES cell expressed Ras. (229 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
GPCPD1Glycerophosphocholine phosphodiesterase 1. (672 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
DGKADiacylglycerol kinase. (744 aa)
WASF3WASP family member 3. (481 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
H0WU85_OTOGAUncharacterized protein. (451 aa)
PCYT1BPhosphate cytidylyltransferase 1, choline, beta. (369 aa)
SLC44A1Solute carrier family 44 member 1; Belongs to the CTL (choline transporter-like) family. (661 aa)
DGKGDiacylglycerol kinase. (751 aa)
SLC22A2Solute carrier family 22 member 2. (554 aa)
SLC22A1Solute carrier family 22 member 1. (554 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (559 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1143 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
SLC22A3Solute carrier family 22 member 3. (421 aa)
RAC2Rac family small GTPase 2. (192 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (859 aa)
DGKEDiacylglycerol kinase. (567 aa)
LYPLA1Lysophospholipase 1. (230 aa)
WASWASP actin nucleation promoting factor. (503 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
DGKBDiacylglycerol kinase. (803 aa)
PLPP1Phospholipid phosphatase 1. (267 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (563 aa)
DGKZDiacylglycerol kinase. (928 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
MAP2K2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
PCYT1APhosphate cytidylyltransferase 1, choline, alpha. (367 aa)
SLC44A5Solute carrier family 44 member 5; Belongs to the CTL (choline transporter-like) family. (678 aa)
CHPT1Choline phosphotransferase 1; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (366 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
H0WHZ3_OTOGAUncharacterized protein. (731 aa)
CHKACholine kinase alpha. (383 aa)
CHKBCholine kinase beta. (396 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
Your Current Organism:
Otolemur garnettii
NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago
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