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| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (359 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (338 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (411 aa) |
| | trpS | tryptophanyl-tRNA synthetase; Pfam match to PF00579.16 tRNA-synt_1b; Belongs to the class-I aminoacyl-tRNA synthetase family. (319 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (165 aa) |
| | kdsA | 3-deoxy-D-manno-2-octulosonate-8-phosphate synthase; Pfam match to PF00793.11 DAHP_synth_1; Belongs to the KdsA family. (268 aa) |
| | ribH | Riboflavin synthase, beta subunit; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (156 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (227 aa) |
| | purH | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Pfam matches to PF02142.13 MGS, and to PF01808.9 AICARFT_IMPCHas. (510 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase, PurL subunit; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (725 aa) |
| | folD | 5,10-methylene-tetrahydrofolate dehydrogenase/5,10-methylene-tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (298 aa) |
| | tgt | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form th [...] (373 aa) |
| | pycA | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (480 aa) |
| | csdA | Conserved hypothetical protein, putative NifS-like aminotransferase; Pfam match to PF00266.10 Aminotran_5. (421 aa) |
| | glyS | glycyl-tRNA synthetase, beta subunit; Pfam match to PF02092.8 tRNA_synt_2f. (664 aa) |
| | ribB | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. Belongs to the DHBP synthase family. (340 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (241 aa) |
| | spoT | ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3' pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (729 aa) |
| | tyrS | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily. (400 aa) |
| | Cla_0625 | Oxidoreductase, short chain dehydrogenase/reductase family; Pfam match to PF00106.16 adh_short. (259 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (298 aa) |
| | pyrD | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (352 aa) |
| | cysS | cysteinyl-tRNA synthetase; Pfam matches to PF01406.10 tRNA-synt_1e, and to PF09190.2 DALR_2; Belongs to the class-I aminoacyl-tRNA synthetase family. (460 aa) |
| | Cla_0636 | Putative hydrolase, alpha/beta fold family; Pfam match to PF00561.11 Abhydrolase_1. (247 aa) |
| | pta | Phosphate acetyltransferase; Pfam match to PF01515.10 PTA_PTB. (489 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (394 aa) |
| | valS | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (870 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (190 aa) |
| | aspS | aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (583 aa) |
| | nadK | Conserved hypothetical protein, putative inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (276 aa) |
| | queA | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (342 aa) |
| | lysC | Aspartate kinase; Pfam matches to PF00696.19 AA_kinase, and to PF01842.16 ACT; Belongs to the aspartokinase family. (400 aa) |
| | ribF | Riboflavin kinase/FAD synthase; Pfam matches to PF06574.3 FAD_syn, and to PF01687.8 Flavokinase; Belongs to the ribF family. (280 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (179 aa) |
| | mqnC | Radical SAM domain protein; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). (348 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (352 aa) |
| | Cla_0701 | Rhodanese domain protein, putative; Pfam match to PF00581.11 Rhodanese. (124 aa) |
| | Cla_0702 | Conserved hypothetical protein. (111 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase, PurQ subunit; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (216 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase, PurS subunit; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (78 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Pfam match to PF01259.9 SAICAR_synt; Belongs to the SAICAR synthetase family. (237 aa) |
| | gltX1 | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (431 aa) |
| | fbp | Fructose-1,6-biphosphatase; Pfam match to PF00316.11 FBPase. (282 aa) |
| | metS | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (629 aa) |
| | queC | Transcriptional regulator, ExsB family; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (221 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (418 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (159 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (194 aa) |
| | hisS | histidyl-tRNA synthetase; Pfam match to PF00587.16 tRNA-synt_2b. (408 aa) |
| | speA | Arginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily. (609 aa) |
| | cysE | Serine O-acetyltransferase. (201 aa) |
| | argG | Argininosuccinate synthetase; Pfam match to PF00764.10 Arginosuc_synth; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (406 aa) |
| | ubiD | 3-octaprenyl-4-hydroxybenzoate decarboxylase; Pfam match to PF01977.7 UbiD; Belongs to the UbiD family. (597 aa) |
| | proS | prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] (565 aa) |
| | Cla_0774 | Conserved hypothetical protein, putative HAD superfamily hydrolase; Pfam match to PF00702.17 Hydrolase. (208 aa) |
| | ilvH | Acetolactate synthase III, valine-sensitive, small subunit; Pfam match to PF01842.16 ACT. (155 aa) |
| | ilvB | Acetolactate synthase III, valine-sensitive, large subunit; Pfam matches to PF02776.9 TPP_enzyme_N, and to PF00205.13 TPP_enzyme_M. (569 aa) |
| | mdh | Malate dehydrogenase; Pfam matches to PF00056.14 Ldh_1_N, and to PF02866.9 Ldh_1_C; Belongs to the LDH/MDH superfamily. (298 aa) |
| | nadE | NH(3)-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (246 aa) |
| | thrC | Threonine synthase; Pfam match to PF00291.16 PALP. (469 aa) |
| | fba | Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (354 aa) |
| | Cla_0926 | Conserved hypothetical protein, putative indole-3-glycerol phosphate synthase; Pfam match to PF00218.12 IGPS. (200 aa) |
| | Cla_0927 | HIT family hydrolase; Pfam match to PF01230.14 HIT. (162 aa) |
| | pdxA | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (366 aa) |
| | pdxJ | Pyridoxal phosphate biosynthetic protein J; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (255 aa) |
| | Cla_0932 | Ppx/GppA phosphatase family superfamily; Pfam match to PF02541.7 Ppx-GppA. (321 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (340 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Pfam match to PF03807.8 F420_oxidored. (231 aa) |
| | ilvA | Threonine dehydratase; Pfam match to PF00291.16 PALP. (403 aa) |
| | uppS | Undecaprenyl diphosphate synthetase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (222 aa) |
| | dfp | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (385 aa) |
| | glmU | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (429 aa) |
| | pabA | Para-aminobenzoate synthase component II, glutamine amidotransferase; Pfam match to PF00117.19 GATase. (190 aa) |
| | aroG | 3-deoxy-D-arabinoheptulosonate 7-phosphate synthase (DAHP synthetase); Pfam match to PF01474.7 DAHP_synth_2. (446 aa) |
| | glyQ | glycyl-tRNA synthetase, alpha chain; Pfam match to PF02091.6 tRNA-synt_2e. (286 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (164 aa) |
| | glnA | Glutamine synthetase; Pfam matches to PF03951.10 Gln-synt_N, and to PF00120.15 Gln-synt_C; Belongs to the glutamine synthetase family. (476 aa) |
| | cca | tRNA nucleotidyltransferase/formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (644 aa) |
| | napA | Periplasmic nitrate reductase, large subunit; Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite. (924 aa) |
| | ppk | Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP); Belongs to the polyphosphate kinase 1 (PPK1) family. (697 aa) |
| | thiC | Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (433 aa) |
| | rpe | D-ribulose-5-phosphate 3-epimerase; Pfam match to PF00834.10 Ribul_P_3_epim; Belongs to the ribulose-phosphate 3-epimerase family. (215 aa) |
| | Cla_1033 | NUDIX domain protein; Pfam match to PF00293.19 NUDIX. (189 aa) |
| | folC | Folylpolyglutamate synthase/dihydrofolate synthase; Pfam match to PF08245.3 Mur_ligase_M. (389 aa) |
| | leuS | leucyl-tRNA synthetase; Pfam match to PF00133.13 tRNA-synt_1; Belongs to the class-I aminoacyl-tRNA synthetase family. (809 aa) |
| | metK | S-adenosylmethionine synthetase; Pfam matches to PF00438.11 S-AdoMet_synt_N, and to PF02772.7 S-AdoMet_synt_M; Belongs to the AdoMet synthase family. (397 aa) |
| | pyrB | Aspartate carbamoyltransferase; Pfam matches to PF02729.12 OTCace_N, and to PF00185.15 OTCace; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (292 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (845 aa) |
| | maf | Septum formation protein Maf; Pfam match to PF02545.5 Maf; Belongs to the Maf family. (180 aa) |
| | argS | arginyl-tRNA synthetase; Pfam matches to PF03485.7 Arg_tRNA_synt_N, and to PF00750.10 tRNA-synt_1d. (531 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (204 aa) |
| | ribE | Riboflavin synthase, alpha subunit; Pfam match to PF00677.8 Lum_binding. (202 aa) |
| | hemD | Uroporphyrinogen III cosynthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (212 aa) |
| | thiE | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (208 aa) |
| | thiM | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (260 aa) |
| | thiD | Phosphomethylpyrimidine kinase; Pfam match to PF08543.3 Phos_pyr_kin. (270 aa) |
| | ribA | GTP cyclohydrolase II; Pfam match to PF00925.11 GTP_cyclohydro2. (186 aa) |
| | alr | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (335 aa) |
| | Cla_1146 | Thiamine-phosphate pyrophosphorylase/regulatory protein TenI, putative; Pfam match to PF02581.8 TMP-TENI. (200 aa) |
| | thiH | Thiamine biosynthesis ThiGH complex, ThiH subunit; Pfam matches to PF04055.12 Radical_SAM, and to PF06968.4 BATS. (377 aa) |
| | thiG | Thiamine biosynthesis ThiGH complex, ThiG subunit; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (252 aa) |
| | thiS | Thiamine biosynthesis protein ThiS; Pfam match to PF02597.11 ThiS. (63 aa) |
| | dapE | N-succinyl-diaminopimelate deacylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (366 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (483 aa) |
| | ileS | isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (921 aa) |
| | cinA | Competence/damage-inducible protein, CinA family; Pfam match to PF02464.8 CinA; Belongs to the CinA family. (363 aa) |
| | Cla_1171 | D-amino acid aminotransferase; Pfam match to PF01063.10 Aminotran_4. (285 aa) |
| | Cla_1176 | Conserved hypothetical protein. (192 aa) |
| | pncB | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (458 aa) |
| | ispG | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (356 aa) |
| | serA | D-3-phosphoglycerate dehydrogenase; Pfam matches to PF00389.21 2-Hacid_dh, and to PF01842.16 ACT; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (526 aa) |
| | ispH | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (278 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (428 aa) |
| | pheT | phenylalanyl-tRNA synthetase, beta subunit; Pfam matches to PF01588.11 tRNA_bind, and to PF03484.6 B5; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (776 aa) |
| | pheS | phenylalanyl-tRNA synthetase, alpha subunit; Pfam matches to PF02912.9 Phe_tRNA-synt_N, and to PF01409.11 tRNA-synt_2d; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (330 aa) |
| | Cla_1195 | HIT family hydrolase; Pfam match to PF01230.14 HIT. (121 aa) |
| | pckA | Phosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (524 aa) |
| | atpE | ATP synthase F0 sector, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (107 aa) |
| | pyrC2 | Dihydroorotase; Pfam match to PF01979.11 Amidohydro_1. (385 aa) |
| | atpB | ATP synthase F0 sector, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (226 aa) |
| | Cla_1213 | Conserved hypothetical protein, 5-formyltetrahydrofolate cyclo-ligase family; Pfam match to PF01812.11 5-FTHF_cyc-lig; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (209 aa) |
| | glcD | Glycolate oxidase; Pfam matches to PF01565.14 FAD_binding_4, and to PF02913.10 FAD-oxidase_C. (460 aa) |
| | cysK | Cysteine synthase A; Pfam match to PF00291.16 PALP; Belongs to the cysteine synthase/cystathionine beta- synthase family. (300 aa) |
| | ptmA | Flagellin modification protein PtmA, putative oxidoreductase. (254 aa) |
| | Cla_1232 | LmbE-like protein; Pfam match to PF02585.8 PIG-L. (223 aa) |
| | ptmD | Flagellin modification protein PtmD, putative UDP-N-acetylglucosamine 2-epimerase; Pfam match to PF02350.10 Epimerase_2. (390 aa) |
| | Cla_1237 | NAD-dependent epimerase/dehydratase family protein; Pfam match to PF01370.12 Epimerase. (335 aa) |
| | galE | UDP-glucose 4-epimerase; Pfam match to PF01370.12 Epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (328 aa) |
| | Cla_1269 | Conserved hypothetical protein, putative acyl-coA thioester hydrolase; Pfam match to PF03061.13 4HBT. (134 aa) |
| | prsA | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (309 aa) |
| | Cla_1278 | Putative purine NTP pyrophosphatase - RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (205 aa) |
| | gdhA | Glutamate dehydrogenase; Pfam matches to PF02812.9 ELFV_dehydrog_N, and to PF00208.12 ELFV_dehydrog; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (455 aa) |
| | mqnA | Conserved hypothetical protein (DUF178 domain protein); Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). (221 aa) |
| | mez | Malate oxidoreductase; Pfam matches to PF00390.10 malic, and to PF03949.6 Malic_M. (411 aa) |
| | gltX2 | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (463 aa) |
| | accC | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (443 aa) |
| | accB | acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (149 aa) |
| | dcd | 2'-deoxycytidine 5'-triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (186 aa) |
| | acpP2 | Acyl carrier protein, putative. (74 aa) |
| | fabH1 | 3-oxoacyl-(acyl carrier protein) synthase III; Pfam matches to PF08545.1 ACP_syn_III, and to PF08541.1 ACP_syn_III_C. (355 aa) |
| | acpP3 | Acyl carrier protein, putative. (72 aa) |
| | Cla_1314 | 3-oxoacyl-(acyl carrier protein) synthase III FabH2, putative. (321 aa) |
| | Cla_1324 | LmbE-like protein; Pfam match to PF02585.8 PIG-L. (223 aa) |
| | hisF2 | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (243 aa) |
| | hisH2 | Imidazoleglycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (200 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (137 aa) |
| | plsX | Fatty acidphospholipid synthesis protein; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (329 aa) |
| | fabH3 | 3-oxoacyl-(acyl carrier protein) synthase III; Pfam matches to PF08545.1 ACP_syn_III, and to PF08541.1 ACP_syn_III_C. (327 aa) |
| | Cla_1343 | Inosine-uridine preferring nucleoside hydrolase family protein; Pfam match to PF01156.10 IU_nuc_hydro. (335 aa) |
| | trpB | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (391 aa) |
| | serC | Phosphohydroxythreonine transaminase/phosphoserine transaminase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (358 aa) |
| | ubiE | Ubiquinone/menaquinone biosynthesis methlytransferase; Pfam match to PF01209.9 Ubie_methyltran. (233 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (609 aa) |
| | hisC | Histidinol-phosphate aminotransferase; Pfam match to PF00155.12 Aminotran_1_2; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (363 aa) |
| | pheA | Chorismate mutase/prephenate dehydratase; Pfam matches to PF01817.12 CM_2, and to PF00800.9 PDT. (357 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (401 aa) |
| | ilvD | Dihydroxyacid dehydratase; Pfam match to PF00920.12 ILVD_EDD; Belongs to the IlvD/Edd family. (558 aa) |
| | serB | 3-phosphoserine phosphatase; Pfam match to PF00702.17 Hydrolase. (208 aa) |
| | surE | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (257 aa) |
| | bioA | Adenosylmethionine--8-amino-7-oxononanoate aminotransferase; Pfam match to PF00202.12 Aminotran_3; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (422 aa) |
| | bioD | Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (190 aa) |
| | carB | Carbamoylphosphate synthase, large subunit; Pfam matches to PF00289.13 CPSase_L_chain, and to PF02786.8 CPSase_L_D2; Belongs to the CarB family. (1087 aa) |
| | fabZ | 3-hydroxymyristoyl-(acyl carrier protein) dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (146 aa) |
| | Cla_1401 | Conserved hypothetical protein (DUF208 domain protein); Pfam match to PF02677.5 DUF208. (357 aa) |
| | ilvE | Branched-chain amino-acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (304 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (446 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (242 aa) |
| | hom | Homoserine dehydrogenase; Pfam matches to PF03447.7 NAD_binding_3, and to PF00742.10 Homoserine_dh. (417 aa) |
| | queD | Conserved hypothetical protein, putative 6-pyruvoyl tetrahydropterin synthase. (194 aa) |
| | queE | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (249 aa) |
| | ubiA | 4-hydroxybenzoate octaprenyltranferase; Pfam match to PF01040.9 UbiA; Belongs to the UbiA prenyltransferase family. (291 aa) |
| | lldG | Conserved hypothetical protein (DUF162 domain protein); Pfam match to PF02589.6 DUF162. (216 aa) |
| | lldF | Putative iron-sulfur cluster binding protein; Pfam match to PF02589.6 DUF162. (471 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (190 aa) |
| | folE | Pfam match to PF01227.13 GTP_cyclohydroI. (190 aa) |
| | fliI | Flagellum-specific ATP synthase FliI; Pfam match to PF00006.16 ATP-synt_ab. (436 aa) |
| | iscS | Cysteine desulfurase/aminotransferase, IscS/NifS family; Pfam match to PF00266.10 Aminotran_5. (392 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (362 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (202 aa) |
| | nrdB | Ribonucleoside-diphosphate reductase, beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (340 aa) |
| | cah | Conserved hypothetical protein, putative carbonic anhydrase; Pfam match to PF00194.12 Carb_anhydrase. (246 aa) |
| | Add | Putative adenosine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. (330 aa) |
| | queF | Conserved hypothetical protein, putative GTP cyclohydrolase I; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. (127 aa) |
| | thyX | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (210 aa) |
| | pyrG | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa) |
| | Cla_0020 | Conserved hypothetical protein, putative purine nucleoside phosphorylase. (177 aa) |
| | purB1 | Pfam match to PF00206.11 Lyase_1; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (442 aa) |
| | thrS | threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr). (603 aa) |
| | Cla_0033 | Conserved hypothetical protein, putative MoxR/RavA-like ATPase; Pfam matches to PF07728.5 AAA_5, and to PF03382.5 DUF285. (560 aa) |
| | Cla_0040 | Conserved hypothetical protein. (232 aa) |
| | pyrC1 | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (330 aa) |
| | nrdG | Anaerobic ribonucleoside triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (177 aa) |
| | purM | Phosphoribosylaminoimidazole synthetase; Pfam matches to PF00586.15 AIRS, and to PF02769.13 AIRS_C. (329 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (193 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (249 aa) |
| | ansA | L-asparaginase; Pfam match to PF00710.11 Asparaginase. (348 aa) |
| | sdaA | L-serine dehydratase; Pfam matches to PF03315.6 SDH_beta, and to PF03313.6 SDH_alpha; Belongs to the iron-sulfur dependent L-serine dehydratase family. (455 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (299 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (426 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase/histidinol-phosphatase; Pfam matches to PF08645.2 PNK3P, and to PF00475.9 IGPD; In the N-terminal section; belongs to the histidinol- phosphatase family. (355 aa) |
| | hisH1 | Imidazoleglycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (193 aa) |
| | hisA | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Pfam match to PF00977.12 His_biosynth. (244 aa) |
| | hisF1 | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (255 aa) |
| | hisIE | phosphoribosyl-AMP cyclohydrolase/ phosphoribosyl-ATP pyrophosphohydrolase; Pfam matches to PF01502.9 PRA-CH, and to PF01503.8 PRA-PH; In the N-terminal section; belongs to the PRA-CH family. (208 aa) |
| | Cla_0124 | Conserved hypothetical protein, probable ATP/GTP-binding protein. (278 aa) |
| | Cla_0132 | Pfam match to PF04055.12 Radical_SAM. (285 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (414 aa) |
| | mqnD | Conserved hypothetical protein (DUF191 domain protein); Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2); Belongs to the MqnA/MqnD family. MqnD subfamily. (287 aa) |
| | cysQ | 3'(2'),5'-bisphosphate nucleotidase; Pfam match to PF00459.16 Inositol_P. (231 aa) |
| | bioB | Biotin synthetase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (278 aa) |
| | gppA | Phosphatase, Ppx/GppA family; Pfam match to PF02541.7 Ppx-GppA. (498 aa) |
| | atpF | ATP synthase F0 sector, B' subunit; Pfam match to PF00430.9 ATP-synt_B; Belongs to the ATPase B chain family. (141 aa) |
| | atpF-2 | ATP synthase F0 sector, B subunit; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (170 aa) |
| | atpH | ATP synthase F1 sector, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (173 aa) |
| | atpA | ATP synthase F1 sector, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (501 aa) |
| | atpG | ATP synthase F1 sector, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (294 aa) |
| | atpD | ATP synthase F1 sector, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (484 aa) |
| | atpC | ATP synthase F1 sector, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (130 aa) |
| | fabD | Malonyl CoA-acyl carrier protein transacylase. (306 aa) |
| | pfs | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (228 aa) |
| | pncA | Conserved hypothetical protein, putative amidase. (170 aa) |
| | accD | acetyl-CoA carboxylase, carboxyltransferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (280 aa) |
| | tyrA | Prephenate dehydrogenase; Pfam match to PF02153.8 PDH. (275 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (292 aa) |
| | ribD | Riboflavin biosynthesis protein; Pfam match to PF00383.13 dCMP_cyt_deam_1. (330 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (160 aa) |
| | folK | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Pfam match to PF01288.11 HPPK. (157 aa) |
| | ispDF | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF); In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. (371 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (387 aa) |
| | pgi | Glucose-6-phosphate isomerase; Pfam match to PF00342.10 PGI. (407 aa) |
| | galU | UTP-glucose-1-phosphate uridylyltransferase; Pfam match to PF00483.14 NTP_transferase. (274 aa) |
| | pgm | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (492 aa) |
| | fabG | 3-oxoacyl-(acyl-carrier-protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (247 aa) |
| | acpS | Holo-(acyl-carrier-protein) synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (116 aa) |
| | argH | Pfam match to PF00206.11 Lyase_1. (466 aa) |
| | metC | Cystathionase beta-lyase; Pfam match to PF01053.11 Cys_Met_Meta_PP. (389 aa) |
| | purB2 | Pfam match to PF00206.11 Lyase_1; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (454 aa) |
| | Cla_0281 | MmgE/PrpD family protein; Pfam match to PF03972.5 MmgE_PrpD. (446 aa) |
| | Cla_0284 | Conserved hypothetical protein, putative transcriptional regulator, TenA/Thi-4-like protein; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway; Belongs to the TenA family. (221 aa) |
| | acpP1 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (77 aa) |
| | fabF | 3-oxoacyl-(acyl carrier protein) synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (404 aa) |
| | accA | acetyl-CoA carboxylase, carboxyltransferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (311 aa) |
| | Cla_0295 | Glycerol-3-phosphate cytidylyltransferase, putative; Pfam match to PF01467.17 CTP_transf_2. (129 aa) |
| | Cla_0297 | CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase, putative; Pfam matches to PF07719.8 TPR_2, and to PF00515.19 TPR_1. (1098 aa) |
| | Cla_0302 | Capsular polysaccharide biosynthesis protein. (243 aa) |
| | fdhA | Formate dehydrogenase, alpha subunit (selenocysteine-containing); Pfam matches to PF04879.7 Molybdop_Fe4S4, and to PF00384.13 Molybdopterin; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (940 aa) |
| | selD | Selenide, water dikinase (possible start at 335663); Pfam match to PF02769.13 AIRS_C. (320 aa) |
| | putA | Proline dehydrogenase/delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family. (1165 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (416 aa) |
| | pyrAa | Carbamoylphosphate synthase, small subunit; Pfam matches to PF00988.13 CPSase_sm_chain, and to PF00117.19 GATase; Belongs to the CarA family. (372 aa) |
| | Cla_0403 | Conserved hypothetical protein. (234 aa) |
| | thiL | Thiamine monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (273 aa) |
| | Cla_0411 | Conserved hypothetical integral membrane protein (DUF540 domain protein). (236 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (226 aa) |
| | pgk | Phosphoglycerate kinase; Pfam match to PF00162.10 PGK; Belongs to the phosphoglycerate kinase family. (400 aa) |
| | gapA | Glyceraldehyde-3-phosphate dehydrogenase; Pfam matches to PF00044.15 Gp_dh_N, and to PF02800.11 Gp_dh_C; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (331 aa) |
| | nadD | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (181 aa) |
| | Cla_0423 | HIT family hydrolase. (124 aa) |
| | fumC | Fumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (463 aa) |
| | glmS | Glucosamine fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (599 aa) |
| | mqnE | Radical SAM domain protein; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. (354 aa) |
| | Cla_0429 | Nucleotide phosphoribosyltransferase, putative; Pfam match to PF00156.18 Pribosyltran. (146 aa) |
| | gmhB | Conserved hypothetical protein, putative phosphatase; Possible pseudogene; Pfam match to PF08645.2 PNK3P. (171 aa) |
| | waaE | D,D-heptose 1-phosphate adenosyltransferase/7-phosphate kinase; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (457 aa) |
| | pyk | Pyruvate kinase; Pfam matches to PF00224.12 PK, and to PF02887.7 PK_C; Belongs to the pyruvate kinase family. (483 aa) |
| | coaX | Transcriptional activator, putative, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (207 aa) |
| | lysS | lysyl-tRNA synthetase; Pfam matches to PF01336.16 tRNA_anti, and to PF00152.11 tRNA-synt_2; Belongs to the class-II aminoacyl-tRNA synthetase family. (500 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (413 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (261 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (511 aa) |
| | purD | Phosphoribosylamine--glycine ligase; Pfam matches to PF02844.6 GARS_N, and to PF01071.10 GARS_A; Belongs to the GARS family. (416 aa) |
