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hemL hemL hemB hemB hemD hemD hemC hemC hemA hemA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hemLGlutamate-1-semialdehyde 21-aminomutase (EC 5.4.3.8) (GSA) (Glutamate-1-semialdehyde aminotransferase) (GSA-AT). (443 aa)
hemBPorphobilinogen synthase; Delta-aminolevulinic acid dehydratase (EC 4.2.1.24) (Porphobilinogen synthase) (ALAD) (ALADH); Belongs to the ALAD family. (334 aa)
hemDuroporphyrin-III C-methyltransferase / uroporphyrinogen-III synthase; Porphyrin biosynthesis protein HEMD [Includes: Uroporphyrin-III C- methyltransferase (EC 2.1.1.107) (Urogen III methylase) (SUMT) (Uroporphyrinogen III methylase) (UROM); Uroporphyrinogen-III synthase (EC 4.2.1.75) (UROS) (Uroporphyrinogen-III cosynthetase) (Hydroxymethylbilane hydrolyase [cyclizing])].,May catalyze sequential reactions to synthesize UroIII from hydroxymethylbilane (HMB) and then precorrin-2 which are intermediate compounds in both vitamin B12 and siroheme biosyntheses. (628 aa)
hemCHydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (367 aa)
hemAGlutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (497 aa)
Your Current Organism:
Corynebacterium jeikeium
NCBI taxonomy Id: 306537
Other names: C. jeikeium K411, Corynebacterium jeikeium K411, Corynebacterium jeikeium str. K411, Corynebacterium jeikeium strain K411
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