(76 nodes) APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 network (Volvox carteri)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	rpn6	26S proteasome regulatory complex. (421 aa)
	D8TIP0_VOLCA	Protein kinase domain-containing protein. (229 aa)
	D8TIQ6_VOLCA	Protein kinase domain-containing protein. (421 aa)
	D8TIQ9_VOLCA	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family. (204 aa)
	D8TIW5_VOLCA	Uncharacterized protein. (981 aa)
	rpt5	26S proteasome regulatory complex; Belongs to the AAA ATPase family. (428 aa)
	D8TJW9_VOLCA	Protein kinase domain-containing protein. (227 aa)
	poa5	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (249 aa)
	alk4	Aurora like protein kinase. (624 aa)
	rpt3	26S proteasome regulatory complex. (416 aa)
	D8TL56_VOLCA	Protein kinase domain-containing protein. (680 aa)
	D8TL58_VOLCA	Protein kinase domain-containing protein. (585 aa)
	alk5a	Aurora like protein kinase. (898 aa)
	poa6	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (283 aa)
	D8TMA0_VOLCA	Uncharacterized protein. (242 aa)
	D8TMU3_VOLCA	Protein kinase domain-containing protein. (262 aa)
	D8TN31_VOLCA	Protein kinase domain-containing protein. (390 aa)
	D8TN32_VOLCA	Protein kinase domain-containing protein. (719 aa)
	alk3	Serine/threonine protein kinase. (788 aa)
	D8TP90_VOLCA	Uncharacterized protein. (116 aa)
	poa3	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (253 aa)
	D8TQZ4_VOLCA	Uncharacterized protein. (76 aa)
	D8TQZ5_VOLCA	Uncharacterized protein. (89 aa)
	poa1	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (249 aa)
	D8TTL6_VOLCA	Protein kinase domain-containing protein. (265 aa)
	D8TTP7_VOLCA	ATPase_AAA_core domain-containing protein. (323 aa)
	D8TUA3_VOLCA	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family. (272 aa)
	D8TUA8_VOLCA	Protein kinase domain-containing protein. (147 aa)
	D8TUD3_VOLCA	CULLIN_2 domain-containing protein; Belongs to the cullin family. (615 aa)
	D8TVR2_VOLCA	Protein kinase domain-containing protein. (257 aa)
	D8TIN4_VOLCA	Protein kinase domain-containing protein. (358 aa)
	rpn10	26S proteasome regulatory complex. (363 aa)
	D8TWR1_VOLCA	Protein kinase domain-containing protein. (346 aa)
	rpt6	26S proteasome regulatory complex; Belongs to the AAA ATPase family. (396 aa)
	alk2a	Serine/threonine protein kinase; Belongs to the protein kinase superfamily. (328 aa)
	alk2b	Aurora kinase; Belongs to the protein kinase superfamily. (344 aa)
	rpt4	26S proteasome regulatory complex; Belongs to the AAA ATPase family. (361 aa)
	rpn2	26S proteasome non-ATPase regulatory subunit 1 homolog; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (986 aa)
	D8TYX8_VOLCA	Protein kinase domain-containing protein. (259 aa)
	D8TZS7_VOLCA	Protein kinase domain-containing protein. (303 aa)
	D8TZU3_VOLCA	ATPase_AAA_core domain-containing protein. (409 aa)
	D8TZV7_VOLCA	Nas2_N domain-containing protein. (211 aa)
	D8U030_VOLCA	DUF3437 domain-containing protein. (279 aa)
	D8U031_VOLCA	Uncharacterized protein. (1885 aa)
	rpt1	26S proteasome regulatory complex; Belongs to the AAA ATPase family. (426 aa)
	rpn9	26S proteasome regulatory complex. (391 aa)
	D8U1R0_VOLCA	Uncharacterized protein. (212 aa)
	D8U259_VOLCA	Protein kinase domain-containing protein. (207 aa)
	poa7	Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (249 aa)
	D8U2B3_VOLCA	Protein kinase domain-containing protein. (756 aa)
	D8U2C4_VOLCA	Protein kinase domain-containing protein. (210 aa)
	D8U2C5_VOLCA	Protein kinase domain-containing protein. (291 aa)
	D8TGV7_VOLCA	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family. (223 aa)
	D8U3G8_VOLCA	Protein kinase domain-containing protein. (553 aa)
	D8U3P5_VOLCA	Protein kinase domain-containing protein. (325 aa)
	alk1	Serine/threonine protein kinase. (773 aa)
	D8U622_VOLCA	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (224 aa)
	D8U693_VOLCA	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family. (269 aa)
	D8U7G9_VOLCA	Protein kinase domain-containing protein. (213 aa)
	poa4	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (252 aa)
	poa2	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (235 aa)
	rpn8	26S proteasome regulatory complex. (335 aa)
	D8UB99_VOLCA	Protein kinase domain-containing protein. (157 aa)
	D8UBG1_VOLCA	TPR_REGION domain-containing protein. (340 aa)
	D8UCV7_VOLCA	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family. (193 aa)
	D8UF69_VOLCA	RING-type domain-containing protein. (87 aa)
	D8UGM3_VOLCA	TPR_REGION domain-containing protein. (536 aa)
	D8UHT9_VOLCA	Protein kinase domain-containing protein. (309 aa)
	D8UI42_VOLCA	Protein kinase domain-containing protein. (77 aa)
	D8UIU8_VOLCA	Proteasome subunit beta; Belongs to the peptidase T1B family. (284 aa)
	D8UJR8_VOLCA	Protein kinase domain-containing protein. (397 aa)
	D8UJZ4_VOLCA	TPR_REGION domain-containing protein. (535 aa)
	rpt2	26S proteasome regulatory complex; Belongs to the AAA ATPase family. (444 aa)
	D8ULD9_VOLCA	ANAPC5 domain-containing protein. (672 aa)
	D8ULN3_VOLCA	Protein kinase domain-containing protein. (229 aa)
	rps27A	Ribosomal protein S27A component of cytosolic 80S ribosome and 40S small subunit. (181 aa)

Your Current Organism:

Volvox carteri

NCBI taxonomy Id: 3068
Other names: V. carteri f. nagariensis, Volvox carteri f. nagariensis, Volvox carteri f. nagariensis M.O.P.Iyengar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
D8TGV7_VOLCA	D8TIQ9_VOLCA	D8TGV7	D8TIQ9	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	0.995
D8TGV7_VOLCA	D8TMA0_VOLCA	D8TGV7	D8TMA0	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Uncharacterized protein.	0.904
D8TGV7_VOLCA	D8TP90_VOLCA	D8TGV7	D8TP90	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Uncharacterized protein.	0.768
D8TGV7_VOLCA	D8TTP7_VOLCA	D8TGV7	D8TTP7	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	ATPase_AAA_core domain-containing protein.	0.870
D8TGV7_VOLCA	D8TUA3_VOLCA	D8TGV7	D8TUA3	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	0.992
D8TGV7_VOLCA	D8TZU3_VOLCA	D8TGV7	D8TZU3	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	ATPase_AAA_core domain-containing protein.	0.870
D8TGV7_VOLCA	D8TZV7_VOLCA	D8TGV7	D8TZV7	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Nas2_N domain-containing protein.	0.657
D8TGV7_VOLCA	D8U030_VOLCA	D8TGV7	D8U030	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	DUF3437 domain-containing protein.	0.768
D8TGV7_VOLCA	D8U031_VOLCA	D8TGV7	D8U031	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Uncharacterized protein.	0.768
D8TGV7_VOLCA	D8U1R0_VOLCA	D8TGV7	D8U1R0	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Uncharacterized protein.	0.994
D8TGV7_VOLCA	D8U622_VOLCA	D8TGV7	D8U622	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.564
D8TGV7_VOLCA	D8U693_VOLCA	D8TGV7	D8U693	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	0.991
D8TGV7_VOLCA	D8UCV7_VOLCA	D8TGV7	D8UCV7	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	0.993
D8TGV7_VOLCA	D8UF69_VOLCA	D8TGV7	D8UF69	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	RING-type domain-containing protein.	0.529
D8TGV7_VOLCA	D8UIU8_VOLCA	D8TGV7	D8UIU8	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Proteasome subunit beta; Belongs to the peptidase T1B family.	0.995
D8TGV7_VOLCA	D8UJZ4_VOLCA	D8TGV7	D8UJZ4	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	TPR_REGION domain-containing protein.	0.555
D8TGV7_VOLCA	poa1	D8TGV7	D8TTE7	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.988
D8TGV7_VOLCA	poa2	D8TGV7	D8UA34	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.994
D8TGV7_VOLCA	poa3	D8TGV7	D8TPS0	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.992
D8TGV7_VOLCA	poa4	D8TGV7	D8U9R8	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.991