(64 nodes) Steroid biosynthetic process, and Terpenoid backbone biosynthesis network (Chaetomium globosum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CHGG_11051	Uncharacterized protein; Belongs to the cytochrome P450 family. (504 aa)
	CHGG_10894	Uncharacterized protein. (585 aa)
	CHGG_10866	Uncharacterized protein. (469 aa)
	CHGG_10737	Fungal_trans domain-containing protein. (401 aa)
	CHGG_10107	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (330 aa)
	CHGG_09760	Uncharacterized protein. (795 aa)
	CHGG_09600	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (452 aa)
	CHGG_09522	FAD-binding PCMH-type domain-containing protein. (392 aa)
	CHGG_09459	Uncharacterized protein; Belongs to the cytochrome P450 family. (434 aa)
	CHGG_09430	Uncharacterized protein. (385 aa)
	CHGG_09400	Uncharacterized protein. (1089 aa)
	CHGG_09366	Uncharacterized protein; Belongs to the cytochrome P450 family. (202 aa)
	CHGG_09365	Uncharacterized protein. (235 aa)
	CHGG_09164	FAD-binding PCMH-type domain-containing protein. (467 aa)
	CHGG_09134	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (447 aa)
	CHGG_09111	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding. (546 aa)
	CHGG_09100	Uncharacterized protein. (466 aa)
	CHGG_09030	Uncharacterized protein. (316 aa)
	CHGG_08782	Uncharacterized protein. (273 aa)
	CHGG_08176	ING domain-containing protein. (1204 aa)
	CHGG_07733	Farnesyl pyrophosphate synthetase; Belongs to the FPP/GGPP synthase family. (267 aa)
	CHGG_07692	Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. (756 aa)
	CHGG_07576	zf-C2H2_jaz domain-containing protein. (305 aa)
	CHGG_07393	Uncharacterized protein; Belongs to the cytochrome P450 family. (366 aa)
	CHGG_07141	Uncharacterized protein. (233 aa)
	CHGG_07136	Methyltransf_11 domain-containing protein. (343 aa)
	CHGG_06921	Uncharacterized protein. (715 aa)
	CHGG_05225	Uncharacterized protein. (430 aa)
	CHGG_05209	EXPERA domain-containing protein. (238 aa)
	CHGG_04989	Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (460 aa)
	CHGG_04825	Uncharacterized protein; Belongs to the cytochrome P450 family. (533 aa)
	CHGG_04758	Uncharacterized protein. (509 aa)
	CHGG_04744	Uncharacterized protein; Belongs to the sterol desaturase family. (269 aa)
	CHGG_04641	Nudix hydrolase domain-containing protein. (239 aa)
	CHGG_04572	Uncharacterized protein; Belongs to the cytochrome P450 family. (540 aa)
	CHGG_04259	PLD phosphodiesterase domain-containing protein. (669 aa)
	CHGG_04240	Uncharacterized protein. (172 aa)
	CHGG_04085	Uncharacterized protein. (358 aa)
	CHGG_03995	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (340 aa)
	CHGG_03993	FAD-binding PCMH-type domain-containing protein. (513 aa)
	CHGG_06761	Methyltransf_11 domain-containing protein. (301 aa)
	CHGG_06432	Uncharacterized protein. (497 aa)
	CHGG_06141	Sterol 24-C-methyltransferase; Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol. (381 aa)
	CHGG_06091	Methyltransf_11 domain-containing protein. (212 aa)
	CHGG_03418	Uncharacterized protein. (485 aa)
	CHGG_03343	Uncharacterized protein. (473 aa)
	CHGG_03082	Uncharacterized protein; Belongs to the cytochrome P450 family. (428 aa)
	CHGG_02984	EXPERA domain-containing protein. (237 aa)
	CHGG_02819	3Beta_HSD domain-containing protein. (372 aa)
	CHGG_02656	ANK_REP_REGION domain-containing protein. (1118 aa)
	CHGG_02507	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (532 aa)
	CHGG_02506	Uncharacterized protein. (561 aa)
	CHGG_02240	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (254 aa)
	CHGG_02144	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family. (394 aa)
	CHGG_01934	Uncharacterized protein. (631 aa)
	CHGG_01855	FAD-binding PCMH-type domain-containing protein. (465 aa)
	CHGG_01652	Uncharacterized protein; Belongs to the cytochrome P450 family. (530 aa)
	CHGG_01542	Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. (662 aa)
	CHGG_01310	Uncharacterized protein. (305 aa)
	CHGG_01115	Sterol 24-C-methyltransferase; Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol. (310 aa)
	CHGG_01045	Epimerase domain-containing protein. (376 aa)
	CHGG_01017	3Beta_HSD domain-containing protein. (482 aa)
	CHGG_00792	Uncharacterized protein. (258 aa)
	CHGG_00570	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (352 aa)

Your Current Organism:

Chaetomium globosum

NCBI taxonomy Id: 306901
Other names: C. globosum CBS 148.51, Chaetomium globosum CBS 148.51

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHGG_00570	CHGG_00792	Q2HGT4	Q2HG62	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Uncharacterized protein.	0.836
CHGG_00570	CHGG_01310	Q2HGT4	Q2HEP4	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Uncharacterized protein.	0.656
CHGG_00570	CHGG_01542	Q2HGT4	Q2HE12	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family.	0.519
CHGG_00570	CHGG_02144	Q2HGT4	Q2HCB0	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family.	0.934
CHGG_00570	CHGG_02506	Q2HGT4	Q2HB98	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Uncharacterized protein.	0.898
CHGG_00570	CHGG_02507	Q2HGT4	Q2HB97	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.627
CHGG_00570	CHGG_04641	Q2HGT4	Q2H0Q5	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Nudix hydrolase domain-containing protein.	0.917
CHGG_00570	CHGG_04758	Q2HGT4	Q2H0D8	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Uncharacterized protein.	0.474
CHGG_00570	CHGG_04989	Q2HGT4	Q2GZQ7	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.530
CHGG_00570	CHGG_06921	Q2HGT4	Q2GYN3	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Uncharacterized protein.	0.584
CHGG_00570	CHGG_07692	Q2HGT4	Q2GWG2	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family.	0.519
CHGG_00570	CHGG_07733	Q2HGT4	Q2GWC1	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Farnesyl pyrophosphate synthetase; Belongs to the FPP/GGPP synthase family.	0.935
CHGG_00570	CHGG_08176	Q2HGT4	Q2GV28	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	ING domain-containing protein.	0.875
CHGG_00570	CHGG_09030	Q2HGT4	Q2GSM4	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Uncharacterized protein.	0.816
CHGG_00570	CHGG_09111	Q2HGT4	Q2GSE3	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	0.890
CHGG_00570	CHGG_09134	Q2HGT4	Q2GSC0	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.692
CHGG_00570	CHGG_09400	Q2HGT4	Q2GRK4	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Uncharacterized protein.	0.850
CHGG_00570	CHGG_09430	Q2HGT4	Q2GRH4	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Uncharacterized protein.	0.593
CHGG_00570	CHGG_09600	Q2HGT4	Q2GR04	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.886
CHGG_00570	CHGG_10866	Q2HGT4	Q2GMD8	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Uncharacterized protein.	0.945