(34 nodes) Mixed, incl. mRNA cleavage factor complex, and Termination of RNA polymerase II transcription network (Chaetomium globosum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CHGG_10352	CID domain-containing protein. (729 aa)
	CHGG_10339	Uncharacterized protein. (755 aa)
	RAT1	5'-3' exoribonuclease 2; Possesses 5'->3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote termination of transcription by RNA polymerase II (By similarity); Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily. (1039 aa)
	CHGG_09687	Cleavage and polyadenylation specificity factor subunit 2. (956 aa)
	CHGG_09681	TPR_REGION domain-containing protein. (1013 aa)
	CHGG_09668	RRM domain-containing protein. (833 aa)
	CHGG_09069	Uncharacterized protein. (496 aa)
	CHGG_08748	Uncharacterized protein. (780 aa)
	CHGG_08312	Uncharacterized protein. (638 aa)
	CHGG_08173	Uncharacterized protein. (854 aa)
	CHGG_07274	CID domain-containing protein. (428 aa)
	CHGG_07192	Uncharacterized protein. (651 aa)
	RAI1	Decapping nuclease RAI1; Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping and pyrophosphohydrolase activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates (By similarity). Belongs to the DXO/Dom3Z family. (373 aa)
	CHGG_07095	C3H1-type domain-containing protein. (1555 aa)
	CHGG_05127	Fip1 domain-containing protein. (340 aa)
	CHGG_04790	PAP_central domain-containing protein. (891 aa)
	CHGG_04537	Uncharacterized protein. (896 aa)
	CLP1	mRNA cleavage and polyadenylation factor CLP1; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation. (497 aa)
	CHGG_03711	Uncharacterized protein. (878 aa)
	CHGG_06515	Uncharacterized protein. (2053 aa)
	CHGG_05976	DRMBL domain-containing protein. (830 aa)
	CHGG_05966	Uncharacterized protein. (180 aa)
	CHGG_05754	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (322 aa)
	CHGG_05742	WD_REPEATS_REGION domain-containing protein. (687 aa)
	CHGG_05580	WD_REPEATS_REGION domain-containing protein. (299 aa)
	CHGG_03202	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...] (265 aa)
	CHGG_03036	Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (592 aa)
	CHGG_02726	YTH domain-containing protein. (429 aa)
	CHGG_01795	DUF3453 domain-containing protein. (751 aa)
	CHGG_01713	CPSF_A domain-containing protein. (1394 aa)
	CHGG_01583	RRM domain-containing protein. (315 aa)
	SSU72	RNA polymerase II subunit A C-terminal domain phosphatase SSU72; Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1); Belongs to the SSU72 phosphatase family. (257 aa)
	CHGG_00701	Uncharacterized protein. (763 aa)
	CHGG_00511	Uncharacterized protein. (445 aa)

Your Current Organism:

Chaetomium globosum

NCBI taxonomy Id: 306901
Other names: C. globosum CBS 148.51, Chaetomium globosum CBS 148.51

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHGG_00511	CHGG_03036	Q2HGZ3	Q2H9R8	Uncharacterized protein.	Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's.	0.443
CHGG_00511	CHGG_04790	Q2HGZ3	Q2H0A6	Uncharacterized protein.	PAP_central domain-containing protein.	0.443
CHGG_00511	CHGG_06515	Q2HGZ3	Q2H4A0	Uncharacterized protein.	Uncharacterized protein.	0.497
CHGG_00511	CHGG_08748	Q2HGZ3	Q2GTF6	Uncharacterized protein.	Uncharacterized protein.	0.921
CHGG_00511	CHGG_09668	Q2HGZ3	Q2GQT6	Uncharacterized protein.	RRM domain-containing protein.	0.630
CHGG_00511	CHGG_10339	Q2HGZ3	Q2GNW5	Uncharacterized protein.	Uncharacterized protein.	0.462
CHGG_00701	CHGG_03711	Q2HGF3	Q2H3D5	Uncharacterized protein.	Uncharacterized protein.	0.738
CHGG_00701	CHGG_10339	Q2HGF3	Q2GNW5	Uncharacterized protein.	Uncharacterized protein.	0.738
CHGG_00701	CHGG_10352	Q2HGF3	Q2GNV2	Uncharacterized protein.	CID domain-containing protein.	0.441
CHGG_00701	RAT1	Q2HGF3	Q2GNZ6	Uncharacterized protein.	5'-3' exoribonuclease 2; Possesses 5'->3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote termination of transcription by RNA polymerase II (By similarity); Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.	0.489
CHGG_01583	CHGG_01713	Q2HDX1	Q2HDJ1	RRM domain-containing protein.	CPSF_A domain-containing protein.	0.993
CHGG_01583	CHGG_01795	Q2HDX1	Q2HDA9	RRM domain-containing protein.	DUF3453 domain-containing protein.	0.991
CHGG_01583	CHGG_02726	Q2HDX1	Q2HAM8	RRM domain-containing protein.	YTH domain-containing protein.	0.917
CHGG_01583	CHGG_03036	Q2HDX1	Q2H9R8	RRM domain-containing protein.	Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's.	0.919
CHGG_01583	CHGG_03202	Q2HDX1	Q2H9A2	RRM domain-containing protein.	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...]	0.848
CHGG_01583	CHGG_04537	Q2HDX1	Q2H109	RRM domain-containing protein.	Uncharacterized protein.	0.496
CHGG_01583	CHGG_04790	Q2HDX1	Q2H0A6	RRM domain-containing protein.	PAP_central domain-containing protein.	0.919
CHGG_01583	CHGG_05127	Q2HDX1	Q2GZB9	RRM domain-containing protein.	Fip1 domain-containing protein.	0.983
CHGG_01583	CHGG_05580	Q2HDX1	Q2H6Y5	RRM domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.945
CHGG_01583	CHGG_05742	Q2HDX1	Q2H6H3	RRM domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.980