(38 nodes) Negative regulation of response to stimulus network (Chaetomium globosum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CHGG_06085	Uncharacterized protein. (356 aa)
	CHGG_03975	Senescence domain-containing protein. (513 aa)
	CHGG_04528	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
	CHGG_04628	FNIP_N domain-containing protein. (1226 aa)
	CHGG_04666	Uncharacterized protein. (1006 aa)
	CHGG_04677	Uncharacterized protein. (687 aa)
	CHGG_04868	Fungal_trans domain-containing protein. (950 aa)
	CHGG_07125	Guanine nucleotide-binding protein alpha-2 subunit. (355 aa)
	CHGG_07177	Rap-GAP domain-containing protein. (1506 aa)
	CHGG_07180	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (269 aa)
	CHGG_07477	UBIQUITIN_CONJUGAT_2 domain-containing protein. (973 aa)
	CHGG_07548	Fungal_trans domain-containing protein. (772 aa)
	CHGG_07721	Uncharacterized protein. (1554 aa)
	CHGG_08423	Guanine nucleotide-binding protein beta subunit-like protein. (316 aa)
	CHGG_09703	Ras-GAP domain-containing protein. (752 aa)
	CHGG_10231	Uncharacterized protein. (997 aa)
	CHGG_10543	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (272 aa)
	CHGG_10933	C2 domain-containing protein. (537 aa)
	CHGG_00101	Uncharacterized protein. (726 aa)
	CHGG_00953	HIT-type domain-containing protein. (569 aa)
	CHGG_01101	Uncharacterized protein. (2335 aa)
	CHGG_01561	Uncharacterized protein. (495 aa)
	CHGG_01661	Uncharacterized protein. (491 aa)
	CHGG_01748	Uncharacterized protein. (286 aa)
	CHGG_01879	Rab-GAP TBC domain-containing protein. (488 aa)
	CHGG_02024	Uncharacterized protein; Belongs to the BI1 family. (341 aa)
	CHGG_02070	Uncharacterized protein. (735 aa)
	CHGG_02737	Protein phosphatase PP2A regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (480 aa)
	CHGG_02772	Uncharacterized protein. (904 aa)
	CHGG_02820	Uncharacterized protein. (1152 aa)
	CHGG_03090	FHA domain-containing protein. (623 aa)
	CHGG_03110	PPM-type phosphatase domain-containing protein. (580 aa)
	CHGG_03257	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. (2748 aa)
	CHGG_03398	Uncharacterized protein. (502 aa)
	CHGG_05754	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (322 aa)
	CHGG_05813	Uncharacterized protein. (911 aa)
	CHGG_05928	Fe2OG dioxygenase domain-containing protein. (657 aa)
	CHGG_06011	Uncharacterized protein. (207 aa)

Your Current Organism:

Chaetomium globosum

NCBI taxonomy Id: 306901
Other names: C. globosum CBS 148.51, Chaetomium globosum CBS 148.51

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHGG_01101	CHGG_02820	Q2HFA3	Q2HAD4	Uncharacterized protein.	Uncharacterized protein.	0.539
CHGG_01748	CHGG_02772	Q2HDF6	Q2HAI2	Uncharacterized protein.	Uncharacterized protein.	0.998
CHGG_01748	CHGG_07177	Q2HDF6	Q2GXX7	Uncharacterized protein.	Rap-GAP domain-containing protein.	0.461
CHGG_01879	CHGG_02737	Q2HD25	Q2HAL7	Rab-GAP TBC domain-containing protein.	Protein phosphatase PP2A regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	0.961
CHGG_01879	CHGG_03090	Q2HD25	Q2H9L4	Rab-GAP TBC domain-containing protein.	FHA domain-containing protein.	0.635
CHGG_01879	CHGG_10231	Q2HD25	Q2GP73	Rab-GAP TBC domain-containing protein.	Uncharacterized protein.	0.968
CHGG_02737	CHGG_01879	Q2HAL7	Q2HD25	Protein phosphatase PP2A regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	Rab-GAP TBC domain-containing protein.	0.961
CHGG_02737	CHGG_05754	Q2HAL7	Q2H6G1	Protein phosphatase PP2A regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.	0.784
CHGG_02772	CHGG_01748	Q2HAI2	Q2HDF6	Uncharacterized protein.	Uncharacterized protein.	0.998
CHGG_02772	CHGG_07177	Q2HAI2	Q2GXX7	Uncharacterized protein.	Rap-GAP domain-containing protein.	0.480
CHGG_02820	CHGG_01101	Q2HAD4	Q2HFA3	Uncharacterized protein.	Uncharacterized protein.	0.539
CHGG_03090	CHGG_01879	Q2H9L4	Q2HD25	FHA domain-containing protein.	Rab-GAP TBC domain-containing protein.	0.635
CHGG_03090	CHGG_03257	Q2H9L4	Q2H947	FHA domain-containing protein.	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily.	0.525
CHGG_03110	CHGG_05813	Q2H9J4	Q2H6A2	PPM-type phosphatase domain-containing protein.	Uncharacterized protein.	0.435
CHGG_03257	CHGG_03090	Q2H947	Q2H9L4	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily.	FHA domain-containing protein.	0.525
CHGG_03257	CHGG_07477	Q2H947	Q2GX27	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.560
CHGG_04528	CHGG_07477	Q2H118	Q2GX27	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.892
CHGG_04666	CHGG_07177	Q2H0N0	Q2GXX7	Uncharacterized protein.	Rap-GAP domain-containing protein.	0.936
CHGG_04677	CHGG_07125	Q2H0L9	Q2GY29	Uncharacterized protein.	Guanine nucleotide-binding protein alpha-2 subunit.	0.874
CHGG_05754	CHGG_02737	Q2H6G1	Q2HAL7	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.	Protein phosphatase PP2A regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	0.784