(69 nodes) Folate biosynthesis network (Chaetomium globosum)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CHGG_02451	Uncharacterized protein; Belongs to the alkaline phosphatase family. (666 aa)
	CHGG_00045	FSH1 domain-containing protein. (426 aa)
	CHGG_00162	ANK_REP_REGION domain-containing protein. (864 aa)
	CHGG_00342	MOSC domain-containing protein. (265 aa)
	CHGG_00859	MFS domain-containing protein. (565 aa)
	CHGG_00937	Uncharacterized protein. (479 aa)
	CHGG_01108	MFS domain-containing protein. (531 aa)
	MEF1	Elongation factor G, mitochondrial; Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. (798 aa)
	hxB	Molybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. (778 aa)
	CHGG_01506	FolB domain-containing protein. (354 aa)
	CHGG_01783	F-box domain-containing protein. (681 aa)
	CHGG_01961	Uncharacterized protein. (456 aa)
	CHGG_01962	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (507 aa)
	CHGG_02660	Mur_ligase_M domain-containing protein. (338 aa)
	CHGG_02729	Uncharacterized protein. (447 aa)
	CHGG_03050	Alkaline phosphatase. (586 aa)
	CHGG_03102	FSH1 domain-containing protein. (342 aa)
	CHGG_03160	Elp3 domain-containing protein. (677 aa)
	CHGG_03312	ANK_REP_REGION domain-containing protein. (2670 aa)
	CHGG_03542	Myb-like domain-containing protein. (350 aa)
	CHGG_05515	Uncharacterized protein. (449 aa)
	CHGG_05654	Uncharacterized protein. (405 aa)
	CHGG_05769	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (218 aa)
	CHGG_06103	Epimerase domain-containing protein. (324 aa)
	CHGG_10922	Uncharacterized protein. (874 aa)
	CHGG_10779	GTP_cyclohydroI domain-containing protein. (124 aa)
	CHGG_10775	Uncharacterized protein. (318 aa)
	CHGG_10454	Uncharacterized protein. (210 aa)
	CHGG_10439	Uncharacterized protein. (274 aa)
	CHGG_10045	Uncharacterized protein. (432 aa)
	CHGG_09847	SANT domain-containing protein. (336 aa)
	CHGG_09780	ANK_REP_REGION domain-containing protein. (331 aa)
	CHGG_09578	Molybdopterin molybdenumtransferase; Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. (414 aa)
	CHGG_09441	Uncharacterized protein. (849 aa)
	CHGG_09363	Uncharacterized protein. (360 aa)
	CHGG_09016	PhoD_N domain-containing protein. (627 aa)
	CHGG_08745	FSH1 domain-containing protein. (274 aa)
	CHGG_08704	Uncharacterized protein. (175 aa)
	CHGG_08132	Uncharacterized protein. (1402 aa)
	CHGG_07881	ANK_REP_REGION domain-containing protein. (905 aa)
	CHGG_06319	Uncharacterized protein. (158 aa)
	CHGG_06339	Uncharacterized protein. (236 aa)
	CHGG_06499	MFS domain-containing protein. (454 aa)
	CHGG_06529	Uncharacterized protein. (269 aa)
	CHGG_06662	Uncharacterized protein. (580 aa)
	CHGG_06742	ANK_REP_REGION domain-containing protein. (642 aa)
	CHGG_06755	FSH1 domain-containing protein. (176 aa)
	CHGG_03752	ANK_REP_REGION domain-containing protein. (1456 aa)
	CHGG_03857	Tr-type G domain-containing protein. (789 aa)
	CHGG_03876	Uncharacterized protein. (418 aa)
	CHGG_03896	Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. (681 aa)
	CHGG_03919	Pterin-binding domain-containing protein. (500 aa)
	CHGG_04502	Molybdopterin molybdenumtransferase; Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. (675 aa)
	CHGG_04571	FSH1 domain-containing protein. (282 aa)
	CHGG_04685	MFS domain-containing protein. (528 aa)
	CHGG_04745	Uncharacterized protein. (161 aa)
	CHGG_04817	Uncharacterized protein. (70 aa)
	CHGG_04980	Uncharacterized protein. (796 aa)
	CHGG_05122	Uncharacterized protein. (113 aa)
	CHGG_05191	Uncharacterized protein. (529 aa)
	CHGG_06822	GTP_cyclohydroI domain-containing protein. (233 aa)
	CHGG_06835	GTP_cyclohydro2 domain-containing protein. (137 aa)
	CHGG_07047	PRELI/MSF1 domain-containing protein. (201 aa)
	CHGG_07254	TauD domain-containing protein. (999 aa)
	CHGG_07296	Uncharacterized protein. (606 aa)
	CHGG_07558	ANK_REP_REGION domain-containing protein. (255 aa)
	CHGG_07761	ZT_dimer domain-containing protein. (478 aa)
	CHGG_07778	Uncharacterized protein. (845 aa)
	CHGG_07800	GTP_CH_N domain-containing protein. (480 aa)

Your Current Organism:

Chaetomium globosum

NCBI taxonomy Id: 306901
Other names: C. globosum CBS 148.51, Chaetomium globosum CBS 148.51

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHGG_00342	CHGG_03160	Q2HHG2	Q2H9E4	MOSC domain-containing protein.	Elp3 domain-containing protein.	0.914
CHGG_00342	CHGG_04502	Q2HHG2	Q2H144	MOSC domain-containing protein.	Molybdopterin molybdenumtransferase; Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.	0.795
CHGG_00342	CHGG_06319	Q2HHG2	Q2H4U6	MOSC domain-containing protein.	Uncharacterized protein.	0.914
CHGG_00342	CHGG_09578	Q2HHG2	Q2GR26	MOSC domain-containing protein.	Molybdopterin molybdenumtransferase; Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.	0.795
CHGG_00937	CHGG_04502	Q2HFR7	Q2H144	Uncharacterized protein.	Molybdopterin molybdenumtransferase; Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.	0.837
CHGG_00937	CHGG_09578	Q2HFR7	Q2GR26	Uncharacterized protein.	Molybdopterin molybdenumtransferase; Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.	0.780
CHGG_00937	CHGG_10775	Q2HFR7	Q2GMM9	Uncharacterized protein.	Uncharacterized protein.	0.627
CHGG_00937	hxB	Q2HFR7	Q2HE65	Uncharacterized protein.	Molybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.	0.833
CHGG_01506	CHGG_01961	Q2HE48	Q2HCU3	FolB domain-containing protein.	Uncharacterized protein.	0.709
CHGG_01506	CHGG_01962	Q2HE48	Q2HCU2	FolB domain-containing protein.	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	0.709
CHGG_01506	CHGG_02660	Q2HE48	Q2HAU4	FolB domain-containing protein.	Mur_ligase_M domain-containing protein.	0.709
CHGG_01506	CHGG_05769	Q2HE48	Q2H6E6	FolB domain-containing protein.	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	0.747
CHGG_01506	CHGG_06822	Q2HE48	Q2GYY2	FolB domain-containing protein.	GTP_cyclohydroI domain-containing protein.	0.868
CHGG_01506	CHGG_07778	Q2HE48	Q2GW76	FolB domain-containing protein.	Uncharacterized protein.	0.773
CHGG_01506	CHGG_10779	Q2HE48	Q2GMM5	FolB domain-containing protein.	GTP_cyclohydroI domain-containing protein.	0.868
CHGG_01783	CHGG_01961	Q2HDC1	Q2HCU3	F-box domain-containing protein.	Uncharacterized protein.	0.401
CHGG_01783	CHGG_01962	Q2HDC1	Q2HCU2	F-box domain-containing protein.	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	0.401
CHGG_01783	CHGG_02660	Q2HDC1	Q2HAU4	F-box domain-containing protein.	Mur_ligase_M domain-containing protein.	0.401
CHGG_01961	CHGG_01506	Q2HCU3	Q2HE48	Uncharacterized protein.	FolB domain-containing protein.	0.709
CHGG_01961	CHGG_01783	Q2HCU3	Q2HDC1	Uncharacterized protein.	F-box domain-containing protein.	0.401