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got1 got1 nit2 nit2 LOC112153948 LOC112153948 sucla2 sucla2 suclg1 suclg1 fh fh ENSOMEP00000008874 ENSOMEP00000008874 idh1 idh1 GOT1 GOT1 dhtkd1 dhtkd1 IDH2 IDH2 ENSOMEP00000012622 ENSOMEP00000012622 SDHB SDHB sdha sdha idh3g idh3g mdh1 mdh1 dlst dlst LOC112149803 LOC112149803 idh3a idh3a ACLY ACLY LOC112161617 LOC112161617 ENSOMEP00000022794 ENSOMEP00000022794 got2 got2 idh3b idh3b aco1 aco1 aco2 aco2 LOC112138440 LOC112138440 LOC112139659 LOC112139659 ENSOMEP00000031390 ENSOMEP00000031390 ENSOMEP00000034591 ENSOMEP00000034591 ACLY-2 ACLY-2 LOC112163122 LOC112163122 LOC112152846 LOC112152846 ENSOMEP00000036170 ENSOMEP00000036170 ddo ddo
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
got1Aspartate aminotransferase. (441 aa)
nit2Nitrilase family, member 2. (286 aa)
LOC112153948ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family. (1124 aa)
sucla2Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (466 aa)
suclg1Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (329 aa)
fhFumarate hydratase. (499 aa)
ENSOMEP00000008874Succinate-CoA ligase, GDP-forming, beta subunit. (409 aa)
idh1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
GOT1Aspartate aminotransferase. (410 aa)
dhtkd1Dehydrogenase E1 and transketolase domain containing 1. (924 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
ENSOMEP00000012622Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (385 aa)
SDHBSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (284 aa)
sdhaSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (663 aa)
idh3gIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (392 aa)
mdh1Malate dehydrogenase. (350 aa)
dlstDihydrolipoamide S-succinyltransferase. (483 aa)
LOC112149803Succinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (158 aa)
idh3aIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (368 aa)
ACLYATP citrate lyase. (428 aa)
LOC112161617Malate dehydrogenase. (333 aa)
ENSOMEP00000022794Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (276 aa)
got2Aspartate aminotransferase. (428 aa)
idh3bIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (390 aa)
aco1Aconitase 1, soluble; Belongs to the aconitase/IPM isomerase family. (892 aa)
aco2Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (781 aa)
LOC112138440Transket_pyr domain-containing protein. (1032 aa)
LOC112139659Succinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (104 aa)
ENSOMEP00000031390Malate dehydrogenase. (209 aa)
ENSOMEP00000034591Citrate synthase; Belongs to the citrate synthase family. (471 aa)
ACLY-2ATP citrate lyase. (438 aa)
LOC112163122Oxoglutarate (alpha-ketoglutarate) dehydrogenase b (lipoamide). (996 aa)
LOC112152846Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
ENSOMEP00000036170Succinate dehydrogenase complex, subunit C, integral membrane protein. (192 aa)
ddoZgc:172341. (337 aa)
Your Current Organism:
Oryzias melastigma
NCBI taxonomy Id: 30732
Other names: Aplocheilus melastigmus, Indian medaka, Java medaka, O. melastigma, marine medaka
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