(110 nodes) Mixed, incl. Valine, leucine and isoleucine degradation, and Fatty acid oxidation network (Oryzias melastigma)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HTD2	Hydroxyacyl-thioester dehydratase type 2. (168 aa)
	LOC112151519	Si:dkey-61p9.11. (2097 aa)
	ENSOMEP00000000580	Ubiquitin associated protein 2b. (1141 aa)
	ENSOMEP00000000761	Vesicle amine transport 1-like. (334 aa)
	ehhadh	Enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. (713 aa)
	aasdhppt	Aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase. (318 aa)
	ENSOMEP00000001870	Uncharacterized protein. (161 aa)
	LOC112148844	Uncharacterized protein. (634 aa)
	ENSOMEP00000003032	Acyl-CoA synthetase short chain family member 3. (669 aa)
	VAT1	Vesicle amine transport 1. (419 aa)
	LOC112151098	3-hydroxybutyrate dehydrogenase, type 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (361 aa)
	acad8	Acyl-CoA dehydrogenase family, member 8. (419 aa)
	ENSOMEP00000004941	Uncharacterized protein. (84 aa)
	ENSOMEP00000005246	PKS_ER domain-containing protein. (387 aa)
	acat2	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
	auh	AU RNA binding protein/enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (323 aa)
	ivd	Isovaleryl-CoA dehydrogenase. (434 aa)
	ENSOMEP00000006797	Acyl-CoA_dh_N domain-containing protein. (142 aa)
	LOC112142944	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (489 aa)
	abhd10	Transgelin 3b. (290 aa)
	acox1	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (661 aa)
	dhrs11	Dehydrogenase/reductase (SDR family) member 11a; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (255 aa)
	ZADH2	Zinc binding alcohol dehydrogenase domain containing 2. (401 aa)
	ENSOMEP00000009786	Aminoadipate-semialdehyde dehydrogenase. (1039 aa)
	ACADSB	Acyl-CoA dehydrogenase short/branched chain. (432 aa)
	pecr	Peroxisomal trans-2-enoyl-CoA reductase. (298 aa)
	LOC112146482	Uncharacterized protein. (107 aa)
	acadvl	Acyl-CoA dehydrogenase very long chain. (656 aa)
	LOC112150940	Si:ch211-198n5.11. (566 aa)
	mccc2	Methylcrotonoyl-CoA carboxylase 2 (beta). (564 aa)
	cunh15orf41	Zgc:154061. (291 aa)
	etfdh	Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (622 aa)
	LOC112150832	Cocaine- and amphetamine-regulated transcript 1. (107 aa)
	LOC112151636	Zgc:101569; Belongs to the enoyl-CoA hydratase/isomerase family. (312 aa)
	ECHDC1	Ethylmalonyl-CoA decarboxylase 1; Belongs to the enoyl-CoA hydratase/isomerase family. (241 aa)
	pccb	Propionyl-CoA carboxylase subunit beta. (560 aa)
	cbr4	Carbonyl reductase 4. (238 aa)
	hsd17b8	Hydroxysteroid (17-beta) dehydrogenase 8. (256 aa)
	LOC112136284	Zgc:85777. (431 aa)
	ENSOMEP00000015480	Dehydrogenase/reductase (SDR family) member 7B; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (305 aa)
	eci1	Enoyl-CoA delta isomerase 1; Belongs to the enoyl-CoA hydratase/isomerase family. (303 aa)
	ENSOMEP00000015791	Uncharacterized protein. (122 aa)
	GCDH	Glutaryl-CoA dehydrogenase b. (440 aa)
	ENSOMEP00000015969	Zgc:113142; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (377 aa)
	ACSF3	Acyl-CoA synthetase family member 3. (583 aa)
	ENSOMEP00000016606	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (543 aa)
	LOC112157997	Aldedh domain-containing protein. (527 aa)
	hsd17b4	Hydroxysteroid (17-beta) dehydrogenase 4. (737 aa)
	etfb	Electron transfer flavoprotein subunit beta. (254 aa)
	mlycd	Malonyl-CoA decarboxylase. (502 aa)
	LOC112151857	Acetyl-coenzyme A synthetase. (673 aa)
	oxsm	3-oxoacyl-[acyl-carrier-protein] synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (453 aa)
	acss1	Acetyl-coenzyme A synthetase. (680 aa)
	ALDH6A1	Aldehyde dehydrogenase 6 family member A1. (482 aa)
	hibch	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (381 aa)
	olah	Oleoyl-ACP hydrolase. (253 aa)
	acadm	Acyl-CoA dehydrogenase medium chain. (423 aa)
	LOC112158350	Retinol dehydrogenase 14b; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (323 aa)
	acads	Acyl-CoA dehydrogenase short chain. (405 aa)
	etfa	Electron transfer flavoprotein subunit alpha. (333 aa)
	HSD17B1	Hydroxysteroid (17-beta) dehydrogenase 1. (291 aa)
	hadha	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha b; Belongs to the enoyl-CoA hydratase/isomerase family. (763 aa)
	ENSOMEP00000021847	Uncharacterized protein. (65 aa)
	ENSOMEP00000021901	Carrier domain-containing protein. (1992 aa)
	LOC112151122	Carrier domain-containing protein. (2084 aa)
	cpt2	Carnitine palmitoyltransferase 2; Belongs to the carnitine/choline acetyltransferase family. (666 aa)
	LOC112150670	Aldehyde dehydrogenase 9 family, member A1a, tandem duplicate 1; Belongs to the aldehyde dehydrogenase family. (505 aa)
	acat1	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (418 aa)
	echdc2	Enoyl CoA hydratase domain containing 2; Belongs to the enoyl-CoA hydratase/isomerase family. (320 aa)
	pcca	Propionyl-CoA carboxylase subunit alpha. (713 aa)
	ENSOMEP00000022446	3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1. (310 aa)
	echs1	Enoyl CoA hydratase, short chain, 1, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family. (291 aa)
	ENSOMEP00000022780	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (491 aa)
	aldh3b1	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (477 aa)
	LOC112149002	Dehydrogenase/reductase (SDR family) member 11b; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (255 aa)
	aldh5a1	Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (505 aa)
	ENSOMEP00000024299	APH domain-containing protein. (446 aa)
	ENSOMEP00000024330	Acyl-CoA dehydrogenase family, member 11. (306 aa)
	ENSOMEP00000024473	Solute carrier family 34 member 1a. (663 aa)
	mcat	Malonyl CoA:ACP acyltransferase (mitochondrial). (362 aa)
	hadh	Hydroxyacyl-CoA dehydrogenase. (309 aa)
	dhrs7	Dehydrogenase/reductase (SDR family) member 7; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (336 aa)
	ENSOMEP00000025391	Acetyl-CoA carboxylase alpha. (2331 aa)
	acss2	Acyl-CoA synthetase short chain family member 2. (698 aa)
	bdh2	3-hydroxybutyrate dehydrogenase, type 2. (338 aa)
	cryl1	Crystallin, lambda 1. (317 aa)
	ENSOMEP00000027260	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (383 aa)
	LOC112147259	Aldehyde dehydrogenase 9 family, member A1b; Belongs to the aldehyde dehydrogenase family. (518 aa)
	LOC112148467	Zgc:101858; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (297 aa)
	mccc1	Methylcrotonoyl-CoA carboxylase 1 (alpha). (716 aa)
	ENSOMEP00000028705	YqaJ domain-containing protein. (357 aa)
	ENSOMEP00000029220	annotation not available (95 aa)
	ENSOMEP00000029361	Acyl-CoA dehydrogenase long chain. (442 aa)
	ENSOMEP00000029414	Dehydrogenase/reductase (SDR family) member 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (303 aa)
	aacs	Acetoacetyl-CoA synthetase. (676 aa)
	ENSOMEP00000029902	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (480 aa)
	hsd17b1	Hydroxysteroid 17-beta dehydrogenase 1. (291 aa)
	ECHDC1-2	Ethylmalonyl-CoA decarboxylase 1. (133 aa)
	ENSOMEP00000032155	Si:dkey-61n16.5. (130 aa)
	ENSOMEP00000032273	Acetyl-CoA acyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (357 aa)
	LOC112137876	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. (329 aa)
	acox3	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (692 aa)
	acot9	Acyl-CoA thioesterase 9, tandem duplicate 2. (432 aa)
	DIP2C	Disco interacting protein 2 homolog C. (1596 aa)
	rtn4ip1	Reticulon 4 interacting protein 1. (396 aa)
	LOC112152507	Uncharacterized protein. (242 aa)
	LOC112143917	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. (329 aa)
	oxct1	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (527 aa)
	ENSOMEP00000034990	Stomatin (EPB72)-like 1. (419 aa)
	hadhb	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta; Belongs to the thiolase-like superfamily. Thiolase family. (470 aa)

Your Current Organism:

Oryzias melastigma

NCBI taxonomy Id: 30732
Other names: Aplocheilus melastigmus, Indian medaka, Java medaka, O. melastigma, marine medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACADSB	ACSF3	ENSOMEP00000010020	ENSOMEP00000016415	Acyl-CoA dehydrogenase short/branched chain.	Acyl-CoA synthetase family member 3.	0.641
ACADSB	ALDH6A1	ENSOMEP00000010020	ENSOMEP00000019956	Acyl-CoA dehydrogenase short/branched chain.	Aldehyde dehydrogenase 6 family member A1.	0.775
ACADSB	DIP2C	ENSOMEP00000010020	ENSOMEP00000033456	Acyl-CoA dehydrogenase short/branched chain.	Disco interacting protein 2 homolog C.	0.552
ACADSB	ECHDC1	ENSOMEP00000010020	ENSOMEP00000014641	Acyl-CoA dehydrogenase short/branched chain.	Ethylmalonyl-CoA decarboxylase 1; Belongs to the enoyl-CoA hydratase/isomerase family.	0.880
ACADSB	ECHDC1-2	ENSOMEP00000010020	ENSOMEP00000031355	Acyl-CoA dehydrogenase short/branched chain.	Ethylmalonyl-CoA decarboxylase 1.	0.860
ACADSB	ENSOMEP00000000580	ENSOMEP00000010020	ENSOMEP00000000580	Acyl-CoA dehydrogenase short/branched chain.	Ubiquitin associated protein 2b.	0.513
ACADSB	ENSOMEP00000000761	ENSOMEP00000010020	ENSOMEP00000000761	Acyl-CoA dehydrogenase short/branched chain.	Vesicle amine transport 1-like.	0.565
ACADSB	ENSOMEP00000001870	ENSOMEP00000010020	ENSOMEP00000001870	Acyl-CoA dehydrogenase short/branched chain.	Uncharacterized protein.	0.787
ACADSB	ENSOMEP00000003032	ENSOMEP00000010020	ENSOMEP00000003032	Acyl-CoA dehydrogenase short/branched chain.	Acyl-CoA synthetase short chain family member 3.	0.779
ACADSB	ENSOMEP00000004941	ENSOMEP00000010020	ENSOMEP00000004941	Acyl-CoA dehydrogenase short/branched chain.	Uncharacterized protein.	0.565
ACADSB	ENSOMEP00000005246	ENSOMEP00000010020	ENSOMEP00000005246	Acyl-CoA dehydrogenase short/branched chain.	PKS_ER domain-containing protein.	0.565
ACADSB	ENSOMEP00000009786	ENSOMEP00000010020	ENSOMEP00000009786	Acyl-CoA dehydrogenase short/branched chain.	Aminoadipate-semialdehyde dehydrogenase.	0.828
ACADSB	ENSOMEP00000015480	ENSOMEP00000010020	ENSOMEP00000015480	Acyl-CoA dehydrogenase short/branched chain.	Dehydrogenase/reductase (SDR family) member 7B; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.485
ACADSB	ENSOMEP00000015791	ENSOMEP00000010020	ENSOMEP00000015791	Acyl-CoA dehydrogenase short/branched chain.	Uncharacterized protein.	0.750
ACADSB	ENSOMEP00000021847	ENSOMEP00000010020	ENSOMEP00000021847	Acyl-CoA dehydrogenase short/branched chain.	Uncharacterized protein.	0.522
ACADSB	ENSOMEP00000021901	ENSOMEP00000010020	ENSOMEP00000021901	Acyl-CoA dehydrogenase short/branched chain.	Carrier domain-containing protein.	0.607
ACADSB	ENSOMEP00000022446	ENSOMEP00000010020	ENSOMEP00000022446	Acyl-CoA dehydrogenase short/branched chain.	3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1.	0.489
ACADSB	ENSOMEP00000022780	ENSOMEP00000010020	ENSOMEP00000022780	Acyl-CoA dehydrogenase short/branched chain.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.617
ACADSB	ENSOMEP00000024299	ENSOMEP00000010020	ENSOMEP00000024299	Acyl-CoA dehydrogenase short/branched chain.	APH domain-containing protein.	0.748
ACADSB	ENSOMEP00000024330	ENSOMEP00000010020	ENSOMEP00000024330	Acyl-CoA dehydrogenase short/branched chain.	Acyl-CoA dehydrogenase family, member 11.	0.748