(115 nodes) Regulation of endocytosis network (Oryzias melastigma)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC112148460	Serine/threonine-protein phosphatase. (515 aa)
	CDC42	Cell division cycle 42. (191 aa)
	ENSOMEP00000003548	PDZ domain-containing protein. (162 aa)
	ENSOMEP00000003553	Membrane associated guanylate kinase, WW and PDZ domain containing 2a. (1306 aa)
	lrsam1	Leucine rich repeat and sterile alpha motif containing 1. (737 aa)
	ENSOMEP00000003958	Serine/threonine-protein phosphatase. (496 aa)
	syt4	Synaptotagmin IV. (469 aa)
	rufy2	RUN and FYVE domain containing 2. (709 aa)
	pacsin1	Protein kinase C and casein kinase substrate in neurons 1a. (439 aa)
	syt11	Synaptotagmin XIb. (467 aa)
	snap91	Synaptosome associated protein 91a. (931 aa)
	rab4a	RAB4a, member RAS oncogene family. (213 aa)
	pick1	Protein interacting with prkca 1. (406 aa)
	ppt1	Palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile). (304 aa)
	ENSOMEP00000005114	Dickkopf WNT signaling pathway inhibitor 1a. (251 aa)
	picalm	Phosphatidylinositol binding clathrin assembly protein b. (736 aa)
	drd4	Dopamine receptor D4a; Belongs to the G-protein coupled receptor 1 family. (377 aa)
	wdr54	WD repeat domain 54. (336 aa)
	GSG1	Uncharacterized protein. (415 aa)
	eef2k	Eukaryotic elongation factor 2 kinase. (759 aa)
	LOC112142943	Vitronectin b. (428 aa)
	LOC112142941	GMP_PDE_delta domain-containing protein. (251 aa)
	appl2	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2. (666 aa)
	ENSOMEP00000008043	Notch receptor 1b. (2317 aa)
	LOC112163451	Notch receptor 1a. (2477 aa)
	ENSOMEP00000008678	RUN and FYVE domain containing 1. (652 aa)
	LOC112152431	Membrane associated guanylate kinase, WW and PDZ domain containing 2b. (1422 aa)
	LOC112137170	Uncharacterized protein. (298 aa)
	LOC112162956	RAB5A, member RAS oncogene family, a. (248 aa)
	ENSOMEP00000010491	Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family. (679 aa)
	vps28	Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. (256 aa)
	LOC112136333	Low density lipoprotein receptor adaptor protein 1a. (297 aa)
	LOC112143725	Uncharacterized protein. (191 aa)
	ldlrap1	Low density lipoprotein receptor adaptor protein 1b. (312 aa)
	LOC112145542	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (157 aa)
	ENSOMEP00000013643	PID domain-containing protein. (151 aa)
	ENSOMEP00000013655	Uncharacterized protein. (521 aa)
	LOC112153053	Serine/threonine-protein phosphatase. (492 aa)
	LOC112137131	Uncharacterized protein. (191 aa)
	ENSOMEP00000015104	Muskelin 1, intracellular mediator containing kelch motifs. (741 aa)
	vtn	Vitronectin a. (550 aa)
	unc119	Unc-119 lipid binding chaperone. (204 aa)
	fmr1	Fragile X mental retardation 1. (625 aa)
	LOC112156176	Si:ch211-200p22.4. (629 aa)
	tbc1d5	TBC1 domain family, member 5. (857 aa)
	ENSOMEP00000016850	Synaptosome associated protein 91b. (579 aa)
	LOC112146923	Si:ch211-51c14.1. (397 aa)
	GREM1	Gremlin 1, DAN family BMP antagonist. (163 aa)
	ENSOMEP00000017766	Galectin. (274 aa)
	ENSOMEP00000018381	Ataxin 2. (1046 aa)
	LOC112142009	Serine/threonine-protein phosphatase. (522 aa)
	btbd9	BTB (POZ) domain containing 9. (612 aa)
	arfgap1	ADP-ribosylation factor GTPase activating protein 1. (414 aa)
	ENSOMEP00000018673	SH2 domain-containing protein. (266 aa)
	ENSOMEP00000018709	Ankyrin repeat domain 13 family, member D. (609 aa)
	ENSOMEP00000018750	Protein kinase C and casein kinase substrate in neurons 2. (336 aa)
	LOC112157078	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (405 aa)
	cd63	Tetraspanin. (240 aa)
	LOC112161025	Apolipoprotein Ea. (262 aa)
	rab5c	RAB5C, member RAS oncogene family. (218 aa)
	LOC112148464	Galectin. (371 aa)
	LOC112152074	Protein tyrosine phosphatase non-receptor type 5. (568 aa)
	LOC112144774	Cell division cycle 42. (191 aa)
	LOC112163075	AP2 associated kinase 1b. (1081 aa)
	clu	Clusterin; Belongs to the clusterin family. (490 aa)
	rabgef1	RAB guanine nucleotide exchange factor (GEF) 1. (495 aa)
	hip1	Huntingtin interacting protein 1. (1047 aa)
	ENSOMEP00000023309	Clusterin; Belongs to the clusterin family. (462 aa)
	LOC112149423	VPS9 domain-containing protein. (1038 aa)
	pacsin2	Protein kinase C and casein kinase substrate in neurons 2. (502 aa)
	nr1h3	Nuclear receptor subfamily 1, group H, member 3. (460 aa)
	SCYL2	SCY1 like pseudokinase 2. (897 aa)
	LOC112142978	ENTH domain-containing protein. (576 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (532 aa)
	ENSOMEP00000026259	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1. (675 aa)
	ankrd13b	Ankyrin repeat domain 13B. (646 aa)
	tsc2	TSC complex subunit 2. (1823 aa)
	ENSOMEP00000029174	Battenin. (244 aa)
	LOC112149869	RAB guanine nucleotide exchange factor (GEF) 1, like. (495 aa)
	LOC112145558	Protein kinase C and casein kinase substrate in neurons 1b. (444 aa)
	LOC112147684	Clusterin; Belongs to the clusterin family. (477 aa)
	lrrtm2	Leucine rich repeat transmembrane neuronal 2. (548 aa)
	ano6	Anoctamin. (929 aa)
	ENSOMEP00000027465	Ankyrin repeat and FYVE domain containing 1. (1151 aa)
	LOC112147908	AP2 associated kinase 1a. (1065 aa)
	lrrtm1	Leucine rich repeat transmembrane neuronal 1. (525 aa)
	ENSOMEP00000026742	Mindbomb E3 ubiquitin protein ligase 1. (1036 aa)
	ENSOMEP00000002155	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family. (394 aa)
	ENSOMEP00000001807	ANK_REP_REGION domain-containing protein. (1116 aa)
	ENSOMEP00000001794	Protein kinase domain-containing protein. (545 aa)
	ankrd13a	Ankyrin repeat domain 13A. (598 aa)
	neu3	Sialidase 3 (membrane sialidase), tandem duplicate 1. (410 aa)
	LOC112148336	Huntingtin interacting protein 1 related b. (1065 aa)
	ENSOMEP00000000464	Stonin-1; May be involved in the endocytic machinery. (756 aa)
	bmp2k	BMP2 inducible kinase. (1086 aa)
	ppp3r1	Uncharacterized protein. (170 aa)
	ENSOMEP00000035992	Uncharacterized protein. (220 aa)
	LOC112139281	Uncharacterized protein. (176 aa)
	LOC112136549	RAB5A, member RAS oncogene family, b. (216 aa)
	LOC112149434	RAB4B, member RAS oncogene family. (213 aa)
	LOC112146221	Gsg1-like. (312 aa)
	ENSOMEP00000030265	Battenin. (520 aa)
	LOC112153848	Zgc:91999. (387 aa)
	smpd1	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (604 aa)
	gpc3	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (598 aa)
	ENSOMEP00000031896	Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase. (478 aa)
	LOC112143596	Apolipoprotein Eb. (265 aa)
	ENSOMEP00000032187	C2 domain-containing protein. (227 aa)
	vegfa	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. (214 aa)
	LOC112151790	Tumor susceptibility 101a. (384 aa)
	pacsin3	Protein kinase C and casein kinase substrate in neurons 3. (440 aa)
	LOC112137972	RAB5B, member RAS oncogene family. (216 aa)
	LOC112145350	Galectin. (292 aa)
	ENSOMEP00000034823	Low density lipoprotein receptor-related protein associated protein 1. (401 aa)
	DGKQ	Diacylglycerol kinase. (896 aa)

Your Current Organism:

Oryzias melastigma

NCBI taxonomy Id: 30732
Other names: Aplocheilus melastigmus, Indian medaka, Java medaka, O. melastigma, marine medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC42	ENSOMEP00000003548	ENSOMEP00000003168	ENSOMEP00000003548	Cell division cycle 42.	PDZ domain-containing protein.	0.513
CDC42	ENSOMEP00000003553	ENSOMEP00000003168	ENSOMEP00000003553	Cell division cycle 42.	Membrane associated guanylate kinase, WW and PDZ domain containing 2a.	0.513
CDC42	ENSOMEP00000026259	ENSOMEP00000003168	ENSOMEP00000026259	Cell division cycle 42.	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1.	0.407
CDC42	ENSOMEP00000027465	ENSOMEP00000003168	ENSOMEP00000027465	Cell division cycle 42.	Ankyrin repeat and FYVE domain containing 1.	0.674
CDC42	ENSOMEP00000035992	ENSOMEP00000003168	ENSOMEP00000035992	Cell division cycle 42.	Uncharacterized protein.	0.407
CDC42	LOC112137131	ENSOMEP00000003168	ENSOMEP00000014906	Cell division cycle 42.	Uncharacterized protein.	0.628
CDC42	LOC112139281	ENSOMEP00000003168	ENSOMEP00000036040	Cell division cycle 42.	Uncharacterized protein.	0.628
CDC42	LOC112142941	ENSOMEP00000003168	ENSOMEP00000007162	Cell division cycle 42.	GMP_PDE_delta domain-containing protein.	0.476
CDC42	LOC112143725	ENSOMEP00000003168	ENSOMEP00000012109	Cell division cycle 42.	Uncharacterized protein.	0.860
CDC42	LOC112145542	ENSOMEP00000003168	ENSOMEP00000012507	Cell division cycle 42.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.468
CDC42	LOC112152431	ENSOMEP00000003168	ENSOMEP00000008782	Cell division cycle 42.	Membrane associated guanylate kinase, WW and PDZ domain containing 2b.	0.513
CDC42	appl2	ENSOMEP00000003168	ENSOMEP00000007941	Cell division cycle 42.	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2.	0.407
CDC42	arfgap1	ENSOMEP00000003168	ENSOMEP00000018664	Cell division cycle 42.	ADP-ribosylation factor GTPase activating protein 1.	0.549
CDC42	tsc2	ENSOMEP00000003168	ENSOMEP00000029743	Cell division cycle 42.	TSC complex subunit 2.	0.631
CDC42	unc119	ENSOMEP00000003168	ENSOMEP00000015519	Cell division cycle 42.	Unc-119 lipid binding chaperone.	0.476
DGKQ	ppt1	ENSOMEP00000035285	ENSOMEP00000005016	Diacylglycerol kinase.	Palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile).	0.442
ENSOMEP00000001794	ENSOMEP00000001807	ENSOMEP00000001794	ENSOMEP00000001807	Protein kinase domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.945
ENSOMEP00000001794	LOC112136549	ENSOMEP00000001794	ENSOMEP00000002341	Protein kinase domain-containing protein.	RAB5A, member RAS oncogene family, b.	0.436
ENSOMEP00000001794	LOC112137972	ENSOMEP00000001794	ENSOMEP00000033547	Protein kinase domain-containing protein.	RAB5B, member RAS oncogene family.	0.436
ENSOMEP00000001794	LOC112162956	ENSOMEP00000001794	ENSOMEP00000009485	Protein kinase domain-containing protein.	RAB5A, member RAS oncogene family, a.	0.436