69 items (Oryzias melastigma) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HSPA8	Heat shock protein 8; Belongs to the heat shock protein 70 family. (650 aa)
	creb3l2	cAMP responsive element binding protein 3-like 2. (536 aa)
	ENSOMEP00000035725	Eukaryotic translation initiation factor 2, subunit 1 alpha b. (325 aa)
	LOC112154792	Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family. (65 aa)
	LOC112146289	Activating transcription factor 4b. (431 aa)
	wfs1	Wolfram syndrome 1b (wolframin). (955 aa)
	LOC112158237	Si:ch211-153j24.3. (364 aa)
	HSPA2	Heat shock protein family A (Hsp70) member 2. (310 aa)
	ENSOMEP00000033742	Uncharacterized protein; Belongs to the protein kinase superfamily. (471 aa)
	ddit3	DNA-damage-inducible transcript 3. (326 aa)
	bag3	BCL2 associated athanogene 3. (512 aa)
	yod1	YOD1 deubiquitinase. (300 aa)
	LOC112156968	Wolfram syndrome 1a (wolframin). (1032 aa)
	ENSOMEP00000029053	X-box binding protein 1. (260 aa)
	DERL1	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (153 aa)
	optn	Optineurin. (530 aa)
	creb3l1	cAMP responsive element binding protein 3-like 1. (482 aa)
	ENSOMEP00000026220	Uncharacterized protein. (98 aa)
	dnajc10	DnaJ (Hsp40) homolog, subfamily C, member 10. (795 aa)
	LOC112141503	Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family. (66 aa)
	LOC112156217	Uncharacterized protein. (923 aa)
	LOC112149440	Uncharacterized protein; Belongs to the heat shock protein 70 family. (648 aa)
	eif2ak3	Eukaryotic translation initiation factor 2-alpha kinase 3. (1083 aa)
	creb3l4	BZIP domain-containing protein. (383 aa)
	LOC112151967	Protein phosphatase 1, regulatory subunit 15B. (511 aa)
	ERMP1	Endoplasmic reticulum metallopeptidase 1. (869 aa)
	tbl2	Transducin (beta)-like 2. (442 aa)
	tmed2	Transmembrane p24 trafficking protein 2. (207 aa)
	tm7sf3	Transmembrane 7 superfamily member 3. (563 aa)
	ENSOMEP00000021108	Activating transcription factor 3. (231 aa)
	rhbdd1	Rhomboid domain containing 1. (316 aa)
	LOC112137492	Endoplasmic reticulum to nucleus signaling 2. (961 aa)
	hspa14	Heat shock protein 14; Belongs to the heat shock protein 70 family. (532 aa)
	LOC112148825	cAMP responsive element binding protein 3-like 3 like. (487 aa)
	ENSOMEP00000018988	Si:ch211-199o1.2. (295 aa)
	LOC112147604	BZIP domain-containing protein. (411 aa)
	ENSOMEP00000018301	Uncharacterized protein. (301 aa)
	ENSOMEP00000018144	Uncharacterized protein. (620 aa)
	hspa9	Heat shock protein 9; Belongs to the heat shock protein 70 family. (679 aa)
	ENSOMEP00000017783	cAMP responsive element binding protein 3-like 3a. (418 aa)
	hspd1	Heat shock 60 protein 1; Belongs to the chaperonin (HSP60) family. (575 aa)
	derl2	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (239 aa)
	LOC112143863	Heat shock cognate 70; Belongs to the heat shock protein 70 family. (643 aa)
	serp1	Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family. (65 aa)
	atf4	Activating transcription factor 4a. (439 aa)
	LOC112141169	Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1. (397 aa)
	ENSOMEP00000014308	Rhomboid domain-containing protein. (340 aa)
	pacrg	PARK2 co-regulated. (241 aa)
	parp16	Poly [ADP-ribose] polymerase. (328 aa)
	ENSOMEP00000013072	Testis enhanced gene transcript (BAX inhibitor 1); Belongs to the BI1 family. (251 aa)
	ENSOMEP00000012758	Transmembrane O-mannosyltransferase targeting cadherins 4. (712 aa)
	hspb8	Heat shock protein b8; Belongs to the small heat shock protein (HSP20) family. (220 aa)
	ern1	Endoplasmic reticulum to nucleus signaling 1. (1072 aa)
	atf6b	BZIP domain-containing protein. (715 aa)
	LOC112140530	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (255 aa)
	os9	OS9 endoplasmic reticulum lectin. (673 aa)
	LOC112153984	E1A binding protein p300 a. (2690 aa)
	ENSOMEP00000007333	Uncharacterized protein. (164 aa)
	LOC112162685	Ubiquitin-like domain-containing protein. (379 aa)
	ENSOMEP00000006097	Activating transcription factor 6. (629 aa)
	bhlha15	Basic helix-loop-helix family, member a15. (186 aa)
	hspa13	Heat shock protein 70 family, member 13. (432 aa)
	LOC112146043	E1A binding protein p300 b. (2771 aa)
	nfe2l2	Nuclear factor, erythroid 2-like 2a. (607 aa)
	LOC112136675	HERPUD family member 2. (430 aa)
	hspa5	Heat shock protein 5; Belongs to the heat shock protein 70 family. (667 aa)
	cdk5rap3	CDK5 regulatory subunit associated protein 3. (523 aa)
	ENSOMEP00000000520	Endoplasmic reticulum lectin 1. (460 aa)
	daxx	Death-domain associated protein. (706 aa)

Your Current Organism:

Oryzias melastigma

NCBI taxonomy Id: 30732
Other names: Aplocheilus melastigmus, Indian medaka, Java medaka, O. melastigma, marine medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DERL1	ENSOMEP00000000520	ENSOMEP00000028965	ENSOMEP00000000520	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Endoplasmic reticulum lectin 1.	0.966
DERL1	ENSOMEP00000007333	ENSOMEP00000028965	ENSOMEP00000007333	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Uncharacterized protein.	0.918
DERL1	ENSOMEP00000018301	ENSOMEP00000028965	ENSOMEP00000018301	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Uncharacterized protein.	0.415
DERL1	ENSOMEP00000018988	ENSOMEP00000028965	ENSOMEP00000018988	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Si:ch211-199o1.2.	0.415
DERL1	ENSOMEP00000026220	ENSOMEP00000028965	ENSOMEP00000026220	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Uncharacterized protein.	0.415
DERL1	ENSOMEP00000029053	ENSOMEP00000028965	ENSOMEP00000029053	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	X-box binding protein 1.	0.428
DERL1	HSPA2	ENSOMEP00000028965	ENSOMEP00000033788	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Heat shock protein family A (Hsp70) member 2.	0.415
DERL1	HSPA8	ENSOMEP00000028965	ENSOMEP00000009689	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Heat shock protein 8; Belongs to the heat shock protein 70 family.	0.415
DERL1	LOC112143863	ENSOMEP00000028965	ENSOMEP00000016880	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Heat shock cognate 70; Belongs to the heat shock protein 70 family.	0.415
DERL1	LOC112149440	ENSOMEP00000028965	ENSOMEP00000025047	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.415
DERL1	derl2	ENSOMEP00000028965	ENSOMEP00000017333	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.985
DERL1	hspa13	ENSOMEP00000028965	ENSOMEP00000005333	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Heat shock protein 70 family, member 13.	0.415
DERL1	hspa14	ENSOMEP00000028965	ENSOMEP00000019521	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Heat shock protein 14; Belongs to the heat shock protein 70 family.	0.415
DERL1	hspa5	ENSOMEP00000028965	ENSOMEP00000003704	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Heat shock protein 5; Belongs to the heat shock protein 70 family.	0.950
DERL1	hspa9	ENSOMEP00000028965	ENSOMEP00000018104	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Heat shock protein 9; Belongs to the heat shock protein 70 family.	0.480
DERL1	os9	ENSOMEP00000028965	ENSOMEP00000008097	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	OS9 endoplasmic reticulum lectin.	0.966
ENSOMEP00000000520	DERL1	ENSOMEP00000000520	ENSOMEP00000028965	Endoplasmic reticulum lectin 1.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.966
ENSOMEP00000000520	LOC112137492	ENSOMEP00000000520	ENSOMEP00000020415	Endoplasmic reticulum lectin 1.	Endoplasmic reticulum to nucleus signaling 2.	0.452
ENSOMEP00000000520	LOC112140530	ENSOMEP00000000520	ENSOMEP00000009578	Endoplasmic reticulum lectin 1.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.966
ENSOMEP00000000520	LOC112156217	ENSOMEP00000000520	ENSOMEP00000025111	Endoplasmic reticulum lectin 1.	Uncharacterized protein.	0.452