(14 nodes) Negative regulation of Rho protein signal transduction network (Oryzias melastigma)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSOMEP00000023220	RIPOR family member 3. (858 aa)
	LOC112149657	CULLIN_2 domain-containing protein; Belongs to the cullin family. (803 aa)
	CUL3	Cullin 3; Belongs to the cullin family. (766 aa)
	scai	Suppressor of cancer cell invasion. (566 aa)
	LOC112146828	Potassium channel tetramerization domain containing 13. (331 aa)
	ENSOMEP00000011834	BTB_2 domain-containing protein. (81 aa)
	ripor2	RHO family interacting cell polarization regulator 2. (1100 aa)
	LOC112138975	Myocilin. (463 aa)
	MYOC	Myocilin. (458 aa)
	kctd10	Potassium channel tetramerization domain containing 10. (339 aa)
	ENSOMEP00000024026	Uncharacterized protein. (123 aa)
	itga3	Integrin, alpha 3b; Belongs to the integrin alpha chain family. (1054 aa)
	flcn	Folliculin. (557 aa)
	ENSOMEP00000034847	RHO family interacting cell polarization regulator 1. (884 aa)

Your Current Organism:

Oryzias melastigma

NCBI taxonomy Id: 30732
Other names: Aplocheilus melastigmus, Indian medaka, Java medaka, O. melastigma, marine medaka

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CUL3	ENSOMEP00000011834	ENSOMEP00000021092	ENSOMEP00000011834	Cullin 3; Belongs to the cullin family.	BTB_2 domain-containing protein.	0.646
CUL3	LOC112146828	ENSOMEP00000021092	ENSOMEP00000014838	Cullin 3; Belongs to the cullin family.	Potassium channel tetramerization domain containing 13.	0.646
CUL3	LOC112149657	ENSOMEP00000021092	ENSOMEP00000023103	Cullin 3; Belongs to the cullin family.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.890
CUL3	kctd10	ENSOMEP00000021092	ENSOMEP00000001699	Cullin 3; Belongs to the cullin family.	Potassium channel tetramerization domain containing 10.	0.646
ENSOMEP00000011834	CUL3	ENSOMEP00000011834	ENSOMEP00000021092	BTB_2 domain-containing protein.	Cullin 3; Belongs to the cullin family.	0.646
ENSOMEP00000011834	LOC112149657	ENSOMEP00000011834	ENSOMEP00000023103	BTB_2 domain-containing protein.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.646
LOC112146828	CUL3	ENSOMEP00000014838	ENSOMEP00000021092	Potassium channel tetramerization domain containing 13.	Cullin 3; Belongs to the cullin family.	0.646
LOC112146828	LOC112149657	ENSOMEP00000014838	ENSOMEP00000023103	Potassium channel tetramerization domain containing 13.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.646
LOC112149657	CUL3	ENSOMEP00000023103	ENSOMEP00000021092	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Cullin 3; Belongs to the cullin family.	0.890
LOC112149657	ENSOMEP00000011834	ENSOMEP00000023103	ENSOMEP00000011834	CULLIN_2 domain-containing protein; Belongs to the cullin family.	BTB_2 domain-containing protein.	0.646
LOC112149657	LOC112146828	ENSOMEP00000023103	ENSOMEP00000014838	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Potassium channel tetramerization domain containing 13.	0.646
LOC112149657	kctd10	ENSOMEP00000023103	ENSOMEP00000001699	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Potassium channel tetramerization domain containing 10.	0.646
kctd10	CUL3	ENSOMEP00000001699	ENSOMEP00000021092	Potassium channel tetramerization domain containing 10.	Cullin 3; Belongs to the cullin family.	0.646
kctd10	LOC112149657	ENSOMEP00000001699	ENSOMEP00000023103	Potassium channel tetramerization domain containing 10.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.646