(45 nodes) Organ growth network (Oryzias melastigma)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	fgf7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (202 aa)
	sav1	Salvador family WW domain containing protein 1. (403 aa)
	LOC112153869	Mitogen-activated protein kinase kinase 4b; Belongs to the protein kinase superfamily. (495 aa)
	LOC112144558	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
	LOC112146279	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (423 aa)
	nkx2-5	NK2 homeobox 5. (327 aa)
	UBE3A	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (896 aa)
	anxa6	Annexin. (665 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	lepr	Leptin receptor. (1109 aa)
	tsku	Tsukushi small leucine rich proteoglycan homolog (Xenopus laevis). (348 aa)
	LOC112143975	Uncharacterized protein. (493 aa)
	dipk2a	Divergent protein kinase domain 2Ab. (434 aa)
	spry2	Sprouty RTK signaling antagonist 2. (417 aa)
	tbx20	T-box transcription factor 20. (438 aa)
	ENSOMEP00000024165	DUF3496 domain-containing protein. (451 aa)
	bcl2	BCL2 apoptosis regulator b. (225 aa)
	hlx	H2.0-like homeo box 1 (Drosophila). (394 aa)
	ENSOMEP00000021143	AT rich interactive domain 2 (ARID, RFX-like). (1399 aa)
	ENSOMEP00000021123	C2H2-type domain-containing protein. (280 aa)
	LOC112155385	Uncharacterized protein. (197 aa)
	ENSOMEP00000019452	Uncharacterized protein. (83 aa)
	LOC112163288	Immediate early response 3 interacting protein 1. (82 aa)
	LOC112152993	Transforming growth factor beta; Belongs to the TGF-beta family. (420 aa)
	LOC112139177	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (181 aa)
	ENSOMEP00000016614	Mesoderm posterior ba. (229 aa)
	hey2	Uncharacterized protein. (264 aa)
	LOC112144686	RAP1A, member of RAS oncogene family b. (185 aa)
	evc	Uncharacterized protein. (964 aa)
	ENSOMEP00000014736	Uncharacterized protein. (350 aa)
	LOC112159194	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
	smpd3	Sphingomyelin phosphodiesterase 3, neutral. (711 aa)
	LOC112153467	Uncharacterized protein. (678 aa)
	ENSOMEP00000010971	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (361 aa)
	LOC112155588	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (574 aa)
	ENSOMEP00000004802	Extracellular matrix protein 1a. (123 aa)
	LOC112139901	Androgen receptor. (718 aa)
	LOC112150628	Ubiquitin protein ligase E3A. (814 aa)
	LOC112158849	RAP1A, member of RAS oncogene family a. (184 aa)
	ENSOMEP00000010571	Intraflagellar transport 80 homolog (Chlamydomonas). (716 aa)
	LOC112149903	UTP25 small subunit processor component. (757 aa)
	zmpste24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (467 aa)
	FXN	Frataxin. (136 aa)
	LOC112152829	Uncharacterized protein. (155 aa)
	LOC112148685	Stanniocalcin 1. (265 aa)

Your Current Organism:

Oryzias melastigma

NCBI taxonomy Id: 30732
Other names: Aplocheilus melastigmus, Indian medaka, Java medaka, O. melastigma, marine medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSOMEP00000010971	LOC112139177	ENSOMEP00000010971	ENSOMEP00000006209	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.678
ENSOMEP00000010971	nkx2-5	ENSOMEP00000010971	ENSOMEP00000028257	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	NK2 homeobox 5.	0.519
ENSOMEP00000016614	nkx2-5	ENSOMEP00000016614	ENSOMEP00000028257	Mesoderm posterior ba.	NK2 homeobox 5.	0.453
ENSOMEP00000021123	ENSOMEP00000021143	ENSOMEP00000021123	ENSOMEP00000021143	C2H2-type domain-containing protein.	AT rich interactive domain 2 (ARID, RFX-like).	0.843
ENSOMEP00000021123	ENSOMEP00000024165	ENSOMEP00000021123	ENSOMEP00000024165	C2H2-type domain-containing protein.	DUF3496 domain-containing protein.	0.607
ENSOMEP00000021143	ENSOMEP00000021123	ENSOMEP00000021143	ENSOMEP00000021123	AT rich interactive domain 2 (ARID, RFX-like).	C2H2-type domain-containing protein.	0.843
ENSOMEP00000021143	ENSOMEP00000024165	ENSOMEP00000021143	ENSOMEP00000024165	AT rich interactive domain 2 (ARID, RFX-like).	DUF3496 domain-containing protein.	0.607
ENSOMEP00000024165	ENSOMEP00000021123	ENSOMEP00000024165	ENSOMEP00000021123	DUF3496 domain-containing protein.	C2H2-type domain-containing protein.	0.607
ENSOMEP00000024165	ENSOMEP00000021143	ENSOMEP00000024165	ENSOMEP00000021143	DUF3496 domain-containing protein.	AT rich interactive domain 2 (ARID, RFX-like).	0.607
LOC112139177	ENSOMEP00000010971	ENSOMEP00000006209	ENSOMEP00000010971	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.678
LOC112139177	LOC112139901	ENSOMEP00000006209	ENSOMEP00000004685	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Androgen receptor.	0.445
LOC112139177	LOC112153467	ENSOMEP00000006209	ENSOMEP00000012388	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Uncharacterized protein.	0.445
LOC112139901	LOC112139177	ENSOMEP00000004685	ENSOMEP00000006209	Androgen receptor.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.445
LOC112139901	LOC112150628	ENSOMEP00000004685	ENSOMEP00000002573	Androgen receptor.	Ubiquitin protein ligase E3A.	0.440
LOC112139901	LOC112152829	ENSOMEP00000004685	ENSOMEP00000006688	Androgen receptor.	Uncharacterized protein.	0.404
LOC112139901	LOC112153467	ENSOMEP00000004685	ENSOMEP00000012388	Androgen receptor.	Uncharacterized protein.	0.897
LOC112139901	UBE3A	ENSOMEP00000004685	ENSOMEP00000027837	Androgen receptor.	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.	0.491
LOC112144686	LOC112158849	ENSOMEP00000015800	ENSOMEP00000001824	RAP1A, member of RAS oncogene family b.	RAP1A, member of RAS oncogene family a.	0.890
LOC112146279	LOC112153869	ENSOMEP00000030700	ENSOMEP00000035135	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase kinase 4b; Belongs to the protein kinase superfamily.	0.896
LOC112150628	LOC112139901	ENSOMEP00000002573	ENSOMEP00000004685	Ubiquitin protein ligase E3A.	Androgen receptor.	0.440