(57 nodes) Multi-multicellular organism process network (Oryzias melastigma)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC112146323	Erythropoietin receptor. (524 aa)
	LOC112153452	Stork_head domain-containing protein. (964 aa)
	ENSOMEP00000011126	15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (373 aa)
	ENSOMEP00000011334	Sp3b transcription factor. (607 aa)
	ENSOMEP00000012149	Apobec1 complementation factor. (603 aa)
	LOC112153467	Uncharacterized protein. (678 aa)
	LOC112156694	Insulin-like growth factor binding protein 5a. (251 aa)
	ENSOMEP00000013484	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1782 aa)
	ENSOMEP00000013910	Uncharacterized protein. (369 aa)
	ENSOMEP00000014149	Peroxiredoxin 3. (248 aa)
	pam	Peptidylglycine alpha-amidating monooxygenase. (871 aa)
	ghsr	Growth hormone secretagogue receptor b; Belongs to the G-protein coupled receptor 1 family. (410 aa)
	pla2g6	Phospholipase A2, group VI (cytosolic, calcium-independent). (820 aa)
	LOC112145521	JunB proto-oncogene, AP-1 transcription factor subunit a. (331 aa)
	ENSOMEP00000016511	Ig-like domain-containing protein. (142 aa)
	tppp3	Tubulin polymerization-promoting protein family member 3. (178 aa)
	ENSOMEP00000017566	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; Belongs to the serpin family. (440 aa)
	ppard	Peroxisome proliferator-activated receptor delta b. (505 aa)
	prl	Prolactin 2. (227 aa)
	LOC112148046	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (162 aa)
	tmed2	Transmembrane p24 trafficking protein 2. (207 aa)
	dazap1	DAZ associated protein 1. (435 aa)
	SP3	Sp3a transcription factor. (666 aa)
	LOC112136609	Hydroxysteroid (11-beta) dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (407 aa)
	ENSOMEP00000025341	Uncharacterized protein. (745 aa)
	LOC112137571	Tubulin polymerization-promoting protein family member 2. (251 aa)
	LOC112151033	Corticotropin releasing hormone b. (165 aa)
	p2rx1	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (418 aa)
	acod1	Aconitate decarboxylase 1. (445 aa)
	ENSOMEP00000030911	Uncharacterized protein. (542 aa)
	crhbp	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
	ENSOMEP00000032284	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1089 aa)
	prdm1	PR domain containing 1a, with ZNF domain. (848 aa)
	LOC112153186	FOS-like antigen 1a. (335 aa)
	ENSOMEP00000033076	Uncharacterized protein. (356 aa)
	LOC112155410	Insulin-like growth factor binding protein 5a. (266 aa)
	LOC112144393	CRF domain-containing protein. (135 aa)
	ddo	Zgc:172341. (337 aa)
	ENSOMEP00000008888	Integrin beta. (687 aa)
	ENSOMEP00000008846	Fibronectin type-III domain-containing protein. (151 aa)
	ENSOMEP00000008401	PR domain containing 14. (515 aa)
	junb	JunB proto-oncogene, AP-1 transcription factor subunit b. (327 aa)
	TCF24	Transcription factor 24. (172 aa)
	ENSOMEP00000007371	Si:dkey-23i12.7. (113 aa)
	ash1l	Uncharacterized protein. (1945 aa)
	LOC112153498	Immunoresponsive gene 1, like. (495 aa)
	ENSOMEP00000005809	Ash1 (absent, small, or homeotic)-like (Drosophila). (2799 aa)
	ENSOMEP00000005678	Corin, serine peptidase. (372 aa)
	ENSOMEP00000005611	PR domain containing 1b, with ZNF domain. (550 aa)
	tekt3	Tektin 3. (487 aa)
	ptgs2	Prostaglandin-endoperoxide synthase 2b. (607 aa)
	LOC112139901	Androgen receptor. (718 aa)
	polr1b	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1135 aa)
	LOC112154598	Pleiotrophin. (162 aa)
	LOC112142444	Zgc:56585; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (258 aa)
	stox2	Storkhead box 2a. (1068 aa)
	bmpr2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1056 aa)

Your Current Organism:

Oryzias melastigma

NCBI taxonomy Id: 30732
Other names: Aplocheilus melastigmus, Indian medaka, Java medaka, O. melastigma, marine medaka

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSOMEP00000005611	ENSOMEP00000005809	ENSOMEP00000005611	ENSOMEP00000005809	PR domain containing 1b, with ZNF domain.	Ash1 (absent, small, or homeotic)-like (Drosophila).	0.439
ENSOMEP00000005611	ash1l	ENSOMEP00000005611	ENSOMEP00000007318	PR domain containing 1b, with ZNF domain.	Uncharacterized protein.	0.439
ENSOMEP00000005678	ENSOMEP00000032284	ENSOMEP00000005678	ENSOMEP00000032284	Corin, serine peptidase.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.595
ENSOMEP00000005678	bmpr2	ENSOMEP00000005678	ENSOMEP00000001228	Corin, serine peptidase.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.595
ENSOMEP00000005809	ENSOMEP00000005611	ENSOMEP00000005809	ENSOMEP00000005611	Ash1 (absent, small, or homeotic)-like (Drosophila).	PR domain containing 1b, with ZNF domain.	0.439
ENSOMEP00000005809	ENSOMEP00000025341	ENSOMEP00000005809	ENSOMEP00000025341	Ash1 (absent, small, or homeotic)-like (Drosophila).	Uncharacterized protein.	0.439
ENSOMEP00000005809	polr1b	ENSOMEP00000005809	ENSOMEP00000004120	Ash1 (absent, small, or homeotic)-like (Drosophila).	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.423
ENSOMEP00000005809	prdm1	ENSOMEP00000005809	ENSOMEP00000032311	Ash1 (absent, small, or homeotic)-like (Drosophila).	PR domain containing 1a, with ZNF domain.	0.439
ENSOMEP00000007371	ENSOMEP00000013484	ENSOMEP00000007371	ENSOMEP00000013484	Si:dkey-23i12.7.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.469
ENSOMEP00000007371	LOC112145521	ENSOMEP00000007371	ENSOMEP00000015700	Si:dkey-23i12.7.	JunB proto-oncogene, AP-1 transcription factor subunit a.	0.891
ENSOMEP00000007371	junb	ENSOMEP00000007371	ENSOMEP00000008135	Si:dkey-23i12.7.	JunB proto-oncogene, AP-1 transcription factor subunit b.	0.891
ENSOMEP00000008846	ENSOMEP00000008888	ENSOMEP00000008846	ENSOMEP00000008888	Fibronectin type-III domain-containing protein.	Integrin beta.	0.509
ENSOMEP00000008888	ENSOMEP00000008846	ENSOMEP00000008888	ENSOMEP00000008846	Integrin beta.	Fibronectin type-III domain-containing protein.	0.509
ENSOMEP00000011126	LOC112136609	ENSOMEP00000011126	ENSOMEP00000024828	15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Hydroxysteroid (11-beta) dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.466
ENSOMEP00000011126	crhbp	ENSOMEP00000011126	ENSOMEP00000032115	15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family.	0.465
ENSOMEP00000012149	dazap1	ENSOMEP00000012149	ENSOMEP00000023157	Apobec1 complementation factor.	DAZ associated protein 1.	0.445
ENSOMEP00000013484	ENSOMEP00000007371	ENSOMEP00000013484	ENSOMEP00000007371	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Si:dkey-23i12.7.	0.469
ENSOMEP00000013484	LOC112139901	ENSOMEP00000013484	ENSOMEP00000004685	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Androgen receptor.	0.741
ENSOMEP00000013484	LOC112153186	ENSOMEP00000013484	ENSOMEP00000032344	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	FOS-like antigen 1a.	0.469
ENSOMEP00000013484	LOC112153467	ENSOMEP00000013484	ENSOMEP00000012388	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Uncharacterized protein.	0.741