STRINGSTRING
CLOCK CLOCK kdm8 kdm8 LOC112145448 LOC112145448 mtnr1a mtnr1a LOC112142453 LOC112142453 dhx9 dhx9 ENSOMEP00000001786 ENSOMEP00000001786 LOC112160055 LOC112160055 ENSOMEP00000002804 ENSOMEP00000002804 PPP1CB PPP1CB LOC112154598 LOC112154598 LOC112137721 LOC112137721 LOC112148105 LOC112148105 LOC112146043 LOC112146043 ENSOMEP00000004461 ENSOMEP00000004461 ENSOMEP00000004505 ENSOMEP00000004505 ENSOMEP00000005014 ENSOMEP00000005014 ZNF830 ZNF830 ENSOMEP00000005155 ENSOMEP00000005155 ezh2 ezh2 LOC112137572 LOC112137572 drd4 drd4 LOC112153439 LOC112153439 ENSOMEP00000006112 ENSOMEP00000006112 cdk5 cdk5 PER2 PER2 impdh2 impdh2 LOC112136359 LOC112136359 ogt ogt LOC112146110 LOC112146110 LOC112154530 LOC112154530 egr3 egr3 LOC112153984 LOC112153984 LOC112148701 LOC112148701 ncoa2 ncoa2 ENSOMEP00000009385 ENSOMEP00000009385 DNM1L DNM1L LOC112163232 LOC112163232 LOC112153354 LOC112153354 ENSOMEP00000009764 ENSOMEP00000009764 LOC112143507 LOC112143507 ENSOMEP00000009953 ENSOMEP00000009953 nampt nampt rorb rorb prkaa1 prkaa1 LOC112155035 LOC112155035 ENSOMEP00000011298 ENSOMEP00000011298 ENSOMEP00000011372 ENSOMEP00000011372 LOC112148730 LOC112148730 LOC112160524 LOC112160524 prmt5 prmt5 ENSOMEP00000011937 ENSOMEP00000011937 LOC112158861 LOC112158861 ENSOMEP00000011966 ENSOMEP00000011966 fbxl3 fbxl3 enox2 enox2 ENSOMEP00000012190 ENSOMEP00000012190 ppp1cb ppp1cb LOC112157867 LOC112157867 LOC112142853 LOC112142853 tnfrsf11a tnfrsf11a naglu naglu ENSOMEP00000012879 ENSOMEP00000012879 LOC112153024 LOC112153024 LOC112150580 LOC112150580 hlf hlf ENSOMEP00000013625 ENSOMEP00000013625 LOC112148513 LOC112148513 pam pam LOC112141154 LOC112141154 ENSOMEP00000014669 ENSOMEP00000014669 LOC112159272 LOC112159272 nrip1 nrip1 ENSOMEP00000014890 ENSOMEP00000014890 atf4 atf4 ENSOMEP00000014951 ENSOMEP00000014951 ENSOMEP00000014983 ENSOMEP00000014983 LOC112140772 LOC112140772 gas2 gas2 ENSOMEP00000015594 ENSOMEP00000015594 ENSOMEP00000015821 ENSOMEP00000015821 ENSOMEP00000015868 ENSOMEP00000015868 ENSOMEP00000015877 ENSOMEP00000015877 LOC112154914 LOC112154914 ENSOMEP00000016060 ENSOMEP00000016060 sfpq sfpq ENSOMEP00000016761 ENSOMEP00000016761 piwil2 piwil2 ENSOMEP00000016789 ENSOMEP00000016789 ENSOMEP00000016841 ENSOMEP00000016841 ENSOMEP00000016866 ENSOMEP00000016866 ENSOMEP00000017018 ENSOMEP00000017018 LOC112146006 LOC112146006 LOC112158001 LOC112158001 LOC112154165 LOC112154165 ENSOMEP00000017475 ENSOMEP00000017475 per3 per3 LOC112147602 LOC112147602 LOC112162495 LOC112162495 sirt6 sirt6 btbd9 btbd9 ENSOMEP00000018652 ENSOMEP00000018652 gpr176 gpr176 atg7 atg7 nfya nfya LOC112157078 LOC112157078 PPARG PPARG LOC112145491 LOC112145491 tnfaip6 tnfaip6 LOC112154198 LOC112154198 ndufa9 ndufa9 ENSOMEP00000020139 ENSOMEP00000020139 ppp1cc ppp1cc timeless timeless LOC112154655 LOC112154655 kiaa2013 kiaa2013 ENSOMEP00000021017 ENSOMEP00000021017 ARNTL2 ARNTL2 LOC112146445 LOC112146445 id1 id1 LOC112145418 LOC112145418 cunh3orf70 cunh3orf70 LOC112161471 LOC112161471 fzd4 fzd4 CRTC1 CRTC1 LOC112136691 LOC112136691 ENSOMEP00000023641 ENSOMEP00000023641 ENSOMEP00000023649 ENSOMEP00000023649 ptx3 ptx3 LOC112147429 LOC112147429 ENSOMEP00000024352 ENSOMEP00000024352 LOC112140813 LOC112140813 LOC112153234 LOC112153234 LOC112136966 LOC112136966 LOC112140772-2 LOC112140772-2 egr1 egr1 LOC112146572 LOC112146572 ENSOMEP00000025532 ENSOMEP00000025532 nfil3 nfil3 LOC112162538 LOC112162538 PPARA PPARA id2 id2 LOC112143927 LOC112143927 mapk8 mapk8 AANAT AANAT crebbp crebbp LOC112152716 LOC112152716 GPR149 GPR149 id3 id3 ENSOMEP00000028785 ENSOMEP00000028785 ENSOMEP00000029251 ENSOMEP00000029251 ENSOMEP00000030509 ENSOMEP00000030509 ENSOMEP00000030825 ENSOMEP00000030825 hes7 hes7 LOC112160314 LOC112160314 sirt1 sirt1 ENSOMEP00000032123 ENSOMEP00000032123 ENSOMEP00000032154 ENSOMEP00000032154 ENSOMEP00000032175 ENSOMEP00000032175 LOC112158702 LOC112158702 LOC112138664 LOC112138664 LOC112151877 LOC112151877 ENSOMEP00000032744 ENSOMEP00000032744 ENSOMEP00000032764 ENSOMEP00000032764 ENSOMEP00000032785 ENSOMEP00000032785 ENSOMEP00000032826 ENSOMEP00000032826 lgr4 lgr4 ENSOMEP00000033103 ENSOMEP00000033103 LOC112156678 LOC112156678 LOC112156658 LOC112156658 LOC112161090 LOC112161090 GRIN3A GRIN3A LOC112152225 LOC112152225 gpr157 gpr157 ENSOMEP00000034793 ENSOMEP00000034793 LOC112147711 LOC112147711 LOC112152639 LOC112152639 scaper scaper BHLHE40 BHLHE40 dtl dtl ENSOMEP00000036053 ENSOMEP00000036053 LOC112145789 LOC112145789 LOC112147051 LOC112147051
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CLOCKClock circadian regulator. (818 aa)
kdm8Lysine (K)-specific demethylase 8. (480 aa)
LOC112145448Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (491 aa)
mtnr1aMelatonin receptor 1A a; Belongs to the G-protein coupled receptor 1 family. (347 aa)
LOC112142453Activating transcription factor 5a. (503 aa)
dhx9DEAH (Asp-Glu-Ala-His) box helicase 9. (1187 aa)
ENSOMEP00000001786MYB binding protein (P160) 1a. (807 aa)
LOC112160055Family with sequence similarity 155 member A. (389 aa)
ENSOMEP00000002804Paraspeckle component 1. (218 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (376 aa)
LOC112154598Pleiotrophin. (162 aa)
LOC112137721RRM domain-containing protein. (632 aa)
LOC112148105Homer scaffold protein 1b. (358 aa)
LOC112146043E1A binding protein p300 b. (2771 aa)
ENSOMEP00000004461Neuronal PAS domain protein 2. (828 aa)
ENSOMEP00000004505CREB binding protein a. (2295 aa)
ENSOMEP00000005014Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha. (929 aa)
ZNF830Zinc finger protein 830. (323 aa)
ENSOMEP00000005155Damage-specific DNA binding protein 1. (1105 aa)
ezh2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (775 aa)
LOC112137572Nuclear factor, interleukin 3 regulated, member 5. (587 aa)
drd4Dopamine receptor D4a; Belongs to the G-protein coupled receptor 1 family. (377 aa)
LOC112153439F-box and leucine-rich repeat protein 3, like. (431 aa)
ENSOMEP00000006112Si:ch1073-390k14.1. (760 aa)
cdk5Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
PER2Period circadian regulator 2. (1460 aa)
impdh2Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (514 aa)
LOC112136359Activating transcription factor 5b. (504 aa)
ogtO-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 1. (1038 aa)
LOC112146110N-acetyltransferase domain-containing protein. (227 aa)
LOC112154530Casein kinase 1, epsilon; Belongs to the protein kinase superfamily. (416 aa)
egr3Early growth response 3. (410 aa)
LOC112153984E1A binding protein p300 a. (2690 aa)
LOC112148701Si:dkey-32e23.4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (710 aa)
ncoa2Nuclear receptor coactivator. (1503 aa)
ENSOMEP00000009385Nuclear receptor corepressor 1. (2228 aa)
DNM1LDynamin 1-like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (721 aa)
LOC112163232Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (794 aa)
LOC112153354Nocturnin. (427 aa)
ENSOMEP00000009764Nuclear receptor subfamily 0, group B, member 2a. (279 aa)
LOC112143507D site albumin promoter binding protein b. (375 aa)
ENSOMEP00000009953Basic helix-loop-helix family, member e41. (386 aa)
namptNicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (491 aa)
rorbRAR-related orphan receptor B. (476 aa)
prkaa1Non-specific serine/threonine protein kinase. (572 aa)
LOC112155035Uncharacterized protein. (878 aa)
ENSOMEP00000011298Uncharacterized protein. (775 aa)
ENSOMEP00000011372Period circadian clock 1b. (1422 aa)
LOC112148730Non-POU domain containing, octamer-binding. (438 aa)
LOC112160524Cryptochrome circadian regulator 5. (521 aa)
prmt5Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (650 aa)
ENSOMEP00000011937Uncharacterized protein. (361 aa)
LOC112158861Cryptochrome circadian regulator 3a. (691 aa)
ENSOMEP00000011966RING-type domain-containing protein. (252 aa)
fbxl3F-box and leucine-rich repeat protein 3a. (438 aa)
enox2Ecto-NOX disulfide-thiol exchanger 2. (681 aa)
ENSOMEP00000012190Uncharacterized protein. (157 aa)
ppp1cbSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
LOC112157867Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (682 aa)
LOC112142853E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (338 aa)
tnfrsf11aTNFR-Cys domain-containing protein. (625 aa)
nagluN-acetylglucosaminidase, alpha. (754 aa)
ENSOMEP000000128795-hydroxytryptamine (serotonin) receptor 7a. (396 aa)
LOC112153024Peroxisome proliferator-activated receptor alpha a. (477 aa)
LOC112150580Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1114 aa)
hlfHLF transcription factor, PAR bZIP family member b. (298 aa)
ENSOMEP00000013625Clock circadian regulator b. (881 aa)
LOC112148513EGF-like domain-containing protein. (154 aa)
pamPeptidylglycine alpha-amidating monooxygenase. (871 aa)
LOC112141154Aryl hydrocarbon receptor nuclear translocator-like 1a. (639 aa)
ENSOMEP00000014669Nuclear receptor corepressor 2. (2130 aa)
LOC112159272Nuclear receptor subfamily 1, group D, member 4a. (572 aa)
nrip1Nuclear receptor interacting protein 1b. (1187 aa)
ENSOMEP00000014890Serine/threonine-protein kinase TOR. (1003 aa)
atf4Activating transcription factor 4a. (439 aa)
ENSOMEP00000014951Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (293 aa)
ENSOMEP00000014983Protein kinase domain-containing protein. (137 aa)
LOC112140772Sphingosine-1-phosphate lyase 1. (565 aa)
gas2Growth arrest-specific 2a. (343 aa)
ENSOMEP00000015594Uncharacterized protein. (113 aa)
ENSOMEP00000015821Hist_deacetyl domain-containing protein. (193 aa)
ENSOMEP00000015868Hist_deacetyl domain-containing protein. (227 aa)
ENSOMEP00000015877Hist_deacetyl domain-containing protein. (143 aa)
LOC112154914BZIP domain-containing protein. (603 aa)
ENSOMEP00000016060Inhibitor of DNA binding 4. (139 aa)
sfpqSplicing factor proline/glutamine-rich. (731 aa)
ENSOMEP00000016761Hist_deacetyl domain-containing protein. (223 aa)
piwil2Piwi-like RNA-mediated gene silencing 2; Belongs to the argonaute family. (1049 aa)
ENSOMEP00000016789Histone deacetylase 3. (310 aa)
ENSOMEP00000016841HECT domain-containing protein. (105 aa)
ENSOMEP00000016866Uncharacterized protein. (723 aa)
ENSOMEP00000017018Cytochrome P450, family 1, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family. (522 aa)
LOC112146006Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
LOC112158001CLOCK-interacting pacemaker b. (356 aa)
LOC112154165Pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1b. (423 aa)
ENSOMEP00000017475Growth arrest-specific 2b. (366 aa)
per3Period circadian clock 3. (1260 aa)
LOC112147602RAR-related orphan receptor C b. (494 aa)
LOC112162495Nuclear receptor subfamily 1, group D, member 2b. (582 aa)
sirt6Sirtuin 6. (347 aa)
btbd9BTB (POZ) domain containing 9. (612 aa)
ENSOMEP00000018652Nerve growth factor receptor a (TNFR superfamily, member 16). (406 aa)
gpr176G protein-coupled receptor 176. (542 aa)
atg7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (720 aa)
nfyaNuclear transcription factor Y, alpha, like. (345 aa)
LOC112157078G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (405 aa)
PPARGPeroxisome proliferator activated receptor gamma. (549 aa)
LOC112145491Nuclear receptor subfamily 1, group D, member 4b. (561 aa)
tnfaip6Tumor necrosis factor, alpha-induced protein 6. (259 aa)
LOC112154198Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (325 aa)
ndufa9NADH:ubiquinone oxidoreductase subunit A9a. (381 aa)
ENSOMEP00000020139Non-specific serine/threonine protein kinase. (474 aa)
ppp1ccSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (323 aa)
timelessTimeless circadian clock. (1244 aa)
LOC112154655Nerve growth factor receptor b. (436 aa)
kiaa2013Si:dkeyp-104h9.5. (614 aa)
ENSOMEP00000021017Uncharacterized protein. (89 aa)
ARNTL2Aryl hydrocarbon receptor nuclear translocator like 2. (622 aa)
LOC112146445Arylalkylamine N-acetyltransferase 2. (208 aa)
id1Inhibitor of DNA binding 1, HLH protein. (129 aa)
LOC112145418Basic helix-loop-helix family, member e40. (383 aa)
cunh3orf70Zgc:162707. (286 aa)
LOC112161471Mitogen-activated protein kinase. (438 aa)
fzd4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (525 aa)
CRTC1CREB regulated transcription coactivator 1b. (607 aa)
LOC112136691Nuclear receptor subfamily 1, group D, member 2a. (562 aa)
ENSOMEP00000023641Protein kinase domain-containing protein. (95 aa)
ENSOMEP00000023649Nudix (nucleoside diphosphate linked moiety X)-type motif 12. (469 aa)
ptx3Pentraxin 3, long b. (443 aa)
LOC112147429Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1153 aa)
ENSOMEP00000024352Protein kinase domain-containing protein. (104 aa)
LOC112140813Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (523 aa)
LOC112153234Mitogen-activated protein kinase. (420 aa)
LOC112136966RAR-related orphan receptor C a. (474 aa)
LOC112140772-2Sphingosine-1-phosphate lyase 1-like. (565 aa)
egr1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (511 aa)
LOC112146572Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (495 aa)
ENSOMEP00000025532Mitogen-activated protein kinase. (402 aa)
nfil3Nuclear factor, interleukin 3 regulated. (404 aa)
LOC112162538Circadian associated repressor of transcription a. (330 aa)
PPARAPeroxisome proliferator-activated receptor alpha b. (469 aa)
id2Inhibitor of DNA binding 2a. (136 aa)
LOC112143927Uncharacterized protein. (423 aa)
mapk8Mitogen-activated protein kinase. (384 aa)
AANATArylalkylamine N-acetyltransferase 1. (202 aa)
crebbpCREB binding protein b. (2411 aa)
LOC112152716Aryl hydrocarbon receptor nuclear translocator-like 2. (637 aa)
GPR149G protein-coupled receptor 149. (763 aa)
id3Inhibitor of DNA binding 3. (117 aa)
ENSOMEP00000028785Activity-dependent neuroprotector homeobox b. (986 aa)
ENSOMEP00000029251DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (503 aa)
ENSOMEP00000030509Uncharacterized protein. (69 aa)
ENSOMEP00000030825Melatonin receptor 1Bb; Belongs to the G-protein coupled receptor 1 family. (386 aa)
hes7Hairy-related 11. (244 aa)
LOC112160314F-box domain-containing protein. (431 aa)
sirt1Deacetylase sirtuin-type domain-containing protein. (685 aa)
ENSOMEP00000032123Uncharacterized protein. (233 aa)
ENSOMEP00000032154Hist_deacetyl domain-containing protein. (233 aa)
ENSOMEP00000032175annotation not available (223 aa)
LOC112158702Nuclear factor, interleukin 3 regulated, member 6. (375 aa)
LOC112138664Coiled-coil domain containing 90B. (238 aa)
LOC112151877Cryptochrome circadian regulator 2. (671 aa)
ENSOMEP00000032744Hist_deacetyl domain-containing protein. (205 aa)
ENSOMEP00000032764annotation not available (223 aa)
ENSOMEP00000032785Hist_deacetyl domain-containing protein. (205 aa)
ENSOMEP000000328265-hydroxytryptamine (serotonin) receptor 7b. (379 aa)
lgr4Leucine-rich repeat containing G protein-coupled receptor 4. (972 aa)
ENSOMEP00000033103Uncharacterized protein. (597 aa)
LOC112156678Aryl hydrocarbon receptor 1b. (831 aa)
LOC112156658Aryl hydrocarbon receptor 2. (917 aa)
LOC112161090Endothelin 2. (164 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1217 aa)
LOC112152225DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (735 aa)
gpr157G protein-coupled receptor 157. (334 aa)
ENSOMEP00000034793Nocturnin. (421 aa)
LOC112147711CLOCK-interacting pacemaker a. (344 aa)
LOC112152639Uncharacterized protein. (334 aa)
scaperS-phase cyclin A-associated protein in the ER. (1491 aa)
BHLHE40Basic helix-loop-helix family member e40. (427 aa)
dtlDenticleless E3 ubiquitin protein ligase homolog (Drosophila). (646 aa)
ENSOMEP00000036053Enhancer of zeste 1 polycomb repressive complex 2 subunit. (121 aa)
LOC112145789DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (751 aa)
LOC112147051Period circadian clock 2. (1452 aa)
Your Current Organism:
Oryzias melastigma
NCBI taxonomy Id: 30732
Other names: Aplocheilus melastigmus, Indian medaka, Java medaka, O. melastigma, marine medaka
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