(79 nodes) Embryonic skeletal system development network (Oryzias melastigma)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSOMEP00000000089	Sulfatase 2a. (855 aa)
	wnt9b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	ENSOMEP00000036152	Nipped-B protein. (2333 aa)
	gata3	GATA binding protein 3. (439 aa)
	ALX3	ALX homeobox 3. (373 aa)
	LOC112141101	Growth differentiation factor 6a. (432 aa)
	dlx5	Distal-less homeobox 5a. (286 aa)
	ENSOMEP00000032206	Neuroblastoma amplified sequence. (2269 aa)
	LOC112138641	Uncharacterized protein. (545 aa)
	ENSOMEP00000031697	Intraflagellar transport 140 homolog (Chlamydomonas). (591 aa)
	LOC112159050	Extracellular sulfatase. (869 aa)
	LOC112158724	Homeobox C10a. (322 aa)
	hoxc9	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (279 aa)
	hoxc4	Homeobox C4a. (263 aa)
	hand2	Heart and neural crest derivatives expressed 2. (236 aa)
	ENSOMEP00000030642	Growth arrest-specific 1b. (242 aa)
	LOC112159843	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (379 aa)
	ENSOMEP00000029867	Upper zone of growth plate and cartilage matrix associated a. (138 aa)
	ENSOMEP00000029865	Growth arrest-specific 1a. (264 aa)
	med12	Mediator complex subunit 12. (2126 aa)
	RING1	Ring finger protein 1. (393 aa)
	ENSOMEP00000027958	LEO1 homolog, Paf1/RNA polymerase II complex component. (639 aa)
	LOC112155939	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (371 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	wnt9a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (375 aa)
	sema3d	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D; Belongs to the semaphorin family. (795 aa)
	LOC112149837	Activated leukocyte cell adhesion molecule b. (569 aa)
	ENSOMEP00000025230	Uncharacterized protein. (459 aa)
	egr1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (511 aa)
	ilvbl	IlvB (bacterial acetolactate synthase)-like; Belongs to the TPP enzyme family. (625 aa)
	dlx3	Distal-less homeobox 3b. (278 aa)
	gnptab	N-acetylglucosamine-1-phosphate transferase subunits alpha and beta. (1229 aa)
	LOC112153320	Platelet-derived growth factor receptor, beta polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1108 aa)
	SP3	Sp3a transcription factor. (666 aa)
	dlx2	Distal-less homeobox 2b. (277 aa)
	LOC112145792	Si:dkey-49n23.1; Belongs to the semaphorin family. (804 aa)
	ednra	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family. (441 aa)
	ENSOMEP00000023269	Uncharacterized protein. (823 aa)
	ENSOMEP00000023259	Uncharacterized protein. (104 aa)
	mab21l2	Mab-21-like 2. (359 aa)
	LOC112159547	RAD21 cohesin complex component like 1. (556 aa)
	mab21l1	Mab-21-like 1. (359 aa)
	mmachc	Metabolism of cobalamin associated C. (265 aa)
	LOC112151134	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
	LOC112156013	Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family. (462 aa)
	ENSOMEP00000020599	SET domain containing 2, histone lysine methyltransferase. (2351 aa)
	LOC112144000	RNA binding motif protein 24b. (238 aa)
	ENSOMEP00000019180	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (612 aa)
	ENSOMEP00000019164	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (74 aa)
	tbx1	T-box transcription factor 1. (499 aa)
	bmp2	Bone morphogenetic protein 2b. (408 aa)
	LOC112144533	Uncharacterized protein. (301 aa)
	rnf2	Ring finger protein 2. (342 aa)
	wnt4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (405 aa)
	fam20b	FAM20B glycosaminoglycan xylosylkinase. (409 aa)
	mks1	MKS transition zone complex subunit 1. (563 aa)
	ENSOMEP00000001777	ALX homeobox 1. (324 aa)
	ENSOMEP00000002153	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (240 aa)
	LOC112155636	Cytochrome P450, family 26, subfamily b, polypeptide 1; Belongs to the cytochrome P450 family. (512 aa)
	gdf5	Growth differentiation factor 5. (561 aa)
	ENSOMEP00000002886	WD repeat domain 60. (767 aa)
	dlx1	Distal-less homeobox 1a. (253 aa)
	shh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
	hoxd3	Homeobox D3a. (399 aa)
	deaf1	DEAF1 transcription factor. (542 aa)
	pitx2	Homeobox protein. (316 aa)
	sulf1	Sulfatase 1. (1141 aa)
	dmrt2	Doublesex and mab-3 related transcription factor 2a. (491 aa)
	LOC112160348	RNA binding motif protein 24a. (232 aa)
	LOC112151821	Upper zone of growth plate and cartilage matrix associated b. (157 aa)
	ENSOMEP00000010971	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (361 aa)
	wdr19	WD repeat domain 19. (1346 aa)
	ENSOMEP00000011334	Sp3b transcription factor. (607 aa)
	LOC112151417	Sharpin and rbck1 related. (732 aa)
	ENSOMEP00000013455	RNA polymerase I and III subunit D. (150 aa)
	disp1	Dispatched homolog 1 (Drosophila). (1597 aa)
	rad21	RAD21 cohesin complex component a. (636 aa)
	fst	Follistatin a. (346 aa)
	ENSOMEP00000015096	Uncharacterized protein. (174 aa)

Your Current Organism:

Oryzias melastigma

NCBI taxonomy Id: 30732
Other names: Aplocheilus melastigmus, Indian medaka, Java medaka, O. melastigma, marine medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALX3	gata3	ENSOMEP00000034220	ENSOMEP00000035998	ALX homeobox 3.	GATA binding protein 3.	0.517
ALX3	hand2	ENSOMEP00000034220	ENSOMEP00000030709	ALX homeobox 3.	Heart and neural crest derivatives expressed 2.	0.479
ENSOMEP00000001777	gata3	ENSOMEP00000001777	ENSOMEP00000035998	ALX homeobox 1.	GATA binding protein 3.	0.429
ENSOMEP00000001777	hand2	ENSOMEP00000001777	ENSOMEP00000030709	ALX homeobox 1.	Heart and neural crest derivatives expressed 2.	0.427
ENSOMEP00000002153	LOC112151134	ENSOMEP00000002153	ENSOMEP00000021956	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.822
ENSOMEP00000002153	LOC112153320	ENSOMEP00000002153	ENSOMEP00000024178	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Platelet-derived growth factor receptor, beta polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.940
ENSOMEP00000002153	fst	ENSOMEP00000002153	ENSOMEP00000014528	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Follistatin a.	0.408
ENSOMEP00000002153	tbx1	ENSOMEP00000002153	ENSOMEP00000018110	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	T-box transcription factor 1.	0.557
ENSOMEP00000002886	ENSOMEP00000015096	ENSOMEP00000002886	ENSOMEP00000015096	WD repeat domain 60.	Uncharacterized protein.	0.622
ENSOMEP00000002886	ENSOMEP00000031697	ENSOMEP00000002886	ENSOMEP00000031697	WD repeat domain 60.	Intraflagellar transport 140 homolog (Chlamydomonas).	0.622
ENSOMEP00000002886	wdr19	ENSOMEP00000002886	ENSOMEP00000011042	WD repeat domain 60.	WD repeat domain 19.	0.799
ENSOMEP00000011334	LOC112159547	ENSOMEP00000011334	ENSOMEP00000023125	Sp3b transcription factor.	RAD21 cohesin complex component like 1.	0.469
ENSOMEP00000011334	rad21	ENSOMEP00000011334	ENSOMEP00000014259	Sp3b transcription factor.	RAD21 cohesin complex component a.	0.469
ENSOMEP00000015096	ENSOMEP00000002886	ENSOMEP00000015096	ENSOMEP00000002886	Uncharacterized protein.	WD repeat domain 60.	0.622
ENSOMEP00000015096	ENSOMEP00000031697	ENSOMEP00000015096	ENSOMEP00000031697	Uncharacterized protein.	Intraflagellar transport 140 homolog (Chlamydomonas).	0.894
ENSOMEP00000015096	wdr19	ENSOMEP00000015096	ENSOMEP00000011042	Uncharacterized protein.	WD repeat domain 19.	0.983
ENSOMEP00000020599	ENSOMEP00000023259	ENSOMEP00000020599	ENSOMEP00000023259	SET domain containing 2, histone lysine methyltransferase.	Uncharacterized protein.	0.741
ENSOMEP00000020599	ENSOMEP00000023269	ENSOMEP00000020599	ENSOMEP00000023269	SET domain containing 2, histone lysine methyltransferase.	Uncharacterized protein.	0.741
ENSOMEP00000020599	ENSOMEP00000027958	ENSOMEP00000020599	ENSOMEP00000027958	SET domain containing 2, histone lysine methyltransferase.	LEO1 homolog, Paf1/RNA polymerase II complex component.	0.769
ENSOMEP00000020599	ENSOMEP00000036152	ENSOMEP00000020599	ENSOMEP00000036152	SET domain containing 2, histone lysine methyltransferase.	Nipped-B protein.	0.788