(100 nodes) Tyrosine-protein kinase, catalytic domain network (Oryzias melastigma)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	met	MET proto-oncogene, receptor tyrosine kinase. (1398 aa)
	ENSOMEP00000000217	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (403 aa)
	mertk	C-mer proto-oncogene tyrosine kinase a. (927 aa)
	LOC112151354	Receptor protein-tyrosine kinase. (1179 aa)
	ephb4	Eph receptor B4a. (984 aa)
	ddr2	Discoidin domain receptor tyrosine kinase 2a. (861 aa)
	YES1	Tyrosine-protein kinase. (552 aa)
	frk	Tyrosine-protein kinase. (523 aa)
	LOC112137774	Discoidin domain receptor family, member 2, like. (886 aa)
	abl1	Tyrosine-protein kinase. (1083 aa)
	LOC112158419	Tyrosine-protein kinase. (528 aa)
	fgfr3	Fibroblast growth factor receptor. (820 aa)
	LOC112152311	Tyrosine-protein kinase receptor. (1413 aa)
	LOC112147434	Eph receptor B3a. (926 aa)
	ENSOMEP00000006513	Tyrosine-protein kinase receptor. (1379 aa)
	ENSOMEP00000006649	Fms-related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (807 aa)
	LOC112147140	Tyrosine kinase, non-receptor, 2b; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1206 aa)
	ENSOMEP00000007723	Fms-related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1398 aa)
	LOC112138372	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (948 aa)
	hck	Tyrosine-protein kinase. (504 aa)
	LOC112147204	Discoidin domain receptor tyrosine kinase 2b. (887 aa)
	tnk1	Tyrosine kinase, non-receptor, 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (755 aa)
	LOC112143634	Receptor protein-tyrosine kinase. (1020 aa)
	ENSOMEP00000010900	Protein tyrosine kinase 2ab; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1125 aa)
	insr	Tyrosine-protein kinase receptor. (1359 aa)
	LOC112150803	Tyrosine-protein kinase receptor. (1377 aa)
	ENSOMEP00000011129	Tyrosine-protein kinase. (572 aa)
	ENSOMEP00000011538	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (885 aa)
	ENSOMEP00000011997	Tyrosine-protein kinase. (1090 aa)
	src	Tyrosine-protein kinase. (550 aa)
	LOC112146402	Tyrosine-protein kinase. (537 aa)
	ENSOMEP00000012573	Tyrosine-protein kinase. (637 aa)
	ddr1	Discoidin domain receptor tyrosine kinase 1. (977 aa)
	kdr	Kinase insert domain receptor (a type III receptor tyrosine kinase); Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1327 aa)
	LOC112144920	Eph receptor B2b. (1058 aa)
	ENSOMEP00000014363	Protein kinase domain-containing protein. (107 aa)
	blk	Tyrosine-protein kinase. (487 aa)
	LOC112148278	Fibroblast growth factor receptor. (831 aa)
	LOC112158705	Tyrosine-protein kinase. (551 aa)
	LOC112160736	Eph receptor A6. (1030 aa)
	LOC112153421	Kinase insert domain receptor like; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1299 aa)
	ntrk3	Tyrosine-protein kinase receptor. (815 aa)
	ptk2b	Protein tyrosine kinase 2 beta, b; Belongs to the protein kinase superfamily. Tyr protein kinase family. (995 aa)
	LOC112150124	Tyrosine-protein kinase. (1112 aa)
	ENSOMEP00000017622	Eph receptor A4b. (1040 aa)
	LOC112147698	Uncharacterized protein. (1076 aa)
	epha5	Uncharacterized protein. (1011 aa)
	ENSOMEP00000019166	Tyrosine-protein kinase receptor. (807 aa)
	ephb3	Uncharacterized protein. (983 aa)
	ntrk1	Tyrosine-protein kinase receptor. (800 aa)
	LOC112154010	Receptor protein-tyrosine kinase. (1284 aa)
	AXL	AXL receptor tyrosine kinase. (928 aa)
	LOC112147554	EPH receptor B1. (1007 aa)
	ENSOMEP00000021505	TXK tyrosine kinase. (170 aa)
	ENSOMEP00000021525	Tyrosine-protein kinase. (709 aa)
	ENSOMEP00000021604	Macrophage stimulating 1 receptor b. (1374 aa)
	LOC112163270	Tyrosine-protein kinase. (1131 aa)
	ntrk2	Tyrosine-protein kinase receptor. (807 aa)
	tyk2	Tyrosine-protein kinase. (1173 aa)
	epha8	Uncharacterized protein. (1032 aa)
	ENSOMEP00000022058	Receptor protein-tyrosine kinase. (1207 aa)
	epha2	Eph receptor A2 a. (997 aa)
	LOC112145561	Macrophage stimulating 1 receptor a. (1366 aa)
	epha7	Eph receptor A7. (992 aa)
	fes	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (823 aa)
	LOC112142653	Fibroblast growth factor receptor 4. (1072 aa)
	LOC112162937	Fibroblast growth factor receptor. (703 aa)
	LOC112153320	Platelet-derived growth factor receptor, beta polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1108 aa)
	csf1r	Colony stimulating factor 1 receptor, a; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (983 aa)
	LOC112150138	Tyrosine-protein kinase. (622 aa)
	jak1	Tyrosine-protein kinase. (1173 aa)
	LOC112138531	Eph receptor A2 b. (994 aa)
	flt1	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1274 aa)
	tie1	Tyrosine kinase with immunoglobulin-like and EGF-like domains 1. (1138 aa)
	LOC112137425	Tyrosine-protein kinase. (529 aa)
	egfr	Receptor protein-tyrosine kinase. (1185 aa)
	LOC112150448	Uncharacterized protein. (1027 aa)
	LOC112163033	Neurotrophic tyrosine kinase, receptor, type 2b. (801 aa)
	abl2	Tyrosine-protein kinase. (1170 aa)
	LOC112147393	Tyrosine-protein kinase. (547 aa)
	matk	Tyrosine-protein kinase. (455 aa)
	ENSOMEP00000029504	Receptor protein-tyrosine kinase. (1346 aa)
	LOC112152938	Tyrosine-protein kinase. (447 aa)
	lck	Tyrosine-protein kinase. (498 aa)
	LOC112147318	Tyrosine-protein kinase. (511 aa)
	ENSOMEP00000030940	Tyrosine-protein kinase. (496 aa)
	kit	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (983 aa)
	ENSOMEP00000031022	KIT proto-oncogene, receptor tyrosine kinase b; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (909 aa)
	pdgfra	Platelet-derived growth factor receptor, alpha polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1465 aa)
	LOC112159099	Tyrosine-protein kinase. (504 aa)
	ENSOMEP00000031678	Ret proto-oncogene receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1001 aa)
	CSK	Tyrosine-protein kinase. (450 aa)
	fgfr2	Fibroblast growth factor receptor. (832 aa)
	ENSOMEP00000032841	Tyrosine-protein kinase receptor. (1405 aa)
	epha4	Eph receptor A4, like. (990 aa)
	MUSK	Muscle associated receptor tyrosine kinase. (835 aa)
	tyro3	TYRO3 protein tyrosine kinase. (864 aa)
	LOC112138591	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
	EPHA6	EPH receptor A6. (986 aa)
	epha3	Eph receptor A3. (990 aa)

Your Current Organism:

Oryzias melastigma

NCBI taxonomy Id: 30732
Other names: Aplocheilus melastigmus, Indian medaka, Java medaka, O. melastigma, marine medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AXL	CSK	ENSOMEP00000020448	ENSOMEP00000032085	AXL receptor tyrosine kinase.	Tyrosine-protein kinase.	0.529
AXL	ENSOMEP00000007723	ENSOMEP00000020448	ENSOMEP00000007723	AXL receptor tyrosine kinase.	Fms-related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.403
AXL	ENSOMEP00000011997	ENSOMEP00000020448	ENSOMEP00000011997	AXL receptor tyrosine kinase.	Tyrosine-protein kinase.	0.645
AXL	ENSOMEP00000022058	ENSOMEP00000020448	ENSOMEP00000022058	AXL receptor tyrosine kinase.	Receptor protein-tyrosine kinase.	0.485
AXL	ENSOMEP00000029504	ENSOMEP00000020448	ENSOMEP00000029504	AXL receptor tyrosine kinase.	Receptor protein-tyrosine kinase.	0.485
AXL	ENSOMEP00000030940	ENSOMEP00000020448	ENSOMEP00000030940	AXL receptor tyrosine kinase.	Tyrosine-protein kinase.	0.530
AXL	LOC112137425	ENSOMEP00000020448	ENSOMEP00000026955	AXL receptor tyrosine kinase.	Tyrosine-protein kinase.	0.530
AXL	LOC112138591	ENSOMEP00000020448	ENSOMEP00000034313	AXL receptor tyrosine kinase.	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.	0.414
AXL	LOC112146402	ENSOMEP00000020448	ENSOMEP00000012176	AXL receptor tyrosine kinase.	Tyrosine-protein kinase.	0.530
AXL	LOC112147318	ENSOMEP00000020448	ENSOMEP00000030199	AXL receptor tyrosine kinase.	Tyrosine-protein kinase.	0.594
AXL	LOC112147393	ENSOMEP00000020448	ENSOMEP00000028263	AXL receptor tyrosine kinase.	Tyrosine-protein kinase.	0.594
AXL	LOC112150124	ENSOMEP00000020448	ENSOMEP00000017393	AXL receptor tyrosine kinase.	Tyrosine-protein kinase.	0.645
AXL	LOC112150138	ENSOMEP00000020448	ENSOMEP00000024574	AXL receptor tyrosine kinase.	Tyrosine-protein kinase.	0.405
AXL	LOC112151354	ENSOMEP00000020448	ENSOMEP00000000444	AXL receptor tyrosine kinase.	Receptor protein-tyrosine kinase.	0.485
AXL	LOC112152938	ENSOMEP00000020448	ENSOMEP00000029969	AXL receptor tyrosine kinase.	Tyrosine-protein kinase.	0.529
AXL	LOC112153320	ENSOMEP00000020448	ENSOMEP00000024178	AXL receptor tyrosine kinase.	Platelet-derived growth factor receptor, beta polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.439
AXL	LOC112153421	ENSOMEP00000020448	ENSOMEP00000015767	AXL receptor tyrosine kinase.	Kinase insert domain receptor like; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.403
AXL	LOC112154010	ENSOMEP00000020448	ENSOMEP00000020095	AXL receptor tyrosine kinase.	Receptor protein-tyrosine kinase.	0.485
AXL	LOC112158419	ENSOMEP00000020448	ENSOMEP00000002696	AXL receptor tyrosine kinase.	Tyrosine-protein kinase.	0.530
AXL	LOC112158705	ENSOMEP00000020448	ENSOMEP00000015391	AXL receptor tyrosine kinase.	Tyrosine-protein kinase.	0.594