(55 nodes) Synthesis of bile acids and bile salts network (Oryzias melastigma)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSOMEP00000024663	Hydroxysteroid dehydrogenase like 2. (400 aa)
	ENSOMEP00000036321	Uncharacterized protein. (415 aa)
	ENSOMEP00000035958	Bile_Hydr_Trans domain-containing protein. (269 aa)
	LOC112145720	Uncharacterized protein. (466 aa)
	rxra	Retinoid X receptor, alpha a. (496 aa)
	LOC112137569	Oxysterol-binding protein; Belongs to the OSBP family. (811 aa)
	ENSOMEP00000032998	Si:ch211-113j14.1; Belongs to the cytochrome P450 family. (455 aa)
	ENSOMEP00000032900	Uncharacterized protein. (509 aa)
	ENSOMEP00000032190	Cholesterol 25-hydroxylase like 2; Belongs to the sterol desaturase family. (284 aa)
	LOC112138814	Uncharacterized protein. (424 aa)
	ptgis	Uncharacterized protein; Belongs to the cytochrome P450 family. (485 aa)
	ENSOMEP00000029512	Oxysterol-binding protein; Belongs to the OSBP family. (468 aa)
	osbpl9	Oxysterol-binding protein; Belongs to the OSBP family. (739 aa)
	LOC112155857	Oxysterol-binding protein; Belongs to the OSBP family. (760 aa)
	acot8	Acyl-CoA thioesterase 8. (337 aa)
	ENSOMEP00000000434	Succinyl-CoA:glutarate-CoA transferase. (360 aa)
	ENSOMEP00000001024	Oxysterol-binding protein; Belongs to the OSBP family. (734 aa)
	LOC112144503	Prostaglandin I2 (prostacyclin) synthase; Belongs to the cytochrome P450 family. (470 aa)
	ENSOMEP00000001604	Oxysterol-binding protein; Belongs to the OSBP family. (663 aa)
	LOC112159597	Oxysterol-binding protein; Belongs to the OSBP family. (465 aa)
	LOC112157767	Oxysterol-binding protein; Belongs to the OSBP family. (920 aa)
	ENSOMEP00000003096	Oxysterol-binding protein; Belongs to the OSBP family. (341 aa)
	ENSOMEP00000006496	BAAT_C domain-containing protein. (204 aa)
	LOC112147054	Cytochrome P450, family 8, subfamily B, polypeptide 2; Belongs to the cytochrome P450 family. (511 aa)
	LOC112159312	Oxysterol-binding protein; Belongs to the OSBP family. (472 aa)
	ncoa2	Nuclear receptor coactivator. (1503 aa)
	ENSOMEP00000009588	Nuclear receptor subfamily 1, group H, member 4. (487 aa)
	LOC112160817	Solute carrier family 27 member 2a. (615 aa)
	ENSOMEP00000009838	Uncharacterized protein. (620 aa)
	ENSOMEP00000011972	ANK_REP_REGION domain-containing protein. (102 aa)
	LOC112151704	AMP-binding domain-containing protein. (669 aa)
	ENSOMEP00000013814	Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family. (279 aa)
	LOC112155582	Cytochrome P450; Belongs to the cytochrome P450 family. (524 aa)
	ENSOMEP00000015108	Nuclear receptor subfamily 1, group H, member 5. (482 aa)
	ENSOMEP00000015946	Uncharacterized protein. (345 aa)
	hsd3b7	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase; Belongs to the 3-beta-HSD family. (366 aa)
	hsd17b4	Hydroxysteroid (17-beta) dehydrogenase 4. (737 aa)
	LOC112157725	Uncharacterized protein. (507 aa)
	LOC112157723	Uncharacterized protein. (507 aa)
	LOC112144008	Oxysterol-binding protein; Belongs to the OSBP family. (880 aa)
	LOC112154786	Cytochrome P450, family 27, subfamily A, polypeptide 7; Belongs to the cytochrome P450 family. (516 aa)
	LOC112151827	Cholesterol 25-hydroxylase like 1, tandem duplicate 2; Belongs to the sterol desaturase family. (284 aa)
	LOC112158782	Acyl-CoA thioesterase 16. (427 aa)
	ENSOMEP00000021434	Cholesterol 25-hydroxylase like 1, tandem duplicate 1; Belongs to the sterol desaturase family. (269 aa)
	LOC112162957	Uncharacterized protein. (423 aa)
	ENSOMEP00000021624	BAAT_C domain-containing protein. (250 aa)
	ENSOMEP00000022206	Podocan. (594 aa)
	ENSOMEP00000022357	Oxysterol-binding protein; Belongs to the OSBP family. (749 aa)
	LOC112144318	Cytochrome P450, family 7, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (492 aa)
	LOC112144311	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (512 aa)
	ENSOMEP00000023701	Oxysterol-binding protein; Belongs to the OSBP family. (826 aa)
	ENSOMEP00000023770	ANK_REP_REGION domain-containing protein. (132 aa)
	osbpl6	Oxysterol-binding protein; Belongs to the OSBP family. (920 aa)
	amacr	Alpha-methylacyl-CoA racemase. (382 aa)
	scp2	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (540 aa)

Your Current Organism:

Oryzias melastigma

NCBI taxonomy Id: 30732
Other names: Aplocheilus melastigmus, Indian medaka, Java medaka, O. melastigma, marine medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSOMEP00000000434	ENSOMEP00000009838	ENSOMEP00000000434	ENSOMEP00000009838	Succinyl-CoA:glutarate-CoA transferase.	Uncharacterized protein.	0.608
ENSOMEP00000000434	ENSOMEP00000024663	ENSOMEP00000000434	ENSOMEP00000024663	Succinyl-CoA:glutarate-CoA transferase.	Hydroxysteroid dehydrogenase like 2.	0.910
ENSOMEP00000000434	LOC112151704	ENSOMEP00000000434	ENSOMEP00000013766	Succinyl-CoA:glutarate-CoA transferase.	AMP-binding domain-containing protein.	0.608
ENSOMEP00000000434	LOC112160817	ENSOMEP00000000434	ENSOMEP00000009823	Succinyl-CoA:glutarate-CoA transferase.	Solute carrier family 27 member 2a.	0.608
ENSOMEP00000000434	hsd17b4	ENSOMEP00000000434	ENSOMEP00000018153	Succinyl-CoA:glutarate-CoA transferase.	Hydroxysteroid (17-beta) dehydrogenase 4.	0.768
ENSOMEP00000000434	scp2	ENSOMEP00000000434	ENSOMEP00000027268	Succinyl-CoA:glutarate-CoA transferase.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.849
ENSOMEP00000003096	ENSOMEP00000011972	ENSOMEP00000003096	ENSOMEP00000011972	Oxysterol-binding protein; Belongs to the OSBP family.	ANK_REP_REGION domain-containing protein.	0.471
ENSOMEP00000006496	ENSOMEP00000009838	ENSOMEP00000006496	ENSOMEP00000009838	BAAT_C domain-containing protein.	Uncharacterized protein.	0.677
ENSOMEP00000006496	ENSOMEP00000024663	ENSOMEP00000006496	ENSOMEP00000024663	BAAT_C domain-containing protein.	Hydroxysteroid dehydrogenase like 2.	0.460
ENSOMEP00000006496	ENSOMEP00000032900	ENSOMEP00000006496	ENSOMEP00000032900	BAAT_C domain-containing protein.	Uncharacterized protein.	0.672
ENSOMEP00000006496	ENSOMEP00000036321	ENSOMEP00000006496	ENSOMEP00000036321	BAAT_C domain-containing protein.	Uncharacterized protein.	0.629
ENSOMEP00000006496	LOC112138814	ENSOMEP00000006496	ENSOMEP00000030441	BAAT_C domain-containing protein.	Uncharacterized protein.	0.632
ENSOMEP00000006496	LOC112145720	ENSOMEP00000006496	ENSOMEP00000034134	BAAT_C domain-containing protein.	Uncharacterized protein.	0.668
ENSOMEP00000006496	LOC112151704	ENSOMEP00000006496	ENSOMEP00000013766	BAAT_C domain-containing protein.	AMP-binding domain-containing protein.	0.677
ENSOMEP00000006496	LOC112160817	ENSOMEP00000006496	ENSOMEP00000009823	BAAT_C domain-containing protein.	Solute carrier family 27 member 2a.	0.677
ENSOMEP00000006496	LOC112162957	ENSOMEP00000006496	ENSOMEP00000021602	BAAT_C domain-containing protein.	Uncharacterized protein.	0.629
ENSOMEP00000006496	acot8	ENSOMEP00000006496	ENSOMEP00000000238	BAAT_C domain-containing protein.	Acyl-CoA thioesterase 8.	0.796
ENSOMEP00000006496	hsd17b4	ENSOMEP00000006496	ENSOMEP00000018153	BAAT_C domain-containing protein.	Hydroxysteroid (17-beta) dehydrogenase 4.	0.526
ENSOMEP00000006496	scp2	ENSOMEP00000006496	ENSOMEP00000027268	BAAT_C domain-containing protein.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.844
ENSOMEP00000009588	ENSOMEP00000015946	ENSOMEP00000009588	ENSOMEP00000015946	Nuclear receptor subfamily 1, group H, member 4.	Uncharacterized protein.	0.900