47 items (Oryzias melastigma) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	frs2	Fibroblast growth factor receptor substrate 2b. (525 aa)
	LOC112153328	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (212 aa)
	LOC112158705	Tyrosine-protein kinase. (551 aa)
	LOC112146278	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (389 aa)
	hras	HRas proto-oncogene, GTPase a. (189 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	ENSOMEP00000020966	Ribosomal protein S27a. (183 aa)
	ENSOMEP00000021196	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	KRAS	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
	LOC112151134	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
	GALNT3	Polypeptide N-acetylgalactosaminyltransferase. (624 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa)
	ppp2cb	Serine/threonine-protein phosphatase. (309 aa)
	grb2	Growth factor receptor-bound protein 2b. (217 aa)
	ppp2ca	Serine/threonine-protein phosphatase. (309 aa)
	fgf23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (257 aa)
	spry2	Sprouty RTK signaling antagonist 2. (417 aa)
	LOC112137449	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (269 aa)
	fgf16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
	LOC112147412	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	ENSOMEP00000005379	Fibroblast growth factor receptor substrate 3. (606 aa)
	fgf1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (268 aa)
	mknk2	MAPK interacting serine/threonine kinase 2b; Belongs to the protein kinase superfamily. (476 aa)
	gab1	GRB2-associated binding protein 1. (762 aa)
	LOC112153795	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (210 aa)
	src	Tyrosine-protein kinase. (550 aa)
	ENSOMEP00000002833	Ubiquitin A-52 residue ribosomal protein fusion product 1. (129 aa)
	LOC112150729	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
	fgf4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	LOC112142874	Uncharacterized protein. (856 aa)
	fndc3a	Fibronectin type III domain containing 3A. (1238 aa)
	LOC112155731	PH domain-containing protein. (737 aa)
	ENSOMEP00000035400	Ubiquitin-like domain-containing protein. (137 aa)
	LOC112159027	Polypeptide N-acetylgalactosaminyltransferase. (621 aa)
	ENSOMEP00000031976	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (196 aa)
	LOC112143591	Cbl proto-oncogene C, E3 ubiquitin protein ligase. (560 aa)
	LOC112146394	Zgc:55558. (186 aa)
	ENSOMEP00000031576	Fibronectin type III domain containing 3Ba. (1233 aa)
	cbl	Cbl proto-oncogene, E3 ubiquitin protein ligase. (942 aa)
	CSDE1	Cold shock domain containing E1, RNA-binding. (869 aa)
	plcg1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1311 aa)
	SHC4	SHC adaptor protein 4. (494 aa)
	mapk1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa)
	ENSOMEP00000006056	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (201 aa)
	shc1	SHC (Src homology 2 domain containing) transforming protein 1. (588 aa)
	mknk1	MAPK interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (457 aa)
	ENSOMEP00000013464	Protein phosphatase 2, regulatory subunit A, beta b. (647 aa)

Your Current Organism:

Oryzias melastigma

NCBI taxonomy Id: 30732
Other names: Aplocheilus melastigmus, Indian medaka, Java medaka, O. melastigma, marine medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSDE1	ENSOMEP00000002833	ENSOMEP00000031024	ENSOMEP00000002833	Cold shock domain containing E1, RNA-binding.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.687
CSDE1	ENSOMEP00000005379	ENSOMEP00000031024	ENSOMEP00000005379	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor receptor substrate 3.	0.577
CSDE1	ENSOMEP00000006056	ENSOMEP00000031024	ENSOMEP00000006056	Cold shock domain containing E1, RNA-binding.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.481
CSDE1	ENSOMEP00000013464	ENSOMEP00000031024	ENSOMEP00000013464	Cold shock domain containing E1, RNA-binding.	Protein phosphatase 2, regulatory subunit A, beta b.	0.600
CSDE1	ENSOMEP00000020966	ENSOMEP00000031024	ENSOMEP00000020966	Cold shock domain containing E1, RNA-binding.	Ribosomal protein S27a.	0.679
CSDE1	ENSOMEP00000021196	ENSOMEP00000031024	ENSOMEP00000021196	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.538
CSDE1	ENSOMEP00000031976	ENSOMEP00000031024	ENSOMEP00000031976	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.526
CSDE1	ENSOMEP00000035400	ENSOMEP00000031024	ENSOMEP00000035400	Cold shock domain containing E1, RNA-binding.	Ubiquitin-like domain-containing protein.	0.686
CSDE1	LOC112137449	ENSOMEP00000031024	ENSOMEP00000025940	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.410
CSDE1	LOC112146278	ENSOMEP00000031024	ENSOMEP00000016922	Cold shock domain containing E1, RNA-binding.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.661
CSDE1	LOC112147412	ENSOMEP00000031024	ENSOMEP00000025220	Cold shock domain containing E1, RNA-binding.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.733
CSDE1	LOC112150729	ENSOMEP00000031024	ENSOMEP00000002474	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.554
CSDE1	LOC112151134	ENSOMEP00000031024	ENSOMEP00000021956	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.588
CSDE1	LOC112153328	ENSOMEP00000031024	ENSOMEP00000013856	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.410
CSDE1	LOC112153795	ENSOMEP00000031024	ENSOMEP00000002985	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.	0.554
CSDE1	LOC112155731	ENSOMEP00000031024	ENSOMEP00000000713	Cold shock domain containing E1, RNA-binding.	PH domain-containing protein.	0.448
CSDE1	LOC112158705	ENSOMEP00000031024	ENSOMEP00000015391	Cold shock domain containing E1, RNA-binding.	Tyrosine-protein kinase.	0.634
CSDE1	PIK3CA	ENSOMEP00000031024	ENSOMEP00000028331	Cold shock domain containing E1, RNA-binding.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.733
CSDE1	SHC4	ENSOMEP00000031024	ENSOMEP00000008409	Cold shock domain containing E1, RNA-binding.	SHC adaptor protein 4.	0.511
CSDE1	fgf1	ENSOMEP00000031024	ENSOMEP00000004387	Cold shock domain containing E1, RNA-binding.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.481