STRINGSTRING
eme2 eme2 exo1 exo1 rad51d rad51d rcbtb2 rcbtb2 kat5 kat5 LOC112149564 LOC112149564 pold3 pold3 pole pole pole3 pole3 ENSOMEP00000002422 ENSOMEP00000002422 ENSOMEP00000002833 ENSOMEP00000002833 ENSOMEP00000003330 ENSOMEP00000003330 rpa1 rpa1 rad51ap1 rad51ap1 ENSOMEP00000004138 ENSOMEP00000004138 ENSOMEP00000004154 ENSOMEP00000004154 top3a top3a polk polk ENSOMEP00000004644 ENSOMEP00000004644 rad50 rad50 nbn nbn meiob meiob LOC112159947 LOC112159947 RPA1 RPA1 ENSOMEP00000010830 ENSOMEP00000010830 RCBTB1 RCBTB1 ENSOMEP00000011219 ENSOMEP00000011219 LOC112148474 LOC112148474 pole2 pole2 rfc4 rfc4 pold1 pold1 rbbp8 rbbp8 ankrd11 ankrd11 palb2 palb2 ankrd12 ankrd12 ENSOMEP00000020966 ENSOMEP00000020966 ENSOMEP00000021087 ENSOMEP00000021087 ENSOMEP00000021629 ENSOMEP00000021629 rmi2 rmi2 ENSOMEP00000021991 ENSOMEP00000021991 rad51 rad51 ENSOMEP00000024355 ENSOMEP00000024355 LOC112156448 LOC112156448 slx4 slx4 SPIDR SPIDR rpa3 rpa3 pole4 pole4 kxd1 kxd1 gen1 gen1 ENSOMEP00000027927 ENSOMEP00000027927 ENSOMEP00000028431 ENSOMEP00000028431 ENSOMEP00000028590 ENSOMEP00000028590 ENSOMEP00000028815 ENSOMEP00000028815 ENSOMEP00000028916 ENSOMEP00000028916 rfc2 rfc2 ENSOMEP00000029282 ENSOMEP00000029282 mre11 mre11 tdrd3 tdrd3 rpa2 rpa2 pcna pcna eme1 eme1 chek1 chek1 ENSOMEP00000035400 ENSOMEP00000035400 ENSOMEP00000035472 ENSOMEP00000035472 blm blm exd2 exd2 rmi1 rmi1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
eme2ERCC4 domain-containing protein. (429 aa)
exo1Exonuclease 1. (757 aa)
rad51dRAD51 paralog D. (358 aa)
rcbtb2Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (547 aa)
kat5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (558 aa)
LOC112149564BRCA2 DNA repair associated. (2893 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (438 aa)
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2291 aa)
pole3Polymerase (DNA directed), epsilon 3 (p17 subunit). (147 aa)
ENSOMEP00000002422MUS81 structure-specific endonuclease subunit. (514 aa)
ENSOMEP00000002833Ubiquitin A-52 residue ribosomal protein fusion product 1. (129 aa)
ENSOMEP00000003330RING-type domain-containing protein. (841 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (598 aa)
rad51ap1RAD51 associated protein 1. (313 aa)
ENSOMEP00000004138TAN domain-containing protein. (176 aa)
ENSOMEP00000004154Uncharacterized protein. (133 aa)
top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1024 aa)
polkPolymerase (DNA directed) kappa. (847 aa)
ENSOMEP00000004644Polymerase (DNA directed), eta. (302 aa)
rad50RAD50 homolog, double strand break repair protein. (1311 aa)
nbnNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (827 aa)
meiobMethionine sulfoxide reductase B1b. (461 aa)
LOC112159947Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (573 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (649 aa)
ENSOMEP00000010830Replication factor C (activator 1) 5. (326 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (527 aa)
ENSOMEP00000011219Uncharacterized protein. (96 aa)
LOC112148474Polymerase (DNA directed), delta 2, regulatory subunit. (471 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (528 aa)
rfc4Replication factor C (activator 1) 4. (355 aa)
pold1DNA polymerase. (1105 aa)
rbbp8Uncharacterized protein. (614 aa)
ankrd11Ankyrin repeat domain 11. (2829 aa)
palb2PALB2_WD40 domain-containing protein. (1266 aa)
ankrd12Ankyrin repeat domain 12. (1899 aa)
ENSOMEP00000020966Ribosomal protein S27a. (183 aa)
ENSOMEP00000021087ANK_REP_REGION domain-containing protein. (663 aa)
ENSOMEP00000021629RecQ helicase-like 4. (991 aa)
rmi2RecQ mediated genome instability 2. (140 aa)
ENSOMEP00000021991RECA_2 domain-containing protein. (275 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (340 aa)
ENSOMEP00000024355Uncharacterized protein. (981 aa)
LOC112156448Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (276 aa)
slx4SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae). (1506 aa)
SPIDRUncharacterized protein. (912 aa)
rpa3Replication protein A3. (122 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (148 aa)
kxd1KxDL motif containing 1. (195 aa)
gen1Uncharacterized protein. (852 aa)
ENSOMEP00000027927Ubiquitin-like domain-containing protein. (77 aa)
ENSOMEP00000028431RAD51 paralog C. (307 aa)
ENSOMEP00000028590Uncharacterized protein. (106 aa)
ENSOMEP00000028815Replication factor C (activator 1) 3. (279 aa)
ENSOMEP00000028916Replication factor C subunit 1. (1042 aa)
rfc2Replication factor C (activator 1) 2. (357 aa)
ENSOMEP00000029282AAA_23 domain-containing protein. (51 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (691 aa)
tdrd3Tudor domain containing 3. (779 aa)
rpa2Replication protein A2. (270 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
eme1Essential meiotic structure-specific endonuclease 1. (498 aa)
chek1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (455 aa)
ENSOMEP00000035400Ubiquitin-like domain-containing protein. (137 aa)
ENSOMEP00000035472DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (348 aa)
blmBLM RecQ like helicase. (1368 aa)
exd2Exonuclease 3'-5' domain containing 2. (627 aa)
rmi1RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (647 aa)
Your Current Organism:
Oryzias melastigma
NCBI taxonomy Id: 30732
Other names: Aplocheilus melastigmus, Indian medaka, Java medaka, O. melastigma, marine medaka
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