STRINGSTRING
ENSOMEP00000000665 ENSOMEP00000000665 uimc1 uimc1 kat5 kat5 tp53bp1 tp53bp1 apbb1 apbb1 baz1b baz1b ENSOMEP00000002606 ENSOMEP00000002606 abl1 abl1 ENSOMEP00000002833 ENSOMEP00000002833 smarca5 smarca5 ENSOMEP00000003330 ENSOMEP00000003330 nsd2 nsd2 LOC112146732 LOC112146732 ENSOMEP00000031710 ENSOMEP00000031710 eya4 eya4 LOC112145672 LOC112145672 ube2i ube2i mre11 mre11 ENSOMEP00000029974 ENSOMEP00000029974 ENSOMEP00000029282 ENSOMEP00000029282 ube2n ube2n ENSOMEP00000027927 ENSOMEP00000027927 ENSOMEP00000027698 ENSOMEP00000027698 kxd1 kxd1 eya1 eya1 babam2 babam2 ENSOMEP00000026997 ENSOMEP00000026997 ENSOMEP00000026824 ENSOMEP00000026824 ENSOMEP00000026302 ENSOMEP00000026302 ENSOMEP00000025108 ENSOMEP00000025108 ENSOMEP00000024413 ENSOMEP00000024413 ENSOMEP00000023460 ENSOMEP00000023460 rnf8 rnf8 ENSOMEP00000021087 ENSOMEP00000021087 ENSOMEP00000020966 ENSOMEP00000020966 ENSOMEP00000020174 ENSOMEP00000020174 ENSOMEP00000019762 ENSOMEP00000019762 ankrd12 ankrd12 ENSOMEP00000016897 ENSOMEP00000016897 ENSOMEP00000016821 ENSOMEP00000016821 ankrd11 ankrd11 ENSOMEP00000015130 ENSOMEP00000015130 rnf168 rnf168 ENSOMEP00000013345 ENSOMEP00000013345 ENSOMEP00000013312 ENSOMEP00000013312 mdc1 mdc1 LOC112149581 LOC112149581 LOC112156701 LOC112156701 ENSOMEP00000009479 ENSOMEP00000009479 LOC112156259 LOC112156259 ENSOMEP00000009187 ENSOMEP00000009187 ENSOMEP00000009168 ENSOMEP00000009168 ENSOMEP00000009159 ENSOMEP00000009159 KPNA2 KPNA2 ENSOMEP00000007665 ENSOMEP00000007665 ENSOMEP00000007389 ENSOMEP00000007389 ENSOMEP00000007189 ENSOMEP00000007189 LOC112138059 LOC112138059 ENSOMEP00000006627 ENSOMEP00000006627 ENSOMEP00000006622 ENSOMEP00000006622 ENSOMEP00000006493 ENSOMEP00000006493 ube2v2 ube2v2 nbn nbn rad50 rad50 eya3 eya3 ENSOMEP00000004154 ENSOMEP00000004154 ENSOMEP00000004138 ENSOMEP00000004138 babam1 babam1 pias4 pias4 ENSOMEP00000035766 ENSOMEP00000035766 ENSOMEP00000035400 ENSOMEP00000035400 ppp5c ppp5c ENSOMEP00000034414 ENSOMEP00000034414 LOC112150551 LOC112150551 ENSOMEP00000033039 ENSOMEP00000033039 ENSOMEP00000032934 ENSOMEP00000032934 ENSOMEP00000032897 ENSOMEP00000032897 ENSOMEP00000032839 ENSOMEP00000032839 ENSOMEP00000000016 ENSOMEP00000000016
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSOMEP00000000665Reverse transcriptase domain-containing protein. (964 aa)
uimc1Uncharacterized protein. (838 aa)
kat5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (558 aa)
tp53bp1Tumor protein p53 binding protein, 1. (1505 aa)
apbb1Amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65). (683 aa)
baz1bBromodomain adjacent to zinc finger domain, 1B. (1608 aa)
ENSOMEP00000002606Uncharacterized protein. (161 aa)
abl1Tyrosine-protein kinase. (1083 aa)
ENSOMEP00000002833Ubiquitin A-52 residue ribosomal protein fusion product 1. (129 aa)
smarca5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1036 aa)
ENSOMEP00000003330RING-type domain-containing protein. (841 aa)
nsd2Nuclear receptor binding SET domain protein 2. (1279 aa)
LOC112146732UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
ENSOMEP00000031710Histone H2B; Belongs to the histone H2B family. (115 aa)
eya4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (642 aa)
LOC112145672Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (476 aa)
ube2iUbiquitin-conjugating enzyme E2Ib; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (691 aa)
ENSOMEP00000029974Reverse transcriptase domain-containing protein. (1319 aa)
ENSOMEP00000029282AAA_23 domain-containing protein. (51 aa)
ube2nUbiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
ENSOMEP00000027927Ubiquitin-like domain-containing protein. (77 aa)
ENSOMEP00000027698Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (96 aa)
kxd1KxDL motif containing 1. (195 aa)
eya1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (608 aa)
babam2BRISC and BRCA1 A complex member 2. (386 aa)
ENSOMEP00000026997BRCA1/BRCA2-containing complex, subunit 3. (262 aa)
ENSOMEP00000026824Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (98 aa)
ENSOMEP00000026302Si:dkey-261m9.6; Belongs to the histone H2B family. (111 aa)
ENSOMEP00000025108Reverse transcriptase domain-containing protein. (792 aa)
ENSOMEP00000024413Abraxas 1, BRCA1 A complex subunit. (356 aa)
ENSOMEP00000023460Uncharacterized protein. (85 aa)
rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (527 aa)
ENSOMEP00000021087ANK_REP_REGION domain-containing protein. (663 aa)
ENSOMEP00000020966Ribosomal protein S27a. (183 aa)
ENSOMEP00000020174Reverse transcriptase domain-containing protein. (460 aa)
ENSOMEP00000019762Reverse transcriptase domain-containing protein. (1029 aa)
ankrd12Ankyrin repeat domain 12. (1899 aa)
ENSOMEP00000016897Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (101 aa)
ENSOMEP00000016821Histone H2B; Belongs to the histone H2B family. (130 aa)
ankrd11Ankyrin repeat domain 11. (2829 aa)
ENSOMEP00000015130Histone H2B; Belongs to the histone H2B family. (114 aa)
rnf168RING-type domain-containing protein. (393 aa)
ENSOMEP00000013345Uncharacterized protein. (122 aa)
ENSOMEP00000013312Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (145 aa)
mdc1Uncharacterized protein. (1925 aa)
LOC112149581Histone H2A; Belongs to the histone H2A family. (138 aa)
LOC112156701UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (153 aa)
ENSOMEP00000009479Uncharacterized protein; Belongs to the histone H2A family. (245 aa)
LOC112156259Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (346 aa)
ENSOMEP00000009187Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (95 aa)
ENSOMEP00000009168Reverse transcriptase domain-containing protein. (962 aa)
ENSOMEP00000009159Histone H2B; Belongs to the histone H2B family. (110 aa)
KPNA2Importin subunit alpha; Belongs to the importin alpha family. (533 aa)
ENSOMEP00000007665Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (92 aa)
ENSOMEP00000007389Importin subunit alpha; Belongs to the importin alpha family. (517 aa)
ENSOMEP00000007189Reverse transcriptase domain-containing protein. (227 aa)
LOC112138059Histone H2B 1/2. (124 aa)
ENSOMEP00000006627Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (149 aa)
ENSOMEP00000006622Histone H2B; Belongs to the histone H2B family. (170 aa)
ENSOMEP00000006493Reverse transcriptase domain-containing protein. (1265 aa)
ube2v2Ubiquitin-conjugating enzyme E2 variant 2. (145 aa)
nbnNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (827 aa)
rad50RAD50 homolog, double strand break repair protein. (1311 aa)
eya3Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (574 aa)
ENSOMEP00000004154Uncharacterized protein. (133 aa)
ENSOMEP00000004138TAN domain-containing protein. (176 aa)
babam1BRISC and BRCA1 A complex member 1. (376 aa)
pias4Protein inhibitor of activated STAT, 4a. (503 aa)
ENSOMEP00000035766Reverse transcriptase domain-containing protein. (1156 aa)
ENSOMEP00000035400Ubiquitin-like domain-containing protein. (137 aa)
ppp5cSerine/threonine-protein phosphatase. (491 aa)
ENSOMEP00000034414Reverse transcriptase domain-containing protein. (1075 aa)
LOC112150551Lysine (K)-specific demethylase 4B. (1255 aa)
ENSOMEP00000033039Small ubiquitin-related modifier. (76 aa)
ENSOMEP00000032934Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (94 aa)
ENSOMEP00000032897Histone H2B; Belongs to the histone H2B family. (113 aa)
ENSOMEP00000032839Histone H2B; Belongs to the histone H2B family. (115 aa)
ENSOMEP00000000016Reverse transcriptase domain-containing protein. (913 aa)
Your Current Organism:
Oryzias melastigma
NCBI taxonomy Id: 30732
Other names: Aplocheilus melastigmus, Indian medaka, Java medaka, O. melastigma, marine medaka
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