60 items (Oryzias melastigma) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSOMEP00000020858	Poly [ADP-ribose] polymerase. (610 aa)
	vwa5b2	Von Willebrand factor A domain containing 5B2. (1396 aa)
	LOC112152588	Protein inhibitor of activated STAT, 1b. (658 aa)
	ENSOMEP00000016531	Ubiquitin-like domain-containing protein. (201 aa)
	gtf2h1	General transcription factor IIH, polypeptide 1. (550 aa)
	ENSOMEP00000015229	XPGN domain-containing protein. (301 aa)
	ENSOMEP00000015209	XPGI domain-containing protein. (382 aa)
	ENSOMEP00000014615	Cullin 4A; Belongs to the cullin family. (760 aa)
	ENSOMEP00000012865	Uncharacterized protein. (281 aa)
	wdr76	WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family. (595 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (649 aa)
	LOC112156701	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (153 aa)
	gtf2h5	General transcription factor IIH, polypeptide 5. (71 aa)
	ENSOMEP00000028097	Uncharacterized protein. (393 aa)
	ube2n	Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
	ENSOMEP00000027927	Ubiquitin-like domain-containing protein. (77 aa)
	kxd1	KxDL motif containing 1. (195 aa)
	ENSOMEP00000027295	Si:cabz01080528.1. (644 aa)
	ENSOMEP00000001119	Ring finger protein 111. (981 aa)
	kctd2	Potassium channel tetramerization domain containing 2. (276 aa)
	LOC112137766	General transcription factor IIH subunit. (392 aa)
	LOC112151659	Centrin 4. (171 aa)
	ENSOMEP00000002833	Ubiquitin A-52 residue ribosomal protein fusion product 1. (129 aa)
	LOC112146732	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
	rpa1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (598 aa)
	usp45	Ubiquitin carboxyl-terminal hydrolase. (794 aa)
	ENSOMEP00000005155	Damage-specific DNA binding protein 1. (1105 aa)
	ube2v2	Ubiquitin-conjugating enzyme E2 variant 2. (145 aa)
	mnat1	CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (311 aa)
	meiob	Methionine sulfoxide reductase B1b. (461 aa)
	xpa	Xeroderma pigmentosum, complementation group A. (275 aa)
	ENSOMEP00000006733	PARP-type domain-containing protein. (104 aa)
	ENSOMEP00000006747	Poly [ADP-ribose] polymerase. (395 aa)
	xpc	Xeroderma pigmentosum, complementation group C. (895 aa)
	RAD23B	RAD23 homolog B, nucleotide excision repair protein. (395 aa)
	gtf2h4	General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (460 aa)
	ercc4	Excision repair cross-complementation group 4. (917 aa)
	rpa3	Replication protein A3. (122 aa)
	ccnh	Cyclin H; Belongs to the cyclin family. (326 aa)
	ENSOMEP00000025024	Chromodomain helicase DNA binding protein 1-like. (843 aa)
	rbx1	Ring-box 1, E3 ubiquitin protein ligase. (108 aa)
	cdk7	Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (343 aa)
	ENSOMEP00000023320	Basic, immunoglobulin-like variable motif containing. (493 aa)
	gtf2h3	General transcription factor IIH, polypeptide 3. (300 aa)
	ercc1	Excision repair cross-complementation group 1. (403 aa)
	LOC112160828	Protein inhibitor of activated STAT, 1a. (716 aa)
	ENSOMEP00000035400	Ubiquitin-like domain-containing protein. (137 aa)
	ENSOMEP00000033845	Rad60-SLD domain-containing protein. (142 aa)
	ddb2	Damage-specific DNA binding protein 2. (476 aa)
	ENSOMEP00000033039	Small ubiquitin-related modifier. (76 aa)
	rpa2	Replication protein A2. (270 aa)
	ube2i	Ubiquitin-conjugating enzyme E2Ib; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
	ercc3	Excision repair cross-complementation group 3. (783 aa)
	cul4b	Cullin 4B; Belongs to the cullin family. (864 aa)
	sumo2	Small ubiquitin-related modifier. (115 aa)
	parp3	Poly [ADP-ribose] polymerase. (530 aa)
	LOC112155690	Small ubiquitin like modifier 3b. (137 aa)
	ercc2	Excision repair cross-complementation group 2. (760 aa)
	cetn3	Centrin 3. (194 aa)
	ENSOMEP00000020966	Ribosomal protein S27a. (183 aa)

Your Current Organism:

Oryzias melastigma

NCBI taxonomy Id: 30732
Other names: Aplocheilus melastigmus, Indian medaka, Java medaka, O. melastigma, marine medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSOMEP00000001119	ENSOMEP00000002833	ENSOMEP00000001119	ENSOMEP00000002833	Ring finger protein 111.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.889
ENSOMEP00000001119	ENSOMEP00000005155	ENSOMEP00000001119	ENSOMEP00000005155	Ring finger protein 111.	Damage-specific DNA binding protein 1.	0.629
ENSOMEP00000001119	ENSOMEP00000006733	ENSOMEP00000001119	ENSOMEP00000006733	Ring finger protein 111.	PARP-type domain-containing protein.	0.439
ENSOMEP00000001119	ENSOMEP00000006747	ENSOMEP00000001119	ENSOMEP00000006747	Ring finger protein 111.	Poly [ADP-ribose] polymerase.	0.439
ENSOMEP00000001119	ENSOMEP00000014615	ENSOMEP00000001119	ENSOMEP00000014615	Ring finger protein 111.	Cullin 4A; Belongs to the cullin family.	0.534
ENSOMEP00000001119	ENSOMEP00000016531	ENSOMEP00000001119	ENSOMEP00000016531	Ring finger protein 111.	Ubiquitin-like domain-containing protein.	0.657
ENSOMEP00000001119	ENSOMEP00000020858	ENSOMEP00000001119	ENSOMEP00000020858	Ring finger protein 111.	Poly [ADP-ribose] polymerase.	0.435
ENSOMEP00000001119	ENSOMEP00000020966	ENSOMEP00000001119	ENSOMEP00000020966	Ring finger protein 111.	Ribosomal protein S27a.	0.889
ENSOMEP00000001119	ENSOMEP00000025024	ENSOMEP00000001119	ENSOMEP00000025024	Ring finger protein 111.	Chromodomain helicase DNA binding protein 1-like.	0.597
ENSOMEP00000001119	ENSOMEP00000027927	ENSOMEP00000001119	ENSOMEP00000027927	Ring finger protein 111.	Ubiquitin-like domain-containing protein.	0.735
ENSOMEP00000001119	ENSOMEP00000028097	ENSOMEP00000001119	ENSOMEP00000028097	Ring finger protein 111.	Uncharacterized protein.	0.661
ENSOMEP00000001119	ENSOMEP00000033039	ENSOMEP00000001119	ENSOMEP00000033039	Ring finger protein 111.	Small ubiquitin-related modifier.	0.766
ENSOMEP00000001119	ENSOMEP00000035400	ENSOMEP00000001119	ENSOMEP00000035400	Ring finger protein 111.	Ubiquitin-like domain-containing protein.	0.824
ENSOMEP00000001119	LOC112146732	ENSOMEP00000001119	ENSOMEP00000003756	Ring finger protein 111.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.556
ENSOMEP00000001119	LOC112151659	ENSOMEP00000001119	ENSOMEP00000002361	Ring finger protein 111.	Centrin 4.	0.576
ENSOMEP00000001119	LOC112155690	ENSOMEP00000001119	ENSOMEP00000029603	Ring finger protein 111.	Small ubiquitin like modifier 3b.	0.657
ENSOMEP00000001119	LOC112156701	ENSOMEP00000001119	ENSOMEP00000009481	Ring finger protein 111.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.749
ENSOMEP00000001119	RAD23B	ENSOMEP00000001119	ENSOMEP00000007321	Ring finger protein 111.	RAD23 homolog B, nucleotide excision repair protein.	0.661
ENSOMEP00000001119	cul4b	ENSOMEP00000001119	ENSOMEP00000030585	Ring finger protein 111.	Cullin 4B; Belongs to the cullin family.	0.531
ENSOMEP00000001119	ddb2	ENSOMEP00000001119	ENSOMEP00000033412	Ring finger protein 111.	Damage-specific DNA binding protein 2.	0.652