STRINGSTRING
RPA1 RPA1 ENSOMEP00000010830 ENSOMEP00000010830 RCBTB1 RCBTB1 ENSOMEP00000011219 ENSOMEP00000011219 LOC112148474 LOC112148474 wdr76 wdr76 LOC112138175 LOC112138175 ENSOMEP00000012865 ENSOMEP00000012865 LOC112138173 LOC112138173 LOC112146405 LOC112146405 pole2 pole2 ino80e ino80e rfc4 rfc4 ENSOMEP00000014615 ENSOMEP00000014615 ino80b ino80b pold1 pold1 ENSOMEP00000015209 ENSOMEP00000015209 ENSOMEP00000015229 ENSOMEP00000015229 gtf2h1 gtf2h1 cops8 cops8 ENSOMEP00000016531 ENSOMEP00000016531 YY1 YY1 LOC112152588 LOC112152588 nfrkb nfrkb LOC112156383 LOC112156383 mcrs1 mcrs1 vwa5b2 vwa5b2 ENSOMEP00000020858 ENSOMEP00000020858 ENSOMEP00000020966 ENSOMEP00000020966 cetn3 cetn3 ercc2 ercc2 ENSOMEP00000021553 ENSOMEP00000021553 gtf2h3 gtf2h3 ENSOMEP00000023320 ENSOMEP00000023320 ino80 ino80 cdk7 cdk7 rbx1 rbx1 actr5 actr5 ENSOMEP00000025024 ENSOMEP00000025024 ccnh ccnh LOC112145411 LOC112145411 rpa3 rpa3 ercc4 ercc4 cops2 cops2 pole4 pole4 ENSOMEP00000027295 ENSOMEP00000027295 kxd1 kxd1 ENSOMEP00000027514 ENSOMEP00000027514 ENSOMEP00000027927 ENSOMEP00000027927 ube2n ube2n ENSOMEP00000028097 ENSOMEP00000028097 ENSOMEP00000028590 ENSOMEP00000028590 ENSOMEP00000028815 ENSOMEP00000028815 ENSOMEP00000028916 ENSOMEP00000028916 COPS6 COPS6 rfc2 rfc2 LOC112155690 LOC112155690 parp3 parp3 sumo2 sumo2 COPS7B COPS7B ercc3 ercc3 ube2i ube2i cops4 cops4 rpa2 rpa2 pcna pcna ENSOMEP00000033039 ENSOMEP00000033039 ENSOMEP00000033367 ENSOMEP00000033367 ddb2 ddb2 ENSOMEP00000033845 ENSOMEP00000033845 LOC112137204 LOC112137204 ENSOMEP00000035400 ENSOMEP00000035400 cul4b cul4b ercc1 ercc1 rcbtb2 rcbtb2 ENSOMEP00000001119 ENSOMEP00000001119 pold3 pold3 gps1 gps1 pole pole kctd2 kctd2 LOC112137766 LOC112137766 LOC112151659 LOC112151659 pole3 pole3 ENSOMEP00000002833 ENSOMEP00000002833 ino80c ino80c LOC112146732 LOC112146732 rpa1 rpa1 actb actb ENSOMEP00000004465 ENSOMEP00000004465 polk polk usp45 usp45 ENSOMEP00000005155 ENSOMEP00000005155 ube2v2 ube2v2 mnat1 mnat1 LOC112157444 LOC112157444 actr8 actr8 meiob meiob xpa xpa ENSOMEP00000006733 ENSOMEP00000006733 ENSOMEP00000006747 ENSOMEP00000006747 xpc xpc LOC112159947 LOC112159947 RAD23B RAD23B gtf2h4 gtf2h4 cops5 cops5 LOC112160828 LOC112160828 LOC112150438 LOC112150438 tfpt tfpt gtf2h5 gtf2h5 cops3 cops3 LOC112156701 LOC112156701
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (649 aa)
ENSOMEP00000010830Replication factor C (activator 1) 5. (326 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (527 aa)
ENSOMEP00000011219Uncharacterized protein. (96 aa)
LOC112148474Polymerase (DNA directed), delta 2, regulatory subunit. (471 aa)
wdr76WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family. (595 aa)
LOC112138175Uncharacterized protein. (375 aa)
ENSOMEP00000012865Uncharacterized protein. (281 aa)
LOC112138173Uncharacterized protein. (377 aa)
LOC112146405ATPase family AAA domain containing 5a. (1739 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (528 aa)
ino80eINO80 complex subunit E. (245 aa)
rfc4Replication factor C (activator 1) 4. (355 aa)
ENSOMEP00000014615Cullin 4A; Belongs to the cullin family. (760 aa)
ino80bINO80 complex subunit B. (338 aa)
pold1DNA polymerase. (1105 aa)
ENSOMEP00000015209XPGI domain-containing protein. (382 aa)
ENSOMEP00000015229XPGN domain-containing protein. (301 aa)
gtf2h1General transcription factor IIH, polypeptide 1. (550 aa)
cops8COP9 signalosome subunit 8. (192 aa)
ENSOMEP00000016531Ubiquitin-like domain-containing protein. (201 aa)
YY1YY1 transcription factor b. (391 aa)
LOC112152588Protein inhibitor of activated STAT, 1b. (658 aa)
nfrkbNuclear factor related to kappaB binding protein. (1274 aa)
LOC112156383Si:ch73-290k24.6. (761 aa)
mcrs1Microspherule protein 1. (461 aa)
vwa5b2Von Willebrand factor A domain containing 5B2. (1396 aa)
ENSOMEP00000020858Poly [ADP-ribose] polymerase. (610 aa)
ENSOMEP00000020966Ribosomal protein S27a. (183 aa)
cetn3Centrin 3. (194 aa)
ercc2Excision repair cross-complementation group 2. (760 aa)
ENSOMEP00000021553TPR_REGION domain-containing protein. (224 aa)
gtf2h3General transcription factor IIH, polypeptide 3. (300 aa)
ENSOMEP00000023320Basic, immunoglobulin-like variable motif containing. (493 aa)
ino80INO80 complex ATPase subunit. (1558 aa)
cdk7Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (343 aa)
rbx1Ring-box 1, E3 ubiquitin protein ligase. (108 aa)
actr5Actin related protein 5; Belongs to the actin family. (625 aa)
ENSOMEP00000025024Chromodomain helicase DNA binding protein 1-like. (843 aa)
ccnhCyclin H; Belongs to the cyclin family. (326 aa)
LOC112145411Uncharacterized protein. (349 aa)
rpa3Replication protein A3. (122 aa)
ercc4Excision repair cross-complementation group 4. (917 aa)
cops2COP9 signalosome subunit 2. (443 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (148 aa)
ENSOMEP00000027295Si:cabz01080528.1. (644 aa)
kxd1KxDL motif containing 1. (195 aa)
ENSOMEP00000027514RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (451 aa)
ENSOMEP00000027927Ubiquitin-like domain-containing protein. (77 aa)
ube2nUbiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
ENSOMEP00000028097Uncharacterized protein. (393 aa)
ENSOMEP00000028590Uncharacterized protein. (106 aa)
ENSOMEP00000028815Replication factor C (activator 1) 3. (279 aa)
ENSOMEP00000028916Replication factor C subunit 1. (1042 aa)
COPS6COP9 signalosome subunit 6. (323 aa)
rfc2Replication factor C (activator 1) 2. (357 aa)
LOC112155690Small ubiquitin like modifier 3b. (137 aa)
parp3Poly [ADP-ribose] polymerase. (530 aa)
sumo2Small ubiquitin-related modifier. (115 aa)
COPS7BCOP9 signalosome subunit 7B. (291 aa)
ercc3Excision repair cross-complementation group 3. (783 aa)
ube2iUbiquitin-conjugating enzyme E2Ib; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
cops4COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis). (406 aa)
rpa2Replication protein A2. (270 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
ENSOMEP00000033039Small ubiquitin-related modifier. (76 aa)
ENSOMEP00000033367RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (85 aa)
ddb2Damage-specific DNA binding protein 2. (476 aa)
ENSOMEP00000033845Rad60-SLD domain-containing protein. (142 aa)
LOC112137204Actin, beta 1. (375 aa)
ENSOMEP00000035400Ubiquitin-like domain-containing protein. (137 aa)
cul4bCullin 4B; Belongs to the cullin family. (864 aa)
ercc1Excision repair cross-complementation group 1. (403 aa)
rcbtb2Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (547 aa)
ENSOMEP00000001119Ring finger protein 111. (981 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (438 aa)
gps1G protein pathway suppressor 1. (487 aa)
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2291 aa)
kctd2Potassium channel tetramerization domain containing 2. (276 aa)
LOC112137766General transcription factor IIH subunit. (392 aa)
LOC112151659Centrin 4. (171 aa)
pole3Polymerase (DNA directed), epsilon 3 (p17 subunit). (147 aa)
ENSOMEP00000002833Ubiquitin A-52 residue ribosomal protein fusion product 1. (129 aa)
ino80cINO80 complex subunit C. (197 aa)
LOC112146732UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (598 aa)
actbActin beta. (375 aa)
ENSOMEP00000004465INO80 complex subunit Da. (1013 aa)
polkPolymerase (DNA directed) kappa. (847 aa)
usp45Ubiquitin carboxyl-terminal hydrolase. (794 aa)
ENSOMEP00000005155Damage-specific DNA binding protein 1. (1105 aa)
ube2v2Ubiquitin-conjugating enzyme E2 variant 2. (145 aa)
mnat1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (311 aa)
LOC112157444Uncharacterized protein. (506 aa)
actr8Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (642 aa)
meiobMethionine sulfoxide reductase B1b. (461 aa)
xpaXeroderma pigmentosum, complementation group A. (275 aa)
ENSOMEP00000006733PARP-type domain-containing protein. (104 aa)
ENSOMEP00000006747Poly [ADP-ribose] polymerase. (395 aa)
xpcXeroderma pigmentosum, complementation group C. (895 aa)
LOC112159947Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (573 aa)
RAD23BRAD23 homolog B, nucleotide excision repair protein. (395 aa)
gtf2h4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (460 aa)
cops5COP9 signalosome subunit 5. (334 aa)
LOC112160828Protein inhibitor of activated STAT, 1a. (716 aa)
LOC112150438SCY domain-containing protein. (126 aa)
tfptTCF3 (E2A) fusion partner. (195 aa)
gtf2h5General transcription factor IIH, polypeptide 5. (71 aa)
cops3COP9 signalosome subunit 3. (559 aa)
LOC112156701UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (153 aa)
Your Current Organism:
Oryzias melastigma
NCBI taxonomy Id: 30732
Other names: Aplocheilus melastigmus, Indian medaka, Java medaka, O. melastigma, marine medaka
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