52 items (Oryzias melastigma) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	ercc1	Excision repair cross-complementation group 1. (403 aa)
	rcbtb2	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (547 aa)
	pold3	Polymerase (DNA-directed), delta 3, accessory subunit. (438 aa)
	pole	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2291 aa)
	LOC112137766	General transcription factor IIH subunit. (392 aa)
	pole3	Polymerase (DNA directed), epsilon 3 (p17 subunit). (147 aa)
	ENSOMEP00000002833	Ubiquitin A-52 residue ribosomal protein fusion product 1. (129 aa)
	rpa1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (598 aa)
	polk	Polymerase (DNA directed) kappa. (847 aa)
	ENSOMEP00000005155	Damage-specific DNA binding protein 1. (1105 aa)
	xpa	Xeroderma pigmentosum, complementation group A. (275 aa)
	ENSOMEP00000035400	Ubiquitin-like domain-containing protein. (137 aa)
	ENSOMEP00000006733	PARP-type domain-containing protein. (104 aa)
	ENSOMEP00000006747	Poly [ADP-ribose] polymerase. (395 aa)
	LOC112159947	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (573 aa)
	gtf2h4	General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (460 aa)
	gtf2h5	General transcription factor IIH, polypeptide 5. (71 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (649 aa)
	ENSOMEP00000010830	Replication factor C (activator 1) 5. (326 aa)
	RCBTB1	RCC1 and BTB domain containing protein 1. (527 aa)
	ENSOMEP00000011219	Uncharacterized protein. (96 aa)
	LOC112148474	Polymerase (DNA directed), delta 2, regulatory subunit. (471 aa)
	ENSOMEP00000012865	Uncharacterized protein. (281 aa)
	pole2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (528 aa)
	rfc4	Replication factor C (activator 1) 4. (355 aa)
	ENSOMEP00000014615	Cullin 4A; Belongs to the cullin family. (760 aa)
	pold1	DNA polymerase. (1105 aa)
	ENSOMEP00000015209	XPGI domain-containing protein. (382 aa)
	ENSOMEP00000015229	XPGN domain-containing protein. (301 aa)
	gtf2h1	General transcription factor IIH, polypeptide 1. (550 aa)
	ENSOMEP00000020858	Poly [ADP-ribose] polymerase. (610 aa)
	ENSOMEP00000020966	Ribosomal protein S27a. (183 aa)
	ercc2	Excision repair cross-complementation group 2. (760 aa)
	gtf2h3	General transcription factor IIH, polypeptide 3. (300 aa)
	ddb2	Damage-specific DNA binding protein 2. (476 aa)
	ENSOMEP00000023320	Basic, immunoglobulin-like variable motif containing. (493 aa)
	rbx1	Ring-box 1, E3 ubiquitin protein ligase. (108 aa)
	ENSOMEP00000025024	Chromodomain helicase DNA binding protein 1-like. (843 aa)
	rpa3	Replication protein A3. (122 aa)
	ercc4	Excision repair cross-complementation group 4. (917 aa)
	pole4	Polymerase (DNA-directed), epsilon 4, accessory subunit. (148 aa)
	kxd1	KxDL motif containing 1. (195 aa)
	ENSOMEP00000027927	Ubiquitin-like domain-containing protein. (77 aa)
	ENSOMEP00000028590	Uncharacterized protein. (106 aa)
	ENSOMEP00000028815	Replication factor C (activator 1) 3. (279 aa)
	ENSOMEP00000028916	Replication factor C subunit 1. (1042 aa)
	rfc2	Replication factor C (activator 1) 2. (357 aa)
	parp3	Poly [ADP-ribose] polymerase. (530 aa)
	cul4b	Cullin 4B; Belongs to the cullin family. (864 aa)
	ercc3	Excision repair cross-complementation group 3. (783 aa)
	rpa2	Replication protein A2. (270 aa)

Your Current Organism:

Oryzias melastigma

NCBI taxonomy Id: 30732
Other names: Aplocheilus melastigmus, Indian medaka, Java medaka, O. melastigma, marine medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSOMEP00000002833	ENSOMEP00000005155	ENSOMEP00000002833	ENSOMEP00000005155	Ubiquitin A-52 residue ribosomal protein fusion product 1.	Damage-specific DNA binding protein 1.	0.682
ENSOMEP00000002833	ENSOMEP00000010830	ENSOMEP00000002833	ENSOMEP00000010830	Ubiquitin A-52 residue ribosomal protein fusion product 1.	Replication factor C (activator 1) 5.	0.672
ENSOMEP00000002833	ENSOMEP00000015209	ENSOMEP00000002833	ENSOMEP00000015209	Ubiquitin A-52 residue ribosomal protein fusion product 1.	XPGI domain-containing protein.	0.590
ENSOMEP00000002833	ENSOMEP00000015229	ENSOMEP00000002833	ENSOMEP00000015229	Ubiquitin A-52 residue ribosomal protein fusion product 1.	XPGN domain-containing protein.	0.590
ENSOMEP00000002833	ENSOMEP00000020966	ENSOMEP00000002833	ENSOMEP00000020966	Ubiquitin A-52 residue ribosomal protein fusion product 1.	Ribosomal protein S27a.	0.999
ENSOMEP00000002833	ENSOMEP00000023320	ENSOMEP00000002833	ENSOMEP00000023320	Ubiquitin A-52 residue ribosomal protein fusion product 1.	Basic, immunoglobulin-like variable motif containing.	0.590
ENSOMEP00000002833	ENSOMEP00000025024	ENSOMEP00000002833	ENSOMEP00000025024	Ubiquitin A-52 residue ribosomal protein fusion product 1.	Chromodomain helicase DNA binding protein 1-like.	0.781
ENSOMEP00000002833	ENSOMEP00000027927	ENSOMEP00000002833	ENSOMEP00000027927	Ubiquitin A-52 residue ribosomal protein fusion product 1.	Ubiquitin-like domain-containing protein.	0.989
ENSOMEP00000002833	ENSOMEP00000028815	ENSOMEP00000002833	ENSOMEP00000028815	Ubiquitin A-52 residue ribosomal protein fusion product 1.	Replication factor C (activator 1) 3.	0.672
ENSOMEP00000002833	ENSOMEP00000035400	ENSOMEP00000002833	ENSOMEP00000035400	Ubiquitin A-52 residue ribosomal protein fusion product 1.	Ubiquitin-like domain-containing protein.	0.999
ENSOMEP00000002833	LOC112159947	ENSOMEP00000002833	ENSOMEP00000007229	Ubiquitin A-52 residue ribosomal protein fusion product 1.	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1.	0.467
ENSOMEP00000002833	RCBTB1	ENSOMEP00000002833	ENSOMEP00000011023	Ubiquitin A-52 residue ribosomal protein fusion product 1.	RCC1 and BTB domain containing protein 1.	0.467
ENSOMEP00000002833	ercc3	ENSOMEP00000002833	ENSOMEP00000030867	Ubiquitin A-52 residue ribosomal protein fusion product 1.	Excision repair cross-complementation group 3.	0.693
ENSOMEP00000002833	gtf2h5	ENSOMEP00000002833	ENSOMEP00000009017	Ubiquitin A-52 residue ribosomal protein fusion product 1.	General transcription factor IIH, polypeptide 5.	0.673
ENSOMEP00000002833	kxd1	ENSOMEP00000002833	ENSOMEP00000027436	Ubiquitin A-52 residue ribosomal protein fusion product 1.	KxDL motif containing 1.	0.779
ENSOMEP00000002833	pcna	ENSOMEP00000002833	ENSOMEP00000032797	Ubiquitin A-52 residue ribosomal protein fusion product 1.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.972
ENSOMEP00000002833	pold1	ENSOMEP00000002833	ENSOMEP00000015183	Ubiquitin A-52 residue ribosomal protein fusion product 1.	DNA polymerase.	0.719
ENSOMEP00000002833	pole	ENSOMEP00000002833	ENSOMEP00000001907	Ubiquitin A-52 residue ribosomal protein fusion product 1.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.706
ENSOMEP00000002833	polk	ENSOMEP00000002833	ENSOMEP00000004587	Ubiquitin A-52 residue ribosomal protein fusion product 1.	Polymerase (DNA directed) kappa.	0.841
ENSOMEP00000002833	rbx1	ENSOMEP00000002833	ENSOMEP00000024715	Ubiquitin A-52 residue ribosomal protein fusion product 1.	Ring-box 1, E3 ubiquitin protein ligase.	0.969