STRINGSTRING
cdk2 cdk2 noc2l noc2l ENSOMEP00000000668 ENSOMEP00000000668 supt16h supt16h ankrd11 ankrd11 taf12 taf12 aurka aurka ENSOMEP00000015819 ENSOMEP00000015819 rbbp8 rbbp8 LOC112160752 LOC112160752 tbpl1 tbpl1 ENSOMEP00000014983 ENSOMEP00000014983 LOC112155400 LOC112155400 taf7l taf7l rfc4 rfc4 LOC112141166 LOC112141166 tp53rk tp53rk taf5l taf5l LOC112159789 LOC112159789 ENSOMEP00000011704 ENSOMEP00000011704 LOC112158875 LOC112158875 prkaa1 prkaa1 ccna1 ccna1 ENSOMEP00000010830 ENSOMEP00000010830 taf3 taf3 taf5 taf5 RPA1 RPA1 LOC112156259 LOC112156259 taf2 taf2 LOC112145399 LOC112145399 hus1 hus1 exo1 exo1 kat5 kat5 ccna2 ccna2 ENSOMEP00000002606 ENSOMEP00000002606 LOC112142430 LOC112142430 ENSOMEP00000002833 ENSOMEP00000002833 ENSOMEP00000002867 ENSOMEP00000002867 ENSOMEP00000003330 ENSOMEP00000003330 rpa1 rpa1 taf10 taf10 ENSOMEP00000004138 ENSOMEP00000004138 ENSOMEP00000004154 ENSOMEP00000004154 top3a top3a tbp tbp rad50 rad50 nbn nbn LOC112142205 LOC112142205 ENSOMEP00000005746 ENSOMEP00000005746 slf1 slf1 meiob meiob TAF4 TAF4 LOC112160004 LOC112160004 cdk5 cdk5 ENSOMEP00000006416 ENSOMEP00000006416 atrip atrip LOC112162629 LOC112162629 ENSOMEP00000007596 ENSOMEP00000007596 nuak1 nuak1 ssrp1 ssrp1 rad9a rad9a LOC112144746 LOC112144746 prkab1 prkab1 ENSOMEP00000033458 ENSOMEP00000033458 chek1 chek1 LOC112145151 LOC112145151 rpa2 rpa2 ENSOMEP00000032554 ENSOMEP00000032554 LOC112159487 LOC112159487 ENSOMEP00000031347 ENSOMEP00000031347 ENSOMEP00000031192 ENSOMEP00000031192 tdrd3 tdrd3 LOC112141860 LOC112141860 ENSOMEP00000030972 ENSOMEP00000030972 nuak2 nuak2 mre11 mre11 LOC112142861 LOC112142861 ENSOMEP00000029714 ENSOMEP00000029714 CSNK2A2 CSNK2A2 ENSOMEP00000029282 ENSOMEP00000029282 rfc2 rfc2 ENSOMEP00000029181 ENSOMEP00000029181 ENSOMEP00000028815 ENSOMEP00000028815 LOC112141961 LOC112141961 ENSOMEP00000028560 ENSOMEP00000028560 ENSOMEP00000027927 ENSOMEP00000027927 kxd1 kxd1 LOC112136370 LOC112136370 rad1 rad1 rpa3 rpa3 taf11 taf11 ENSOMEP00000024355 ENSOMEP00000024355 ENSOMEP00000024352 ENSOMEP00000024352 cdca7 cdca7 rhno1 rhno1 cdk5r1 cdk5r1 hipk3 hipk3 ENSOMEP00000023641 ENSOMEP00000023641 ENSOMEP00000023460 ENSOMEP00000023460 taf6 taf6 ENSOMEP00000021937 ENSOMEP00000021937 ENSOMEP00000021800 ENSOMEP00000021800 rmi2 rmi2 ENSOMEP00000021629 ENSOMEP00000021629 mdm2 mdm2 LOC112139315 LOC112139315 ENSOMEP00000021087 ENSOMEP00000021087 ENSOMEP00000020966 ENSOMEP00000020966 tpx2 tpx2 hipk2 hipk2 LOC112136917 LOC112136917 ENSOMEP00000020156 ENSOMEP00000020156 ENSOMEP00000020139 ENSOMEP00000020139 PRKAB2 PRKAB2 tp53inp1 tp53inp1 dyrk4 dyrk4 stk11 stk11 ankrd12 ankrd12 ENSOMEP00000018902 ENSOMEP00000018902 pin1 pin1 LOC112158855 LOC112158855 ENSOMEP00000018464 ENSOMEP00000018464 mapkapk5 mapkapk5 LOC112143884 LOC112143884 LOC112143536 LOC112143536 ENSOMEP00000017745 ENSOMEP00000017745 mdm4 mdm4 rmi1 rmi1 rad17 rad17 exd2 exd2 blm blm ENSOMEP00000035932 ENSOMEP00000035932 dyrk2 dyrk2 ENSOMEP00000035400 ENSOMEP00000035400
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
noc2lNOC2-like nucleolar associated transcriptional repressor. (748 aa)
ENSOMEP00000000668DNA topoisomerase II binding protein 1. (1377 aa)
supt16hSPT16 homolog, facilitates chromatin remodeling subunit. (1033 aa)
ankrd11Ankyrin repeat domain 11. (2829 aa)
taf12TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (131 aa)
aurkaAurora kinase A; Belongs to the protein kinase superfamily. (427 aa)
ENSOMEP00000015819Protein kinase domain-containing protein. (358 aa)
rbbp8Uncharacterized protein. (614 aa)
LOC112160752TAFH domain-containing protein. (1041 aa)
tbpl1TBP-like 1. (192 aa)
ENSOMEP00000014983Protein kinase domain-containing protein. (137 aa)
LOC112155400Cyclin-dependent kinase 5, regulatory subunit 2b (p39). (292 aa)
taf7lTAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (362 aa)
rfc4Replication factor C (activator 1) 4. (355 aa)
LOC112141166TAFH domain-containing protein. (897 aa)
tp53rkTP53 regulating kinase. (230 aa)
taf5lTAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor. (591 aa)
LOC112159789Si:ch211-117c9.1. (651 aa)
ENSOMEP00000011704Protein kinase, AMP-activated, gamma 3b non-catalytic subunit. (451 aa)
LOC112158875Uncharacterized protein. (292 aa)
prkaa1Non-specific serine/threonine protein kinase. (572 aa)
ccna1Cyclin A1; Belongs to the cyclin family. (457 aa)
ENSOMEP00000010830Replication factor C (activator 1) 5. (326 aa)
taf3TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto. (936 aa)
taf5TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (747 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (649 aa)
LOC112156259Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (346 aa)
taf2TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (1213 aa)
LOC112145399Protein kinase, AMP-activated, gamma 1 non-catalytic subunit. (330 aa)
hus1Checkpoint protein; Belongs to the HUS1 family. (283 aa)
exo1Exonuclease 1. (757 aa)
kat5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (558 aa)
ccna2Cyclin A2; Belongs to the cyclin family. (431 aa)
ENSOMEP00000002606Uncharacterized protein. (161 aa)
LOC112142430Transcription initiation factor TFIID subunit. (1985 aa)
ENSOMEP00000002833Ubiquitin A-52 residue ribosomal protein fusion product 1. (129 aa)
ENSOMEP00000002867Protein kinase, AMP-activated, gamma 2 non-catalytic subunit b. (409 aa)
ENSOMEP00000003330RING-type domain-containing protein. (841 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (598 aa)
taf10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (186 aa)
ENSOMEP00000004138TAN domain-containing protein. (176 aa)
ENSOMEP00000004154Uncharacterized protein. (133 aa)
top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1024 aa)
tbpTATA box binding protein. (302 aa)
rad50RAD50 homolog, double strand break repair protein. (1311 aa)
nbnNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (827 aa)
LOC112142205Uncharacterized protein. (295 aa)
ENSOMEP00000005746Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (357 aa)
slf1SMC5-SMC6 complex localization factor 1. (873 aa)
meiobMethionine sulfoxide reductase B1b. (461 aa)
TAF4TATA-box binding protein associated factor 4. (1002 aa)
LOC112160004Protein kinase, AMP-activated, gamma 3a non-catalytic subunit. (337 aa)
cdk5Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
ENSOMEP00000006416TAFH domain-containing protein. (662 aa)
atripUncharacterized protein. (739 aa)
LOC112162629Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (215 aa)
ENSOMEP00000007596Uncharacterized protein. (129 aa)
nuak1NUAK family, SNF1-like kinase, 1b. (640 aa)
ssrp1FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (704 aa)
rad9aCell cycle checkpoint control protein; Belongs to the rad9 family. (387 aa)
LOC112144746Dual specificity tyrosine phosphorylation regulated kinase 3. (605 aa)
prkab1Protein kinase, AMP-activated, beta 1 non-catalytic subunit, a. (269 aa)
ENSOMEP00000033458Protein kinase domain-containing protein. (422 aa)
chek1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (455 aa)
LOC112145151Si:ch211-160o17.4. (1135 aa)
rpa2Replication protein A2. (270 aa)
ENSOMEP00000032554Uncharacterized protein. (732 aa)
LOC112159487Homeodomain interacting protein kinase 1a. (1108 aa)
ENSOMEP00000031347Aurora kinase B; Belongs to the protein kinase superfamily. (312 aa)
ENSOMEP00000031192Uncharacterized protein. (116 aa)
tdrd3Tudor domain containing 3. (779 aa)
LOC112141860Uncharacterized protein. (284 aa)
ENSOMEP00000030972Protein kinase domain-containing protein. (401 aa)
nuak2NUAK family, SNF1-like kinase, 2. (621 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (691 aa)
LOC112142861TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (244 aa)
ENSOMEP00000029714Protein kinase domain-containing protein. (102 aa)
CSNK2A2Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (350 aa)
ENSOMEP00000029282AAA_23 domain-containing protein. (51 aa)
rfc2Replication factor C (activator 1) 2. (357 aa)
ENSOMEP00000029181Protein kinase domain-containing protein. (1250 aa)
ENSOMEP00000028815Replication factor C (activator 1) 3. (279 aa)
LOC112141961Cyclin-dependent kinase 5 activator. (334 aa)
ENSOMEP00000028560Casein kinase 2, alpha prime polypeptide a; Belongs to the protein kinase superfamily. (499 aa)
ENSOMEP00000027927Ubiquitin-like domain-containing protein. (77 aa)
kxd1KxDL motif containing 1. (195 aa)
LOC112136370Uncharacterized protein. (455 aa)
rad1RAD1 homolog (S. pombe). (279 aa)
rpa3Replication protein A3. (122 aa)
taf11TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (203 aa)
ENSOMEP00000024355Uncharacterized protein. (981 aa)
ENSOMEP00000024352Protein kinase domain-containing protein. (104 aa)
cdca7Cell division cycle associated 7a. (448 aa)
rhno1Si:ch73-352p4.5. (261 aa)
cdk5r1Cyclin-dependent kinase 5 activator. (302 aa)
hipk3Homeodomain interacting protein kinase 3b. (1346 aa)
ENSOMEP00000023641Protein kinase domain-containing protein. (95 aa)
ENSOMEP00000023460Uncharacterized protein. (85 aa)
taf6TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (638 aa)
ENSOMEP00000021937Uncharacterized protein. (304 aa)
ENSOMEP00000021800TAF4A RNA polymerase II, TATA box binding protein (TBP)-associated factor. (873 aa)
rmi2RecQ mediated genome instability 2. (140 aa)
ENSOMEP00000021629RecQ helicase-like 4. (991 aa)
mdm2MDM2 proto-oncogene; Belongs to the MDM2/MDM4 family. (497 aa)
LOC112139315Mitogen-activated protein kinase. (361 aa)
ENSOMEP00000021087ANK_REP_REGION domain-containing protein. (663 aa)
ENSOMEP00000020966Ribosomal protein S27a. (183 aa)
tpx2TPX2 microtubule nucleation factor. (703 aa)
hipk2Homeodomain interacting protein kinase 2. (1233 aa)
LOC112136917Cyclin-dependent kinase 5 activator. (331 aa)
ENSOMEP00000020156Uncharacterized protein. (127 aa)
ENSOMEP00000020139Non-specific serine/threonine protein kinase. (474 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (268 aa)
tp53inp1Tumor protein p53 inducible nuclear protein 1. (291 aa)
dyrk4Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4. (642 aa)
stk11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (440 aa)
ankrd12Ankyrin repeat domain 12. (1899 aa)
ENSOMEP00000018902Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (301 aa)
pin1Peptidyl-prolyl cis-trans isomerase. (156 aa)
LOC112158855Mitogen-activated protein kinase. (360 aa)
ENSOMEP00000018464TATA box binding protein like 2. (434 aa)
mapkapk5MAPK activated protein kinase 5. (469 aa)
LOC112143884Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (215 aa)
LOC112143536Zgc:86598; Belongs to the protein kinase superfamily. (392 aa)
ENSOMEP00000017745Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (281 aa)
mdm4MDM4 regulator of p53; Belongs to the MDM2/MDM4 family. (491 aa)
rmi1RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (647 aa)
rad17RAD17 checkpoint clamp loader component. (664 aa)
exd2Exonuclease 3'-5' domain containing 2. (627 aa)
blmBLM RecQ like helicase. (1368 aa)
ENSOMEP00000035932Mitogen-activated protein kinase. (351 aa)
dyrk2Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2. (580 aa)
ENSOMEP00000035400Ubiquitin-like domain-containing protein. (137 aa)
Your Current Organism:
Oryzias melastigma
NCBI taxonomy Id: 30732
Other names: Aplocheilus melastigmus, Indian medaka, Java medaka, O. melastigma, marine medaka
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