48 items (Oryzias melastigma) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ccna2	Cyclin A2; Belongs to the cyclin family. (431 aa)
	cdk1	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (303 aa)
	LOC112143020	Ubiquitin carboxyl-terminal hydrolase. (401 aa)
	LOC112163435	Ring finger protein 34b. (407 aa)
	daxx	Death-domain associated protein. (706 aa)
	kxd1	KxDL motif containing 1. (195 aa)
	ENSOMEP00000027927	Ubiquitin-like domain-containing protein. (77 aa)
	rictor	RPTOR independent companion of MTOR, complex 2 a. (1776 aa)
	ENSOMEP00000029329	Uncharacterized protein. (156 aa)
	ENSOMEP00000029380	Ring finger protein 34a. (394 aa)
	pdpk1	3-phosphoinositide dependent protein kinase 1b. (579 aa)
	SGK1	Non-specific serine/threonine protein kinase. (610 aa)
	prdm1	PR domain containing 1a, with ZNF domain. (848 aa)
	ENSOMEP00000032318	Ring finger and FYVE-like domain containing E3 ubiquitin protein ligase. (428 aa)
	mapkap1	MAPK associated protein 1. (529 aa)
	ENSOMEP00000034450	Ubiquitin specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family. (1117 aa)
	cdk2	Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
	ENSOMEP00000035400	Ubiquitin-like domain-containing protein. (137 aa)
	ENSOMEP00000036314	Tudor domain-containing protein. (147 aa)
	LOC112149180	Ubiquitin carboxyl-terminal hydrolase. (594 aa)
	ENSOMEP00000020966	Ribosomal protein S27a. (183 aa)
	mdm2	MDM2 proto-oncogene; Belongs to the MDM2/MDM4 family. (497 aa)
	ENSOMEP00000023460	Uncharacterized protein. (85 aa)
	ppp2ca	Serine/threonine-protein phosphatase. (309 aa)
	ENSOMEP00000025341	Uncharacterized protein. (745 aa)
	ENSOMEP00000025445	Cyclin G1; Belongs to the cyclin family. (273 aa)
	LOC112157322	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	ppp2cb	Serine/threonine-protein phosphatase. (309 aa)
	mdm4	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family. (491 aa)
	txndc11	Thioredoxin domain containing 11. (833 aa)
	akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
	ENSOMEP00000015819	Protein kinase domain-containing protein. (358 aa)
	LOC112140005	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	ENSOMEP00000014951	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (293 aa)
	ENSOMEP00000014890	Serine/threonine-protein kinase TOR. (1003 aa)
	ENSOMEP00000013464	Protein phosphatase 2, regulatory subunit A, beta b. (647 aa)
	ccna1	Cyclin A1; Belongs to the cyclin family. (457 aa)
	LOC112161991	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	LOC112156259	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (346 aa)
	LOC112158630	Uncharacterized protein. (470 aa)
	mlst8	MTOR associated protein, LST8 homolog (S. cerevisiae). (326 aa)
	ENSOMEP00000005632	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (483 aa)
	ENSOMEP00000005611	PR domain containing 1b, with ZNF domain. (550 aa)
	ENSOMEP00000004306	Uncharacterized protein. (70 aa)
	ENSOMEP00000004154	Uncharacterized protein. (133 aa)
	ENSOMEP00000004138	TAN domain-containing protein. (176 aa)
	ENSOMEP00000002833	Ubiquitin A-52 residue ribosomal protein fusion product 1. (129 aa)
	ENSOMEP00000002606	Uncharacterized protein. (161 aa)

Your Current Organism:

Oryzias melastigma

NCBI taxonomy Id: 30732
Other names: Aplocheilus melastigmus, Indian medaka, Java medaka, O. melastigma, marine medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSOMEP00000002606	ENSOMEP00000004138	ENSOMEP00000002606	ENSOMEP00000004138	Uncharacterized protein.	TAN domain-containing protein.	0.962
ENSOMEP00000002606	ENSOMEP00000004154	ENSOMEP00000002606	ENSOMEP00000004154	Uncharacterized protein.	Uncharacterized protein.	0.933
ENSOMEP00000002606	ENSOMEP00000014890	ENSOMEP00000002606	ENSOMEP00000014890	Uncharacterized protein.	Serine/threonine-protein kinase TOR.	0.521
ENSOMEP00000002606	ENSOMEP00000014951	ENSOMEP00000002606	ENSOMEP00000014951	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.521
ENSOMEP00000002606	ENSOMEP00000015819	ENSOMEP00000002606	ENSOMEP00000015819	Uncharacterized protein.	Protein kinase domain-containing protein.	0.517
ENSOMEP00000002606	ENSOMEP00000020966	ENSOMEP00000002606	ENSOMEP00000020966	Uncharacterized protein.	Ribosomal protein S27a.	0.662
ENSOMEP00000002606	ENSOMEP00000025445	ENSOMEP00000002606	ENSOMEP00000025445	Uncharacterized protein.	Cyclin G1; Belongs to the cyclin family.	0.493
ENSOMEP00000002606	ENSOMEP00000027927	ENSOMEP00000002606	ENSOMEP00000027927	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.553
ENSOMEP00000002606	ENSOMEP00000035400	ENSOMEP00000002606	ENSOMEP00000035400	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.629
ENSOMEP00000002606	LOC112156259	ENSOMEP00000002606	ENSOMEP00000009309	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.961
ENSOMEP00000002606	ccna1	ENSOMEP00000002606	ENSOMEP00000011174	Uncharacterized protein.	Cyclin A1; Belongs to the cyclin family.	0.422
ENSOMEP00000002606	ccna2	ENSOMEP00000002606	ENSOMEP00000002027	Uncharacterized protein.	Cyclin A2; Belongs to the cyclin family.	0.495
ENSOMEP00000002606	cdk1	ENSOMEP00000002606	ENSOMEP00000001417	Uncharacterized protein.	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	0.517
ENSOMEP00000002606	cdk2	ENSOMEP00000002606	ENSOMEP00000035386	Uncharacterized protein.	Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily.	0.517
ENSOMEP00000002606	mdm2	ENSOMEP00000002606	ENSOMEP00000021574	Uncharacterized protein.	MDM2 proto-oncogene; Belongs to the MDM2/MDM4 family.	0.862
ENSOMEP00000002606	mdm4	ENSOMEP00000002606	ENSOMEP00000017594	Uncharacterized protein.	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family.	0.805
ENSOMEP00000002606	ppp2ca	ENSOMEP00000002606	ENSOMEP00000023461	Uncharacterized protein.	Serine/threonine-protein phosphatase.	0.595
ENSOMEP00000002606	ppp2cb	ENSOMEP00000002606	ENSOMEP00000027023	Uncharacterized protein.	Serine/threonine-protein phosphatase.	0.595
ENSOMEP00000002833	ENSOMEP00000005632	ENSOMEP00000002833	ENSOMEP00000005632	Ubiquitin A-52 residue ribosomal protein fusion product 1.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.414
ENSOMEP00000002833	ENSOMEP00000013464	ENSOMEP00000002833	ENSOMEP00000013464	Ubiquitin A-52 residue ribosomal protein fusion product 1.	Protein phosphatase 2, regulatory subunit A, beta b.	0.667