65 items (Oryzias melastigma) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rb1	Retinoblastoma 1. (948 aa)
	fndc3a	Fibronectin type III domain containing 3A. (1238 aa)
	ppp4r4	Protein phosphatase 4, regulatory subunit 4. (901 aa)
	ENSOMEP00000035400	Ubiquitin-like domain-containing protein. (137 aa)
	cdk2	Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
	LOC112152245	Cyclin D2, a; Belongs to the cyclin family. (356 aa)
	LOC112163244	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (445 aa)
	skp2	S-phase kinase-associated protein 2, E3 ubiquitin protein ligase. (428 aa)
	ENSOMEP00000032207	Retinoblastoma-like 1 (p107). (1040 aa)
	ENSOMEP00000031576	Fibronectin type III domain containing 3Ba. (1233 aa)
	ENSOMEP00000030940	Tyrosine-protein kinase. (496 aa)
	LOC112144588	Cyclin-dependent kinase inhibitor 1A. (164 aa)
	ENSOMEP00000029634	E2F_CC-MB domain-containing protein. (190 aa)
	ENSOMEP00000028239	Si:ch211-160f23.5. (422 aa)
	ppp2r3c	Protein phosphatase 2, regulatory subunit B'', gamma. (457 aa)
	ENSOMEP00000027927	Ubiquitin-like domain-containing protein. (77 aa)
	kxd1	KxDL motif containing 1. (195 aa)
	ppp2cb	Serine/threonine-protein phosphatase. (309 aa)
	LOC112150937	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (108 aa)
	ccnh	Cyclin H; Belongs to the cyclin family. (326 aa)
	cul1	Cullin 1b; Belongs to the cullin family. (777 aa)
	LOC112154304	Cyclin D2, b; Belongs to the cyclin family. (306 aa)
	cdk7	Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (343 aa)
	ENSOMEP00000024089	Uncharacterized protein. (154 aa)
	ppp2ca	Serine/threonine-protein phosphatase. (309 aa)
	LOC112160553	E2F_TDP domain-containing protein. (308 aa)
	LOC112163270	Tyrosine-protein kinase. (1131 aa)
	fnbp4	Formin binding protein 4. (870 aa)
	ENSOMEP00000020966	Ribosomal protein S27a. (183 aa)
	cdk4	Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (320 aa)
	ccne2	Cyclin E2; Belongs to the cyclin family. (395 aa)
	ccne1	Cyclin E1; Belongs to the cyclin family. (423 aa)
	e2f4	E2F transcription factor 4. (386 aa)
	ENSOMEP00000016436	Cyclin Dx; Belongs to the cyclin family. (302 aa)
	ENSOMEP00000015819	Protein kinase domain-containing protein. (358 aa)
	LOC112158705	Tyrosine-protein kinase. (551 aa)
	cdkn2d	Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4). (211 aa)
	cdk6	Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (325 aa)
	LOC112145374	Protein phosphatase 2, regulatory subunit B'', alpha. (1361 aa)
	LOC112144604	Cyclin D3; Belongs to the cyclin family. (303 aa)
	ENSOMEP00000013464	Protein phosphatase 2, regulatory subunit A, beta b. (647 aa)
	PPP2R3B	Protein phosphatase 2 regulatory subunit B''beta. (601 aa)
	ENSOMEP00000012955	Uncharacterized protein. (171 aa)
	e2f1	E2F transcription factor 1. (475 aa)
	LOC112158072	Cyclin-dependent kinase inhibitor 1D. (177 aa)
	relch	RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1187 aa)
	src	Tyrosine-protein kinase. (550 aa)
	E2F3	E2F transcription factor 3. (443 aa)
	ppp4r1	WRNPLPNID domain-containing protein. (964 aa)
	ENSOMEP00000011997	Tyrosine-protein kinase. (1090 aa)
	ENSOMEP00000011929	E2F_TDP domain-containing protein. (81 aa)
	ENSOMEP00000011443	Cyclin D1; Belongs to the cyclin family. (290 aa)
	LOC112147850	E2F transcription factor 5. (362 aa)
	LOC112153781	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (446 aa)
	LOC112148067	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (449 aa)
	tfdp1	Transcription factor. (413 aa)
	cdkn2c	Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4). (168 aa)
	cdkn1b	Cyclin-dependent kinase inhibitor 1Bb. (180 aa)
	LOC112157283	Cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4). (129 aa)
	mnat1	CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (311 aa)
	LOC112162651	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (129 aa)
	cdkn1c	Uncharacterized protein. (207 aa)
	ENSOMEP00000002833	Ubiquitin A-52 residue ribosomal protein fusion product 1. (129 aa)
	abl1	Tyrosine-protein kinase. (1083 aa)
	skp1	S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)

Your Current Organism:

Oryzias melastigma

NCBI taxonomy Id: 30732
Other names: Aplocheilus melastigmus, Indian medaka, Java medaka, O. melastigma, marine medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
E2F3	ENSOMEP00000011443	ENSOMEP00000012035	ENSOMEP00000011443	E2F transcription factor 3.	Cyclin D1; Belongs to the cyclin family.	0.670
E2F3	ENSOMEP00000012955	ENSOMEP00000012035	ENSOMEP00000012955	E2F transcription factor 3.	Uncharacterized protein.	0.549
E2F3	ENSOMEP00000015819	ENSOMEP00000012035	ENSOMEP00000015819	E2F transcription factor 3.	Protein kinase domain-containing protein.	0.773
E2F3	ENSOMEP00000016436	ENSOMEP00000012035	ENSOMEP00000016436	E2F transcription factor 3.	Cyclin Dx; Belongs to the cyclin family.	0.454
E2F3	ENSOMEP00000024089	ENSOMEP00000012035	ENSOMEP00000024089	E2F transcription factor 3.	Uncharacterized protein.	0.549
E2F3	ENSOMEP00000028239	ENSOMEP00000012035	ENSOMEP00000028239	E2F transcription factor 3.	Si:ch211-160f23.5.	0.889
E2F3	ENSOMEP00000032207	ENSOMEP00000012035	ENSOMEP00000032207	E2F transcription factor 3.	Retinoblastoma-like 1 (p107).	0.990
E2F3	LOC112144588	ENSOMEP00000012035	ENSOMEP00000030582	E2F transcription factor 3.	Cyclin-dependent kinase inhibitor 1A.	0.549
E2F3	LOC112144604	ENSOMEP00000012035	ENSOMEP00000013566	E2F transcription factor 3.	Cyclin D3; Belongs to the cyclin family.	0.454
E2F3	LOC112147850	ENSOMEP00000012035	ENSOMEP00000010433	E2F transcription factor 3.	E2F transcription factor 5.	0.863
E2F3	LOC112150937	ENSOMEP00000012035	ENSOMEP00000026393	E2F transcription factor 3.	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	0.504
E2F3	LOC112152245	ENSOMEP00000012035	ENSOMEP00000034308	E2F transcription factor 3.	Cyclin D2, a; Belongs to the cyclin family.	0.670
E2F3	LOC112154304	ENSOMEP00000012035	ENSOMEP00000024286	E2F transcription factor 3.	Cyclin D2, b; Belongs to the cyclin family.	0.670
E2F3	LOC112158072	ENSOMEP00000012035	ENSOMEP00000012834	E2F transcription factor 3.	Cyclin-dependent kinase inhibitor 1D.	0.549
E2F3	LOC112160553	ENSOMEP00000012035	ENSOMEP00000022821	E2F transcription factor 3.	E2F_TDP domain-containing protein.	0.471
E2F3	LOC112162651	ENSOMEP00000012035	ENSOMEP00000005356	E2F transcription factor 3.	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	0.504
E2F3	ccne1	ENSOMEP00000012035	ENSOMEP00000019713	E2F transcription factor 3.	Cyclin E1; Belongs to the cyclin family.	0.847
E2F3	ccne2	ENSOMEP00000012035	ENSOMEP00000019850	E2F transcription factor 3.	Cyclin E2; Belongs to the cyclin family.	0.847
E2F3	cdk2	ENSOMEP00000012035	ENSOMEP00000035386	E2F transcription factor 3.	Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily.	0.927
E2F3	cdk4	ENSOMEP00000012035	ENSOMEP00000020317	E2F transcription factor 3.	Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily.	0.668