STRINGSTRING
psme2 psme2 ENSOMEP00000000357 ENSOMEP00000000357 psmd8 psmd8 ENSOMEP00000000533 ENSOMEP00000000533 mcm8 mcm8 psmd9 psmd9 prim2 prim2 rcbtb2 rcbtb2 lig1 lig1 ENSOMEP00000035400 ENSOMEP00000035400 cdk2 cdk2 gins1 gins1 cdc23 cdc23 ENSOMEP00000034970 ENSOMEP00000034970 ENSOMEP00000034008 ENSOMEP00000034008 LOC112140154 LOC112140154 LOC112137884 LOC112137884 psma3 psma3 psmb3 psmb3 pcna pcna rpa2 rpa2 skp2 skp2 LOC112150025 LOC112150025 LOC112137399 LOC112137399 LOC112137393 LOC112137393 LOC112137408 LOC112137408 anapc5 anapc5 psme1 psme1 ENSOMEP00000031513 ENSOMEP00000031513 anapc2 anapc2 cdc16 cdc16 psmd10 psmd10 LOC112147746 LOC112147746 psmc2 psmc2 rfc2 rfc2 ENSOMEP00000028916 ENSOMEP00000028916 ENSOMEP00000028815 ENSOMEP00000028815 ENSOMEP00000028753 ENSOMEP00000028753 ENSOMEP00000028590 ENSOMEP00000028590 ENSOMEP00000028219 ENSOMEP00000028219 ENSOMEP00000027927 ENSOMEP00000027927 ENSOMEP00000027783 ENSOMEP00000027783 gins4 gins4 gins3 gins3 kxd1 kxd1 ENSOMEP00000027431 ENSOMEP00000027431 orc3 orc3 pole4 pole4 psmd7 psmd7 LOC112147217 LOC112147217 mcm5 mcm5 ENSOMEP00000026888 ENSOMEP00000026888 psmd12 psmd12 rpa3 rpa3 psma4 psma4 ENSOMEP00000025203 ENSOMEP00000025203 psmb2 psmb2 cul1 cul1 rbx1 rbx1 LOC112150731 LOC112150731 psmc4 psmc4 ENSOMEP00000024355 ENSOMEP00000024355 ENSOMEP00000024214 ENSOMEP00000024214 gins2 gins2 mcm2 mcm2 cdt1 cdt1 ENSOMEP00000021566 ENSOMEP00000021566 fam89a fam89a tm7sf3 tm7sf3 ENSOMEP00000020966 ENSOMEP00000020966 psmc5 psmc5 psmd1 psmd1 ccne2 ccne2 ccne1 ccne1 ENSOMEP00000019316 ENSOMEP00000019316 FZR1 FZR1 cdc26 cdc26 orc4 orc4 LOC112140152 LOC112140152 LOC112140153 LOC112140153 ENSOMEP00000017782 ENSOMEP00000017782 psmb7 psmb7 ENSOMEP00000015819 ENSOMEP00000015819 psma2 psma2 LOC112136178 LOC112136178 pold1 pold1 orc1 orc1 fen1 fen1 ENSOMEP00000014230 ENSOMEP00000014230 cdc27 cdc27 rfc4 rfc4 mcm3 mcm3 pole2 pole2 LOC112146405 LOC112146405 psmd14 psmd14 ENSOMEP00000013031 ENSOMEP00000013031 ENSOMEP00000012830 ENSOMEP00000012830 psmc1 psmc1 LOC112147624 LOC112147624 ENSOMEP00000011806 ENSOMEP00000011806 psmf1 psmf1 LOC112148474 LOC112148474 ENSOMEP00000011219 ENSOMEP00000011219 mcm7 mcm7 pola1 pola1 ccna1 ccna1 gmnn gmnn RCBTB1 RCBTB1 MCM9 MCM9 ENSOMEP00000010830 ENSOMEP00000010830 psmc6 psmc6 psmd13 psmd13 orc2 orc2 mcm6 mcm6 RPA1 RPA1 ube2s ube2s ENSOMEP00000008693 ENSOMEP00000008693 LOC112150438 LOC112150438 psmd6 psmd6 LOC112159947 LOC112159947 ENSOMEP00000007070 ENSOMEP00000007070 psmb6 psmb6 meiob meiob bicral bicral anapc11 anapc11 ENSOMEP00000005576 ENSOMEP00000005576 prim1 prim1 PSMD4 PSMD4 psmb1 psmb1 psmc3 psmc3 psma5 psma5 LOC112144185 LOC112144185 rpa1 rpa1 psme3 psme3 psma8 psma8 psmd11 psmd11 ENSOMEP00000002833 ENSOMEP00000002833 skp1 skp1 pole3 pole3 LOC112136564 LOC112136564 psma1 psma1 ccna2 ccna2 pole pole anapc15 anapc15 pold3 pold3 ube2c ube2c
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
psme2Proteasome activator subunit 2. (243 aa)
ENSOMEP00000000357BRD4 interacting chromatin remodeling complex associated protein. (1683 aa)
psmd8Proteasome 26S subunit, non-ATPase 8. (265 aa)
ENSOMEP00000000533Proteasome activator subunit 4a. (1817 aa)
mcm8Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (868 aa)
psmd9Proteasome 26S subunit, non-ATPase 9. (212 aa)
prim2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (498 aa)
rcbtb2Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (547 aa)
lig1DNA ligase. (971 aa)
ENSOMEP00000035400Ubiquitin-like domain-containing protein. (137 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
gins1GINS complex subunit 1 (Psf1 homolog). (195 aa)
cdc23CDC23 (cell division cycle 23, yeast, homolog). (642 aa)
ENSOMEP00000034970Anaphase promoting complex subunit 7. (565 aa)
ENSOMEP00000034008Proteasome subunit beta 9a. (114 aa)
LOC112140154Proteasome subunit beta 12. (217 aa)
LOC112137884Ubiquitin-conjugating enzyme E2E 1; Belongs to the ubiquitin-conjugating enzyme family. (208 aa)
psma3Proteasome subunit alpha type. (255 aa)
psmb3Proteasome subunit beta. (206 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
rpa2Replication protein A2. (270 aa)
skp2S-phase kinase-associated protein 2, E3 ubiquitin protein ligase. (428 aa)
LOC112150025Proteasome subunit alpha type. (246 aa)
LOC112137399Proteasome subunit beta. (272 aa)
LOC112137393Proteasome subunit beta. (275 aa)
LOC112137408Proteasome subunit beta 12. (217 aa)
anapc5Anaphase promoting complex subunit 5. (773 aa)
psme1Proteasome activator subunit 1. (261 aa)
ENSOMEP00000031513ANAPC4_WD40 domain-containing protein. (206 aa)
anapc2Anaphase promoting complex subunit 2; Belongs to the cullin family. (806 aa)
cdc16Cell division cycle 16 homolog (S. cerevisiae). (618 aa)
psmd10Proteasome 26S subunit, non-ATPase 10. (226 aa)
LOC112147746Proteasome subunit beta. (298 aa)
psmc2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
rfc2Replication factor C (activator 1) 2. (357 aa)
ENSOMEP00000028916Replication factor C subunit 1. (1042 aa)
ENSOMEP00000028815Replication factor C (activator 1) 3. (279 aa)
ENSOMEP00000028753Anaphase promoting complex subunit 16. (135 aa)
ENSOMEP00000028590Uncharacterized protein. (106 aa)
ENSOMEP00000028219Proteasome endopeptidase complex. (228 aa)
ENSOMEP00000027927Ubiquitin-like domain-containing protein. (77 aa)
ENSOMEP00000027783Proteasome subunit beta; Belongs to the peptidase T1B family. (225 aa)
gins4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa)
gins3GINS complex subunit 3. (211 aa)
kxd1KxDL motif containing 1. (195 aa)
ENSOMEP00000027431BLM10_mid domain-containing protein. (548 aa)
orc3Origin recognition complex, subunit 3. (716 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (148 aa)
psmd7Proteasome 26S subunit, non-ATPase 7. (324 aa)
LOC112147217Fizzy/cell division cycle 20 related 1b. (487 aa)
mcm5DNA helicase; Belongs to the MCM family. (737 aa)
ENSOMEP00000026888Proteasome 26S subunit, non-ATPase 5. (475 aa)
psmd12Proteasome 26S subunit, non-ATPase 12. (456 aa)
rpa3Replication protein A3. (122 aa)
psma4Proteasome subunit alpha type. (261 aa)
ENSOMEP00000025203Proteasome 26S subunit, non-ATPase 4b. (367 aa)
psmb2Proteasome subunit beta. (199 aa)
cul1Cullin 1b; Belongs to the cullin family. (777 aa)
rbx1Ring-box 1, E3 ubiquitin protein ligase. (108 aa)
LOC112150731Proteasome subunit beta11b. (359 aa)
psmc4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (417 aa)
ENSOMEP00000024355Uncharacterized protein. (981 aa)
ENSOMEP00000024214Origin recognition complex, subunit 5. (465 aa)
gins2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (186 aa)
mcm2DNA helicase; Belongs to the MCM family. (887 aa)
cdt1Chromatin licensing and DNA replication factor 1. (580 aa)
ENSOMEP00000021566Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (217 aa)
fam89aFamily with sequence similarity 89 member A. (175 aa)
tm7sf3Transmembrane 7 superfamily member 3. (563 aa)
ENSOMEP00000020966Ribosomal protein S27a. (183 aa)
psmc5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
psmd126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (961 aa)
ccne2Cyclin E2; Belongs to the cyclin family. (395 aa)
ccne1Cyclin E1; Belongs to the cyclin family. (423 aa)
ENSOMEP00000019316Proteasome 26S subunit, non-ATPase 3. (567 aa)
FZR1Fizzy/cell division cycle 20 related 1a. (498 aa)
cdc26Cell division cycle 26 homolog. (93 aa)
orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (433 aa)
LOC112140152Proteasome subunit beta. (275 aa)
LOC112140153Proteasome subunit beta. (275 aa)
ENSOMEP00000017782DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (577 aa)
psmb7Proteasome subunit beta. (307 aa)
ENSOMEP00000015819Protein kinase domain-containing protein. (358 aa)
psma2Proteasome subunit alpha type. (234 aa)
LOC112136178Proteasome subunit beta. (216 aa)
pold1DNA polymerase. (1105 aa)
orc1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (907 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
ENSOMEP00000014230Zgc:110269. (346 aa)
cdc27Cell division cycle 27. (802 aa)
rfc4Replication factor C (activator 1) 4. (355 aa)
mcm3DNA helicase; Belongs to the MCM family. (817 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (528 aa)
LOC112146405ATPase family AAA domain containing 5a. (1739 aa)
psmd14Proteasome 26S subunit, non-ATPase 14. (310 aa)
ENSOMEP00000013031Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (452 aa)
ENSOMEP00000012830Proteasome subunit alpha type. (292 aa)
psmc1Proteasome 26S subunit, ATPase 1b; Belongs to the AAA ATPase family. (440 aa)
LOC112147624Proteasome subunit beta. (271 aa)
ENSOMEP00000011806Anaphase promoting complex subunit 1. (1855 aa)
psmf1Proteasome inhibitor subunit 1. (313 aa)
LOC112148474Polymerase (DNA directed), delta 2, regulatory subunit. (471 aa)
ENSOMEP00000011219Uncharacterized protein. (96 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (727 aa)
pola1DNA polymerase. (1460 aa)
ccna1Cyclin A1; Belongs to the cyclin family. (457 aa)
gmnnGeminin DNA replication inhibitor. (227 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (527 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1100 aa)
ENSOMEP00000010830Replication factor C (activator 1) 5. (326 aa)
psmc6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (389 aa)
psmd13Proteasome 26S subunit, non-ATPase 13. (378 aa)
orc2Origin recognition complex, subunit 2. (564 aa)
mcm6DNA helicase; Belongs to the MCM family. (827 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (649 aa)
ube2sUbiquitin-conjugating enzyme E2S; Belongs to the ubiquitin-conjugating enzyme family. (232 aa)
ENSOMEP00000008693DUF3437 domain-containing protein. (181 aa)
LOC112150438SCY domain-containing protein. (126 aa)
psmd6Proteasome 26S subunit, non-ATPase 6. (389 aa)
LOC112159947Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (573 aa)
ENSOMEP00000007070VWFA domain-containing protein. (229 aa)
psmb6Proteasome subunit beta. (232 aa)
meiobMethionine sulfoxide reductase B1b. (461 aa)
bicralBRD4 interacting chromatin remodeling complex associated protein like. (773 aa)
anapc11APC11 anaphase promoting complex subunit 11 homolog (yeast). (84 aa)
ENSOMEP00000005576DNA helicase; Belongs to the MCM family. (894 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (424 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4a. (372 aa)
psmb1Proteasome subunit beta. (237 aa)
psmc3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (427 aa)
psma5Proteasome subunit alpha type. (241 aa)
LOC112144185Proteasome subunit beta. (278 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (598 aa)
psme3Proteasome activator subunit 3. (256 aa)
psma8Proteasome subunit alpha type. (251 aa)
psmd11Proteasome 26S subunit, non-ATPase 11b. (422 aa)
ENSOMEP00000002833Ubiquitin A-52 residue ribosomal protein fusion product 1. (129 aa)
skp1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
pole3Polymerase (DNA directed), epsilon 3 (p17 subunit). (147 aa)
LOC112136564UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (194 aa)
psma1Proteasome subunit alpha type. (267 aa)
ccna2Cyclin A2; Belongs to the cyclin family. (431 aa)
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2291 aa)
anapc15Anaphase promoting complex subunit 15. (122 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (438 aa)
ube2cUbiquitin-conjugating enzyme E2C; Belongs to the ubiquitin-conjugating enzyme family. (223 aa)
Your Current Organism:
Oryzias melastigma
NCBI taxonomy Id: 30732
Other names: Aplocheilus melastigmus, Indian medaka, Java medaka, O. melastigma, marine medaka
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