(15 nodes) Activation of the TFAP2 (AP-2) family of transcription factors network (Oryzias melastigma)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC112146043	E1A binding protein p300 b. (2771 aa)
	LOC112153984	E1A binding protein p300 a. (2690 aa)
	LOC112158661	Uncharacterized protein. (226 aa)
	ENSOMEP00000005158	Transcription factor AP-2 epsilon. (407 aa)
	LOC112136154	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4a. (231 aa)
	LOC112145778	Transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma). (467 aa)
	LOC112144014	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4b. (252 aa)
	cited1	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1. (162 aa)
	tfap2b	Transcription factor AP-2 beta. (444 aa)
	tfap2d	Transcription factor AP-2 delta (activating enhancer binding protein 2 delta). (457 aa)
	wwox	WW domain containing oxidoreductase. (412 aa)
	ENSOMEP00000027151	YEATS domain containing 4. (226 aa)
	crebbp	CREB binding protein b. (2411 aa)
	ENSOMEP00000004505	CREB binding protein a. (2295 aa)
	tfap2a	Transcription factor AP-2 alpha. (431 aa)

Your Current Organism:

Oryzias melastigma

NCBI taxonomy Id: 30732
Other names: Aplocheilus melastigmus, Indian medaka, Java medaka, O. melastigma, marine medaka

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSOMEP00000004505	ENSOMEP00000005158	ENSOMEP00000004505	ENSOMEP00000005158	CREB binding protein a.	Transcription factor AP-2 epsilon.	0.560
ENSOMEP00000004505	LOC112136154	ENSOMEP00000004505	ENSOMEP00000033959	CREB binding protein a.	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4a.	0.909
ENSOMEP00000004505	LOC112144014	ENSOMEP00000004505	ENSOMEP00000016506	CREB binding protein a.	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4b.	0.909
ENSOMEP00000004505	LOC112145778	ENSOMEP00000004505	ENSOMEP00000031647	CREB binding protein a.	Transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma).	0.560
ENSOMEP00000004505	LOC112146043	ENSOMEP00000004505	ENSOMEP00000004390	CREB binding protein a.	E1A binding protein p300 b.	0.987
ENSOMEP00000004505	LOC112153984	ENSOMEP00000004505	ENSOMEP00000007732	CREB binding protein a.	E1A binding protein p300 a.	0.987
ENSOMEP00000004505	cited1	ENSOMEP00000004505	ENSOMEP00000018439	CREB binding protein a.	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1.	0.798
ENSOMEP00000004505	crebbp	ENSOMEP00000004505	ENSOMEP00000027588	CREB binding protein a.	CREB binding protein b.	0.885
ENSOMEP00000004505	tfap2a	ENSOMEP00000004505	ENSOMEP00000014227	CREB binding protein a.	Transcription factor AP-2 alpha.	0.560
ENSOMEP00000004505	tfap2b	ENSOMEP00000004505	ENSOMEP00000021533	CREB binding protein a.	Transcription factor AP-2 beta.	0.560
ENSOMEP00000004505	tfap2d	ENSOMEP00000004505	ENSOMEP00000021546	CREB binding protein a.	Transcription factor AP-2 delta (activating enhancer binding protein 2 delta).	0.696
ENSOMEP00000005158	ENSOMEP00000004505	ENSOMEP00000005158	ENSOMEP00000004505	Transcription factor AP-2 epsilon.	CREB binding protein a.	0.560
ENSOMEP00000005158	ENSOMEP00000027151	ENSOMEP00000005158	ENSOMEP00000027151	Transcription factor AP-2 epsilon.	YEATS domain containing 4.	0.654
ENSOMEP00000005158	LOC112136154	ENSOMEP00000005158	ENSOMEP00000033959	Transcription factor AP-2 epsilon.	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4a.	0.641
ENSOMEP00000005158	LOC112144014	ENSOMEP00000005158	ENSOMEP00000016506	Transcription factor AP-2 epsilon.	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4b.	0.641
ENSOMEP00000005158	LOC112146043	ENSOMEP00000005158	ENSOMEP00000004390	Transcription factor AP-2 epsilon.	E1A binding protein p300 b.	0.570
ENSOMEP00000005158	LOC112153984	ENSOMEP00000005158	ENSOMEP00000007732	Transcription factor AP-2 epsilon.	E1A binding protein p300 a.	0.570
ENSOMEP00000005158	LOC112158661	ENSOMEP00000005158	ENSOMEP00000008327	Transcription factor AP-2 epsilon.	Uncharacterized protein.	0.654
ENSOMEP00000005158	cited1	ENSOMEP00000005158	ENSOMEP00000018439	Transcription factor AP-2 epsilon.	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1.	0.497
ENSOMEP00000005158	crebbp	ENSOMEP00000005158	ENSOMEP00000027588	Transcription factor AP-2 epsilon.	CREB binding protein b.	0.560