104 items (Oryzias melastigma) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	psmd8	Proteasome 26S subunit, non-ATPase 8. (265 aa)
	LOC112136593	Mothers against decapentaplegic homolog. (536 aa)
	ccn2	Cellular communication network factor 2a. (363 aa)
	ENSOMEP00000023058	Mothers against decapentaplegic homolog. (493 aa)
	zfhx3	Zinc finger homeobox 3. (3860 aa)
	maml2	MamL-1 domain-containing protein. (879 aa)
	yap1	Yes-associated protein 1. (458 aa)
	mdm2	MDM2 proto-oncogene; Belongs to the MDM2/MDM4 family. (497 aa)
	LOC112148176	Mothers against decapentaplegic homolog. (510 aa)
	kat2a	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (810 aa)
	ENSOMEP00000020966	Ribosomal protein S27a. (183 aa)
	psmc5	Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
	LOC112149754	Transforming growth factor beta; Belongs to the TGF-beta family. (379 aa)
	ENSOMEP00000020433	Mastermind-like transcriptional coactivator 1. (754 aa)
	hes1	Hairy-related 6. (274 aa)
	psmd1	26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (961 aa)
	ENSOMEP00000019316	Proteasome 26S subunit, non-ATPase 3. (567 aa)
	LOC112140153	Proteasome subunit beta. (275 aa)
	psmb7	Proteasome subunit beta. (307 aa)
	psma2	Proteasome subunit alpha type. (234 aa)
	LOC112136178	Proteasome subunit beta. (216 aa)
	LOC112158705	Tyrosine-protein kinase. (551 aa)
	LOC112141162	TEA domain family member 1a. (427 aa)
	tead3	Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (493 aa)
	LOC112144436	Uncharacterized protein. (225 aa)
	psmd14	Proteasome 26S subunit, non-ATPase 14. (310 aa)
	ENSOMEP00000013068	Recombination signal binding protein for immunoglobulin kappa J region a. (461 aa)
	ENSOMEP00000012830	Proteasome subunit alpha type. (292 aa)
	psmc1	Proteasome 26S subunit, ATPase 1b; Belongs to the AAA ATPase family. (440 aa)
	runx3	Runt-related transcription factor. (417 aa)
	src	Tyrosine-protein kinase. (550 aa)
	LOC112147624	Proteasome subunit beta. (271 aa)
	psmf1	Proteasome inhibitor subunit 1. (313 aa)
	ENSOMEP00000011443	Cyclin D1; Belongs to the cyclin family. (290 aa)
	psmc6	Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (389 aa)
	psmd13	Proteasome 26S subunit, non-ATPase 13. (378 aa)
	LOC112163232	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (794 aa)
	LOC112156259	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (346 aa)
	LOC112163451	Notch receptor 1a. (2477 aa)
	psmd6	Proteasome 26S subunit, non-ATPase 6. (389 aa)
	ENSOMEP00000008043	Notch receptor 1b. (2317 aa)
	LOC112153984	E1A binding protein p300 a. (2690 aa)
	LOC112139978	Recombination signal binding protein for immunoglobulin kappa J region-like. (526 aa)
	LOC112146480	E3 ubiquitin-protein ligase. (770 aa)
	ENSOMEP00000007070	VWFA domain-containing protein. (229 aa)
	ENSOMEP00000006737	TEA domain-containing protein. (407 aa)
	LOC112136477	Hairy-related 8.2. (182 aa)
	psmb6	Proteasome subunit beta. (232 aa)
	ENSOMEP00000006088	Homeobox domain-containing protein. (163 aa)
	PSMD4	Proteasome 26S subunit, non-ATPase 4a. (372 aa)
	ENSOMEP00000004505	CREB binding protein a. (2295 aa)
	psmb1	Proteasome subunit beta. (237 aa)
	psmc3	Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (427 aa)
	LOC112146043	E1A binding protein p300 b. (2771 aa)
	psma5	Proteasome subunit alpha type. (241 aa)
	LOC112144185	Proteasome subunit beta. (278 aa)
	psme3	Proteasome activator subunit 3. (256 aa)
	psmd11	Proteasome 26S subunit, non-ATPase 11b. (422 aa)
	ENSOMEP00000002833	Ubiquitin A-52 residue ribosomal protein fusion product 1. (129 aa)
	tcf7	Transcription factor 7. (525 aa)
	psma1	Proteasome subunit alpha type. (267 aa)
	fndc3a	Fibronectin type III domain containing 3A. (1238 aa)
	TEAD1	TEA domain family member 1b. (474 aa)
	psmd9	Proteasome 26S subunit, non-ATPase 9. (212 aa)
	psme2	Proteasome activator subunit 2. (243 aa)
	ENSOMEP00000035400	Ubiquitin-like domain-containing protein. (137 aa)
	hes4	Hairy-related 9. (291 aa)
	maml3	Mastermind-like transcriptional coactivator 3. (1142 aa)
	snw1	SNW domain containing 1. (564 aa)
	ENSOMEP00000034008	Proteasome subunit beta 9a. (114 aa)
	LOC112140154	Proteasome subunit beta 12. (217 aa)
	psma3	Proteasome subunit alpha type. (255 aa)
	psmd2	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (906 aa)
	psmb3	Proteasome subunit beta. (206 aa)
	LOC112150025	Proteasome subunit alpha type. (246 aa)
	LOC112137399	Proteasome subunit beta. (272 aa)
	LOC112137408	Proteasome subunit beta 12. (217 aa)
	ENSOMEP00000031576	Fibronectin type III domain containing 3Ba. (1233 aa)
	psme1	Proteasome activator subunit 1. (261 aa)
	ctnnb1	Catenin (cadherin-associated protein), beta 1. (783 aa)
	ENSOMEP00000030764	Core-binding factor subunit beta. (266 aa)
	ENSOMEP00000030540	TEA domain-containing protein. (417 aa)
	tcf7l2	Transcription factor 7 like 2. (628 aa)
	zfhx4	Zinc finger homeobox 4. (3747 aa)
	psmd10	Proteasome 26S subunit, non-ATPase 10. (226 aa)
	rbpj	Recombination signal binding protein for immunoglobulin kappa J region. (570 aa)
	psmc2	Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
	ENSOMEP00000028219	Proteasome endopeptidase complex. (228 aa)
	ENSOMEP00000027783	Proteasome subunit beta; Belongs to the peptidase T1B family. (225 aa)
	LOC112148818	Transcription factor 7 like 1b. (577 aa)
	crebbp	CREB binding protein b. (2411 aa)
	psmd7	Proteasome 26S subunit, non-ATPase 7. (324 aa)
	SMURF2	E3 ubiquitin-protein ligase. (775 aa)
	ENSOMEP00000026888	Proteasome 26S subunit, non-ATPase 5. (475 aa)
	psmd12	Proteasome 26S subunit, non-ATPase 12. (456 aa)
	ENSOMEP00000026430	HMG box domain-containing protein. (293 aa)
	ENSOMEP00000025730	Uncharacterized protein. (759 aa)
	psma4	Proteasome subunit alpha type. (261 aa)
	ENSOMEP00000025203	Proteasome 26S subunit, non-ATPase 4b. (367 aa)
	psmb2	Proteasome subunit beta. (199 aa)
	ENSOMEP00000024995	Lymphoid enhancer-binding factor 1. (363 aa)
	psmc4	Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (417 aa)
	smurf1	E3 ubiquitin-protein ligase. (731 aa)
	LOC112162929	HMG box domain-containing protein. (539 aa)

Your Current Organism:

Oryzias melastigma

NCBI taxonomy Id: 30732
Other names: Aplocheilus melastigmus, Indian medaka, Java medaka, O. melastigma, marine medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSOMEP00000002833	ENSOMEP00000004505	ENSOMEP00000002833	ENSOMEP00000004505	Ubiquitin A-52 residue ribosomal protein fusion product 1.	CREB binding protein a.	0.610
ENSOMEP00000002833	ENSOMEP00000007070	ENSOMEP00000002833	ENSOMEP00000007070	Ubiquitin A-52 residue ribosomal protein fusion product 1.	VWFA domain-containing protein.	0.959
ENSOMEP00000002833	ENSOMEP00000012830	ENSOMEP00000002833	ENSOMEP00000012830	Ubiquitin A-52 residue ribosomal protein fusion product 1.	Proteasome subunit alpha type.	0.951
ENSOMEP00000002833	ENSOMEP00000019316	ENSOMEP00000002833	ENSOMEP00000019316	Ubiquitin A-52 residue ribosomal protein fusion product 1.	Proteasome 26S subunit, non-ATPase 3.	0.970
ENSOMEP00000002833	ENSOMEP00000020433	ENSOMEP00000002833	ENSOMEP00000020433	Ubiquitin A-52 residue ribosomal protein fusion product 1.	Mastermind-like transcriptional coactivator 1.	0.467
ENSOMEP00000002833	ENSOMEP00000020966	ENSOMEP00000002833	ENSOMEP00000020966	Ubiquitin A-52 residue ribosomal protein fusion product 1.	Ribosomal protein S27a.	0.999
ENSOMEP00000002833	ENSOMEP00000025203	ENSOMEP00000002833	ENSOMEP00000025203	Ubiquitin A-52 residue ribosomal protein fusion product 1.	Proteasome 26S subunit, non-ATPase 4b.	0.959
ENSOMEP00000002833	ENSOMEP00000026888	ENSOMEP00000002833	ENSOMEP00000026888	Ubiquitin A-52 residue ribosomal protein fusion product 1.	Proteasome 26S subunit, non-ATPase 5.	0.678
ENSOMEP00000002833	ENSOMEP00000027783	ENSOMEP00000002833	ENSOMEP00000027783	Ubiquitin A-52 residue ribosomal protein fusion product 1.	Proteasome subunit beta; Belongs to the peptidase T1B family.	0.974
ENSOMEP00000002833	ENSOMEP00000028219	ENSOMEP00000002833	ENSOMEP00000028219	Ubiquitin A-52 residue ribosomal protein fusion product 1.	Proteasome endopeptidase complex.	0.951
ENSOMEP00000002833	ENSOMEP00000031576	ENSOMEP00000002833	ENSOMEP00000031576	Ubiquitin A-52 residue ribosomal protein fusion product 1.	Fibronectin type III domain containing 3Ba.	0.497
ENSOMEP00000002833	ENSOMEP00000034008	ENSOMEP00000002833	ENSOMEP00000034008	Ubiquitin A-52 residue ribosomal protein fusion product 1.	Proteasome subunit beta 9a.	0.889
ENSOMEP00000002833	ENSOMEP00000035400	ENSOMEP00000002833	ENSOMEP00000035400	Ubiquitin A-52 residue ribosomal protein fusion product 1.	Ubiquitin-like domain-containing protein.	0.999
ENSOMEP00000002833	LOC112136178	ENSOMEP00000002833	ENSOMEP00000015483	Ubiquitin A-52 residue ribosomal protein fusion product 1.	Proteasome subunit beta.	0.889
ENSOMEP00000002833	LOC112137399	ENSOMEP00000002833	ENSOMEP00000031974	Ubiquitin A-52 residue ribosomal protein fusion product 1.	Proteasome subunit beta.	0.931
ENSOMEP00000002833	LOC112137408	ENSOMEP00000002833	ENSOMEP00000031958	Ubiquitin A-52 residue ribosomal protein fusion product 1.	Proteasome subunit beta 12.	0.889
ENSOMEP00000002833	LOC112140153	ENSOMEP00000002833	ENSOMEP00000018565	Ubiquitin A-52 residue ribosomal protein fusion product 1.	Proteasome subunit beta.	0.931
ENSOMEP00000002833	LOC112140154	ENSOMEP00000002833	ENSOMEP00000034000	Ubiquitin A-52 residue ribosomal protein fusion product 1.	Proteasome subunit beta 12.	0.889
ENSOMEP00000002833	LOC112144185	ENSOMEP00000002833	ENSOMEP00000003923	Ubiquitin A-52 residue ribosomal protein fusion product 1.	Proteasome subunit beta.	0.918
ENSOMEP00000002833	LOC112146043	ENSOMEP00000002833	ENSOMEP00000004390	Ubiquitin A-52 residue ribosomal protein fusion product 1.	E1A binding protein p300 b.	0.599